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Article ; Online: Determining the Direction of Human Immunodeficiency Virus Transmission: Benefits and Potential Harms of Taking Phylogenetic Analysis One Step Further.

Taylor, Barbara S / Sapién, Hugo

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2020 Volume 72, Issue 1, Page(s) 38–40

MeSH term(s)	Diagnostic Tests, Routine ; HIV Infections ; HIV-1/genetics ; Humans ; Phylogeny
Language	English
Publishing date	2020-01-08
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciz1248
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Article ; Online: CROI 2023: Advances in Antiviral Therapy in HIV and Viral Hepatitis.

Gunaratne, Shauna H / Taylor, Barbara S / Wilkin, Timothy J / Tieu, Hong-Van

Topics in antiviral medicine

2023 Volume 31, Issue 3, Page(s) 445–467

Abstract: Several innovative methods were presented at the 2023 Conference on Retroviruses and Opportunistic Infections (CROI) targeting different aspects of the HIV care continuum to improve testing, linkage to care, and viral suppression. Some of these ... ...

Abstract	Several innovative methods were presented at the 2023 Conference on Retroviruses and Opportunistic Infections (CROI) targeting different aspects of the HIV care continuum to improve testing, linkage to care, and viral suppression. Some of these approaches were directed at more vulnerable groups, such as pregnant women, adolescents, and individuals who inject drugs. In contrast was the devastating impact of the COVID-19 pandemic, with negative outcomes on HIV viral load suppression and retention in care. Data were presented on hepatitis B virus (HBV) suppression showing that tenofovir alafenamide (TAF)/emtricitabine (FTC)/bictegravir (BIC) may be superior to tenofovir disoproxil fumarate/FTC plus dolutegravir in suppressing HBV in HIV/HBV-coinfected individuals. A pilot study examining a 4-week trial of direct-acting antiviral therapy to treat hepatitis C in recently infected individuals showed lower rates of sustained virologic response at 12 weeks than longer courses. Additional data were presented on the use of long-acting cabotegravir/rilpivirine, comparing this regimen with oral TAF/FTC/BIC and the use of long-acting cabotegravir/rilpivirine in those with viremia. Data were presented on a novel strategy of lenacapavir with 2 broadly neutralizing antibodies given every 6 months as maintenance antiretroviral therapy (ART). Data were presented on improving HIV care outcomes in adolescents, interventions to prevent mother-to-child transmission, and HIV reservoirs in children and adolescents. Data were also presented on interactions between ART and hormonal contraception, as well as ART-related weight gain and impact on pregnancy. A study examining BIC pharmacokinetics in pregnancy was presented, as well as retrospective data on outcomes of adolescents receiving TAF/FTC/BIC.
MeSH term(s)	Adolescent ; Female ; Humans ; Pregnancy ; Anti-HIV Agents/therapeutic use ; Anti-Retroviral Agents/therapeutic use ; COVID-19 ; Emtricitabine/therapeutic use ; Hepatitis C, Chronic ; Infectious Disease Transmission, Vertical ; Pandemics ; Pilot Projects ; Retrospective Studies ; Retroviridae Infections ; Rilpivirine
Chemical Substances	Anti-HIV Agents ; Anti-Retroviral Agents ; bictegravir (8GB79LOJ07) ; Emtricitabine (G70B4ETF4S) ; Rilpivirine (FI96A8X663)
Language	English
Publishing date	2023-06-12
Publishing country	United States
Document type	Clinical Trial ; Journal Article
ZDB-ID	2656632-1
ISSN	2161-5853 ; 2161-5853
ISSN (online)	2161-5853
ISSN	2161-5853
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Article: Bronchoscopic Endobronchial Valve Therapy for Persistent Air Leaks in COVID-19 Patients Requiring Veno-Venous Extracorporeal Membrane Oxygenation.

