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  1. Book: Lipid oxidation in health and disease

    Spickett, Corinne M. / Forman, Henry Jay

    (Oxidative stress and disease series ; 37)

    2015  

    Author's details ed. by Corinne M. Spickett ; Henry Jay Forman
    Series title Oxidative stress and disease series ; 37
    Oxidative stress and disease
    Collection Oxidative stress and disease
    Keywords Lipids ; Oxidative stress ; Pathology
    Subject code 612.397
    Language English
    Size XIX, 419 S. : Ill., 24 cm
    Publisher CRC Press
    Publishing place Boca Raton u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT018525715
    ISBN 978-1-4822-0285-4 ; 1-4822-0285-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 A 1240 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: On "Biological effects of the superoxide radical" by Irwin Fridovich.

    Forman, Henry Jay

    Archives of biochemistry and biophysics

    2022  Volume 726, Page(s) 109117

    Abstract: Irwin Fridovich, the discoverer of superoxide dismutase, took the opportunity in this invited paper to address the important question, "Can the superoxide radical exert deleterious effects independent of participating with ... ...

    Abstract Irwin Fridovich, the discoverer of superoxide dismutase, took the opportunity in this invited paper to address the important question, "Can the superoxide radical exert deleterious effects independent of participating with H
    MeSH term(s) Hydrogen Peroxide ; Hydroxyl Radical ; Superoxide Dismutase ; Superoxides
    Chemical Substances Superoxides (11062-77-4) ; Hydroxyl Radical (3352-57-6) ; Hydrogen Peroxide (BBX060AN9V) ; Superoxide Dismutase (EC 1.15.1.1)
    Language English
    Publishing date 2022-01-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 523-x
    ISSN 1096-0384 ; 0003-9861
    ISSN (online) 1096-0384
    ISSN 0003-9861
    DOI 10.1016/j.abb.2022.109117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: On “biological effects of the superoxide radical” by Irwin Fridovich [Arch. Biochem. Biophys. 247(1) (1986) 1–11]

    Forman, Henry Jay

    Archives of biochemistry and biophysics. 2022 Jan. 02,

    2022  

    Abstract: Irwin Fridovich, the discoverer of superoxide dismutase, took the opportunity in this invited paper to address the important question, “Can the superoxide radical exert deleterious effects independent of participating with H₂O₂ in the production of the ... ...

    Abstract Irwin Fridovich, the discoverer of superoxide dismutase, took the opportunity in this invited paper to address the important question, “Can the superoxide radical exert deleterious effects independent of participating with H₂O₂ in the production of the hydroxyl radical?” The affirmative answer that he reached was correct although subsequent research on peroxynitrite has provided more complexity.
    Keywords biophysics ; hydroxyl radicals ; superoxide anion ; superoxide dismutase
    Language English
    Dates of publication 2022-0102
    Publishing place Elsevier Inc.
    Document type Article
    Note Pre-press version
    ZDB-ID 523-x
    ISSN 1096-0384 ; 0003-9861
    ISSN (online) 1096-0384
    ISSN 0003-9861
    DOI 10.1016/j.abb.2022.109117
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  4. Article ; Online: Author Correction: Targeting oxidative stress in disease: promise and limitations of antioxidant therapy.

    Forman, Henry Jay / Zhang, Hongqiao

    Nature reviews. Drug discovery

    2021  Volume 20, Issue 8, Page(s) 652

    Language English
    Publishing date 2021-07-13
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2062954-0
    ISSN 1474-1784 ; 1474-1776
    ISSN (online) 1474-1784
    ISSN 1474-1776
    DOI 10.1038/s41573-021-00267-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Targeting oxidative stress in disease: promise and limitations of antioxidant therapy.

    Forman, Henry Jay / Zhang, Hongqiao

    Nature reviews. Drug discovery

    2021  Volume 20, Issue 9, Page(s) 689–709

    Abstract: Oxidative stress is a component of many diseases, including atherosclerosis, chronic obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous small molecules evaluated as antioxidants have exhibited therapeutic potential in ... ...

