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  1. Article: The Lingering Health Challenge: Addressing Obesity in Axial Spondyloarthritis.

    Dinneen, Brona / O'Shea, Finbar

    The Journal of rheumatology

    2023  

    Abstract: Axial spondyloarthritis (axSpA) is a chronic inflammatory disorder that primarily affects the axial skeleton, including the spine and sacroiliac joints. ...

    Abstract Axial spondyloarthritis (axSpA) is a chronic inflammatory disorder that primarily affects the axial skeleton, including the spine and sacroiliac joints.
    Language English
    Publishing date 2023-10-01
    Publishing country Canada
    Document type Editorial
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.2023-0744
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    Zs.A 1168: Show issues Location:
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  2. Article ; Online: Comment on: Bone density and fracture risk factors in ankylosing spondylitis: a meta-analysis.

    Mulkerrin, Patrick / O'Shea, Finbar / Fitzgerald, Gillian

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

    2024  Volume 35, Issue 5, Page(s) 929–930

    MeSH term(s) Humans ; Bone Density ; Spondylitis, Ankylosing/complications ; Fractures, Bone/complications ; Spinal Fractures/etiology ; Risk Factors
    Language English
    Publishing date 2024-01-08
    Publishing country England
    Document type Meta-Analysis ; Letter
    ZDB-ID 1064892-6
    ISSN 1433-2965 ; 0937-941X
    ISSN (online) 1433-2965
    ISSN 0937-941X
    DOI 10.1007/s00198-023-07010-3
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  3. Article ; Online: Structural disease modification in axial spondyloarthritis.

    Dinneen, Brona / O'Shea, Finbar / Gensler, Lianne

    Best practice & research. Clinical rheumatology

    2023  Volume 37, Issue 3, Page(s) 101898

    Abstract: Disease modification" in axial spondyloarthritis (axSpA) seeks to not only alleviate clinical symptoms but also alter the disease's natural course by impeding new bone formation. Recent years have witnessed the effectiveness of treatments, including ... ...

    Abstract "Disease modification" in axial spondyloarthritis (axSpA) seeks to not only alleviate clinical symptoms but also alter the disease's natural course by impeding new bone formation. Recent years have witnessed the effectiveness of treatments, including biologics and nonsteroidal anti-inflammatory drugs, in managing axSpA symptoms. Emerging evidence points toward their potential impact on slowing structural disease progression. This comprehensive review centers on the pivotal role of inhibiting new bone formation in axSpA disease modification. It delves into the significance of imaging techniques for assessing disease progression and explores the disease-modifying properties of available axSpA treatments, encompassing NSAIDs, TNF inhibitors, IL-17 inhibitors, and JAK inhibitors. This article offers valuable insights into the evolving landscape of disease modification strategies in axial spondyloarthritis, highlighting the multifaceted approaches used to attain these objectives.
    MeSH term(s) Humans ; Spondylitis, Ankylosing/drug therapy ; Antirheumatic Agents/therapeutic use ; Spondylarthritis/diagnosis ; Spondylarthritis/drug therapy ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Axial Spondyloarthritis ; Disease Progression
    Chemical Substances Antirheumatic Agents ; Anti-Inflammatory Agents, Non-Steroidal
    Language English
    Publishing date 2023-12-01
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2052323-3
    ISSN 1532-1770 ; 1521-6942
    ISSN (online) 1532-1770
    ISSN 1521-6942
    DOI 10.1016/j.berh.2023.101898
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  4. Article ; Online: The negative impact of depression in women with Axial Spondyloarthropathy.

    Maguire, Sinead / Gallagher, Phil / O'Shea, Finbar

    Joint bone spine

    2021  Volume 89, Issue 1, Page(s) 105261

    MeSH term(s) Depression/epidemiology ; Depression/etiology ; Female ; Humans ; Spondylarthritis ; Spondylarthropathies/complications
    Language English
    Publishing date 2021-09-02
    Publishing country France
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020487-5
    ISSN 1778-7254 ; 1297-319X
    ISSN (online) 1778-7254
    ISSN 1297-319X
    DOI 10.1016/j.jbspin.2021.105261
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  5. Article: The negative impact of undiagnosed depression in axial spondyloarthropathy.

