LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 45

Search options

  1. Article: Dysfunction of the Brown Adipose Organ in HFD-Obese Rats and Effect of Tart Cherry Supplementation.

    Bellitto, Vincenzo / Gabrielli, Maria Gabriella / Martinelli, Ilenia / Roy, Proshanta / Nittari, Giulio / Cocci, Paolo / Palermo, Francesco Alessandro / Amenta, Francesco / Micioni Di Bonaventura, Maria Vittoria / Cifani, Carlo / Tomassoni, Daniele / Tayebati, Seyed Khosrow

    Antioxidants (Basel, Switzerland)

    2024  Volume 13, Issue 4

    Abstract: Obesity has a great impact on adipose tissue biology, based on its function as a master regulator of energy balance. Brown adipose tissue (BAT) undergoes remodeling, and its activity declines in obese subjects due to a whitening process. The anti-obesity ...

    Abstract Obesity has a great impact on adipose tissue biology, based on its function as a master regulator of energy balance. Brown adipose tissue (BAT) undergoes remodeling, and its activity declines in obese subjects due to a whitening process. The anti-obesity properties of fruit extracts have been reported. The effects of tart cherry against oxidative stress, inflammation, and the whitening process in the BAT of obese rats were investigated. Intrascapular BAT (iBAT) alterations and effects of
    Language English
    Publishing date 2024-03-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox13040388
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Starch-enriched diet modulates the glucidic profile in the rat colonic mucosa.

    Gabrielli, Maria Gabriella / Tomassoni, Daniele

    European journal of nutrition

    2017  Volume 57, Issue 3, Page(s) 1109–1121

    Abstract: Purpose: The protective function of the intestinal mucosa largely depends on carbohydrate moieties that as a part of glycoproteins and glycolipids form the epithelial glycocalyx or are secreted as mucins. Modifications of their expression can be induced ...

    Abstract Purpose: The protective function of the intestinal mucosa largely depends on carbohydrate moieties that as a part of glycoproteins and glycolipids form the epithelial glycocalyx or are secreted as mucins. Modifications of their expression can be induced by an altered intestinal microenvironment and have been associated with inflammatory disorders and colorectal cancer. Given the influence of dietary factors on the gut ecosystem, here we have investigated whether a long term feeding on a starch-rich diet can modulate the glucidic profile in the colonic mucosa of rats.
    Methods: Animals were divided into two groups and maintained for 9 months at different diets: one group was fed a standard diet, the second was fed a starch-enriched diet. Samples of colonic mucosa, divided in proximal and distal portions, were processed for microscopic analysis. Conventional stainings and lectin histochemistry were applied to identify acidic glycoconjugates and specific sugar residues in oligosaccharide chains, respectively. Some lectins were applied on adjacent sections after sialidase/fucosidase digestion, deacetylation, and oxidation to characterize either terminal dimers or sialic acid acetylation.
    Results: An increase in sulfomucins was found to be associated with the starch-enriched diet that affected also the expression of several sugar residues as well as fucosylated and sialylated sequences in both proximal and distal colon.
    Conclusions: Although the mechanisms leading to such a modulation are at present unknown, either an altered intestinal microbiota or a dysregulation of glycosylation patterns might be responsible for the types and distribution of changes in the glucidic profile here observed.
    MeSH term(s) Animals ; Carbohydrate Sequence ; Colon/cytology ; Colon/metabolism ; Diet, Carbohydrate Loading/adverse effects ; Enterocytes/cytology ; Enterocytes/metabolism ; Female ; Fucose/metabolism ; Glycolipids/chemistry ; Glycolipids/metabolism ; Glycoproteins/chemistry ; Glycoproteins/metabolism ; Glycosylation ; Goblet Cells/cytology ; Goblet Cells/metabolism ; Indicators and Reagents/analysis ; Indicators and Reagents/metabolism ; Intestinal Mucosa/cytology ; Intestinal Mucosa/metabolism ; Lectins/analysis ; Lectins/metabolism ; Microvilli/metabolism ; Mucins/chemistry ; Mucins/metabolism ; N-Acetylneuraminic Acid/metabolism ; Rats, Sprague-Dawley ; Starch/adverse effects ; Starch/metabolism
    Chemical Substances Glycolipids ; Glycoproteins ; Indicators and Reagents ; Lectins ; Mucins ; sulfomucin ; Fucose (28RYY2IV3F) ; Starch (9005-25-8) ; N-Acetylneuraminic Acid (GZP2782OP0)
    Language English
    Publishing date 2017-04-09
    Publishing country Germany
    Document type Comparative Study ; Journal Article
    ZDB-ID 1466536-0
    ISSN 1436-6215 ; 1436-6207
    ISSN (online) 1436-6215
    ISSN 1436-6207
    DOI 10.1007/s00394-017-1393-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Carbonic anhydrase in minor salivary glands of quail: histochemistry versus immunohistochemistry.

    Gabrielli, Maria Gabriella / Tomassoni, Daniele

    Journal of enzyme inhibition and medicinal chemistry

    2014  Volume 29, Issue 1, Page(s) 87–91

    Abstract: Studies on the mechanisms of saliva secretion have indicated that carbonic anhydrase (CA) is expressed in mammalian salivary glands. The enzyme is present in the saliva as the only known secretory isoenzyme, CAVI; its activity has been related to the ... ...