Ficial, Barbara / Whebell, Stephen / Taylor, Daniel / Fernández-Garda, Rita / Okiror, Lawrence / Meadows, Christopher I S

Journal of clinical medicine

2023 Volume 12, Issue 4

Abstract: COVID-19 acute respiratory distress syndrome (ARDS) can be associated with extensive lung damage, pneumothorax, pneumomediastinum and, in severe cases, persistent air leaks (PALs) via bronchopleural fistulae (BPF). PALs can impede weaning from invasive ... ...

Abstract	COVID-19 acute respiratory distress syndrome (ARDS) can be associated with extensive lung damage, pneumothorax, pneumomediastinum and, in severe cases, persistent air leaks (PALs) via bronchopleural fistulae (BPF). PALs can impede weaning from invasive ventilation or extracorporeal membrane oxygenation (ECMO). We present a series of patients requiring veno-venous ECMO for COVID-19 ARDS who underwent endobronchial valve (EBV) management of PAL. This is a single-centre retrospective observational study. Data were collated from electronic health records. Patients treated with EBV met the following criteria: ECMO for COVID-19 ARDS; the presence of BPF causing PAL; air leak refractory to conventional management preventing ECMO and ventilator weaning. Between March 2020 and March 2022, 10 out of 152 patients requiring ECMO for COVID-19 developed refractory PALs, which were successfully treated with bronchoscopic EBV placement. The mean age was 38.3 years, 60% were male, and half had no prior co-morbidities. The average duration of air leaks prior to EBV deployment was 18 days. EBV placement resulted in the immediate cessation of air leaks in all patients with no peri-procedural complications. Weaning of ECMO, successful ventilator recruitment and removal of pleural drains were subsequently possible. A total of 80% of patients survived to hospital discharge and follow-up. Two patients died from multi-organ failure unrelated to EBV use. This case series presents the feasibility of EBV placement in severe parenchymal lung disease with PAL in patients requiring ECMO for COVID-19 ARDS and its potential to expedite weaning from both ECMO and mechanical ventilation, recovery from respiratory failure and ICU/hospital discharge.
Language	English
Publishing date	2023-02-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12041348
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Article ; Online: Modifying Whole Health Services for Successful Telehealth Delivery: Lessons from Veterans Health Administration's Rapid Transition During the COVID-19 Pandemic.

Wu, Juliet / Bolton, Rendelle E / Anwar, Chitra / Bokhour, Barbara G / Khanna, Aishwarya / Mullur, Rashmi S / Taylor, Stephanie L / Hyde, Justeen

Journal of integrative and complementary medicine

2023 Volume 29, Issue 12, Page(s) 792–804

Abstract: Introduction: ...

Abstract	Introduction:
MeSH term(s)	Humans ; Veterans Health ; Pandemics ; COVID-19/epidemiology ; Telemedicine ; Health Promotion
Language	English
Publishing date	2023-09-01
Publishing country	United States
Document type	Journal Article
ISSN	2768-3613
ISSN (online)	2768-3613
DOI	10.1089/jicm.2023.0106
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Article ; Online: Association between melanin deposits in gill tissue and microbiome across different hatchery reared Atlantic salmon.

Quezada-Rodriguez, Petra R / Taylor, Richard S / Jantawongsri, Khattapan / Nowak, Barbara F / Wynne, James W

Journal of applied microbiology

2023 Volume 134, Issue 2

Abstract: Aims: To investigate the relationship between microbial community profiles and gill pathology during a production cycle of Atlantic salmon in two commercial hatcheries.: Methods and results: Relationships between gill histology, environmental ... ...

