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Article: Collaborative Assessment and Management of Suicidality for Teens: A Promising Frontline Intervention for Addressing Adolescent Suicidality.

Adrian, Molly / Blossom, Jennifer B / Chu, Phuonguyen V / Jobes, David / McCauley, Elizabeth

2022 Volume 7, Issue 2, Page(s) 154–167

Abstract: This pilot open trial examined the feasibility, acceptability, and preliminary outcomes of the Collaborative Assessment and Management of Suicidality for teens (CAMS-4Teens) who presented to outpatient care with suicidal thoughts and behaviors. ... ...

Abstract	This pilot open trial examined the feasibility, acceptability, and preliminary outcomes of the Collaborative Assessment and Management of Suicidality for teens (CAMS-4Teens) who presented to outpatient care with suicidal thoughts and behaviors. Participants were 22 adolescents (13-17; 59% identified as female) with clinical elevations (≥7) on the Suicidal Behaviors Questionnaire-Revised (SBQ-R). Primary outcomes were feasibility and acceptability. We also explored outcomes of suicidal thoughts and behaviors, as well as mixed effects modeling for weekly assessments of the Suicide Status Form (SSF) Core Assessment constructs. Our main implementation outcomes suggest that the intervention is acceptable, appropriate, and feasible to deliver. Clinicians were adherent to the model with high ratings of adherence. In addition, preliminary evaluation of suicidal thoughts and behaviors found a large effect size for reduction in suicidal thoughts. Benchmarking to other adolescent suicide specific interventions and the Collaborative Assessment of Management of Suicidality with adult populations provide promise that suicidal adolescent responses may be on par with established interventions. Findings from the study are preliminary in nature and intended to inform if CAMS with adolescents is a promising approach to engage and treat patient-defined "drivers" of suicide. The results suggest that a future investigation with power to detect significant change over another active intervention is warranted.
Language	English
Publishing date	2022-07-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2854337-3
ISSN	2377-8903 ; 2377-889X
ISSN (online)	2377-8903
ISSN	2377-889X
DOI	10.1037/pri0000156
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Article ; Online: Castleman disease.

Carbone, Antonino / Borok, Margaret / Damania, Blossom / Gloghini, Annunziata / Polizzotto, Mark N / Jayanthan, Raj K / Fajgenbaum, David C / Bower, Mark

Nature reviews. Disease primers

2021 Volume 7, Issue 1, Page(s) 84

Abstract: ... pathological features, and molecular virology. B cell-directed monoclonal antibody therapy is the standard ...

Abstract	Castleman disease (CD), a heterogeneous group of disorders that share morphological features, is divided into unicentric CD and multicentric CD (MCD) according to the clinical presentation and disease course. Unicentric CD involves a solitary enlarged lymph node and mild symptoms and excision surgery is often curative. MCD includes a form associated with Kaposi sarcoma herpesvirus (KSHV) (also known as human herpesvirus 8) and a KSHV-negative idiopathic form (iMCD). iMCD can present in association with severe syndromes such as TAFRO (thrombocytopenia, ascites, fever, reticulin fibrosis and organomegaly) or POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder and skin changes). KSHV-MCD often occurs in the setting of HIV infection or another cause of immune deficiency. The interplay between KSHV and HIV elevates the risk for the development of KSHV-induced disorders, including KSHV-MCD, KSHV-lymphoproliferation, KSHV inflammatory cytokine syndrome, primary effusion lymphoma and Kaposi sarcoma. A CD diagnosis requires a multidimensional approach, including clinical presentation and imaging, pathological features, and molecular virology. B cell-directed monoclonal antibody therapy is the standard of care in KSHV-MCD, and anti-IL-6 therapy is the recommended first-line therapy and only treatment of iMCD approved by the US FDA and EMA.
MeSH term(s)	Antibodies, Monoclonal/therapeutic use ; Castleman Disease/diagnosis ; Castleman Disease/drug therapy ; Castleman Disease/pathology ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Herpesvirus 8, Human ; Humans ; Sarcoma, Kaposi/diagnosis ; Sarcoma, Kaposi/epidemiology
Chemical Substances	Antibodies, Monoclonal
Language	English
Publishing date	2021-11-25
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ISSN	2056-676X
ISSN (online)	2056-676X
DOI	10.1038/s41572-021-00317-7
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Article ; Online: Procedural Effectiveness With a Focused Force Scoring Angioplasty Catheter: Procedural and Clinical Outcomes From the Scoreflex NC Trial.

