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  1. Article ; Online: Osteocalcin: A Multifaceted Bone-Derived Hormone.

    Karsenty, Gerard

    Annual review of nutrition

    2023  Volume 43, Page(s) 55–71

    Abstract: Together, loss- and gain-of-function experiments have identified the bone-derived secreted molecule osteocalcin as a hormone with a broad reach in rodents and primates. Following its binding to one of three receptors, osteocalcin exerts a profound ... ...

    Abstract Together, loss- and gain-of-function experiments have identified the bone-derived secreted molecule osteocalcin as a hormone with a broad reach in rodents and primates. Following its binding to one of three receptors, osteocalcin exerts a profound influence on various aspects of energy metabolism as well as steroidogenesis, neurotransmitter biosynthesis and thereby male fertility, electrolyte homeostasis, cognition, the acute stress response, and exercise capacity. Although this review focuses mostly on the regulation of energy metabolism by osteocalcin, it also touches on its other functions. Lastly, it proposes what could be a common theme between the functions of osteocalcin and between these functions and the structural functions of bone.
    MeSH term(s) Animals ; Male ; Biological Transport ; Cognition ; Energy Metabolism ; Osteocalcin ; Stress Disorders, Traumatic, Acute ; Humans
    Chemical Substances Osteocalcin (104982-03-8) ; BGLAP protein, human
    Language English
    Publishing date 2023-08-20
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 406980-8
    ISSN 1545-4312 ; 0199-9885
    ISSN (online) 1545-4312
    ISSN 0199-9885
    DOI 10.1146/annurev-nutr-061121-091348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1786: Show issues Location:
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  2. Book: Translational endocrinology of bone

    Karsenty, Gerard

    reproduction, metabolism, and the central nervous system

    2013  

    Abstract: The use of model organisms together with the power of genetics has profoundly affected our understanding of the physiology of one organ, the skeleton, in two distinct but complementary ways. This is the first translational reference to focus on these ... ...

    Author's details ed. by Gerard Karsenty
    Abstract The use of model organisms together with the power of genetics has profoundly affected our understanding of the physiology of one organ, the skeleton, in two distinct but complementary ways. This is the first translational reference to focus on these major conceptual advances in bone biology and their development in the clinic. Several advances have already been translated into therapies and others are being tested for diseases as different as osteoporosis, type-2 diabetes, and hypo-fertility. This book is a timely reference for both basic and clinical researchers in bone biology and endocrinology. Summarizes the latest research and translational applications of how the varied growth and development of bone affects appetite, metabolism, reproduction, and a wide range of endocrine functions Provides a common language for bone biologists, endocrinologists, osteologists, and other researchers, such as neuroscientists, who study appetite, fuel metabolism and diabetes, to discuss the development of translational research and new therapeutic strategies for bone, metabolic, and neuro-endocrine diseases. Saves researchers and clinicians time in quickly accessing the very latest details on a broad range of bone research and therapeutics, as opposed to searching through thousands of journal articles
    Keywords Bone and Bones / metabolism ; Bone and Bones / physiology ; Bone Development
    Subject code 612.75
    Language English
    Size X, 226 S., [5] Bl. : Ill., graph. Darst., 28 cm
    Edition 1. ed.
    Publisher Elsevier AP
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT017652592
    ISBN 978-0-12-415784-2 ; 0-12-415784-X
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2013 A 1079 available for loan (reading room) Lesesaal EG

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  3. Article ; Online: Bone marrow runs the (bone) show.

    Karsenty, Gerard

    The Journal of experimental medicine

    2021  Volume 218, Issue 12

    Abstract: In this issue of JEM, a paper by Kim et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20211872), asking a simple question through a remarkable alliance of human and mouse genetics, demonstrates that a prevalent hematological condition can lead to ... ...

    Abstract In this issue of JEM, a paper by Kim et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20211872), asking a simple question through a remarkable alliance of human and mouse genetics, demonstrates that a prevalent hematological condition can lead to osteoporosis. This work is important by virtue of the quality of its results and its implication for the relationship between bone and its marrow.
    MeSH term(s) Animals ; Bone Marrow ; Mice
    Language English
    Publishing date 2021-10-27
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20211996
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: That Feeling in Your Bones.

    Karsenty, Gerard

    Cerebrum : the Dana forum on brain science

    2020  Volume 2020

    Abstract: Research by geneticist Gerard Karsenty of Columbia University has revealed that our bones do much ...