    Maguire, Sinead / Gallagher, Phil / O'Shea, Finbar

    Clinical and experimental rheumatology

    2021  Volume 40, Issue 3, Page(s) 669–670

    MeSH term(s) Depression/diagnosis ; Depression/etiology ; Humans ; Spondylarthritis ; Spondylarthropathies/diagnosis
    Language English
    Publishing date 2021-10-21
    Publishing country Italy
    Document type Letter
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
    DOI 10.55563/clinexprheumatol/d6518k
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  6. Article: Undiagnostizierte Depressionen bei axialer SpA

    Maguire, Sinead / Gallagher, Phil / O'Shea, Finbar

    Morbus-Bechterew-Journal

    2022  Volume 43, Issue 170, Page(s) 16

    Language German
    Document type Article
    ZDB-ID 2119820-2
    ISSN 1861-2105
    Database Current Contents Medicine

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  7. Article: Employment and Functional Ability in Men and Women With Axial Spondyloarthritis as Described in the US-based Corrona Psoriatic Arthritis/Spondyloarthritis Registry.

    Maguire, Sinead / Fitzgerald, Gillian / O'Shea, Finbar

    The Journal of rheumatology

    2021  Volume 48, Issue 12, Page(s) 1890

    MeSH term(s) Arthritis, Psoriatic ; Axial Spondyloarthritis ; Employment ; Female ; Humans ; Male ; Registries ; Spondylarthritis
    Language English
    Publishing date 2021-09-01
    Publishing country Canada
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.210469
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    Zs.A 1168: Show issues Location:
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  8. Article ; Online: Social isolation due to the COVID-19 pandemic has led to worse outcomes in females with inflammatory arthritis.

    Maguire, Sinead / O'Shea, Finbar

    Irish journal of medical science

    2020  Volume 190, Issue 1, Page(s) 33–38

    Abstract: Background: Prolonged social isolation as a result of the COVID-19 global pandemic has been a source of considerable psychological distress for many people. This can manifest in many ways and if left undetected can impact negatively on general health. ... ...

    Abstract Background: Prolonged social isolation as a result of the COVID-19 global pandemic has been a source of considerable psychological distress for many people. This can manifest in many ways and if left undetected can impact negatively on general health. It is essential to understand the impact of these conditions on inflammatory arthritis (IA) patients, especially axial spondyloarthropathy (axSpA).
    Aim: To capture the level of psychological distress for patients with IA following prolonged social isolation.
    Methods: A survey was sent out to patients with a confirmed diagnosis of IA. This captured changes in sleep, mood, disease activity, employment and general health since the beginning of the social isolation period. A PHQ-4 (Patient Health Questionnaire) was included to determine level of psychological distress.
    Results: Females with IA reported significantly higher rates of decline in general health (40% vs 16%, p = 0.01), mood disturbance (43.4% vs 26%, p = 0.03) and increased disease activity (50% vs 16%, p = 0.01) compared to males. Evaluating the mean PHQ-4 scores, no significant difference was noted between genders (4.80 vs 3.44, p = 0.10). However, females demonstrated a non-significant trend toward increased rates of moderate to severe psychological distress (40% vs 30%, p = 0.13). Subanalysis of patients with axSpA found high rates of moderate to severe distress in both genders.
    Conclusions: Females with IA reported significantly higher rates of decline in general health, mood disturbance and increased disease activity during the period of social isolation. This was reflected in a trend towards greater levels of psychological distress.
    MeSH term(s) Affect ; Arthritis/physiopathology ; Arthritis/psychology ; COVID-19 ; Employment ; Female ; Health Status ; Humans ; Ireland ; Male ; Middle Aged ; Pandemics ; Patient Health Questionnaire ; Physical Distancing ; Psychological Distress ; Risk Factors ; SARS-CoV-2 ; Severity of Illness Index ; Sex Factors ; Sleep ; Social Isolation/psychology ; Spondylarthropathies/physiopathology ; Spondylarthropathies/psychology ; Surveys and Questionnaires ; Teleworking ; Unemployment
    Keywords covid19
    Language English
    Publishing date 2020-07-12
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 390895-1
    ISSN 1863-4362 ; 0021-1265
    ISSN (online) 1863-4362
    ISSN 0021-1265
    DOI 10.1007/s11845-020-02307-2
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    Zs.B 323: Show issues Location:
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  9. Article ; Online: Testing the feasibility and acceptability of an online 'Fatigue and Activity Management Education for Work (FAME-W) programme' for individuals with inflammatory arthritis.

    Karkon, Shalaleh / O'Shea, Finbar / Doran, Michelle / McCormack, Hazel / Connolly, Deirdre

    Musculoskeletal care

    2023  Volume 21, Issue 3, Page(s) 815–826

    Abstract: Introduction: Fatigue and Activity Management Education for Work (FAME-W) is a four-week, occupational therapy led programme focussing on fatigue management strategies. FAME-W was designed to be delivered in person; however, due to COVID-19 pandemic it ... ...