Kandzari, David / Hearne, Steven / Kumar, Gautam / Sachdeva, Rajesh / Adams, George / Blossom, Benjamin / Dahle, Thom / Sanghvi, Kintur / Cohen, Mauricio G / Imperi, Gregory / Riley, Robert / Almonacid, Alexandra Popma

Cardiovascular revascularization medicine : including molecular interventions

2021 Volume 35, Page(s) 85–90

Abstract: Background: The Scoreflex NC scoring angioplasty catheter is designed with a short rapid-exchange tip distal to a non-compliant, high-pressure balloon and an integral wire outside of the balloon, such that the guidewire and the integral wire act as ... ...

Abstract	Background: The Scoreflex NC scoring angioplasty catheter is designed with a short rapid-exchange tip distal to a non-compliant, high-pressure balloon and an integral wire outside of the balloon, such that the guidewire and the integral wire act as scoring elements during balloon inflation. The external scoring elements enable a focal stress pattern facilitating expansion of resistant lesions at lower pressures using a focused force angioplasty effect. Methods: Patients undergoing elective percutaneous coronary intervention (PCI) were enrolled in a prospective, single-arm study conducted at 12 centers in the United States. The primary endpoint was device procedural success, defined as the composite of successful device delivery to the target lesion with balloon inflation and deflation; absence of vessel perforation, flow-limiting dissection or reduction in TIMI flow from baseline; and achievement of final TIMI 3 flow. Results: Among 200 patients (234 lesions), lesion complexities included: bifurcation disease (37.6%), moderate/severe calcification (36.6%), and total occlusions (5.0%). Successful delivery to the target lesion, inflation and removal of the balloon catheter was achieved in 95.5% of patients (191/200). Procedural success was achieved in 93.5% (187/200) of patients, and final TIMI 3 flow was observed in 99.0% of cases (198/200). No unanticipated device-related events occurred. In-hospital major adverse events were reported in 4.5% of patients (9/200), related to periprocedural myocardial infarction (8/200, 4.0%) and target lesion revascularization (1/200, 0.5%). Conclusions: Among patients undergoing elective PCI and with varied lesion complexity, these results support the safety and effectiveness of a dilation strategy using the Scoreflex NC scoring catheter.
MeSH term(s)	Angioplasty, Balloon, Coronary/adverse effects ; Catheters ; Coronary Angiography ; Humans ; Myocardial Infarction/etiology ; Percutaneous Coronary Intervention/adverse effects ; Prospective Studies ; Treatment Outcome ; United States
Language	English
Publishing date	2021-03-20
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2212113-4
ISSN	1878-0938 ; 1553-8389
ISSN (online)	1878-0938
ISSN	1553-8389
DOI	10.1016/j.carrev.2021.03.013
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Article ; Online: Secondary impacts of the COVID-19 pandemic at a tertiary children's hospital in Canada: a mixed-methods study.

Diskin, Catherine / Orkin, Julia / Dharmaraj, Blossom / Agarwal, Tanvi / Parmar, Arpita / McNaughton, Kelly / Cohen, Eyal / Sunderji, Alia / Faraoni, David / Fecteau, Annie / Fischer, Jason / Maynes, Jason / Mahant, Sanjay / Friedman, Jeremy

BMJ open

2023 Volume 13, Issue 4, Page(s) e059849

Abstract: Objectives: Decisions to pause all non-essential paediatric hospital activities during the initial phase of the COVID-19 pandemic may have led to significant delays, deferrals and disruptions in medical care. This study explores clinical cases where the ...