    Abstract Research by geneticist Gerard Karsenty of Columbia University has revealed that our bones do much more than provide protection and support. A protein called osteocalcin-released as a hormone by the skeleton-has been linked to sugar levels, exercise, and male fertility. More recently, he has shown that osteocalcin triggers a "fight or flight" response to threat.
    Language English
    Publishing date 2020-07-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2251230-5
    ISSN 1524-6205
    ISSN 1524-6205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The facts of the matter: What is a hormone?

    Karsenty, Gerard

    PLoS genetics

    2020  Volume 16, Issue 6, Page(s) e1008938

    MeSH term(s) Animals ; Bone and Bones/metabolism ; Hormones ; Humans ; Mice ; Models, Animal ; Osteocalcin ; Species Specificity ; Terminology as Topic
    Chemical Substances Hormones ; Osteocalcin (104982-03-8)
    Language English
    Publishing date 2020-06-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2186725-2
    ISSN 1553-7404 ; 1553-7390
    ISSN (online) 1553-7404
    ISSN 1553-7390
    DOI 10.1371/journal.pgen.1008938
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The Central Regulation of Bone Mass: Genetic Evidence and Molecular Bases.

    Karsenty, Gerard

    Handbook of experimental pharmacology

    2020  Volume 262, Page(s) 309–323

    Abstract: The alternation of resorption of preexisting bone by the osteoclasts followed by de novo bone formation by osteoblasts is called bone modeling during childhood and bone remodeling during adulthood. A central question raised by this physiological process ... ...

    Abstract The alternation of resorption of preexisting bone by the osteoclasts followed by de novo bone formation by osteoblasts is called bone modeling during childhood and bone remodeling during adulthood. A central question raised by this physiological process that is fundamental to longitudinal growth during childhood and adolescence and that is attacked at the other end of life in the context of osteoporosis is to know how it is regulated. This question was rejuvenated in the late 1990s and early 2000s years when the application of mouse genetics made it feasible to test whether there were new endocrine determinants of bone (re)modeling. Addressing this question, taking into account fundamental cell biology features of bone led to the hypothesis that there should be a coordinated control of bone growth/mass, energy metabolism, and reproduction. Testing genetically and molecularly, this hypothesis revealed that, in vivo, the adipocyte-derived hormone leptin is a powerful inhibitor of bone mass accrual following its signaling in the brain. This chapter details the molecular bases and biological relevance of this regulation of bone mass accrual by leptin.
    MeSH term(s) Animals ; Bone Remodeling ; Leptin/chemistry ; Leptin/metabolism ; Mice ; Osteoblasts/physiology ; Osteoporosis
    Chemical Substances Leptin
    Language English
    Publishing date 2020-09-22
    Publishing country Germany
    Document type Journal Article
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/164_2020_378
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues
     danach: Sign. bei den Einzelbänden: Show issues

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  7. Article ; Online: Osteocalcin and the physiology of danger.

    Berger, Julian Meyer / Karsenty, Gerard

    FEBS letters

    2022  Volume 596, Issue 5, Page(s) 665–680

    Abstract: Bone biology has long been driven by the question as to what molecules affect cell differentiation or the functions of bone. Exploring this issue has been an extraordinarily powerful way to improve our knowledge of bone development and physiology. More ... ...

    Abstract Bone biology has long been driven by the question as to what molecules affect cell differentiation or the functions of bone. Exploring this issue has been an extraordinarily powerful way to improve our knowledge of bone development and physiology. More recently, a second question has emerged: does bone have other functions besides making bone? Addressing this conundrum revealed that the bone-derived hormone osteocalcin affects a surprisingly large number of organs and physiological processes, including acute stress response. This review will focus on this emerging aspect of bone biology taking osteocalcin as a case study and will show how classical and endocrine functions of bone help to define a new functional identity for this tissue.
    MeSH term(s) Bone Development ; Bone and Bones ; Hormones ; Osteocalcin
    Chemical Substances Hormones ; Osteocalcin (104982-03-8)
    Language English
    Publishing date 2022-01-21
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 212746-5
    ISSN 1873-3468 ; 0014-5793
    ISSN (online) 1873-3468
    ISSN 0014-5793
    DOI 10.1002/1873-3468.14259
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 282: Show issues Location:
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  8. Article ; Online: The crosstalk between bone remodeling and energy metabolism: A translational perspective.

    Karsenty, Gerard / Khosla, Sundeep

    Cell metabolism

    2022  Volume 34, Issue 6, Page(s) 805–817

    Abstract: Genetics in model organisms has progressively broken down walls that previously separated different disciplines of biology. One example of this holistic evolution is the recognition of the complex relationship that exists between the control of bone mass ...

    Abstract Genetics in model organisms has progressively broken down walls that previously separated different disciplines of biology. One example of this holistic evolution is the recognition of the complex relationship that exists between the control of bone mass (bone remodeling) and energy metabolism in mammals. Numerous hormones orchestrate this crosstalk. In particular, the study of the leptin-mediated regulation of bone mass has not only revealed the existence of a central control of bone mass but has also led to the realization that sympathetic innervation is a major regulator of bone remodeling. This happened at a time when the use of drugs aiming at treating osteoporosis, the most frequent bone disease, has dwindled. This review will highlight the main aspects of the leptin-mediated regulation of bone mass and how this led to the realization that β-blockers, which block the effects of the sympathetic nervous system, may be a viable option to prevent osteoporosis.
    MeSH term(s) Animals ; Bone Density ; Bone Remodeling/physiology ; Energy Metabolism/physiology ; Leptin/metabolism ; Mammals/metabolism ; Osteoporosis ; Sympathetic Nervous System/metabolism
    Chemical Substances Leptin
    Language English
    Publishing date 2022-05-10
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2022.04.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Interleukin-6 signaling in osteoblasts regulates bone remodeling during exercise.

    Palmisano, Biagio / Riminucci, Mara / Karsenty, Gerard

    Bone

    2023  Volume 176, Page(s) 116870

    Abstract: Aerobic exercise has many beneficial effects on human health. One of them, is to influence positively bone remodeling through, however, incompletely understood mechanisms. Given its recently demonstrated role as a mediator of the bone to muscle to bone ... ...

    Abstract Aerobic exercise has many beneficial effects on human health. One of them, is to influence positively bone remodeling through, however, incompletely understood mechanisms. Given its recently demonstrated role as a mediator of the bone to muscle to bone crosstalk during exercise, we hypothesized that interleukin-6 (IL-6) signaling in bone may contribute to the beneficial effect that exercise has on bone homeostasis. In this study, we first show that aerobic exercise increases the expression of Il6r in bones of WT mice. Then, we analyzed a mutant mouse strain that lacks the IL-6 receptor alpha specifically in osteoblasts (Il6r
    MeSH term(s) Adult ; Mice ; Humans ; Animals ; Interleukin-6/metabolism ; Osteoblasts/metabolism ; Bone Remodeling ; Bone and Bones/metabolism ; Osteogenesis
    Chemical Substances Interleukin-6
    Language English
    Publishing date 2023-08-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 632515-4
    ISSN 1873-2763 ; 8756-3282
    ISSN (online) 1873-2763
    ISSN 8756-3282
    DOI 10.1016/j.bone.2023.116870
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 332: Show issues

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  10. Article: UPDATE ON THE BIOLOGY OF OSTEOCALCIN.

    Karsenty, Gerard

    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

    2017  Volume 23, Issue 10, Page(s) 1270–1274

    Abstract: A genetics approach has uncovered that bone has more functions than expected. In particular, bone is an endocrine organ that secretes a growing number of hormones. In that context, the discovery of the osteoblast-derived hormone osteocalcin has ... ...

    Abstract A genetics approach has uncovered that bone has more functions than expected. In particular, bone is an endocrine organ that secretes a growing number of hormones. In that context, the discovery of the osteoblast-derived hormone osteocalcin has significantly broadened the field of bone biology because of the number of physiologic processes regulated by this hormone. At present, osteocalcin has been shown to enhance several aspects of energy metabolism, brain development, and cognition. These discoveries shed light on the cross-talk between multiple organs and provide credence to the search for additional endocrine functions of bone.
    Abbreviations: ECM = extracellular matrix; Gprc6a = G protein-coupled receptor family C group 6 member A; IL-6 = interleukin-6; WT = wild-type.
    MeSH term(s) Animals ; Bone and Bones/metabolism ; Brain/metabolism ; Energy Metabolism/physiology ; Exercise/physiology ; Fertility/physiology ; Humans ; Osteocalcin/physiology ; Rest
    Chemical Substances Osteocalcin (104982-03-8)
    Language English
    Publishing date 2017-07-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1473503-9
    ISSN 1530-891X
    ISSN 1530-891X
    DOI 10.4158/EP171966.RA
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 508: Show issues

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