Result 1 - 10 of total 78369
Medical examiner (Philadelphia, Pa.)
2023 Volume 2, Issue 33, Page(s) 518–519
| Language | English |
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| Publishing date | 2023-12-20 |
| Publishing country | United States |
| Document type | Journal Article |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2023 Volume 130, Issue 7, Page(s) 71802
Abstract: An absolute measurement of the Λ_{c}^{+} lifetime is reported using Λ_{c}^{+}→pK^{-}π^{+} decays ... at center-of-mass energies at or near the ϒ(4S) resonance, is 207.2 fb^{-1}. The result, τ(Λ_{c}^{+})=203 ...
| Abstract | An absolute measurement of the Λ_{c}^{+} lifetime is reported using Λ_{c}^{+}→pK^{-}π^{+} decays in events reconstructed from data collected by the Belle II experiment at the SuperKEKB asymmetric-energy electron-positron collider. The total integrated luminosity of the data sample, which was collected at center-of-mass energies at or near the ϒ(4S) resonance, is 207.2 fb^{-1}. The result, τ(Λ_{c}^{+})=203.20±0.89±0.77 fs, where the first uncertainty is statistical and the second systematic, is the most precise measurement to date and is consistent with previous determinations. |
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| Language | English |
| Publishing date | 2023-03-02 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 208853-8 |
| ISSN | 1079-7114 ; 0031-9007 |
| ISSN (online) | 1079-7114 |
| ISSN | 0031-9007 |
| DOI | 10.1103/PhysRevLett.130.071802 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Z 4' 58/153: Show issues |
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Investigative ophthalmology & visual science
2023 Volume 64, Issue 3, Page(s) 10
Abstract: Purpose: To test the hypothesis that the C-X-C chemokines CXCL1, CXCL2, and CXCL10 contribute ...
| Abstract | Purpose: To test the hypothesis that the C-X-C chemokines CXCL1, CXCL2, and CXCL10 contribute to inflammation during Staphylococcus aureus endophthalmitis. Methods: S. aureus endophthalmitis was induced by intravitreal injection of 5000 colony forming units of S. aureus into the eyes of C57BL/6J, CXCL1-/-, CXCL2-/-, or CXCL10-/- mice. At 12, 24, and 36 hours postinfection, bacterial counts, intraocular inflammation, and retinal function were assessed. Based on these results, the effectiveness of intravitreal administration of anti-CXCL1 in reducing inflammation and improving retinal function was evaluated in S. aureus-infected C57BL/6J mice. Results: We observed significant attenuation of inflammation and improvement in retinal function in CXCL1-/- mice relative to C57BL/6J at 12 hours but not at 24 or 36 hours postinfection with S. aureus. Co-administration of anti-CXCL1 antibodies with S. aureus, however, did not improve retinal function or reduce inflammation at 12 hours postinfection. In CXCL2-/- and CXCL10-/- mice, retinal function and intraocular inflammation were not significantly different from those of C57BL/6J mice at 12 and 24 hours postinfection. At 12, 24, or 36 hours, an absence of CXCL1, CXCL2, or CXCL10 did not alter intraocular S. aureus concentrations. Conclusions: CXCL1 appears to contribute to the early host innate response to S. aureus endophthalmitis, but treatment with anti-CXCL1 did not effectively limit inflammation in this infection. CXCL2 and CXCL10 did not seem to play an integral role in inflammation during the early stages of S. aureus endophthalmitis. |
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| MeSH term(s) | Animals ; Mice ; Mice, Inbred C57BL ; Chemokines, CXC ; Staphylococcus aureus ; Endophthalmitis ; Inflammation ; Retina ; Staphylococcal Infections |
| Chemical Substances | Chemokines, CXC |
| Language | English |
| Publishing date | 2023-03-03 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 391794-0 |
| ISSN | 1552-5783 ; 0146-0404 |
| ISSN (online) | 1552-5783 |
| ISSN | 0146-0404 |
| DOI | 10.1167/iovs.64.3.10 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 45: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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Journal of the American Chemical Society
2023 Volume 145, Issue 16, Page(s) 9207–9222
Abstract: ... activity with wild-type CYP199A4, subsequent assays with an F182L mutant demonstrated enzyme-dependent C-C ... bond cleavage toward one of the α-hydroxy ketones. This C-C cleavage reaction was subject to an inverse ...