Abstract	Objectives: Decisions to pause all non-essential paediatric hospital activities during the initial phase of the COVID-19 pandemic may have led to significant delays, deferrals and disruptions in medical care. This study explores clinical cases where the care of children was perceived by hospital clinicians to have been negatively impacted because of the changes in healthcare delivery attributing to the restrictions placed resulting from the COVID-19 pandemic. Design and setting: This study used a mixed-methods approach using the following: (1) a quantitative analysis of overall descriptive hospital activity between May and August 2020, and utilisation of data during the study period was performed, and (2) a qualitative multiple-case study design with descriptive thematic analysis of clinician-reported consequences of the COVID-19 pandemic on care provided at a tertiary children's hospital. Results: Hospital-level utilisation and activity patterns revealed a substantial change to hospital activity including an initial reduction in emergency department attendance by 38% and an increase in ambulatory virtual care from 4% before COVID-19 to 67% between May and August 2020. Two hundred and twelve clinicians reported a total of 116 unique cases. Themes including (1) timeliness of care, (2) disruption of patient-centred care, (3) new pressures in the provision of safe and efficient care and (4) inequity in the experience of the COVID-19 pandemic emerged, each impacting patients, their families and healthcare providers. Conclusion: Being aware of the breadth of the impact of the COVID-19 pandemic across all of the identified themes is important to enable the delivery of timely, safe, high-quality, family-centred paediatric care moving forward.
MeSH term(s)	Humans ; Child ; COVID-19/epidemiology ; Pandemics ; Tertiary Care Centers ; Canada/epidemiology ; Research Design
Language	English
Publishing date	2023-04-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2021-059849
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Article ; Online: PCPro: a clinically accessible, circulating lipid biomarker signature for poor-prognosis metastatic prostate cancer.

Scheinberg, Tahlia / Lin, Hui-Ming / Fitzpatrick, Michael / Azad, Arun A / Bonnitcha, Paul / Davies, Amy / Heller, Gillian / Huynh, Kevin / Mak, Blossom / Mahon, Kate / Sullivan, David / Meikle, Peter J / Horvath, Lisa G

Prostate cancer and prostatic diseases

2023 Volume 27, Issue 1, Page(s) 136–143

Abstract: Background: Using comprehensive plasma lipidomic profiling from men with metastatic castration-resistant prostate cancer (mCRPC), we have previously identified a poor-prognostic lipid profile associated with shorter overall survival (OS). In order to ... ...

Abstract	Background: Using comprehensive plasma lipidomic profiling from men with metastatic castration-resistant prostate cancer (mCRPC), we have previously identified a poor-prognostic lipid profile associated with shorter overall survival (OS). In order to translate this biomarker into the clinic, these men must be identifiable via a clinically accessible, regulatory-compliant assay. Methods: A single regulatory-compliant liquid chromatography-mass spectrometry assay of candidate lipids was developed and tested on a mCRPC Discovery cohort of 105 men. Various risk-score Cox regression prognostic models of OS were built using the Discovery cohort. The model with the highest concordance index (PCPro) was chosen for validation and tested on an independent Validation cohort of 183 men. Results: PCPro, the lipid biomarker, contains Cer(d18:1/18:0), Cer(d18:1/24:0), Cer(d18:1/24:1), triglycerides and total cholesterol. Within the Discovery and Validation cohorts, men who were PCPro positive had significantly shorter OS compared to those who were PCPro negative (Discovery: median OS 12.0 months vs 24.2 months, hazard ratio (HR) 3.75 [95% confidence interval (CI) 2.29-6.15], p < 0.001, Validation: median OS 13.0 months vs 25.7 months, HR = 2.13 [95% CI 1.46-3.12], p < 0.001). Conclusions: We have developed PCPro, a lipid biomarker assay capable of prospectively identifying men with mCRPC with a poor prognosis. Prospective clinical trials are required to determine if men who are PCPro positive will benefit from therapeutic agents targeting lipid metabolism.
MeSH term(s)	Male ; Humans ; Prostatic Neoplasms, Castration-Resistant/pathology ; Prospective Studies ; Biomarkers ; Prognosis ; Lipids
Chemical Substances	Biomarkers ; Lipids
Language	English
Publishing date	2023-05-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1419277-9
ISSN	1476-5608 ; 1365-7852
ISSN (online)	1476-5608
ISSN	1365-7852
DOI	10.1038/s41391-023-00666-2
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Article ; Online: Evidencing the Impact of Web-Based Coproduction With Youth on Mental Health Research: Qualitative Findings From the MindKind Study.

