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Article: Rapid literature review: definition and methodology.

Smela, Beata / Toumi, Mondher / Świerk, Karolina / Francois, Clement / Biernikiewicz, Małgorzata / Clay, Emilie / Boyer, Laurent

Journal of market access & health policy

2023 Volume 11, Issue 1, Page(s) 2241234

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2023-07-28
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2001-6689
ISSN	2001-6689
DOI	10.1080/20016689.2023.2241234
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Systematic literature reviews over the years.

Smela, Beata / Toumi, Mondher / Świerk, Karolina / Gawlik, Konrad / Clay, Emilie / Boyer, Laurent

Journal of market access & health policy

2023 Volume 11, Issue 1, Page(s) 2244305

Abstract: Purpose: ...

Abstract	Purpose:
Language	English
Publishing date	2023-08-21
Publishing country	United States
Document type	Journal Article
ISSN	2001-6689
ISSN	2001-6689
DOI	10.1080/20016689.2023.2244305
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Correction: Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression.

Pierson Smela, Merrick D / Kramme, Christian C / Fortuna, Patrick R J / Adams, Jessica L / Su, Alina Rui / Dong, Edward / Kobayashi, Mutsumi / Brixi, Garyk / Kavirayuni, Venkata Srikar / Tysinger, Emma / Kohman, Richie E / Shioda, Toshi / Chatterjee, Pranam / Church, George M

eLife

2023 Volume 12

Language	English
Publishing date	2023-03-22
Publishing country	England
Document type	Published Erratum
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.87987
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression.

Pierson Smela, Merrick D / Kramme, Christian C / Fortuna, Patrick R J / Adams, Jessica L / Su, Rui / Dong, Edward / Kobayashi, Mutsumi / Brixi, Garyk / Kavirayuni, Venkata Srikar / Tysinger, Emma / Kohman, Richie E / Shioda, Toshi / Chatterjee, Pranam / Church, George M

eLife

2023 Volume 12

Abstract: An in vitro model of human ovarian follicles would greatly benefit the study of female reproduction. Ovarian development requires the combination of germ cells and several types of somatic cells. Among these, granulosa cells play a key role in follicle ... ...

Abstract	An in vitro model of human ovarian follicles would greatly benefit the study of female reproduction. Ovarian development requires the combination of germ cells and several types of somatic cells. Among these, granulosa cells play a key role in follicle formation and support for oogenesis. Whereas efficient protocols exist for generating human primordial germ cell-like cells (hPGCLCs) from human induced pluripotent stem cells (hiPSCs), a method of generating granulosa cells has been elusive. Here, we report that simultaneous overexpression of two transcription factors (TFs) can direct the differentiation of hiPSCs to granulosa-like cells. We elucidate the regulatory effects of several granulosa-related TFs and establish that overexpression of NR5A1 and either RUNX1 or RUNX2 is sufficient to generate granulosa-like cells. Our granulosa-like cells have transcriptomes similar to human fetal ovarian cells and recapitulate key ovarian phenotypes including follicle formation and steroidogenesis. When aggregated with hPGCLCs, our cells form ovary-like organoids (ovaroids) and support hPGCLC development from the premigratory to the gonadal stage as measured by induction of DAZL expression. This model system will provide unique opportunities for studying human ovarian biology and may enable the development of therapies for female reproductive health.
MeSH term(s)	Humans ; Female ; Transcription Factors/metabolism ; Induced Pluripotent Stem Cells ; Ovary/metabolism ; Oogenesis ; Cell Differentiation
Chemical Substances	Transcription Factors
Language	English
Publishing date	2023-02-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.83291
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: High resolution monitoring of chemotherapeutic agent potency in cancer cells using a CMOS capacitance biosensor.

Senevirathna, Bathiya / Lu, Sheung / Dandin, Marc / Basile, John / Smela, Elisabeth / Abshire, Pamela

Biosensors & bioelectronics

2019 Volume 142, Page(s) 111501

Abstract: Monitoring cell viability and proliferation in real-time provides a more comprehensive picture of the changes cells undergo during their lifecycle than can be achieved using traditional end-point assays. Particularly for drug screening applications, high- ...