| Abstract | The cytochrome P450 (CYP) superfamily of heme monooxygenases has demonstrated ability to facilitate hydroxylation, desaturation, sulfoxidation, epoxidation, heteroatom dealkylation, and carbon-carbon bond formation and cleavage (lyase) reactions. Seeking to study the carbon-carbon cleavage reaction of α-hydroxy ketones in mechanistic detail using a microbial P450, we synthesized α-hydroxy ketone probes based on the physiological substrate for a well-characterized benzoic acid metabolizing P450, CYP199A4. After observing low activity with wild-type CYP199A4, subsequent assays with an F182L mutant demonstrated enzyme-dependent C-C bond cleavage toward one of the α-hydroxy ketones. This C-C cleavage reaction was subject to an inverse kinetic solvent isotope effect analogous to that observed in the lyase activity of the human P450 CYP17A1, suggesting the involvement of a species earlier than Compound I in the catalytic cycle. Co-crystallization of F182L-CYP199A4 with this α-hydroxy ketone showed that the substrate bound in the active site with a preference for the (S)-enantiomer in a position which could mimic the topology of the lyase reaction in CYP17A1. Molecular dynamics simulations with an oxy-ferrous model of CYP199A4 revealed a displacement of the substrate to allow for oxygen binding and the formation of the lyase transition state proposed for CYP17A1. This demonstration that a correctly positioned α-hydroxy ketone substrate can realize lyase activity with an unusual inverse solvent isotope effect in an engineered microbial system opens the door for further detailed biophysical and structural characterization of CYP catalytic intermediates. |
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| MeSH term(s) | Humans ; Catalytic Domain ; Catalysis ; Lyases ; Molecular Dynamics Simulation |
| Chemical Substances | Lyases (EC 4.-) |
| Language | English |
| Publishing date | 2023-04-11 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 3155-0 |
| ISSN | 1520-5126 ; 0002-7863 |
| ISSN (online) | 1520-5126 |
| ISSN | 0002-7863 |
| DOI | 10.1021/jacs.3c01456 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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The Chicago medical journal and examiner
2023 Volume 33, Issue 8, Page(s) 720–722
| Language | English |
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| Publishing date | 2023-08-24 |
| Publishing country | United States |
| Document type | Journal Article |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2024
Abstract: ... Bis-(3'-5') cyclic diadenosine monophosphate (c-di-AMP) is a nucleotide secondary messenger ... but is uncharacterized in T. denticola. Here, we studied c-di-AMP signaling in T. denticola to understand ... how it contributes to T. denticola physiology. We demonstrated that T. denticola produces c-di-AMP and ...
| Abstract | Pathobionts associated with periodontitis, such as Treponema denticola, must possess numerous sensory transduction systems to adapt to the highly dynamic subgingival environment. To date, the signaling pathways utilized by T. denticola to rapidly sense and respond to environmental stimuli are mainly unknown. Bis-(3'-5') cyclic diadenosine monophosphate (c-di-AMP) is a nucleotide secondary messenger that regulates osmolyte transport, central metabolism, biofilm development, and pathogenicity in many bacteria but is uncharacterized in T. denticola. Here, we studied c-di-AMP signaling in T. denticola to understand how it contributes to T. denticola physiology. We demonstrated that T. denticola produces c-di-AMP and identified enzymes that function in the synthesis (TDE1909) and hydrolysis (TDE0027) of c-di-AMP. To investigate how c-di-AMP may impact T. denticola cellular processes, a screening assay was performed to identify putative c-di-AMP receptor proteins. This approach identified TDE0087, annotated as a potassium uptake protein, as the first T. denticola c-di-AMP binding protein. As potassium homeostasis is critical for maintaining turgor pressure, we demonstrated that T. denticola c-di-AMP concentrations are impacted by osmolarity, suggesting that c-di-AMP negatively regulates potassium uptake in hypoosmotic solutions. Collectively, this study demonstrates T. denticola utilizes c-di-AMP signaling, identifies c-di-AMP metabolism proteins, identifies putative receptor proteins, and correlates c-di-AMP signaling to osmoregulation. |
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| Language | English |
| Publishing date | 2024-03-04 |
| Publishing country | Denmark |
| Document type | Journal Article |
| ZDB-ID | 2537726-7 |
| ISSN | 2041-1014 ; 2041-1006 |
| ISSN (online) | 2041-1014 |
| ISSN | 2041-1006 |
| DOI | 10.1111/omi.12458 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 2199: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2024
Abstract: Background: Virtually all cases of hepatitis C virus (HCV) infection in children ...
| Abstract | Background: Virtually all cases of hepatitis C virus (HCV) infection in children in the United States occur through vertical transmission, but it is unknown how many children are infected. Cases of maternal HCV infection have increased in the United States, which may increase the number of children vertically infected with HCV. Infection has long-term consequences for a child's health, but treatment options are now available for children ≥3 years old. Reducing HCV infections in adults could decrease HCV infections in children. Methods: Using a stochastic compartmental model, we forecasted incidence of HCV infections in children in the United States from 2022 through 2027. The model considered vertical transmission to children <13 years old and horizontal transmission among individuals 13-49 years old. We obtained model parameters and initial conditions from the literature and the Centers for Disease Control and Prevention's 2021 Viral Hepatitis Surveillance Report. Results: Model simulations assuming direct-acting antiviral treatment for children forecasted that the number of acutely infected children would decrease slightly and the number of chronically infected children would decrease even more. Alone, treatment and early screening in individuals 13-49 years old reduced the number of forecasted cases in children and, together, these policy interventions were even more effective. Conclusions: Based on our simulations, acute and chronic cases of HCV infection are remaining constant or slightly decreasing in the United States. Improving early screening and increasing access to treatment in adults may be an effective strategy for reducing the number of HCV infected children in the United States. |
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| Language | English |
| Publishing date | 2024-04-17 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 1099781-7 |
| ISSN | 1537-6591 ; 1058-4838 |
| ISSN (online) | 1537-6591 |
| ISSN | 1058-4838 |
| DOI | 10.1093/cid/ciae157 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 1505: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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| Zs.MO 480: Show issues |
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
2022 Volume 150, Page(s) 112993
Abstract: ... that drug combinations with Cryptotanshinone (C ...
| Abstract | Osteosarcoma is the most prevalent malignant bone tumor and occurs most commonly in the adolescent and young adult population. Despite the recent advances in surgeries and chemotherapy, the overall survival in patients with resectable metastases is around 20%. This challenge in osteosarcoma is often attributed to the drastic differences in the tumorigenic profiles and mutations among patients. With diverse mutations and multiple oncogenes, it is necessary to identify the therapies that can attack various mutations and simultaneously have minor side-effects. In this paper, we constructed the osteosarcoma pathway from literature and modeled it using ordinary differential equations. We then simulated this network for every possible gene mutation and their combinations and ranked different drug combinations based on their efficacy to drive a mutated osteosarcoma network towards cell death. Our theoretical results predict that drug combinations with Cryptotanshinone (C |
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| MeSH term(s) | Adolescent ; Apoptosis ; Bone Neoplasms/pathology ; Cell Line ; Cell Line, Tumor ; Cell Proliferation ; Humans ; Osteosarcoma/pathology ; Phenanthrenes ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Young Adult |
| Chemical Substances | Phenanthrenes ; cryptotanshinone (5E9SXT166N) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) |
| Language | English |
| Publishing date | 2022-04-21 |
| Publishing country | France |
| Document type | Journal Article |
| ZDB-ID | 392415-4 |
| ISSN | 1950-6007 ; 0753-3322 ; 0300-0893 |
| ISSN (online) | 1950-6007 |
| ISSN | 0753-3322 ; 0300-0893 |
| DOI | 10.1016/j.biopha.2022.112993 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Ud II Zs.198: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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The Journal of chemical physics
2019 Volume 151, Issue 24, Page(s) 244301
Abstract: Rate constants for the reactions of C ...
| Abstract | Rate constants for the reactions of C |
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| Language | English |
| Publishing date | 2019-10-07 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 3113-6 |
| ISSN | 1089-7690 ; 0021-9606 |
| ISSN (online) | 1089-7690 |
| ISSN | 0021-9606 |
| DOI | 10.1063/1.5126689 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Z 4' 49/16: Show issues |
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2023 Volume 111, Issue 22, Page(s) 3570–3589.e5
Abstract: ... in the C. elegans nervous system. This network is characterized by high connection density, extended ... We anticipate that the C. elegans neuropeptidergic connectome will serve as a prototype to understand how ...
| Abstract | Efforts are ongoing to map synaptic wiring diagrams, or connectomes, to understand the neural basis of brain function. However, chemical synapses represent only one type of functionally important neuronal connection; in particular, extrasynaptic, "wireless" signaling by neuropeptides is widespread and plays essential roles in all nervous systems. By integrating single-cell anatomical and gene-expression datasets with biochemical analysis of receptor-ligand interactions, we have generated a draft connectome of neuropeptide signaling in the C. elegans nervous system. This network is characterized by high connection density, extended signaling cascades, autocrine foci, and a decentralized topology, with a large, highly interconnected core containing three constituent communities sharing similar patterns of input connectivity. Intriguingly, several key network hubs are little-studied neurons that appear specialized for peptidergic neuromodulation. We anticipate that the C. elegans neuropeptidergic connectome will serve as a prototype to understand how networks of neuromodulatory signaling are organized. |
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| MeSH term(s) | Animals ; Connectome ; Caenorhabditis elegans/physiology ; Neurons/physiology ; Gene Expression ; Synapses |
| Language | English |
| Publishing date | 2023-11-06 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 808167-0 |
| ISSN | 1097-4199 ; 0896-6273 |
| ISSN (online) | 1097-4199 |
| ISSN | 0896-6273 |
| DOI | 10.1016/j.neuron.2023.09.043 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 2496: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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| Zs.MG 92: Show issues |
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