Fernandes, Blossom / Neelakantan, Lakshmi / Shah, Himani / Sumant, Sushmita / Collins, Pamela Y / Velloza, Jennifer / Bampton, Emily / Ranganathan, Swetha / Sibisi, Refiloe / Bashir, Toiba / Bowes, Joshua / David, Esther Larisa / Kaur, Harsimar / Malik, Umairah / Shannon, Issy / Gurumayum, Suvlaxmi / Burn, Anne-Marie / Sieberts, Solveig K / Fazel, Mina

JMIR public health and surveillance

2023 Volume 9, Page(s) e42963

Abstract: Background: Public involvement in research is a growing phenomenon as well as a condition of research funding, and it is often referred to as coproduction. Coproduction involves stakeholder contributions at every stage of research, but different ... ...

Abstract	Background: Public involvement in research is a growing phenomenon as well as a condition of research funding, and it is often referred to as coproduction. Coproduction involves stakeholder contributions at every stage of research, but different processes exist. However, the impact of coproduction on research is not well understood. Web-based young people's advisory groups (YPAGs) were established as part of the MindKind study at 3 sites (India, South Africa, and the United Kingdom) to coproduce the wider research study. Each group site, led by a professional youth advisor, conducted all youth coproduction activities collaboratively with other research staff. Objective: This study aimed to evaluate the impact of youth coproduction in the MindKind study. Methods: To measure the impact of web-based youth coproduction on all stakeholders, the following methods were used: analysis of project documents, capturing the views of stakeholders using the Most Significant Change technique, and impact frameworks to assess the impact of youth coproduction on specific stakeholder outcomes. Data were analyzed in collaboration with researchers, advisors, and YPAG members to explore the impact of youth coproduction on research. Results: The impact was recorded on 5 levels. First, at the paradigmatic level, a novel method of conducting research allowed for a widely diverse group of YPAG representations, influencing study priorities, conceptualization, and design. Second, at the infrastructural level, the YPAG and youth advisors meaningfully contributed to the dissemination of materials; infrastructural constraints of undertaking coproduction were also identified. Third, at the organizational level, coproduction necessitated implementing new communication practices, such as a web-based shared platform. This meant that materials were easily accessible to the whole team and communication streams remained consistent. Fourth, at the group level, authentic relationships developed between the YPAG members, advisors, and the rest of the team, facilitated by regular web-based contact. Finally, at the individual level, participants reported enhanced insights into mental well-being and appreciation for the opportunity to engage in research. Conclusions: This study revealed several factors that shape the creation of web-based coproduction, with clear positive outcomes for advisors, YPAG members, researchers, and other project staff. However, several challenges of coproduced research were also encountered in multiple contexts and amid pressing timelines. For systematic reporting of the impact of youth coproduction, we propose that monitoring, evaluation, and learning systems be designed and implemented early.
MeSH term(s)	Humans ; Adolescent ; Mental Health ; United Kingdom ; Learning ; Communication ; Internet
Language	English
Publishing date	2023-06-19
Publishing country	Canada
Document type	Journal Article
ISSN	2369-2960
ISSN (online)	2369-2960
DOI	10.2196/42963
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Article ; Online ; Conference proceedings: Innate barriers to viral infection.

Damania, Blossom / Blackbourn, David J

Future microbiology

2012 Volume 7, Issue 7, Page(s) 815–822

Abstract: Innate immunity represents the foremost barrier to viral infection. In order to infect a cell efficiently, viruses need to evade innate immune effectors such as interferons and inflammatory cytokines. Pattern recognition receptors can detect viral ... ...

Abstract	Innate immunity represents the foremost barrier to viral infection. In order to infect a cell efficiently, viruses need to evade innate immune effectors such as interferons and inflammatory cytokines. Pattern recognition receptors can detect viral components or pathogen-associated molecular patterns. These receptors then elicit innate immune responses that result in the generation of type I interferons and proinflammatory cytokines. Organized by the Society for General Microbiology, one session of this conference focused on the current state-of-the-art knowledge on innate barriers to infection of different RNA and DNA viruses. Experts working on innate immunity in the context of viral infection provided insight into different aspects of innate immune recognition and also discussed areas for future research. Here, we provide an overview of the session on innate barriers to infection.
MeSH term(s)	Cytokines/immunology ; DNA Viruses/immunology ; Humans ; Immunity, Innate/immunology ; Inflammation/immunology ; Interferon Type I/immunology ; RNA Viruses/immunology ; Receptors, Pattern Recognition/immunology ; Signal Transduction/immunology ; Virus Diseases/immunology ; Virus Diseases/virology
Chemical Substances	Cytokines ; Interferon Type I ; Receptors, Pattern Recognition
Language	English
Publishing date	2012-07
Publishing country	England
Document type	Congresses ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	1746-0921
ISSN (online)	1746-0921
DOI	10.2217/fmb.12.52
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Article ; Online: The challenges posed by reemerging Clostridium difficile infection.

