LIVIVO - Search results -

Search results

Result 1 - 10 of total 2544

Search options

Article ; Online: Growth Differentiation Factor-15, High-Sensitivity Cardiac Troponin T, and N-Terminal pro-B-type Natriuretic Peptide for Predicting Risk of Venous Thromboembolism in Ambulatory Cancer Patients Receiving Chemotherapy.

Roy, Danielle Carole / Wang, Tzu-Fei / Mallick, Ranjeeta / Carrier, Marc / Mollanji, Eisi / Liu, Peter / Zhang, Liyong / Hawken, Steven / Wells, Philip

Thrombosis and haemostasis

2022 Volume 122, Issue 7, Page(s) 1169–1176

Abstract: Growth differentiation factor-15 (GDF-15), high-sensitivity cardiac troponin T (hs-TnT), and N ...

Abstract	Growth differentiation factor-15 (GDF-15), high-sensitivity cardiac troponin T (hs-TnT), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are associated with increased risk of venous thromboembolism (VTE) in noncancer patients. However, the performance of these biomarkers in cancer patients is unknown. Our objective was to assess performance of these biomarkers in predicting VTE in cancer patients at intermediate to high risk for VTE (Khorana Score ≥ 2). We used 1-month plasma samples from AVERT trial patients to determine if GDF-15, NT-proBNP, and hs-TnT levels are associated with VTE incidence between 1 and 7 months from the start of chemotherapy. The minimal Euclidean distance of the receiver operating characteristic curve was used to derive optimal cut-offs for GDF-15 and NT-proBNP given there was no evidence of a commonly used cut-off. Logistic and Fine and Gray competing risk regression analyses were used to calculate odds ratios (ORs) and subdistribution hazard ratios, respectively, while adjusting for age, sex, anticoagulation, and antiplatelet therapy. We tested in two groups: all patients (
MeSH term(s)	Biomarkers ; Clinical Trials as Topic ; Growth Differentiation Factor 15 ; Humans ; Natriuretic Peptide, Brain ; Neoplasms/drug therapy ; Peptide Fragments ; Troponin T ; Venous Thromboembolism/epidemiology
Chemical Substances	Biomarkers ; Growth Differentiation Factor 15 ; Peptide Fragments ; Troponin T ; pro-brain natriuretic peptide (1-76) ; Natriuretic Peptide, Brain (114471-18-0)
Language	English
Publishing date	2022-03-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	518294-3
ISSN	2567-689X ; 0340-6245
ISSN (online)	2567-689X
ISSN	0340-6245
DOI	10.1055/a-1792-7720
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uh III Zs.192: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 433: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Article: Growth Differentiation Factor-15, High-Sensitivity Cardiac Troponin T, and N-Terminal pro-B-type Natriuretic Peptide for Predicting Risk of Venous Thromboembolism in Ambulatory Cancer Patients Receiving Chemotherapy

Roy, Danielle Carole / Wang, Tzu-Fei / Mallick, Ranjeeta / Carrier, Marc / Mollanji, Eisi / Liu, Peter / Zhang, Liyong / Hawken, Steven / Wells, Philip

Thrombosis and Haemostasis

2022 Volume 122, Issue 07, Page(s) 1169–1176

Abstract: Growth differentiation factor-15 (GDF-15), high-sensitivity cardiac troponin T (hs-TnT), and N ... anticoagulation, and antiplatelet therapy. We tested in two groups: all patients ( n = 476, Model 1) and ... all patients with nonprimary brain cancers ( n = 454, Model 2). In models 1 and 2, GDF-15 ≥2,290.9 pg/mL had ...

