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  1. Book: The immune synapse

    Baldari, Cosima Tatiana / Dustin, Michael L.

    methods and protocols

    (Methods in molecular biology ; 2654 ; Springer protocols)

    2023  

    Author's details edited by Cosima T. Baldari, Michael L. Dustin
    Series title Methods in molecular biology ; 2654
    Springer protocols
    Collection
    Language English
    Size xvi, 516 Seiten, Illustrationen
    Edition Second edition
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT030007389
    ISBN 978-1-0716-3134-8 ; 9781071631355 ; 1-0716-3134-9 ; 1071631357
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Recent advances in understanding TCR signaling: a synaptic perspective.

    Dustin, Michael L

    Faculty reviews

    2023  Volume 12, Page(s) 25

    Abstract: The T cell receptor is a multi-subunit complex that carries out a range of recognition tasks for multiple lymphocyte types and translates recognition into signals that regulate survival, growth, differentiation, and effector functions for innate and ... ...

    Abstract The T cell receptor is a multi-subunit complex that carries out a range of recognition tasks for multiple lymphocyte types and translates recognition into signals that regulate survival, growth, differentiation, and effector functions for innate and adaptive host defense. Recent advances include the cryo-electron microscopy-based structure of the extracellular and transmembrane components of the complex, new information about coupling to intracellular partners, lateral associations in the membrane that all add to our picture of the T cell signaling machinery, and how signal termination relates to effector function. This review endeavors to integrate structural and biochemical information through the lens of the immunological synapse- the critical interface with the antigen-presenting cell.
    Language English
    Publishing date 2023-10-16
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2732-432X
    ISSN (online) 2732-432X
    DOI 10.12703/r/12-25
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: The immune synapse

    Baldari, Cosima T. / Dustin, Michael L.

    methods and protocols

    (Methods in molecular biology ; 1584 ; Springer protocols)

    2017  

    Series title Methods in molecular biology ; 1584
    Springer protocols
    Collection
    Keywords B cell ; T-cell ; immune interactions ; immune synapse ; mast cell immune synapses ; vesicular traffic
    Language English
    Size XIII, 588 S. : Ill., graph. Darst., 25.4 cm x 17.8 cm, 0 g
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT019203383
    ISBN 978-1-4939-6879-4 ; 1-4939-6879-3 ; 9781493968817 ; 1493968815
    Database Catalogue ZB MED Medicine, Health

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  4. Article ; Online: Clathrin controls bidirectional communication between T cells and antigen presenting cells.

    Kvalvaag, Audun / Dustin, Michael L

    BioEssays : news and reviews in molecular, cellular and developmental biology

    2024  Volume 46, Issue 4, Page(s) e2300230

    Abstract: In circulation, T cells are spherical with selectin enriched dynamic microvilli protruding from the surface. Following extravasation, these microvilli serve another role, continuously surveying their environment for antigen in the form of peptide-MHC ( ... ...

    Abstract In circulation, T cells are spherical with selectin enriched dynamic microvilli protruding from the surface. Following extravasation, these microvilli serve another role, continuously surveying their environment for antigen in the form of peptide-MHC (pMHC) expressed on the surface of antigen presenting cells (APCs). Upon recognition of their cognate pMHC, the microvilli are initially stabilized and then flatten into F-actin dependent microclusters as the T cell spreads over the APC. Within 1-5 min, clathrin is recruited by the ESCRT-0 component Hrs to mediate release of T cell receptor (TCR) loaded vesicles directly from the plasma membrane by clathrin and ESCRT-mediated ectocytosis (CEME). After 5-10 min, Hrs is displaced by the endocytic clathrin adaptor epsin-1 to induce clathrin-mediated trans-endocytosis (CMTE) of TCR-pMHC conjugates. Here we discuss some of the functional properties of the clathrin machinery which enables it to control these topologically opposite modes of membrane transfer at the immunological synapse, and how this might be regulated during T cell activation.
    MeSH term(s) T-Lymphocytes ; Clathrin/metabolism ; Antigen-Presenting Cells/metabolism ; Receptors, Antigen, T-Cell ; Endocytosis/physiology ; Endosomal Sorting Complexes Required for Transport/metabolism ; Communication
    Chemical Substances Clathrin ; Receptors, Antigen, T-Cell ; Endosomal Sorting Complexes Required for Transport
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 50140-2
    ISSN 1521-1878 ; 0265-9247
    ISSN (online) 1521-1878
    ISSN 0265-9247
    DOI 10.1002/bies.202300230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The staying power of hematopoietic stem cells.

    Dustin, Michael L

    The Journal of cell biology

    2021  Volume 220, Issue 11

    Abstract: Hematopoietic stem and progenitor cells (HSPCs) use specialized adhesive structures referred to as magnupodium to stay in hematopoietic niches. Bessey et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202005085) define new characteristics of the ... ...

    Abstract Hematopoietic stem and progenitor cells (HSPCs) use specialized adhesive structures referred to as magnupodium to stay in hematopoietic niches. Bessey et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202005085) define new characteristics of the magnupodium, including centriole polarization and the necessary and sufficient role of CXCR4 signaling.
    MeSH term(s) Centrioles ; Hematopoietic Stem Cells ; Signal Transduction
    Language English
    Publishing date 2021-10-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.202109019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Tireless surveillance by exhausted T cells.

    Dustin, Michael L

    The Journal of clinical investigation

    2021  Volume 131, Issue 18

    Abstract: T cell exhaustion is an evocative concept that results in attenuated function in the face of chronic antigen exposure and is critical to avoid immunopathology. However, tumors often exploit this dampened T cell function to escape the antitumor immune ... ...

    Abstract T cell exhaustion is an evocative concept that results in attenuated function in the face of chronic antigen exposure and is critical to avoid immunopathology. However, tumors often exploit this dampened T cell function to escape the antitumor immune response. In this issue of the JCI, You et al. investigated a different aspect of T cell exhaustion in the setting of tumor immunity by characterizing the capacity of T cells for tireless migration. The dynamic nature of normal T cells was first made famous by intravital microscopy studies in explanted tissues. You et al. used a similar imaging strategy with reanimated human tumors, in which exhausted T cells displayed an enhanced capacity for intratumoral motility. These results suggest that exhausted T cells may be able to teach T cell engineers lessons about navigating within the tumor microenvironment.
    MeSH term(s) CD8-Positive T-Lymphocytes ; Humans ; Immunity ; Neoplasms ; Tumor Microenvironment
    Language English
    Publishing date 2021-09-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI152382
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  7. Book: Cell:cell contacts

    Batista, Facundo D. / Dustin, Michael L.

    (Immunological reviews ; 251)

    2013  

    Author's details Facundo D. Batista ; Michael L. Dustin, guest ed
    Series title Immunological reviews ; 251
    Collection
    Language English
    Size 214 S. : Ill., graph. Darst.
    Publisher Wiley-Blackwell
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT017521980
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Se 160 -251- verfügbar in Königswinter Königswinter

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  8. Article ; Online: Editorial: Mechanisms of lymphocyte mediated cytotoxicity in health and disease.

    Baldari, Cosima T / Valitutti, Salvatore / Dustin, Michael L

    Frontiers in immunology

    2023  Volume 14, Page(s) 1226870

    MeSH term(s) Cytotoxicity, Immunologic ; T-Lymphocytes, Cytotoxic
    Language English
    Publishing date 2023-05-31
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1226870
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Magnesium for T cells: strong to the finish!

    Vardhana, Santosha / Dustin, Michael L

    Trends in immunology

    2022  Volume 43, Issue 4, Page(s) 277–279

    Abstract: Popeye, the Sailor' cartoons taught children that eating spinach boosts strength and helps defend against bullies. Lötscher and colleagues report that dietary deficiency of magnesium ions ( ... ...

    Abstract 'Popeye, the Sailor' cartoons taught children that eating spinach boosts strength and helps defend against bullies. Lötscher and colleagues report that dietary deficiency of magnesium ions (Mg
    MeSH term(s) CD8-Positive T-Lymphocytes ; Cell Adhesion Molecules ; Child ; Humans ; Lymphocyte Function-Associated Antigen-1 ; Magnesium
    Chemical Substances Cell Adhesion Molecules ; Lymphocyte Function-Associated Antigen-1 ; Magnesium (I38ZP9992A)
    Language English
    Publishing date 2022-03-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2022.02.004
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  10. Article ; Online: Goldilocks and the three TILs.

    Dada, Hannah / Dustin, Michael L

    The Journal of experimental medicine

    2022  Volume 219, Issue 2

    Abstract: In this issue of JEM, Shakiba et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20201966) tell a tale of three tumor infiltrating lymphocytes (TILs). The first TIL was too strong and became exhausted. The second TIL was too weak and became inert. ... ...

    Abstract In this issue of JEM, Shakiba et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20201966) tell a tale of three tumor infiltrating lymphocytes (TILs). The first TIL was too strong and became exhausted. The second TIL was too weak and became inert. The third TIL lost CD8, and this made it just right.
    MeSH term(s) Lymphocytes, Tumor-Infiltrating
    Language English
    Publishing date 2022-01-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20212269
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