Blossom, David B / McDonald, L Clifford

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2007 Volume 45, Issue 2, Page(s) 222–227

Abstract: ... difficile that produces increased levels of toxins A and B, as well as an extra toxin known as "binary toxin ...

Abstract	There have been recent, marked increases in the incidence and severity of Clostridium difficile-associated disease (CDAD). These may be attributable to the emergence of a hypervirulent strain of C. difficile that produces increased levels of toxins A and B, as well as an extra toxin known as "binary toxin." This previously uncommon strain has become epidemic, coincident with its development of increased resistance to fluoroquinolones, the use of which is increasingly associated with CDAD outbreaks. Although not necessarily related to this epidemic strain, unusually severe CDAD has been reported in populations that had previously been thought to be at low risk, including peripartum women and healthy persons living in the community. Challenges posed by the changing epidemiology of CDAD are compounded by current limitations in diagnostic testing, treatment, and infection control. Overcoming these challenges and limitations will require a concerted effort from a variety of sources, including an ongoing partnership between infectious disease clinicians and public health professionals.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Clostridium difficile/isolation & purification ; Clostridium difficile/pathogenicity ; Communicable Disease Control/organization & administration ; Communicable Diseases, Emerging/diagnosis ; Communicable Diseases, Emerging/epidemiology ; Cross Infection/diagnosis ; Cross Infection/drug therapy ; Cross Infection/epidemiology ; Disease Outbreaks ; Drug Resistance, Bacterial ; Enterocolitis, Pseudomembranous/diagnosis ; Enterocolitis, Pseudomembranous/drug therapy ; Enterocolitis, Pseudomembranous/epidemiology ; Female ; Humans ; Incidence ; Male ; Microbial Sensitivity Tests ; Prognosis ; Risk Assessment ; Severity of Illness Index ; Sex Distribution ; Survival Analysis
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2007-07-15
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1086/518874
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Article ; Online: Photobiocatalysis by a Lytic Polysaccharide Monooxygenase Using Intermittent Illumination

Blossom, Benedikt M. / Russo, David A. / Singh, Raushan K. / Van Oort, Bart / Keller, Malene B. / Simonsen, Tor I. / Perzon, Alixander / Gamon, Luke F. / Davies, Michael J. / Cannella, David / Croce, Roberta / Jensen, Poul Erik / Bjerrum, Morten J. / Felby, Claus

ACS Sustainable Chemistry and Engineering

2020 Volume 8, Issue 25

Abstract: Photobiocatalysis holds great promise toward the development of sustainable and environmentally friendly processes, harnessing light to drive biocatalytic reactions. However, photobiocatalysis at the interface of insoluble substrates, such as cellulose, ... ...

Abstract	Photobiocatalysis holds great promise toward the development of sustainable and environmentally friendly processes, harnessing light to drive biocatalytic reactions. However, photobiocatalysis at the interface of insoluble substrates, such as cellulose, has not been studied in much detail. In this context, the catalytic enhancement of lytic polysaccharide monooxygenases (LPMOs) by light is of great interest to the biorefinery field due to their capacity to oxidatively cleave such recalcitrant polysaccharides which can facilitate the degradation of lignocellulose. It has previously been reported that light-driven LPMO reactions have a huge catalytic potential, but effective continuous illumination in reactors may be challenging. Therefore, we investigated the impact of intermittent illumination. We show that illumination intervals as short as 1 s/min enable LPMO catalysis on phosphoric acid-swollen cellulose (PASC) to the same level as continuous illumination. Additionally, time-resolved measurements indicate that reductant depletion, and not enzyme inactivation, limits light-driven LPMO reactions. This study shows that a 60-fold reduction in illumination time enhances LPMO catalysis while protecting reaction elements, e.g., the reductant. Most importantly, the significant enhancement of LPMO catalysis with minimal and intermittent illumination is promising toward an application of photobiocatalytic depolymerization of lignocellulose where shading and light scattering minimize light availability and continuity.
Keywords	Cellulose oxidation ; Chlorophyllin ; Intermittent light ; Lytic polysaccharide monooxygenases ; Photobiocatalysis ; Photosensitizer ; Reactive oxygen species (ROS)
Subject code	535
Language	English
Publishing country	nl
Document type	Article ; Online
ISSN	2168-0485
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Article ; Online: Modifiable risk factors for dementia and dementia risk profiling. A user manual for Brain Health Services-part 2 of 6.