Abstract	Growth differentiation factor-15 (GDF-15), high-sensitivity cardiac troponin T (hs-TnT), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are associated with increased risk of venous thromboembolism (VTE) in noncancer patients. However, the performance of these biomarkers in cancer patients is unknown. Our objective was to assess performance of these biomarkers in predicting VTE in cancer patients at intermediate to high risk for VTE (Khorana Score ≥ 2). We used 1-month plasma samples from AVERT trial patients to determine if GDF-15, NT-proBNP, and hs-TnT levels are associated with VTE incidence between 1 and 7 months from the start of chemotherapy. The minimal Euclidean distance of the receiver operating characteristic curve was used to derive optimal cut-offs for GDF-15 and NT-proBNP given there was no evidence of a commonly used cut-off. Logistic and Fine and Gray competing risk regression analyses were used to calculate odds ratios (ORs) and subdistribution hazard ratios, respectively, while adjusting for age, sex, anticoagulation, and antiplatelet therapy. We tested in two groups: all patients ( n = 476, Model 1) and all patients with nonprimary brain cancers ( n = 454, Model 2). In models 1 and 2, GDF-15 ≥2,290.9 pg/mL had adjusted ORs for VTE of 1.65 (95% confidence interval [CI]: 0.89–3.08), and 2.28 (95% CI: 1.28–4.09), respectively. hs-TnT ≥14.0 pg/mL was associated with higher odds of VTE in models 1 and 2 (adjusted ORs: 2.26 [95% CI: 1.40–3.65] and 2.03 [95% CI: 1.07–3.84], respectively). For NT-proBNP, levels ≥183.5 pg/mL were not associated with VTE. Similar results were observed in the Fine and Gray analysis. Our results indicate that increased GDF-15 and hs-TnT levels predicted increased VTE risk.
Keywords	venous thromboembolism ; cancer ; prediction ; biomarkers
Language	English
Publishing date	2022-03-09
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	518294-3
ISSN	2567-689X ; 0340-6245
ISSN (online)	2567-689X
ISSN	0340-6245
DOI	10.1055/a-1792-7720
Database	Thieme publisher's database

In stock of ZB MED Cologne/Königswinter

Uh III Zs.192: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 433: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Reply to Kawada-N-Terminal Pro B-Type Natriuretic Peptide, High-Sensitivity Cardiac Troponin T and the Extent of Hibernating Myocardium.

Zelt, Jason G E / Wells, George / Mielniczuk, Lisa M / Beanlands, Rob S

The Canadian journal of cardiology

2018 Volume 34, Issue 5, Page(s) 690.e13

MeSH term(s)	Heart ; Heart Failure ; Humans ; Myocardium ; Natriuretic Peptide, Brain ; Peptide Fragments ; Troponin T
Chemical Substances	Peptide Fragments ; Troponin T ; Natriuretic Peptide, Brain (114471-18-0)
Language	English
Publishing date	2018-02-01
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	632813-1
ISSN	1916-7075 ; 0828-282X
ISSN (online)	1916-7075
ISSN	0828-282X
DOI	10.1016/j.cjca.2018.01.085
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2150: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: N-Terminal Pro B-Type Natriuretic Peptide and High-Sensitivity Cardiac Troponin T Levels Are Related to the Extent of Hibernating Myocardium in Patients With Ischemic Heart Failure.

Zelt, Jason G E / Liu, Peter P / Erthal, Fernanda / deKemp, Robert A / Wells, George / O'Meara, Eileen / Garrard, Linda / Beanlands, Rob S B / Mielniczuk, Lisa M

The Canadian journal of cardiology

2017 Volume 33, Issue 11, Page(s) 1478–1488

Abstract: Background: Increased N-terminal pro b-type natriuretic peptide (NT-proBNP) and high-sensitivity ... cardiac troponin T (hs-cTnT) can identify patients with heart failure (HF) who are at increased risk ...