    Abstract Oxidative stress is a component of many diseases, including atherosclerosis, chronic obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous small molecules evaluated as antioxidants have exhibited therapeutic potential in preclinical studies, clinical trial results have been disappointing. A greater understanding of the mechanisms through which antioxidants act and where and when they are effective may provide a rational approach that leads to greater pharmacological success. Here, we review the relationships between oxidative stress, redox signalling and disease, the mechanisms through which oxidative stress can contribute to pathology, how antioxidant defences work, what limits their effectiveness and how antioxidant defences can be increased through physiological signalling, dietary components and potential pharmaceutical intervention.
    MeSH term(s) Animals ; Antioxidants/pharmacology ; Drug Development ; Drug Evaluation, Preclinical ; Humans ; Molecular Targeted Therapy ; Oxidation-Reduction ; Oxidative Stress/drug effects ; Signal Transduction/drug effects
    Chemical Substances Antioxidants
    Language English
    Publishing date 2021-06-30
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2062954-0
    ISSN 1474-1784 ; 1474-1776
    ISSN (online) 1474-1784
    ISSN 1474-1776
    DOI 10.1038/s41573-021-00233-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Archives of Biochemistry and Biophysics: 80th Anniversary.

    Sies, Helmut / Fitzpatrick, Paul F / Newman, Anthony / Forman, Henry Jay

    Archives of biochemistry and biophysics

    2022  Volume 726, Page(s) 109295

    MeSH term(s) Anniversaries and Special Events ; Biochemistry ; Biophysics ; History, 20th Century
    Language English
    Publishing date 2022-06-22
    Publishing country United States
    Document type Editorial ; Historical Article
    ZDB-ID 523-x
    ISSN 1096-0384 ; 0003-9861
    ISSN (online) 1096-0384
    ISSN 0003-9861
    DOI 10.1016/j.abb.2022.109295
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book: Oxidative stress and signal transduction

    Forman, Henry Jay

    1997  

    Author's details ed. by Henry Jay Forman
    Keywords Oxidative Stress ; Signal Transduction ; Gene Expression Regulation ; Second Messenger Systems ; Oxidativer Stress ; Transkriptionsfaktor ; Signaltransduktion ; Sekundärer Bote
    Subject Signalübertragung ; Signalvermittlung ; Second messenger ; Trans-wirkender Faktor ; Regulatorproteine
    Language English
    Size XV, 475 S. : Ill., graph. Darst.
    Publisher Chapman & Hall
    Publishing place New York
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT008184814
    ISBN 0-412-07681-0 ; 978-0-412-07681-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1998 A 1792 order for loan Magazin

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  8. Article ; Online: Glutathione - From antioxidant to post-translational modifier.

    Forman, Henry Jay

    Archives of biochemistry and biophysics

    2016  Volume 595, Page(s) 64–67

    Abstract: Helmut Sies is one of the leading investigators in the multiple roles of glutathione (GSH) in biology. He has pioneered work on the role of GSH in preventing oxidative stress, in transport of GSSG, in protection of protein thiols from irreversible ... ...

    Abstract Helmut Sies is one of the leading investigators in the multiple roles of glutathione (GSH) in biology. He has pioneered work on the role of GSH in preventing oxidative stress, in transport of GSSG, in protection of protein thiols from irreversible oxidation through mixed disulfide formation and demonstrated a role of protein glutathionylation in response to hormonal stimulation well before redox signaling became a major subject of investigation. Here I will describe the roles of GSH in several aspects of biology, the work of my laboratory in those findings, and how Helmut Sies work influenced our studies.
    MeSH term(s) Antioxidants/metabolism ; Biological Transport ; Glutathione/biosynthesis ; Glutathione/metabolism ; Humans ; Oxidation-Reduction ; Protein Processing, Post-Translational ; Signal Transduction
    Chemical Substances Antioxidants ; Glutathione (GAN16C9B8O)
    Language English
    Publishing date 2016-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 523-x
    ISSN 1096-0384 ; 0003-9861
    ISSN (online) 1096-0384
    ISSN 0003-9861
    DOI 10.1016/j.abb.2015.11.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Age-related alteration in HNE elimination enzymes.