Abstract	Aims: To investigate the relationship between microbial community profiles and gill pathology during a production cycle of Atlantic salmon in two commercial hatcheries. Methods and results: Relationships between gill histology, environmental conditions, and microbiome were determined using high-throughput data, including 16S rDNA amplicon sequencing data, histopathology data, and water quality parameters. Hatchery A used riverine water and operated a mixed system of recirculation aquaculture system (RAS) and flowthrough. Hatchery B was used bore water and operated a RAS. Melanin deposits, hyperplastic, and inflammatory lesions were observed histologically in the gills. A higher prevalence of melanin deposits was detected and correlated to a change in beta diversity of bacterial communities in early time points (fingerling and parr stages). High abundance of Sphaerotilus sp.,Pseudomonas sp.,Nitrospira sp.,Exiguobacterium sp.,Deinococcus sp.,and Comamonas sp. was correlated with a high prevalence of melanin in filaments. Bacterial diversity increased as the fish cohort transitioned from RAS to flowthrough in hatchery A. Conclusions: Under commercial conditions, the commensal community of gill bacteria was related to melanin prevalence.
MeSH term(s)	Animals ; Gills/microbiology ; Salmo salar ; Melanins ; Microbiota/genetics ; Aquaculture ; Bacteria/genetics ; Fish Diseases/microbiology
Chemical Substances	Melanins
Language	English
Publishing date	2023-01-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1358023-1
ISSN	1365-2672 ; 1364-5072
ISSN (online)	1365-2672
ISSN	1364-5072
DOI	10.1093/jambio/lxac073
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Zs.A 259: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Low Prevalence of COVID-19 Vaccine Hesitancy in Students Across Health Science Disciplines in Texas.

Hosek, Meredith G / Chidester, Autumn B / Gelfond, Jonathan / Taylor, Barbara S

Vaccine: X

2022 Volume 10, Page(s) 100154

Abstract: Introduction: Although the development of COVID-19 vaccines represents a triumph of modern medicine, studies suggest vaccine hesitancy exists among key populations, including healthcare professionals. In December 2020, a large academic medical center ... ...

Abstract	Introduction: Although the development of COVID-19 vaccines represents a triumph of modern medicine, studies suggest vaccine hesitancy exists among key populations, including healthcare professionals. In December 2020, a large academic medical center offered COVID-19 vaccination to 3439 students in medicine, nursing, dentistry, and other health professions. With limited vaccine hesitancy research in this population, this study evaluates the prevalence of COVID-19 vaccine hesitancy among healthcare students, including predictors of hesitancy and top concerns with vaccination. Methods: The authors distributed a cross-sectional survey to all healthcare students (n = 3,439) from 12/17/2020 to 12/23/2020. The survey collected age, sex, perceived risk of contracting SARS-CoV-2 without vaccination, perceived impact on health if infected with SARS-CoV-2, vaccine hesitancy, and vaccine concerns. In 2021, logistic regressions identified risk factors associated with hesitancy. Results: The response rate was 30.0% (n = 1030) with median age of 25.0. Of respondents, 19.4% were hesitant to accept COVID-19 vaccination, while 66.6% reported at least one concern with the vaccine. Medical discipline, history of COVID-19 infection, perceived risk of contracting COVID-19, and perceived severity of illness if infected were predictor variables of COVID-19 vaccine hesitancy (p < 0.05). Age, sex, and exposure to in-person clinical care were not predictive of vaccine hesitancy. Conclusions: Fewer students reported COVID-19 vaccine hesitancy than expected from surveys on the general public and on healthcare workers. Continued research is needed to evaluate shifting attitudes around COVID-19 vaccination among healthcare professionals and students. With COVID-19 vaccine hesitancy a growing concern in young adults, a survey of this size and breadth will be helpful to other academic medical centers interested in vaccinating their students and to persons interested in leveraging predictors of COVID-19 vaccine hesitancy for targeted intervention.
Language	English
Publishing date	2022-03-07
Publishing country	England
Document type	Journal Article
ISSN	2590-1362
ISSN (online)	2590-1362
DOI	10.1016/j.jvacx.2022.100154
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Article ; Online: CROI 2022: advances in antiviral therapy for HIV, COVID-19, and viral hepatitis.

Gunaratne, Shauna H / Tieu, Hong-Van / Wilkin, Timothy J / Taylor, Barbara S

Topics in antiviral medicine

2022 Volume 30, Issue 3, Page(s) 490–521

Abstract: The 2022 Conference on Retroviruses and Opportunistic Infections provided a rich source of new data and comprehensive reviews on antiviral therapy. For COVID-19, intramuscular sotrovimab was noninferior to intravenous sotrovimab, serostatus did not ... ...