Abstract	Background: Increased N-terminal pro b-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hs-cTnT) can identify patients with heart failure (HF) who are at increased risk of cardiac events. The relationship of these biomarkers to the extent of hibernating myocardium and scar has not been previously characterized in patients with ischemic left ventricular dysfunction and HF. Methods: Patients with ischemic HF meeting recruitment criteria and undergoing perfusion and fluorodeoxyglucose-positron emission tomography to define myocardial hibernation and scar were included in the study. A total of 39 patients (mean age 67 ± 8 years) with New York Heart Association class II-IV HF and ischemic cardiomyopathy (ejection fraction [EF], 27.9% ± 8.5%) were enrolled in the study. Results: Serum NT-proBNP and hs-cTnT levels were elevated in patients with ≥ 10% hibernating myocardium compared with those with < 10% (NT-pro-BNP, 7419.10 ± 7169.5 pg/mL vs 2894.6 ± 2967.4 pg/mL; hs-cTnT, 789.3 ± 1835.3 pg/mL vs 44.8 ± 78.9 pg/mL; P < 0.05). The overall receiver operating characteristic under the curve value for NT-proBNP and hs-cTnT to predict hibernating myocardium was 0.76 and 0.78, respectively (P < 0.05). The NT-proBNP (P = 0.02) and hs-cTnT (P < 0.0001) levels also correlated with hibernation, particularly in patients with ≥ 10% scar, independent of EF, age, and estimated glomerular filtration rate. No differences were noted in biomarker levels for patients with vs those without ≥ 10% scar. Conclusions: NT-proBNP and hs-cTnT levels are elevated in patients with ischemic HF hibernation and are correlated with the degree of hibernation but not with the presence or extent of scar. Taken together, these data support the novel concept that NT-proBNP and hs-cTnT release in patients with ischemic HF reflects the presence and extent of hibernating myocardium.
MeSH term(s)	Aged ; Biomarkers/blood ; Coronary Angiography ; Female ; Heart Failure/blood ; Heart Failure/complications ; Heart Failure/diagnosis ; Humans ; Male ; Myocardial Ischemia/blood ; Myocardial Ischemia/complications ; Myocardial Ischemia/diagnosis ; Myocardium/metabolism ; Natriuretic Peptide, Brain/blood ; Peptide Fragments/blood ; Positron-Emission Tomography ; ROC Curve ; Severity of Illness Index ; Troponin T/blood
Chemical Substances	Biomarkers ; Peptide Fragments ; Troponin T ; pro-brain natriuretic peptide (1-76) ; Natriuretic Peptide, Brain (114471-18-0)
Language	English
Publishing date	2017-06-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632813-1
ISSN	1916-7075 ; 0828-282X
ISSN (online)	1916-7075
ISSN	0828-282X
DOI	10.1016/j.cjca.2017.06.012
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2150: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Integrative Analysis of Differentially Expressed Genes in Time-Course Multi-Omics Data with MINT-DE.

Xue, Hao / Delbare, Sofie Y N / Wells, Martin T / Basu, Sumanta / Clark, Andrew G

Research square

2024

Abstract: Background: Time-course multi-omics experiments have been highly informative for obtaining a comprehensive understanding of the dynamic relationships between molecules in a biological process, especially if the different profiles are obtained from the ... ...

Abstract	Background: Time-course multi-omics experiments have been highly informative for obtaining a comprehensive understanding of the dynamic relationships between molecules in a biological process, especially if the different profiles are obtained from the same samples. A fundamental step in analyzing time-course multi-omics data involves selecting a short list of genes or gene regions ("sites") that warrant further study. Two important criteria for site selection are the magnitude of change and the temporal dynamic consistency. However, existing methods only consider one of these criteria, while neglecting the other. Results: In our study, we propose a framework called MINT-DE ( Conclusions: These findings suggest the effectiveness of MINT-DE in selecting sites that are both differentially expressed within at least one assay and temporally related across assays. This highlights the potential of MINT-DE to identify biologically important sites for downstream analysis and provide a complementarity of sites that is neglected by existing methods.
Language	English
Publishing date	2024-01-01
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-3806701/v1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article: [Besprechung von:] Smith, David N. and Louis T. Wells jr.: Negotiating Third World mineral agreements. Promises as prologue. Cambridge/Mass. 1975

Gustafson, Charles H / Smith, David N / Wells jr., Louis T

Law and policy in international business : the international journal of Georgetown University Law Center Vol. 9, No. 3 , p. 1045-1052

1977 Volume 9, Issue 3, Page(s) 1045–1052

Author's details	Charles H. Gustafson
Publishing place	Washington, DC
Document type	Article
ZDB-ID	700158-7
Database	ECONomics Information System

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: A phenotypic screen of the Global Health Priority Box identifies an insecticide with anthelmintic activity.

Shanley, Harrison T / Taki, Aya C / Byrne, Joseph J / Nguyen, Nghi / Wells, Tim N C / Jabbar, Abdul / Sleebs, Brad E / Gasser, Robin B

Parasites & vectors

2024 Volume 17, Issue 1, Page(s) 131

Abstract: Background: Infection with parasitic nematodes (helminths), particularly those of the order Strongylida (such as Haemonchus contortus), can cause significant and burdensome diseases in humans and animals. Widespread drug (anthelmintic) resistance in ... ...

