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  1. Article ; Online: Mitochondrial Deep Dive into Hematopoietic Stem Cell Dormancy: Not Much Glycolysis but Plenty of Sluggish Lysosomes.

    Qiu, Jiajing / Ghaffari, Saghi

    Experimental hematology

    2022  Volume 114, Page(s) 1–8

    Abstract: The discovery of hematopoietic stem cells (HSCs) heterogeneity has had major implications for investigations of hematopoietic stem cell disorders, clonal hematopoiesis, and HSC aging. More recent studies of the heterogeneity of HSCs' organelles have ... ...

    Abstract The discovery of hematopoietic stem cells (HSCs) heterogeneity has had major implications for investigations of hematopoietic stem cell disorders, clonal hematopoiesis, and HSC aging. More recent studies of the heterogeneity of HSCs' organelles have begun to provide additional insights into HSCs' behavior with far-reaching ramifications for the mechanistic understanding of aging of HSCs and stem cell-derived diseases. Mitochondrial heterogeneity has been explored to expose HSC subsets with distinct properties and functions. Here we review some of the recent advances in these lines of studies that challenged the classic view of glycolysis in HSCs and led to the identification of lysosomes as dynamic pivotal switches in controlling HSC quiescence versus activation beyond their function in autophagy.
    MeSH term(s) Glycolysis ; Hematopoiesis ; Hematopoietic Stem Cells/metabolism ; Lysosomes/metabolism ; Mitochondria/metabolism
    Language English
    Publishing date 2022-07-29
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 185107-x
    ISSN 1873-2399 ; 0531-5573 ; 0301-472X
    ISSN (online) 1873-2399
    ISSN 0531-5573 ; 0301-472X
    DOI 10.1016/j.exphem.2022.07.299
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 922: Show issues Location:
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  2. Article ; Online: Design of Novel 2-Phenylquinazolin-4-amines as Selective CYP1B1 Inhibitors for Overcoming Paclitaxel Resistance in A549 Cells.

    Yang, Meixian / Yang, Fengyuan / Huang, Xinyue / Cai, Jiajing / Zhang, Yuxin / Jia, Jianhua / Qiu, Dachuan

    Journal of medicinal chemistry

    2024  Volume 67, Issue 7, Page(s) 5883–5901

    Abstract: Cytochrome P450 1B1 (CYP1B1) contributes to the metabolic inactivation of chemotherapeutics when overexpressed in tumor cells. Selective inhibition of CYP1B1 holds promise for reversing drug resistance. In our pursuit of potent CYP1B1 inhibitors, we ... ...

    Abstract Cytochrome P450 1B1 (CYP1B1) contributes to the metabolic inactivation of chemotherapeutics when overexpressed in tumor cells. Selective inhibition of CYP1B1 holds promise for reversing drug resistance. In our pursuit of potent CYP1B1 inhibitors, we designed and synthesized a series of 2-phenylquinazolin-4-amines. A substantial proportion of these newly developed inhibitors demonstrated inhibitory activity against CYP1B1, accompanied by improved water solubility. Remarkably, compound
    MeSH term(s) Animals ; Mice ; Humans ; Paclitaxel/pharmacology ; A549 Cells ; Iodine Radioisotopes ; Molecular Docking Simulation ; Amines ; Cytochrome P-450 CYP1B1/chemistry
    Chemical Substances Paclitaxel (P88XT4IS4D) ; Iodine Radioisotopes ; Amines ; Cytochrome P-450 CYP1B1 (EC 1.14.14.1)
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.4c00164
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 151: Show issues Location:
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    Zs.MB 1: Show issues

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  3. Article ; Online: Prostate carcinoma metastasizing to the colon.

    Qiu, Renhui / Zhang, Jiajing / Wu, Weizhen / Xiao, Chunhong

    Asian journal of surgery

    2022  Volume 45, Issue 10, Page(s) 2083–2084

    MeSH term(s) Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Colon/pathology ; Humans ; Male ; Prostate ; Prostatic Neoplasms/pathology
    Language English
    Publishing date 2022-05-03
    Publishing country China
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2022.04.106
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    Zs.B 2831: Show issues Location:
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  4. Article ; Online: Etiological analysis and risk factors of nosocomial infection in kidney transplantation recipients receiving donation after citizens' death.

    Qiu, Renhui / Zhang, Jiajing / Wei, Junjie / Wu, Weizhen

    Asian journal of surgery

    2022  Volume 46, Issue 4, Page(s) 1643–1644

    MeSH term(s) Humans ; Kidney Transplantation/adverse effects ; Cross Infection/epidemiology ; Cross Infection/etiology ; Brain Death ; Risk Factors ; Tissue Donors ; Graft Survival
    Language English
    Publishing date 2022-10-14
    Publishing country China
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2022.09.104
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  5. Article: Association between weight-adjusted waist index and serum total testosterone in males aged 6-19 years in the United States: Data from NHANES 2013-2016.

    Wu, Zhifei / Bao, Lingling / Wang, Haiyan / Zheng, Jiajing / Chen, Yu / Wang, Wenjuan / Qiu, Dongkai

    Heliyon

    2024  Volume 10, Issue 6, Page(s) e27520

    Abstract: Objective: This study aimed to estimate the association between weight-adjusted waist index and serum total testosterone (sTT) in males aged 6-19 years in the United States.: Methods: A cross-sectional study was conducted using data from the National ...

    Abstract Objective: This study aimed to estimate the association between weight-adjusted waist index and serum total testosterone (sTT) in males aged 6-19 years in the United States.
    Methods: A cross-sectional study was conducted using data from the National Health and Nutrition Examination Survey (NHANES) 2013-2016. sTT was considered as the response variable, and weight-adjusted waist circumference index (WWI) as the independent variable. Multiple linear regression was performed to estimate the association between the two variables, and subgroup analysis was performed to identify sensitive cohorts. Smoothing curve fitting and threshold effects analysis was carried out to assess possible nonlinear relationships between WWI and sTT.
    Results: The study included 4207 participants. The mean value of sTT (117.93 ng/dl) was used as the grouping basis, with 1066 participants having serum total testosterone levels above the mean. A negative association was observed between WWI and sTT [beta coefficient (β) = -72.50, 95% confidence interval (CI): -79.45, -65.55], which decreased as WWI increased (P for trend<0.05). Subgroup analysis indicated a stronger negative correlation in late adolescent (16-19 years) males (β = -128.94, 95% CI: -146.75, -111.13). The smoothing curve fit analysis revealed a U-shaped curve relationship for the negative correlation between WWI and sTT. Threshold effect analysis suggested a significant change when WWI exceeded 10.09 (β = -15.82, 95% CI: -24.11, -7.54), and stepwise threshold effect analysis indicated that this negative correlation became less stable when WWI exceeded 11.45 (β = -0.80, 95% CI: -9.15, 7.56).
    Conclusions: Participants with higher WWI exhibited lower total testosterone levels, and a negative association was found between WWI and total testosterone, particularly in late adolescent males aged 16-19 years. Among males aged 6-19 years, caution should be exercised regarding the risk of lower testosterone levels associated with elevated WWI, particularly when WWI is below 10.09.
    Language English
    Publishing date 2024-03-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e27520
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  6. Article ; Online: Protocol to identify and analyze mouse and human quiescent hematopoietic stem cells using flow cytometry combined with confocal imaging.

    Qiu, Jiajing / Menon, Vijay / Tzavaras, Nikolaos / Liang, Raymond / Ghaffari, Saghi

    STAR protocols

    2022  Volume 3, Issue 4, Page(s) 101828

    Abstract: ... of this protocol, please refer to Liang et al. (2020) and Qiu et al. (2021). ...