Ranson, Janice M / Rittman, Timothy / Hayat, Shabina / Brayne, Carol / Jessen, Frank / Blennow, Kaj / van Duijn, Cornelia / Barkhof, Frederik / Tang, Eugene / Mummery, Catherine J / Stephan, Blossom C M / Altomare, Daniele / Frisoni, Giovanni B / Ribaldi, Federica / Molinuevo, José Luis / Scheltens, Philip / Llewellyn, David J

Alzheimer's research & therapy

2021 Volume 13, Issue 1, Page(s) 169

Abstract: We envisage the development of new Brain Health Services to achieve primary and secondary dementia prevention. These services will complement existing memory clinics by targeting cognitively unimpaired individuals, where the focus is on risk profiling ... ...

Abstract	We envisage the development of new Brain Health Services to achieve primary and secondary dementia prevention. These services will complement existing memory clinics by targeting cognitively unimpaired individuals, where the focus is on risk profiling and personalized risk reduction interventions rather than diagnosing and treating late-stage disease. In this article, we review key potentially modifiable risk factors and genetic risk factors and discuss assessment of risk factors as well as additional fluid and imaging biomarkers that may enhance risk profiling. We then outline multidomain measures and risk profiling and provide practical guidelines for Brain Health Services, with consideration of outstanding uncertainties and challenges. Users of Brain Health Services should undergo risk profiling tailored to their age, level of risk, and availability of local resources. Initial risk assessment should incorporate a multidomain risk profiling measure. For users aged 39-64, we recommend the Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) Dementia Risk Score, whereas for users aged 65 and older, we recommend the Brief Dementia Screening Indicator (BDSI) and the Australian National University Alzheimer's Disease Risk Index (ANU-ADRI). The initial assessment should also include potentially modifiable risk factors including sociodemographic, lifestyle, and health factors. If resources allow, apolipoprotein E ɛ4 status testing and structural magnetic resonance imaging should be conducted. If this initial assessment indicates a low dementia risk, then low intensity interventions can be implemented. If the user has a high dementia risk, additional investigations should be considered if local resources allow. Common variant polygenic risk of late-onset AD can be tested in middle-aged or older adults. Rare variants should only be investigated in users with a family history of early-onset dementia in a first degree relative. Advanced imaging with 18-fluorodeoxyglucose positron emission tomography (FDG-PET) or amyloid PET may be informative in high risk users to clarify the nature and burden of their underlying pathologies. Cerebrospinal fluid biomarkers are not recommended for this setting, and blood-based biomarkers need further validation before clinical use. As new technologies become available, advances in artificial intelligence are likely to improve our ability to combine diverse data to further enhance risk profiling. Ultimately, Brain Health Services have the potential to reduce the future burden of dementia through risk profiling, risk communication, personalized risk reduction, and cognitive enhancement interventions.
MeSH term(s)	Aged ; Alzheimer Disease ; Artificial Intelligence ; Australia ; Biomarkers ; Brain/diagnostic imaging ; Dementia/diagnostic imaging ; Dementia/epidemiology ; Dementia/genetics ; Health Services ; Humans ; Middle Aged ; Positron-Emission Tomography ; Risk Factors
Chemical Substances	Biomarkers
Language	English
Publishing date	2021-10-11
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2506521-X
ISSN	1758-9193 ; 1758-9193
ISSN (online)	1758-9193
ISSN	1758-9193
DOI	10.1186/s13195-021-00895-4
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