Abstract	Background: Infection with parasitic nematodes (helminths), particularly those of the order Strongylida (such as Haemonchus contortus), can cause significant and burdensome diseases in humans and animals. Widespread drug (anthelmintic) resistance in livestock parasites, the absence of vaccines against most of these nematodes, and a lack of new and effective chemical entities on the commercial market demands the discovery of new anthelmintics. In the present study, we searched the Global Health Priority Box (Medicines for Malaria Venture) for new candidates for anthelmintic development. Methods: We employed a whole-organism, motility-based phenotypic screening assay to identify compounds from the Global Health Priority Box with activity against larvae of the model parasite H. contortus, and the free-living comparator nematode Caenorhabditis elegans. Hit compounds were further validated via dose-response assays, with lead candidates then assessed for nematocidal activity against H. contortus adult worms, and additionally, for cytotoxic and mitotoxic effects on human hepatoma (HepG2) cells. Results: The primary screen against H. contortus and C. elegans revealed or reidentified 16 hit compounds; further validation established MMV1794206, otherwise known as 'flufenerim', as a significant inhibitor of H. contortus larval motility (half-maximal inhibitory concentration [IC Conclusions: The in vitro efficacy of MMV1794206 against the most pathogenic stages of H. contortus, as well as the free-living C. elegans, suggests the potential for development as a broad-spectrum anthelmintic compound; however, the high toxicity towards mammalian cells presents a significant hindrance. Further work should seek to establish the protein-drug interactions of MMV1794206 in a nematode model, to unravel the mechanism of action, in addition to an advanced structure-activity relationship investigation to optimise anthelmintic activity and eliminate mammalian cell toxicity.
MeSH term(s)	Adult ; Animals ; Humans ; Female ; Insecticides ; Caenorhabditis elegans ; Carcinoma, Hepatocellular ; Health Priorities ; Anthelmintics/pharmacology ; Anti-Infective Agents ; Liver Neoplasms ; Mammals
Chemical Substances	Insecticides ; Anthelmintics ; Anti-Infective Agents
Language	English
Publishing date	2024-03-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2409480-8
ISSN	1756-3305 ; 1756-3305
ISSN (online)	1756-3305
ISSN	1756-3305
DOI	10.1186/s13071-024-06183-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Investigating the Role of Indoleamine 2,3-Dioxygenase in Acute Myeloid Leukemia: A Systematic Review.

Wells, Georgia / Kennedy, Paul T / Dahal, Lekh N

Frontiers in immunology

2021 Volume 12, Page(s) 651687

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Cell Proliferation/genetics ; Gene Expression Regulation, Leukemic/immunology ; Humans ; Indoleamine-Pyrrole 2,3,-Dioxygenase/antagonists & inhibitors ; Indoleamine-Pyrrole 2,3,-Dioxygenase/genetics ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Kynurenine/metabolism ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/immunology ; Leukemia, Myeloid, Acute/mortality ; Prognosis ; Progression-Free Survival ; Randomized Controlled Trials as Topic ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; Tryptophan/metabolism ; Tumor Escape/genetics ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology
Chemical Substances	Antineoplastic Agents ; IDO1 protein, human ; IDO2 protein, human ; Indoleamine-Pyrrole 2,3,-Dioxygenase ; Kynurenine (343-65-7) ; Tryptophan (8DUH1N11BX)
Language	English
Publishing date	2021-03-10
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.651687
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Modulation of phenytoin teratogenicity and embryonic covalent binding by acetylsalicylic acid, caffeic acid, and alpha-phenyl-N-t-butylnitrone: implications for bioactivation by prostaglandin synthetase.

Wells, P G / Zubovits, J T / Wong, S T / Molinari, L M / Ali, S

Toxicology and applied pharmacology

1989 Volume 97, Issue 2, Page(s) 192–202

Abstract: ... the free radical spin trapping agent alpha-phenyl-N-t-butylnitrone (PBN). Caffeic acid and PBN were given ip ...