Abstract	The 2022 Conference on Retroviruses and Opportunistic Infections provided a rich source of new data and comprehensive reviews on antiviral therapy. For COVID-19, intramuscular sotrovimab was noninferior to intravenous sotrovimab, serostatus did not predict the efficacy of sotrovimab, and molnupiravir appeared safe and modestly effective in decreasing hospitalization rates. Trials from low- and middle-income countries provided data to support transitioning those on first-line therapy with or without virologic suppression and those virologically suppressed on second-line therapy to dolutegravir-based regimens. Additional data supported the use of lenacapavir as a long-acting antiretroviral drug. Data across the United States demonstrate the negative impact of the COVID-19 pandemic on the HIV care continuum, although enhanced outreach efforts and decentralization of antiretroviral therapy delivery were associated with improvements in care engagement outcomes. Researchers described potential mechanisms for the emergence of integrase strand transfer inhibitor resistance. Studies on proviral genotyping high-lighted the limitations of its use in predicting clinically significant resistance. Several studies looked at the epidemiology and treatment of hepatitis C and B and the status of current hepatitis C virus elimination efforts. Data presented on HIV, COVID-19, and maternal and pediatric health included 2-year virologic outcome data of very early antiretroviral therapy in potentially reducing the latent HIV reservoir in infants with HIV. Data presented on COVID-19 and HIV therapeutics in children included SARS-CoV-2-neutralizing monoclonal antibodies in children younger than 12 years of age, remdesivir in hospitalized infants and children, and long-acting therapies for HIV treatment in children.
MeSH term(s)	Child ; Humans ; United States/epidemiology ; HIV Infections/drug therapy ; COVID-19/drug therapy ; Pandemics ; HIV-1 ; SARS-CoV-2 ; Virus Latency ; Anti-Retroviral Agents/therapeutic use ; Hepatitis, Viral, Human
Chemical Substances	sotrovimab (1MTK0BPN8V) ; Anti-Retroviral Agents
Language	English
Publishing date	2022-11-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2656632-1
ISSN	2161-5853 ; 2161-5853
ISSN (online)	2161-5853
ISSN	2161-5853
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Article: Medium chain length polyhydroxyalkanoates as potential matrix materials for peripheral nerve regeneration.

Nigmatullin, Rinat / Taylor, Caroline S / Basnett, Pooja / Lukasiewicz, Barbara / Paxinou, Alexandra / Lizarraga-Valderrama, Lorena R / Haycock, John W / Roy, Ipsita

Regenerative biomaterials

2023 Volume 10, Page(s) rbad063

Abstract: Polyhydroxyalkanoates are natural, biodegradable, thermoplastic and sustainable polymers with a huge potential in fabrication of bioresorbable implantable devices for tissue engineering. We describe a comparative evaluation of three medium chain length ... ...

Abstract	Polyhydroxyalkanoates are natural, biodegradable, thermoplastic and sustainable polymers with a huge potential in fabrication of bioresorbable implantable devices for tissue engineering. We describe a comparative evaluation of three medium chain length polyhydroxyalkanoates (mcl-PHAs), namely poly(3-hydroxyoctanoate), poly(3-hydroxyoctanoate-co-3-hydoxydecanoate) and poly(3-hydroxyoctanoate-co-3-hydroxydecanoate-co-3-hydroxydodecanoate), one short chain length polyhydroxyalkanoate, poly(3-hydroxybutyrate), P(3HB) and synthetic aliphatic polyesters (polycaprolactone and polylactide) with a specific focus on nerve regeneration, due to mechanical properties of mcl-PHAs closely matching nerve tissues.
Language	English
Publishing date	2023-07-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2799042-4
ISSN	2056-3426 ; 2056-3418
ISSN (online)	2056-3426
ISSN	2056-3418
DOI	10.1093/rb/rbad063
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Article: Qualitative Evaluation of a Program to Integrate Hepatitis C Care Into HIV Care Inclusive of Task Shifting to Nonspecialist Providers.