    Zhang, Hongqiao / Morgan, Todd E / Forman, Henry Jay

    Archives of biochemistry and biophysics

    2021  Volume 699, Page(s) 108749

    Abstract: 4-hydroxynonenal (HNE, 4-hydroxy-2-nonenal) is a primary α,β-unsaturated aldehyde product of lipid peroxidation. The accumulation of HNE increases with aging and the mechanisms are mainly attributable to increased oxidative stress and decreased capacity ... ...

    Abstract 4-hydroxynonenal (HNE, 4-hydroxy-2-nonenal) is a primary α,β-unsaturated aldehyde product of lipid peroxidation. The accumulation of HNE increases with aging and the mechanisms are mainly attributable to increased oxidative stress and decreased capacity of HNE elimination. In this review article, we summarize the studies on age-related change of HNE concentration and alteration of HNE metabolizing enzymes (GCL, GST, ALDHs, aldose reductase, and 20S-proteasome), and discuss potential mechanism of age-related decrease in HNE-elimination capacity by focusing on Nrf2 redox signaling.
    MeSH term(s) Aging/metabolism ; Aldehydes/metabolism ; Animals ; Humans ; Oxidative Stress/physiology ; Oxidoreductases/metabolism ; Signal Transduction/physiology
    Chemical Substances Aldehydes ; Oxidoreductases (EC 1.-) ; 4-hydroxy-2-nonenal (K1CVM13F96)
    Language English
    Publishing date 2021-01-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 523-x
    ISSN 1096-0384 ; 0003-9861
    ISSN (online) 1096-0384
    ISSN 0003-9861
    DOI 10.1016/j.abb.2020.108749
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Redox signaling: An evolution from free radicals to aging.

    Forman, Henry Jay

    Free radical biology & medicine

    2016  Volume 97, Page(s) 398–407

    Abstract: Redox biology has evolved from studies of the pathology that involves oxidants to an understanding of how oxidants participate in normal as well as aberrant signal transduction. Although the concept that signal transduction involved changes in the redox ... ...

    Abstract Redox biology has evolved from studies of the pathology that involves oxidants to an understanding of how oxidants participate in normal as well as aberrant signal transduction. Although the concept that signal transduction involved changes in the redox state dates from the 1930s, the modern history of redox biology began with the discovery of superoxide dismutase by McCord and Fridovich. The initial focus was on free radicals and damage of macromolecules, which remains an important topic. But, over time it was realized that hydroperoxides, especially H2O2 produced by NADPH oxidases, and electrophiles derived from lipid peroxidation or metabolism, played essential roles in physiologically relevant signaling. The mechanisms through which H2O2 and other electrophiles signal became an important area of study that provided insight into how these reactive molecules were involved in major signaling pathways and regulation of transcription factors. Thus, the field of redox signaling that is the overlap of signal transduction with redox biology was established. Alterations in redox signaling are observed in aging, but we also now know that redox signaling is essential in physiological homeostasis and that sustained deviation from redox homeostasis results in disease. This is a review of the history of redox biology from a personal perspective of nearly fifty years working in this field that hopefully provides some insights for the reader.
    MeSH term(s) Animals ; Free Radicals/metabolism ; Gene Expression Regulation ; Homeostasis ; Humans ; Lipid Peroxidation ; Oxidative Stress ; Signal Transduction
    Chemical Substances Free Radicals
    Language English
    Publishing date 2016-07-05
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2016.07.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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