Abstract	Teratogenicity of the anticonvulsant drug phenytoin is thought to involve its bioactivation by cytochromes P-450 to a reactive arene oxide intermediate. We hypothesized that phenytoin also may be bioactivated to a teratogenic free radical intermediate by another enzymatic system, prostaglandin synthetase. To evaluate the teratogenic contribution of this latter pathway, an irreversible inhibitor of prostaglandin synthetase, acetylsalicylic acid (ASA), 10 mg/kg intraperitoneally (ip), was administered to pregnant CD-1 mice at 9:00 AM on Gestational Days 12 and 13, 2 hr before phenytoin, 65 mg/kg ip. Other groups were pretreated 2 hr prior to phenytoin administration with either the antioxidant caffeic acid or the free radical spin trapping agent alpha-phenyl-N-t-butylnitrone (PBN). Caffeic acid and PBN were given ip in doses that respectively were up to 1.0 to 0.05 molar equivalents to the dose of phenytoin. Dams were killed on Day 19 and the fetuses were assessed for teratologic anomalies. A similar study evaluated the effect of ASA on the in vivo covalent binding of radiolabeled phenytoin administered on Day 12, in which case dams were killed 24 hr later on Day 13. ASA pretreatment produced a 50% reduction in the incidence of fetal cleft palates induced by phenytoin (p less than 0.05), without significantly altering the incidence of resorptions or mean fetal body weight. Pretreatment with either caffeic acid or PBN resulted in dose-related decreases in the incidence of fetal cleft palates produced by phenytoin, with maximal respective reductions of 71 and 82% at the highest doses of caffeic acid and PBN (p less than 0.05). Caffeic acid and PBN also significantly reduced the incidence of fetal resorptions produced by phenytoin, but not the fetal weight loss. In viable embryos, ASA pretreatment reduced the covalent binding of phenytoin to embryonic protein by 43% (p less than 0.05). Binding of phenytoin to embryonic resorptions was equally high with and without ASA pretreatment, and within each treatment group was 3- to 10-fold higher than that in the respective placentas and associated viable embryos (p less than 0.05). These results suggest that prostaglandin synthetase may contribute to the enzymatic bioactivation of phenytoin to a teratogenic free radical intermediate.
MeSH term(s)	Abnormalities, Drug-Induced/etiology ; Animals ; Aspirin/pharmacology ; Biotransformation ; Caffeic Acids/pharmacology ; Cinnamates/pharmacology ; Cyclic N-Oxides ; Cytochrome P-450 Enzyme System/physiology ; Embryo, Mammalian/metabolism ; Female ; Fetal Resorption/chemically induced ; Free Radicals ; Mice ; Nitrogen Oxides/pharmacology ; Phenytoin/metabolism ; Phenytoin/toxicity ; Pregnancy ; Prostaglandin-Endoperoxide Synthases/physiology
Chemical Substances	Caffeic Acids ; Cinnamates ; Cyclic N-Oxides ; Free Radicals ; Nitrogen Oxides ; phenyl-N-tert-butylnitrone (3I91332OPG) ; Phenytoin (6158TKW0C5) ; Cytochrome P-450 Enzyme System (9035-51-2) ; Prostaglandin-Endoperoxide Synthases (EC 1.14.99.1) ; Aspirin (R16CO5Y76E) ; caffeic acid (U2S3A33KVM)
Language	English
Publishing date	1989-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	204477-8
ISSN	1096-0333 ; 0041-008X
ISSN (online)	1096-0333
ISSN	0041-008X
DOI	10.1016/0041-008x(89)90325-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 14: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Pigs: Large Animal Preclinical Cancer Models.

Joshi, Kirtan / Katam, Tejas / Hegde, Akshata / Cheng, Jianlin / Prather, Randall S / Whitworth, Kristin / Wells, Kevin / Bryan, Jeffrey N / Hoffman, Timothy / Telugu, Bhanu P / Kaifi, Jussuf T / Rachagani, Satyanarayana

World journal of oncology

2024 Volume 15, Issue 2, Page(s) 149–168

Abstract: Pigs are playing an increasingly vital role as translational biomedical models for studying human pathophysiology. The annotation of the pig genome was a huge step forward in translatability of pigs as a biomedical model for various human diseases. ... ...

Abstract	Pigs are playing an increasingly vital role as translational biomedical models for studying human pathophysiology. The annotation of the pig genome was a huge step forward in translatability of pigs as a biomedical model for various human diseases. Similarities between humans and pigs in terms of anatomy, physiology, genetics, and immunology have allowed pigs to become a comprehensive preclinical model for human diseases. With a diverse range, from craniofacial and ophthalmology to reproduction, wound healing, musculoskeletal, and cancer, pigs have provided a seminal understanding of human pathophysiology. This review focuses on the current research using pigs as preclinical models for cancer research and highlights the strengths and opportunities for studying various human cancers.
Language	English
Publishing date	2024-03-21
Publishing country	Canada
Document type	Journal Article ; Review
ZDB-ID	2548989-6
ISSN	1920-454X ; 1920-454X
ISSN (online)	1920-454X
ISSN	1920-454X
DOI	10.14740/wjon1763
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito