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  1. Article: The H

    Filandr, Frantisek / Man, Petr / Halada, Petr / Chang, Hucheng / Ludwig, Roland / Kracher, Daniel

    Biotechnology for biofuels

    2020  Volume 13, Page(s) 37

    Abstract: ... Recent studies showed that H: Results: We probe the reactivity of LPMO9C from the cellulose-degrading ... fungus : Conclusions: We found for all systems that the supply of H ...

    Abstract Background: Lytic polysaccharide monooxygenases (LPMOs) are copper-dependent redox enzymes that cleave recalcitrant biopolymers such as cellulose, chitin, starch and hemicelluloses. Although LPMOs receive ample interest in industry and academia, their reaction mechanism is not yet fully understood. Recent studies showed that H
    Results: We probe the reactivity of LPMO9C from the cellulose-degrading fungus
    Conclusions: We found for all systems that the supply of H
    Language English
    Publishing date 2020-03-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2421351-2
    ISSN 1754-6834
    ISSN 1754-6834
    DOI 10.1186/s13068-020-01673-4
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  2. Article ; Online: The nucleation of C-S-H via prenucleation clusters.

    Sowoidnich, T / Damidot, D / Ludwig, H-M / Germroth, J / Rosenberg, R / Cölfen, H

    The Journal of chemical physics

    2023  Volume 158, Issue 11, Page(s) 114309

    Abstract: The nucleation and growth of calcium-silicate-hydrate (C-S-H) is of fundamental importance ... for the strength development and durability of the concrete. However, the nucleation process of C-S-H is still not ... fully understood. The present work investigates how C-S-H nucleates by analyzing the aqueous phase ...

    Abstract The nucleation and growth of calcium-silicate-hydrate (C-S-H) is of fundamental importance for the strength development and durability of the concrete. However, the nucleation process of C-S-H is still not fully understood. The present work investigates how C-S-H nucleates by analyzing the aqueous phase of hydrating tricalcium silicate (C
    Language English
    Publishing date 2023-02-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/5.0141255
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    In stock of ZB MED Bonn / Germany

    Z 4' 49/16: Show issues

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  3. Article ; Online: Insights into the H

    Hedison, Tobias M / Breslmayr, Erik / Shanmugam, Muralidharan / Karnpakdee, Kwankao / Heyes, Derren J / Green, Anthony P / Ludwig, Roland / Scrutton, Nigel S / Kracher, Daniel

    The FEBS journal

    2021  Volume 288, Issue 13, Page(s) 4115–4128

    Abstract: ... biomanufacturing processes. Recent investigations have shown that H ...

    Abstract Fungal lytic polysaccharide monooxygenases (LPMOs) depolymerise crystalline cellulose and hemicellulose, supporting the utilisation of lignocellulosic biomass as a feedstock for biorefinery and biomanufacturing processes. Recent investigations have shown that H
    MeSH term(s) Biocatalysis ; Cellulose/metabolism ; Electron Spin Resonance Spectroscopy/methods ; Fungal Polysaccharides/metabolism ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Glucans/metabolism ; Hydrogen Peroxide/metabolism ; Mixed Function Oxygenases/genetics ; Mixed Function Oxygenases/metabolism ; Neurospora crassa/enzymology ; Neurospora crassa/genetics ; Oxidation-Reduction ; Polysaccharides/metabolism ; Protein Binding ; Recombinant Proteins/metabolism ; Spectrophotometry/methods ; Substrate Specificity ; Xylans/metabolism
    Chemical Substances Fungal Polysaccharides ; Fungal Proteins ; Glucans ; Polysaccharides ; Recombinant Proteins ; Xylans ; xyloglucan (37294-28-3) ; hemicellulose (8024-50-8) ; Cellulose (9004-34-6) ; Hydrogen Peroxide (BBX060AN9V) ; Mixed Function Oxygenases (EC 1.-)
    Language English
    Publishing date 2021-01-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/febs.15704
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 260: Show issues Location:
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  4. Article ; Online: Prognostic value of the H

    Ludwig, Sebastian / Pellegrini, Costanza / Gossling, Alina / Rheude, Tobias / Voigtländer, Lisa / Bhadra, Oliver D / Linder, Matthias / Kalbacher, Daniel / Koell, Benedikt / Waldschmidt, Lara / Schirmer, Johannes / Seiffert, Moritz / Reichenspurner, Hermann / Blankenberg, Stefan / Westermann, Dirk / Conradi, Lenard / Joner, Michael / Schofer, Niklas

    ESC heart failure

    2020  Volume 8, Issue 1, Page(s) 461–470

    Abstract: Aims: The aim of this study was to assess the prognostic value of the H: Methods and results ... AS and preserved EF (≥50%), were identified for calculation of the H: Conclusions: The H ...

    Abstract Aims: The aim of this study was to assess the prognostic value of the H
    Methods and results: In this multicentre study, a total of 832 patients from two German high-volume centres, who received TAVI for severe AS and preserved EF (≥50%), were identified for calculation of the H
    Conclusions: The H
    MeSH term(s) Aortic Valve Stenosis/diagnosis ; Aortic Valve Stenosis/surgery ; Heart Failure/epidemiology ; Humans ; Prognosis ; Stroke Volume ; Transcatheter Aortic Valve Replacement ; Ventricular Function, Left
    Language English
    Publishing date 2020-11-20
    Publishing country England
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2814355-3
    ISSN 2055-5822 ; 2055-5822
    ISSN (online) 2055-5822
    ISSN 2055-5822
    DOI 10.1002/ehf2.13096
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  5. Article ; Online: Characterizing ligand-induced conformational changes in clinically relevant galectin-1 by H

    Schedlbauer, Andreas / Gilles, Ulrich / Ludwig, Anna-Kristin / Adler, Andreas / Kaltner, Herbert / Lindner, Ingo / Mayo, Kevin H / Diercks, Tammo / Reusch, Dietmar / Gabius, Hans-Joachim

    Biochimie

    2021  Volume 187, Page(s) 48–56

    Abstract: Glycans of cellular glycoconjugates serve as biochemical signals for a multitude of (patho)physiological processes via binding to their receptors (e.g. lectins). In the case of human adhesion/growth-regulatory galectin-1 (Gal-1), small angle neutron ... ...

    Abstract Glycans of cellular glycoconjugates serve as biochemical signals for a multitude of (patho)physiological processes via binding to their receptors (e.g. lectins). In the case of human adhesion/growth-regulatory galectin-1 (Gal-1), small angle neutron scattering and fluorescence correlation spectroscopy have revealed a significant decrease of its gyration radius and increase of its diffusion coefficient upon binding lactose, posing the pertinent question on the nature and region(s) involved in the underlying structural alterations. Requiring neither a neutron source nor labeling, diffusion measurements by
    MeSH term(s) Deuterium Exchange Measurement ; Galectin 1/chemistry ; Humans ; Nuclear Magnetic Resonance, Biomolecular
    Chemical Substances Galectin 1 ; LGALS1 protein, human
    Language English
    Publishing date 2021-05-19
    Publishing country France
    Document type Journal Article
    ZDB-ID 120345-9
    ISSN 1638-6183 ; 0300-9084
    ISSN (online) 1638-6183
    ISSN 0300-9084
    DOI 10.1016/j.biochi.2021.05.008
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.135: Show issues Location:
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  6. Article ; Online: C3d-Targeted factor H inhibits tissue complement in disease models and reduces glomerular injury without affecting circulating complement.

    Liu, Fei / Ryan, Sarah T / Fahnoe, Kelly C / Morgan, Jennifer G / Cheung, Anne E / Storek, Michael J / Best, Alejandro / Chen, Hui A / Locatelli, Monica / Xu, Shuyun / Schmidt, Enno / Schmidt-Jiménez, Leon F / Bieber, Katja / Henderson, Joel M / Lian, Christine G / Verschoor, Admar / Ludwig, Ralf J / Benigni, Ariela / Remuzzi, Giuseppe /
    Salant, David J / Kalled, Susan L / Thurman, Joshua M / Holers, V Michael / Violette, Shelia M / Wawersik, Stefan

    Molecular therapy : the journal of the American Society of Gene Therapy

    2024  Volume 32, Issue 4, Page(s) 1061–1079

    Abstract: ... factor H (fH ...

    Abstract Complement-mediated diseases can be treated using systemic inhibitors. However, complement components are abundant in circulation, affecting systemic inhibitors' exposure and efficacy. Furthermore, because of complement's essential role in immunity, systemic treatments raise infection risk in patients. To address these challenges, we developed antibody fusion proteins combining the alternative-pathway complement inhibitor factor H (fH
    MeSH term(s) Humans ; Mice ; Rats ; Animals ; Complement Factor H/genetics ; Complement C3d/metabolism ; Kidney Diseases/etiology ; Antibodies ; Complement Activation
    Chemical Substances Complement Factor H (80295-65-4) ; Complement C3d (80295-45-0) ; Antibodies
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2010592-7
    ISSN 1525-0024 ; 1525-0016
    ISSN (online) 1525-0024
    ISSN 1525-0016
    DOI 10.1016/j.ymthe.2024.02.001
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5640: Show issues Location:
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  7. Article ; Online: The Kinetics of Adsorption and Desorption of Selected Semivolatile Hydrocarbons and H

    Iannarelli, Riccardo / Ludwig, Christian / Rossi, Michel J

    The journal of physical chemistry. A

    2022  Volume 126, Issue 46, Page(s) 8711–8726

    Abstract: A flowing gas experiment using a Knudsen flow reactor was performed on a series of seven semivolatile probe gases interacting with two often used mineral dust materials, namely, coarse Arizona test dust (ATD-C) and kaolinite. The semivolatile probe gases ...

    Abstract A flowing gas experiment using a Knudsen flow reactor was performed on a series of seven semivolatile probe gases interacting with two often used mineral dust materials, namely, coarse Arizona test dust (ATD-C) and kaolinite. The semivolatile probe gases used were applinate (acetate ester), pipol (ethyl ester of 2-methylvaleric acid), benzylacetate (acetate ester of benzylalcohol), menthol (alcohol), toluene, limonene, and γ-terpinene (terpene hydrocarbon). Uptake experiments under molecular flow conditions resulted in absolute coverages and initial uptake coefficients γ
    Language English
    Publishing date 2022-11-09
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5215
    ISSN (online) 1520-5215
    DOI 10.1021/acs.jpca.2c04903
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  8. Book ; Thesis: Funktionelle Charakterisierung des Faktor-H-verwandten Proteins CFHR-3

    Ludwig, Mirko

    2010  

    Author's details von Mirko Ludwig
    Language German
    Size 120 S., Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Jena, Univ., Diss., 2010
    HBZ-ID HT016880687
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 D 842 order for loan Magazin

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  9. Article ; Online: Uniform, Strain-Free, Large-Scale Graphene and h-BN Monolayers Enabled by Hydrogel Substrates.

    Belyaeva, Liubov / Ludwig, Cyril / Lai, Yu-Cheng / Chou, Chia-Ching / Shih, Chih-Jen

    Small (Weinheim an der Bergstrasse, Germany)

    2023  Volume 20, Issue 9, Page(s) e2307054

    Abstract: ... mismatch by using hexagonal boron nitride (h-BN), with the drawback of limited uniformity and applicability ... demonstrates a new class of substrates based on hydrogels that overcome these limitations and excel h-BN and ...

