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  1. Book ; Online ; E-Book: Precision medicine and artificial intelligence

    Mahler, Michael

    the perfect fit for autoimmunity

    2021  

    Author's details edited by Michael Mahler
    Keywords Artificial intelligence / Medical applications ; Autoimmunity
    Language English
    Size 1 Online-Ressource (xv, 284 Seiten), Illustrationen, Diagramme
    Edition First edition
    Publisher Elsevier Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021362442
    ISBN 978-0-323-85432-0 ; 9780128202395 ; 0-323-85432-X ; 0128202394
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Entwicklung einer Auswertemethode für bruchmechanische Versuche an kleinen Proben auf der Basis eines Kohäsivzonenmodells

    Mahler, Michael

    2016  

    Abstract: In this work, the fracture toughness is predicted by means of a method based on tests using sub-size specimens. For this purpose, the fracture process including crack growth is described using FEM and cohesive zone model. The tests on sub-size specimens ... ...

    Abstract In this work, the fracture toughness is predicted by means of a method based on tests using sub-size specimens. For this purpose, the fracture process including crack growth is described using FEM and cohesive zone model. The tests on sub-size specimens are used for parameter identification. With this set of parameters a standard-size specimen can be simulated. The predicted fracture toughness based on this standard-size specimen meets the size-requirements of the applicable standard
    Keywords Technology (General)
    Size 1 electronic resource (XXVI, 255 p. p.)
    Publisher KIT Scientific Publishing
    Publishing place Verlagsort nicht ermittelbar
    Document type Book ; Online
    Note GERMAN ; Open Access
    HBZ-ID HT020197542
    ISBN 9783731504412 ; 3731504413
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: The Berlin-Buch respiration chamber for energy expenditure measurements.

    Mähler, Anja / Schütte, Till / Steiniger, Jochen / Boschmann, Michael

    European journal of applied physiology

    2023  Volume 123, Issue 6, Page(s) 1359–1368

    Abstract: Purpose: We present a methodological overview of a respiration chamber at the Experimental and Clinical Research Center in Berlin, Germany. Since 2010, we investigated 750 healthy subjects and patients with various diseases. We routinely measure resting ...

    Abstract Purpose: We present a methodological overview of a respiration chamber at the Experimental and Clinical Research Center in Berlin, Germany. Since 2010, we investigated 750 healthy subjects and patients with various diseases. We routinely measure resting energy expenditure (REE), dietary-induced thermogenesis, and activity energy expenditure.
    Methods: The chamber is a pull calorimeter with a total volume of 11,000 L. The majority of measurements is done with a flow rate of 120 L/min, yielding a favorable time constant of 1.53 h. The gas analysis system consists of two paramagnetic O
    Results: Validation factors (calculated/measured) of 20 representative 2 h acetone burning tests were 1.03 ± 0.03 for [Formula: see text], 1.02 ± 0.02 for [Formula: see text], 0.99 ± 0.02 for RER, and 1.03 ± 0.03 for EE. Four repeated 60 min REE measurements of a healthy woman showed variabilities of 231.9 ± 4.8 ml/min for [Formula: see text] (CV 2.1%), 166.0 ± 6.3 ml/min for [Formula: see text] (CV 3.8%), 0.73 ± 0.03 for RER (CV 4.6%), and 4.55 ± 0.07 kJ/min for EE (CV 1.6%).
    Conclusions: The data presented show that our respiration chamber produces precise and valid EE measurements with an exceptionally fast responsiveness.
    MeSH term(s) Female ; Humans ; Acetone ; Berlin ; Calorimetry, Indirect ; Carbon Dioxide ; Energy Metabolism ; Respiration ; Case-Control Studies
    Chemical Substances Acetone (1364PS73AF) ; Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2023-02-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124793-1
    ISSN 1439-6327 ; 1432-1025 ; 0301-5548 ; 1439-6319
    ISSN (online) 1439-6327 ; 1432-1025
    ISSN 0301-5548 ; 1439-6319
    DOI 10.1007/s00421-023-05164-w
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  4. Article ; Online: Lack of standardisation of ANA and implications for drug development and precision medicine.

    Mahler, Michael

    Annals of the rheumatic diseases

    2018  Volume 78, Issue 5, Page(s) e33

    MeSH term(s) Antibodies, Antinuclear ; Drug Development ; Humans ; Patients ; Precision Medicine ; Reference Standards
    Chemical Substances Antibodies, Antinuclear
    Language English
    Publishing date 2018-03-24
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2018-213374
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  5. Article ; Online: Population-based screening for ACPAs: a step in the pathway to the prevention of rheumatoid arthritis?

    Mahler, Michael

    Annals of the rheumatic diseases

    2017  Volume 76, Issue 11, Page(s) e42

    MeSH term(s) Aminosalicylic Acids ; Arthritis, Rheumatoid ; Autoantibodies ; Humans ; Netherlands
    Chemical Substances Aminosalicylic Acids ; Autoantibodies ; acetyl 4-aminosalicylic acid (102338-89-6)
    Language English
    Publishing date 2017-03-08
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2017-211249
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  6. Article ; Online: Response to "troponin thresholds for MI risk stratification" by Dr. Pickering.

    Supples, Michael W / Snavely, Anna C / Ashburn, Nicklaus P / Allen, Brandon R / Mahler, Simon A

    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine

    2024  Volume 31, Issue 3, Page(s) 306–307

    MeSH term(s) Humans ; Troponin ; Myocardial Infarction ; Biomarkers ; Risk Assessment
    Chemical Substances Troponin ; Biomarkers
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Letter
    ZDB-ID 1329813-6
    ISSN 1553-2712 ; 1069-6563
    ISSN (online) 1553-2712
    ISSN 1069-6563
    DOI 10.1111/acem.14862
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  7. Article ; Online: Validation of the ACC Expert Consensus Decision Pathway for Patients With Chest Pain.

    Mahler, Simon A / Ashburn, Nicklaus P / Supples, Michael W / Hashemian, Tara / Snavely, Anna C

    Journal of the American College of Cardiology

    2024  Volume 83, Issue 13, Page(s) 1181–1190

    MeSH term(s) Adult ; Female ; Humans ; Male ; Middle Aged ; Acute Coronary Syndrome/diagnosis ; Acute Coronary Syndrome/therapy ; Acute Coronary Syndrome/complications ; Cardiology ; Chest Pain/diagnosis ; Chest Pain/etiology ; Consensus ; Emergency Service, Hospital ; Myocardial Infarction/complications ; Prospective Studies ; United States/epidemiology ; Aged
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2024.02.004
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  8. Article ; Online: Comment on: Concordance between myositis autoantibodies and anti-nuclear antibody patterns in a real-world, Australian cohort.

    Mahler, Michael / Satoh, Minoru / Fritzler, Marvin J

    Rheumatology (Oxford, England)

    2022  Volume 61, Issue 9, Page(s) e290–e291

    MeSH term(s) Antibodies, Antinuclear ; Australia ; Autoantibodies ; Cohort Studies ; Humans ; Myositis
    Chemical Substances Antibodies, Antinuclear ; Autoantibodies
    Language English
    Publishing date 2022-03-18
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keac155
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  9. Article: Clinical Validity of Anti-Proteinase 3 Antibodies in Patients with Inflammatory Bowel Disease: A Short Meta-Analysis.

    Andalucía, Carmen / Martínez-Prat, Laura / Bentow, Chelsea / Aure, Mary Ann / Horn, Michael P / Mahler, Michael

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 24

    Abstract: Anti-neutrophil cytoplasmic antibodies (ANCA) directed to proteinase 3 (PR3) represent highly established markers for patients with ANCA-associated vasculitis (AAV). PR3-ANCA have also demonstrated utility in the management of inflammatory bowel disease ( ...

    Abstract Anti-neutrophil cytoplasmic antibodies (ANCA) directed to proteinase 3 (PR3) represent highly established markers for patients with ANCA-associated vasculitis (AAV). PR3-ANCA have also demonstrated utility in the management of inflammatory bowel disease (IBD). More specifically, PR3-ANCA discriminate individuals with ulcerative colitis (UC) from Crohn's disease (CD) patients and are associated with disease severity, activity, and treatment non-response. Here, we aim to summarize the current data on the diagnostic utility of PR3-ANCA in IBD. A structured, systematic literature review, including three electronic databases, was conducted on June 6th, 2023, to identify studies assessing the diagnostic accuracy of the QUANTA Flash
    Language English
    Publishing date 2023-12-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13243682
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  10. Article ; Online: Anti-Th/To Antibodies: Association With Lung Disease and Potential Protection From Systemic Sclerosis-Related Cancer? Comment on the Article by Mecoli et al.

    Mahler, Michael / Satoh, Minoru / Fritzler, Marvin

    Arthritis & rheumatology (Hoboken, N.J.)

    2021  Volume 73, Issue 3, Page(s) 545–546

    MeSH term(s) Humans ; Lung Diseases ; Neoplasms ; Scleroderma, Systemic
    Keywords covid19
    Language English
    Publishing date 2021-01-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.41560
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