Allison, Waridibo E / Desai, Anmol / Kawasaki, Keito / Choi, Aro N / Bobadilla, Raudel / Melhado, Trisha V / Taylor, Barbara S

Health promotion practice

2023 Volume 24, Issue 5, Page(s) 990–992

Abstract: The treatment and cure of hepatitis C (HCV) in people with HIV is particularly important as progression of their liver disease is quicker compared with those who have HCV monoinfection. Innovative approaches are needed to maximize access to curative HCV ... ...

Abstract	The treatment and cure of hepatitis C (HCV) in people with HIV is particularly important as progression of their liver disease is quicker compared with those who have HCV monoinfection. Innovative approaches are needed to maximize access to curative HCV treatment. Integration of HCV care into HIV primary care with education and support of nonspecialist providers via telementoring offers a solution to specialist workforce shortages. Using focus group qualitative methodology, health care workers' perspectives regarding this approach, particularly with the Extension for Community Healthcare Outcomes (ECHO) telementoring model, were obtained and are described. Successful integration of HCV care into HIV primary care has demonstrated benefits to patients, including allowing them to remain in their medical home for care. Factors beyond disease that influence their health and wellbeing must also be considered.
MeSH term(s)	Humans ; Hepatitis C/therapy ; Hepacivirus ; HIV Infections/therapy
Language	English
Publishing date	2023-07-13
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	2036801-X
ISSN	1552-6372 ; 1524-8399
ISSN (online)	1552-6372
ISSN	1524-8399
DOI	10.1177/15248399231169927
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Article ; Online: A Call for Youth Voice to Support Engagement in Care for 18- to 29-Year Olds Living with HIV in the US South.

Johnson, Catherine / Chidester, Autumn / Chandramohan, Divya / Lin, Hueylie / Ho, Nhat Minh / Taranova, Anna / Nijhawan, Ank E / Kools, Susan / Ingersoll, Karen / Dillingham, Rebecca / Taylor, Barbara S

AIDS patient care and STDs

2024

Abstract: Youth with HIV (YWH) face challenges in achieving viral suppression, particularly in the Southern United States, and welcome novel interventions responsive to community needs. The Theory of Planned Behavior (TPB) describes factors that influence behavior ...

Abstract	Youth with HIV (YWH) face challenges in achieving viral suppression, particularly in the Southern United States, and welcome novel interventions responsive to community needs. The Theory of Planned Behavior (TPB) describes factors that influence behavior change, and the Positive Youth Development (PYD) supports youth-focused program design. We applied TPB and PYD to explore factors supporting care engagement and challenges for YWH in South Texas. We conducted 14 semi-structured interviews with YWH and 7 focus groups with 26 stakeholders informed by TPB, PYD, and themes from a youth advisory board (YAB). The research team and YAB reviewed emerging themes, and feedback-aided iterative revision of interview guides and codebook. Thematic analysis compared code families by respondent type, TPB, and PYD. All study methods were reviewed by the UT Health San Antonio and University Health Institutional Review Boards. Emerging themes associated with care engagement included: varied reactions to HIV diagnosis from acceptance to fear/grief; financial, insurance, and mental health challenges; history of trauma; high self-efficacy; desire for independence; and desire for engagement with clinic staff from their age group. Stakeholders perceived YWH lifestyle, including partying and substance use, as care barriers. In contrast, YWH viewed "partying" as an unwelcome stereotype, and barriers to care included multiple jobs and family responsibilities. Two key themes captured in PYD but not in TPB were the importance of youth voice in program design and structural barriers to care (e.g., insurance, transportation). Based on these findings, we provide critical and relevant guidance for those seeking to design more effective youth-centered HIV care engagement interventions. By considering the perspectives of YWH in program design and incorporating the PYD framework, stakeholders can better align with YWHs' desire for representation and agency. Our findings provide important and relevant guidance for those seeking to design more effective HIV care engagement interventions for YWH.
Language	English
Publishing date	2024-04-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	1326868-5
ISSN	1557-7449 ; 0893-5068 ; 1087-2914
ISSN (online)	1557-7449
ISSN	0893-5068 ; 1087-2914
DOI	10.1089/apc.2024.0006
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