    Abstract Introduction: Fatigue and Activity Management Education for Work (FAME-W) is a four-week, occupational therapy led programme focussing on fatigue management strategies. FAME-W was designed to be delivered in person; however, due to COVID-19 pandemic it was modified to be an online group-based self-management intervention. The purpose of this study was to test the feasibility and acceptability of the online delivery format of FAME-W.
    Methods: This was a mixed methods study. Participants were randomly allocated to intervention or control group. Participants in the intervention group received a four-week online FAME-W. The control group participants received a FAME-W handbook. Participants were required to complete questionnaires on work presenteeism, fatigue, mood, Health Related Quality of Life and pain at baseline, and 3 months post-intervention. Participants in the intervention group attended a focus group immediately following the completion of the programme and the control group participated in individual interviews.
    Results: Seven of ten individuals recruited participated in the study. Majority of participants had Rheumatoid Arthritis and were working full-time. The mean age of intervention participants was 53 ± 10.4 and 56.5 ± 3.7 for the controls. All participants in the intervention group had 100% attendance, completed all study measures and activities. Participants had positive comments about the programme format, content, and delivery. Improvements were observed in most measures at follow up.
    Conclusion: Results suggest that an online programme to improve work ability was feasible and acceptable to individuals with inflammatory arthritis. The online delivery format was favoured over attending a centre-based programme. The findings support a definitive intervention trial of online FAME-W.
    MeSH term(s) Humans ; Arthritis, Rheumatoid ; COVID-19 ; Fatigue/therapy ; Feasibility Studies ; Pandemics ; Quality of Life ; Adult ; Middle Aged
    Language English
    Publishing date 2023-03-17
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2171452-6
    ISSN 1557-0681 ; 1478-2189
    ISSN (online) 1557-0681
    ISSN 1478-2189
    DOI 10.1002/msc.1756
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  10. Article: Central Obesity in Axial Spondyloarthritis: The Missing Link to Understanding Worse Outcomes in Women?

    Maguire, Sinead / Wilson, Fiona / Gallagher, Phil / O'Shea, Finbar

    The Journal of rheumatology

    2022  Volume 49, Issue 6, Page(s) 577–584

    Abstract: Objective: To determine (1) the prevalence of central obesity in axial spondyloarthritis (axSpA) and its effect on disease-related outcomes and (2) how this differs between sexes.: Methods: Data were extracted from the Ankylosing Spondylitis Registry ...

    Abstract Objective: To determine (1) the prevalence of central obesity in axial spondyloarthritis (axSpA) and its effect on disease-related outcomes and (2) how this differs between sexes.
    Methods: Data were extracted from the Ankylosing Spondylitis Registry of Ireland. Patients with physical measurements for the calculation of anthropometric measures were included. BMI and waist-to-hip ratio (WHR) were used to compare classifications of obesity. Comparison analyses based on sex and central obesity were carried out. Multivariate analysis examined the effects of these factors on the following patient-reported outcomes: the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), the Bath Ankylosing Spondylitis Functional Index (BASFI), the Ankylosing Spondylitis Quality of Life (ASQoL) questionnaire, and the Health Assessment Questionnaire (HAQ).
    Results: In total, 753 patients were included in the analysis. Of these patients, 29.6% (n = 223) were classified as obese based on their BMI, and 41.3% (n = 311) were classified as centrally obese according to the WHR. The prevalence of central obesity was significantly higher among women with axSpA compared to men (71.6% vs 29.9%,
    Conclusion: There was a high prevalence of central obesity as assessed by the WHR in axSpA, most notably among women with axSpA. This modifiable comorbidity was significantly associated with worse quality of life, greater impairment of functional ability, and a trend toward worse disease activity. Regular use of the WHR to screen for central obesity as part of an axSpA assessment would provide an opportunity for prompt identification and intervention for at-risk patients.
    MeSH term(s) Axial Spondyloarthritis ; Cross-Sectional Studies ; Female ; Humans ; Male ; Obesity/complications ; Obesity/epidemiology ; Obesity, Abdominal/complications ; Obesity, Abdominal/epidemiology ; Quality of Life ; Severity of Illness Index ; Spondylarthritis/complications ; Spondylarthritis/epidemiology ; Spondylitis, Ankylosing/complications
    Language English
    Publishing date 2022-03-01
    Publishing country Canada
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.211062
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