    Abstract Translation of the unique properties of 2D monolayers from non-scalable micron-sized samples to macroscopic scale is a longstanding challenge obstructed by the substrate-induced strains, interface nonuniformities, and sample-to-sample variations inherent to the scalable fabrication methods. So far, the most successful strategies to reduce strain in graphene are the reduction of the interface roughness and lattice mismatch by using hexagonal boron nitride (h-BN), with the drawback of limited uniformity and applicability to other 2D monolayers, and liquid water, which is not compatible with electronic devices. This work demonstrates a new class of substrates based on hydrogels that overcome these limitations and excel h-BN and water substrates at strain relaxation enabling superiorly uniform and reproducible centimeter-sized sheets of unstrained monolayers. The ultimate strain relaxation and uniformity are rationalized by the extreme structural adaptability of the hydrogel surface owing to its high liquid content and low Young's modulus, and are universal to all 2D materials irrespective of their crystalline structure. Such platforms can be integrated into field effect transistors and demonstrate enhanced charge carrier mobilities in graphene. These results present a universal strategy for attaining uniform and strain-free sheets of 2D materials and underline the opportunities enabled by interfacing them with soft matter.
    Language English
    Publishing date 2023-10-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202307054
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  10. Article ; Online: Outcomes of chemotherapy-induced (febrile) neutropenia prophylaxis with biosimilar filgrastim (Zarzio®) initiated "same-day" (< 24 h), "per-guidelines" (24-72 h), and "late" (> 72 h): findings from the MONITOR-GCSF study.

    Ludwig, Heinz / Gascón, Pere / Bokemeyer, Carsten / Aapro, Matti / Boccadoro, Mario / Denhaerynck, Kris / Krendyukov, Andriy / MacDonald, Karen / Abraham, Ivo

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2018  Volume 27, Issue 6, Page(s) 2301–2312

    Abstract: ... 24-72 h following chemotherapy; however, some evidence suggests that G-CSF initiated < 24 h ... day, per-guidelines, or late if G-CSF support was initiated < 24 h, 24-72 h, and > 72 h after ... evidence indicates that CIN/FN prophylaxis initiated with biosimilar filgrastim within 24-72 h post ...

    Abstract Purpose: Granulocyte colony-stimulating factors (G-CSFs) are indicated for prophylaxis or management of chemotherapy-induced neutropenia (CIN) and febrile neutropenia (FN). Guidelines recommend G-CSF 24-72 h following chemotherapy; however, some evidence suggests that G-CSF initiated < 24 h may benefit some patients.
    Methods: MONITOR-GCSF was a prospective, observational, multicenter, pan-European study of 1447 chemotherapy-treated patients receiving daily biosimilar (standard) filgrastim (Zarzio®/Zarxio®, filgrastim-sndz, Hexal AG, Sandoz Inc.). In this analysis, cycles were classified as same-day, per-guidelines, or late if G-CSF support was initiated < 24 h, 24-72 h, and > 72 h after chemotherapy. Outcomes included occurrence of CIN of any grade (CIN1/4), grade 3 or 4 (CIN3/4), grade 4 (CIN4), or FN: CIN/FN-related hospitalization or CIN/FN-related chemotherapy disturbance.
    Results: A total of 5930 chemotherapy cycles from 1423 evaluable patients from MONITOR-GCSF had data for day of G-CSF initiation: 795 cycles (13.4%) classified as same-day, 3320 (56.0%) as per-guidelines, and 1815 (30.6%) as late. Groups did not differ as to CIN1/4 and FN episodes, or CIN/FN-related hospitalizations or chemotherapy disturbances. Patients in the same-day and per-guidelines groups had statistically similar odds of not experiencing any outcomes of interest in any given cycle. Patients in the late group had worse odds of experiencing CIN1/4, CIN3/4, and CIN4 episodes in any given cycle. Proportions of patients reporting clinical events of interest were generally similar.
    Conclusions: This real-world evidence indicates that CIN/FN prophylaxis initiated with biosimilar filgrastim within 24-72 h post-chemotherapy is effective and safe. Filgrastim administration on the day of chemotherapy may be appropriate in some patients.
    MeSH term(s) Aged ; Chemotherapy-Induced Febrile Neutropenia/drug therapy ; Chemotherapy-Induced Febrile Neutropenia/prevention & control ; Female ; Filgrastim/pharmacology ; Filgrastim/therapeutic use ; Granulocyte Colony-Stimulating Factor/pharmacology ; Granulocyte Colony-Stimulating Factor/therapeutic use ; Humans ; Male ; Middle Aged ; Prospective Studies
    Chemical Substances Granulocyte Colony-Stimulating Factor (143011-72-7) ; Filgrastim (PVI5M0M1GW)
    Language English
    Publishing date 2018-10-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-018-4513-6
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