Abstract	Monitoring cell viability and proliferation in real-time provides a more comprehensive picture of the changes cells undergo during their lifecycle than can be achieved using traditional end-point assays. Particularly for drug screening applications, high-temporal resolution cell viability data could inform decisions on drug application protocols that might lead to better treatment outcomes. We describe a CMOS biosensor that monitors cell viability through high-resolution capacitance measurements of cell adhesion quality. The system consists of a 3 × 3 mm
MeSH term(s)	Antineoplastic Agents/pharmacology ; Biosensing Techniques/instrumentation ; Cell Death/drug effects ; Cell Line, Tumor ; Cisplatin/pharmacology ; Drug Screening Assays, Antitumor/instrumentation ; Electric Capacitance ; Equipment Design ; Female ; Humans ; Lab-On-A-Chip Devices ; Ovarian Neoplasms/drug therapy
Chemical Substances	Antineoplastic Agents ; Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2019-07-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2019.111501
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Zs.A 2275: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: A novel surface modification technique for forming porous polymer monoliths in poly(dimethylsiloxane).

Burke, Jeffrey M / Smela, Elisabeth

Biomicrofluidics

2012 Volume 6, Issue 1, Page(s) 16506–1650610

Abstract: A new method of surface modification is described for enabling the in situ formation of homogenous porous polymer monoliths (PPMs) within poly(dimethylsiloxane) (PDMS) microfluidic channels that uses 365 nm UV illumination for polymerization. Porous ... ...

Abstract	A new method of surface modification is described for enabling the in situ formation of homogenous porous polymer monoliths (PPMs) within poly(dimethylsiloxane) (PDMS) microfluidic channels that uses 365 nm UV illumination for polymerization. Porous polymer monolith formation in PDMS can be challenging because PDMS readily absorbs the monomers and solvents, changing the final monolith morphology, and because PDMS absorbs oxygen, which inhibits free-radical polymerization. The new approach is based on sequentially absorbing a non-hydrogen-abstracting photoinitiator and the monomers methyl methacrylate and ethylene diacrylate within the walls of the microchannel, and then polymerizing the surface treatment polymer within the PDMS, entangled with it but not covalently bound. Four different monolith compositions were tested, all of which yielded monoliths that were securely anchored and could withstand pressures exceeding the bonding strength of PDMS (40 psi) without dislodging. One was a recipe that was optimized to give a larger average pore size, required for low back pressure. This monolith was used to concentrate and subsequently mechanical lyse B lymphocytes.
Language	English
Publishing date	2012-03-09
Publishing country	United States
Document type	Journal Article
ISSN	1932-1058
ISSN (online)	1932-1058
DOI	10.1063/1.3693589
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Capturing the value of vaccination within health technology assessment and health economics: Literature review and novel conceptual framework.

Beck, Ekkehard / Biundo, Eliana / Devlin, Nancy / Doherty, T Mark / Garcia-Ruiz, Antonio J / Postma, Maarten / Sheikh, Shazia / Smela, Beata / Toumi, Mondher / Wasem, Jurgen / Nolan, Terry / Salisbury, David

Vaccine

2022 Volume 40, Issue 30, Page(s) 4008–4016

Abstract: ... The dimensions were: (I) conventional payer perspective concepts (e.g., health gains in vaccinees, direct medical ... costs); (II) conventional societal perspective concepts (e.g., indirect health/economic gains ... to caregivers/households, productivity in vaccinees); and (III) novel societal concepts (e.g., financial risk ...

Abstract	Background: Vaccination provides significant health gains to individuals and society and can potentially improve health equity, healthcare systems and national economies. Policy decisions, however, are rarely informed by comprehensive economic evaluations (EE) including vaccination's wide-ranging value. The objective of this analysis was to focus on health technology assessment systems to identify relevant value concepts in order to improve current EE of non-pandemic vaccines. Methods: Following a literature review, a novel Value of Vaccination (VoV) framework was developed with experts in vaccine EE from developed countries with established health technology assessment systems. Results: Forty-four studies presenting value frameworks or concepts applicable to vaccination were included. Eighteen unique value concepts relevant to EE were identified and defined. These were categorised within the VoV framework using three dimensions, moving from a narrow payer perspective to a more expansive and societal perspective. The dimensions were: (I) conventional payer perspective concepts (e.g., health gains in vaccinees, direct medical costs); (II) conventional societal perspective concepts (e.g., indirect health/economic gains to caregivers/households, productivity in vaccinees); and (III) novel societal concepts (e.g., financial risk protection, peace of mind, societal health gains, healthcare systems security, political stability, social equity and macroeconomic gains). While good quality evidence and methods are available to support concepts in Dimensions I and II, further work is needed to generate the required evidence for vaccination impact on Dimension III concepts. Conclusions: The devastating effect on nations of the COVID-19 pandemic has helped to highlight the potential far-reaching benefits that many vaccination programmes can offer. This VoV framework is particularly relevant to policy decisions considering EE, and the potential future expansion of non-pandemic vaccination value considerations. The framework helps to understand and compare current value considerations across countries and payer versus societal perspectives. It provides decision-makers with a transparent and logical path to broaden consideration of VoV in EE.
MeSH term(s)	COVID-19/prevention & control ; Cost-Benefit Analysis ; Humans ; Pandemics/prevention & control ; Technology Assessment, Biomedical ; Vaccination ; Vaccines
Chemical Substances	Vaccines
Language	English
Publishing date	2022-05-23
Publishing country	Netherlands
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2022.04.050
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Zs.A 1930: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 458: Show issues

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Article ; Online: MegaGate: A toxin-less gateway molecular cloning tool.