    Abstract Mitochondrial membrane potential (MMP) segregates functionally distinct subsets within highly purified hematopoietic stem cells (HSCs). Here, we detail a protocol for FACS isolation of MMP sub-fractions of phenotypically defined mouse and human HSCs. These steps are followed by high-/super-resolution immunofluorescence microscopy of HSCs' lysosomes. While the protocol describes the isolation of quiescent HSCs, which are the most potent subsets, it could also be applied to other HSC subsets. This protocol overcomes some experimental challenges associated with low HSC numbers. For complete details on the use and execution of this protocol, please refer to Liang et al. (2020) and Qiu et al. (2021).
    MeSH term(s) Humans ; Animals ; Mice ; Flow Cytometry/methods ; Hematopoietic Stem Cells
    Language English
    Publishing date 2022-11-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2022.101828
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  7. Article ; Online: Self-calibrating dual-sensing electrochemical sensors for accurate detection of carbon dioxide in blood.

    Yang, Da / An, Jia / Qiu, Wu / Gao, Yuhan / Zhang, Jiajing / Pan, Wencai / Zhao, Peng / Liu, Yufei

    Mikrochimica acta

    2023  Volume 191, Issue 1, Page(s) 22

    Abstract: A paper-based electrochemical dual-function biosensor capable of determining pH and ... ...

    Abstract A paper-based electrochemical dual-function biosensor capable of determining pH and TCO
    MeSH term(s) Carbon Dioxide ; Electrochemical Techniques/methods ; Biosensing Techniques/methods ; Electrodes
    Chemical Substances Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2023-12-13
    Publishing country Austria
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 89-9
    ISSN 1436-5073 ; 0026-3672
    ISSN (online) 1436-5073
    ISSN 0026-3672
    DOI 10.1007/s00604-023-06101-6
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    In stock of ZB MED Bonn / Germany

    Z 56/171: Show issues
    Z 8.1: Show issues

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  8. Article ; Online: Effectively enhanced photocatalytic performance of layered perovskite Bi

    Lin, Kai / Dong, Xiaoyi / Xu, Liang / Wang, Qi / Wang, Jiajing / Li, Yongjin / Yin, Zhaoyi / Han, Jin / Qiu, Jianbei / Song, Zhiguo

    Nanoscale

    2023  Volume 15, Issue 4, Page(s) 1849–1859

    Abstract: The coupling between piezoelectricity and photoexcitation is an attractive method for improving the photocatalytic efficiency of semiconductors. Herein, a novel layered perovskite photocatalyst ... ...

    Abstract The coupling between piezoelectricity and photoexcitation is an attractive method for improving the photocatalytic efficiency of semiconductors. Herein, a novel layered perovskite photocatalyst Bi
    Language English
    Publishing date 2023-01-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d2nr05302k
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  9. Article ; Online: Design, Synthesis, and Evaluation of

    Cai, Jiajing / Yi, Lan / Xia, Zhu / Huang, Xinyue / Yang, Meixian / Zhao, Zhenghuan / Gao, Chenyang / Yang, Hengyi / Zhang, Jiayuan / Peng, Zhiping / Qiu, Dachuan

    Bioorganic & medicinal chemistry letters

    2023  Volume 96, Page(s) 129533

    Abstract: Cytochrome P450 (CYP)1B1 has been identified to be specifically overexpressed in several solid tumors, thus it's a potential target for the detection of tumors. Based on the 2-Phenylquinazolin CYP1B1 inhibitors, we designed and synthesized several ... ...

    Abstract Cytochrome P450 (CYP)1B1 has been identified to be specifically overexpressed in several solid tumors, thus it's a potential target for the detection of tumors. Based on the 2-Phenylquinazolin CYP1B1 inhibitors, we designed and synthesized several positron emission computed tomography (PET) imaging probes targeting CYP1B1. Through IC
    MeSH term(s) Cell Line, Tumor ; Positron-Emission Tomography/methods ; Radiopharmaceuticals/pharmacology ; Radiopharmaceuticals/chemistry ; Fluorine Radioisotopes
    Chemical Substances Radiopharmaceuticals ; Fluorine Radioisotopes
    Language English
    Publishing date 2023-10-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1063195-1
    ISSN 1464-3405 ; 0960-894X
    ISSN (online) 1464-3405
    ISSN 0960-894X
    DOI 10.1016/j.bmcl.2023.129533
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    Zs.A 3203: Show issues Location:
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  10. Article ; Online: Loss of macrophage TSC1 exacerbates sterile inflammatory liver injury through inhibiting the AKT/MST1/NRF2 signaling pathway.

    Ni, Ming / Qiu, Jiannan / Liu, Guoqing / Sun, Xiaohu / Zhu, Wenjie / Wu, Peng / Chen, Zheng / Qiu, Jiajing / Wu, Ziming / Zhang, Yang / Zhang, Feng / Li, Changyong / Gao, Yuan / Zhou, Jun / Zhu, Qiang

    Cell death & disease

    2024  Volume 15, Issue 2, Page(s) 146

    Abstract: Tuberous sclerosis complex 1 (TSC1) plays important roles in regulating innate immunity. However, the precise role of TSC1 in macrophages in the regulation of oxidative stress response and hepatic inflammation in liver ischemia/reperfusion injury (I/R) ... ...

    Abstract Tuberous sclerosis complex 1 (TSC1) plays important roles in regulating innate immunity. However, the precise role of TSC1 in macrophages in the regulation of oxidative stress response and hepatic inflammation in liver ischemia/reperfusion injury (I/R) remains unknown. In a mouse model of liver I/R injury, deletion of myeloid-specific TSC1 inhibited AKT and MST1 phosphorylation, and decreased NRF2 accumulation, whereas activated TLR4/NF-κB pathway, leading to increased hepatic inflammation. Adoptive transfer of AKT- or MST1-overexpressing macrophages, or Keap1 disruption in myeloid-specific TSC1-knockout mice promoted NRF2 activation but reduced TLR4 activity and mitigated I/R-induced liver inflammation. Mechanistically, TSC1 in macrophages promoted AKT and MST1 phosphorylation, and protected NRF2 from Keap1-mediated ubiquitination. Furthermore, overexpression AKT or MST1 in TSC1-knockout macrophages upregulated NRF2 expression, downregulated TLR4/NF-κB, resulting in reduced inflammatory factors, ROS and inflammatory cytokine-mediated hepatocyte apoptosis. Strikingly, TSC1 induction in NRF2-deficient macrophages failed to reverse the TLR4/NF-κB activity and production of pro-inflammatory factors. Conclusions: Macrophage TSC1 promoted the activation of the AKT/MST1 signaling pathway, increased NRF2 levels via reducing Keap1-mediated ubiquitination, and modulated oxidative stress-driven inflammatory responses in liver I/R injury. Our findings underscore the critical role of macrophage TSC1 as a novel regulator of innate immunity and imply the therapeutic potential for the treatment of sterile liver inflammation in transplant recipients. Schematic illustration of macrophage TSC1-mediated AKT/MST1/NRF2 signaling pathway in I/R-triggered liver inflammation. Macrophage TSC1 can be activated in I/R-stressed livers. TSC1 activation promotes phosphorylation of AKT and MST1, which in turn increases NRF2 expression and inhibits ROS production and TLR4/NF-κB activation, resulting in reduced hepatocellular apoptosis in I/R-triggered liver injury.
    MeSH term(s) Animals ; Mice ; Proto-Oncogene Proteins c-akt/metabolism ; Kelch-Like ECH-Associated Protein 1/genetics ; Kelch-Like ECH-Associated Protein 1/metabolism ; NF-E2-Related Factor 2/metabolism ; NF-kappa B/metabolism ; Reactive Oxygen Species/metabolism ; Toll-Like Receptor 4/genetics ; Toll-Like Receptor 4/metabolism ; Tuberous Sclerosis/metabolism ; Liver/metabolism ; Signal Transduction ; Macrophages/metabolism ; Inflammation/metabolism ; Reperfusion Injury/metabolism
    Chemical Substances Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2 ; NF-kappa B ; Reactive Oxygen Species ; Toll-Like Receptor 4
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2541626-1
    ISSN 2041-4889 ; 2041-4889
    ISSN (online) 2041-4889
    ISSN 2041-4889
    DOI 10.1038/s41419-024-06538-4
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