Kramme, Christian / Plesa, Alexandru M / Wang, Helen H / Wolf, Bennett / Smela, Merrick Pierson / Guo, Xiaoge / Kohman, Richie E / Chatterjee, Pranam / Church, George M

STAR protocols

2021 Volume 2, Issue 4, Page(s) 100907

Abstract: Gateway cloning employs the use of ... ...

Abstract	Gateway cloning employs the use of the
MeSH term(s)	Cloning, Molecular/methods ; DNA, Complementary/genetics ; Escherichia coli/genetics ; Gene Library ; Plasmids/genetics ; Polymerase Chain Reaction/methods ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism
Chemical Substances	DNA, Complementary ; Recombinant Fusion Proteins
Language	English
Publishing date	2021-10-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2666-1667
ISSN (online)	2666-1667
DOI	10.1016/j.xpro.2021.100907
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: An integrated pipeline for mammalian genetic screening.

Kramme, Christian / Plesa, Alexandru M / Wang, Helen H / Wolf, Bennett / Smela, Merrick Pierson / Guo, Xiaoge / Kohman, Richie E / Chatterjee, Pranam / Church, George M

Cell reports methods

2021 Volume 1, Issue 6, Page(s) 100082

Abstract: With the recent advancements in genome editing, next-generation sequencing (NGS), and scalable cloning techniques, scientists can now conduct genetic screens at unprecedented levels of scale and precision. With such a multitude of technologies, there is ... ...

Abstract	With the recent advancements in genome editing, next-generation sequencing (NGS), and scalable cloning techniques, scientists can now conduct genetic screens at unprecedented levels of scale and precision. With such a multitude of technologies, there is a need for a simple yet comprehensive pipeline to enable systematic mammalian genetic screening. In this study, we develop unique algorithms for target identification and a toxin-less Gateway cloning tool, termed MegaGate, for library cloning which, when combined with existing genetic perturbation methods and NGS-coupled readouts, enable versatile engineering of relevant mammalian cell lines. Our integrated pipeline for sequencing-based target ascertainment and modular perturbation screening (STAMPScreen) can thus be utilized for a host of cell state engineering applications.
MeSH term(s)	Animals ; CRISPR-Cas Systems ; Gene Editing ; Mammals/genetics ; Gene Library ; Genetic Testing
Language	English
Publishing date	2021-09-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2667-2375
ISSN (online)	2667-2375
DOI	10.1016/j.crmeth.2021.100082
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: High-throughput particle separation and concentration using spiral inertial filtration.

Burke, Jeffrey M / Zubajlo, Rebecca E / Smela, Elisabeth / White, Ian M

Biomicrofluidics

2014 Volume 8, Issue 2, Page(s) 24105

Abstract: A spiral inertial filtration (SIFT) device that is capable of high-throughput (1 ml/min), high-purity particle separation while concentrating recovered target particles by more than an order of magnitude is reported. This device is able to remove large ... ...

Abstract	A spiral inertial filtration (SIFT) device that is capable of high-throughput (1 ml/min), high-purity particle separation while concentrating recovered target particles by more than an order of magnitude is reported. This device is able to remove large fractions of sample fluid from a microchannel without disruption of concentrated particle streams by taking advantage of particle focusing in inertial spiral microfluidics, which is achieved by balancing inertial lift forces and Dean drag forces. To enable the calculation of channel geometries in the SIFT microsystem for specific concentration factors, an equivalent circuit model was developed and experimentally validated. Large particle concentration factors were then achieved by maintaining either the average fluid velocity or the Dean number throughout the entire length of the channel during the incremental removal of sample fluid. The SIFT device was able to separate MCF7 cells spiked into whole blood from the non-target white blood cells (WBC) with a recovery of nearly 100% while removing 93% of the sample volume, which resulted in a concentration enhancement of the MCF7 cancer cells by a factor of 14.
Language	English
Publishing date	2014-04-01
Publishing country	United States
Document type	Journal Article
ISSN	1932-1058
ISSN	1932-1058
DOI	10.1063/1.4870399
Database	MEDical Literature Analysis and Retrieval System OnLINE

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