    Abstract Studies on the mechanisms of saliva secretion have indicated that carbonic anhydrase (CA) is expressed in mammalian salivary glands. The enzyme is present in the saliva as the only known secretory isoenzyme, CAVI; its activity has been related to the modulation of taste and caries development. Unlike mammals, in birds, saliva is produced by the so-called minor salivary glands, mostly concentrated in the tongue. The involvement of CA has never been explored in avian salivary secretion. Thus, we aimed here to ascertain the enzyme occurrence in the quail lingual glands by a parallel investigation of the distributional patterns of CA activity sites, as visualized by histochemistry, and the immunohistochemical patterns of cytosolic CAII and secretory CAVI. The comparative evaluation of our findings does not rule out that some CA isoforms, associated to basolateral borders of the secretory cells and antigenically different from cytosolic CAII and secretory CAVI, may be involved in the salivary secretion in the quail lingual glands.
    MeSH term(s) Animals ; Carbonic Anhydrases/metabolism ; Quail ; Salivary Glands/enzymology
    Chemical Substances Carbonic Anhydrases (EC 4.2.1.1)
    Language English
    Publishing date 2014-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2082578-X
    ISSN 1475-6374 ; 1475-6366
    ISSN (online) 1475-6374
    ISSN 1475-6366
    DOI 10.3109/14756366.2012.753883
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article: Clinical Impact and Prognostic Role of Triglyceride to High-Density Lipoprotein Cholesterol Ratio in Patients With Chronic Coronary Syndromes at Very High Risk: Insights From the START Study.

    De Luca, Leonardo / Temporelli, Pier Luigi / Colivicchi, Furio / Gonzini, Lucio / Fasano, Maria Luisa / Pantaleoni, Massimo / Greco, Gabriella / Oliva, Fabrizio / Gabrielli, Domenico / Gulizia, Michele Massimo

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 874087

    Abstract: Background: Several studies have reported that the combination of high TG and low HDL-C, as simplified by the TG/HDL-C ratio, was a predictor of cardiovascular disease independent of LDL-C level. Nevertheless, poor data are available on the predictive ... ...

    Abstract Background: Several studies have reported that the combination of high TG and low HDL-C, as simplified by the TG/HDL-C ratio, was a predictor of cardiovascular disease independent of LDL-C level. Nevertheless, poor data are available on the predictive role of TG/HDL-C ratio in very high risk (VHR) patients with chronic coronary syndromes (CCS).
    Methods: Using the data from the STable Coronary Artery Diseases RegisTry (START) study, an Italian nationwide registry, we assessed the association between the TG/HDL-C ratio and baseline clinical characteristics, pharmacological treatment, and major adverse cardio-cerebrovascular events (MACCE) at 1 year in a large cohort of CCS patients at VHR.
    Results: VHR patients with both TG and HDL-C levels available were grouped in tertiles of TG/HDL-C ratio: low (TG/HDL-C ratio <2,
    Conclusions: In the present large, nationwide cohort of CCS patients at VHR a high TG/HD ratio did not emerge as independent predictor of MACCE at 1 year. Further studies with a longer follow-up are needed to better define the prognostic role of TG/HDL ratio in CCS.
    Language English
    Publishing date 2022-04-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.874087
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article: Effect of steam frothing on milk microfoam: Chemical composition, texture, stability and organoleptic properties

    Klimanova, Yulia / Polzonetti, Valeria / Pucciarelli, Stefania / Perinelli, Diego Romano / Bonacucina, Giulia / Cespi, Marco / Gabrielli, Maria Gabriella / Santini, Giuseppe / Fioretti, Lauro / Cognigni, Luca / Vincenzetti, Silvia

    International dairy journal. 2022 Aug. 14,

    2022  

    Abstract: This study focuses on the evaluation of microfoam, produced from processed dairy milk using a steamer of the espresso machine, as a function of temperature (30–80 °C), milk type (pasteurised or UHT), and whey protein content. Foam characteristics, i.e., ... ...

    Abstract This study focuses on the evaluation of microfoam, produced from processed dairy milk using a steamer of the espresso machine, as a function of temperature (30–80 °C), milk type (pasteurised or UHT), and whey protein content. Foam characteristics, i.e., foam stability, viscosity, bubble size distribution noticeably varied depending on milk processing type and steam heating temperature. Foams made from pasteurised whole milk tended to be more stable. Bubbles in pasteurised milk foam were better distributed, especially at the temperature of 60 °C. It was observed that the optimal final temperature of steam frothing was in the range of 50 °C to 60 °C. The results of sensory tests showed that consumers differentiated between the aroma and flavour of pasteurised and UHT milk, describing the degree of this difference from moderate to strong.
    Keywords UHT milk ; flavor ; foams ; odors ; pasteurization ; pasteurized milk ; protein content ; steam ; temperature ; texture ; viscosity ; whey protein ; whole milk
    Language English
    Dates of publication 2022-0814
    Publishing place Elsevier Ltd
    Document type Article
    Note Pre-press version
    ZDB-ID 1076400-8
    ISSN 0958-6946
    ISSN 0958-6946
    DOI 10.1016/j.idairyj.2022.105476
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  6. Article ; Online: Supplementation with

    Micioni Di Bonaventura, Maria Vittoria / Coman, Maria Magdalena / Tomassoni, Daniele / Micioni Di Bonaventura, Emanuela / Botticelli, Luca / Gabrielli, Maria Gabriella / Rossolini, Gian Maria / Di Pilato, Vincenzo / Cecchini, Cinzia / Amedei, Amedeo / Silvi, Stefania / Verdenelli, Maria Cristina / Cifani, Carlo

    International journal of molecular sciences

    2021  Volume 22, Issue 20

    Abstract: Changes in functionality and composition of gut microbiota (GM) have been associated and may contribute to the development and maintenance of obesity and related diseases. The aim of our study was to investigate for the first time the impact ... ...

    Abstract Changes in functionality and composition of gut microbiota (GM) have been associated and may contribute to the development and maintenance of obesity and related diseases. The aim of our study was to investigate for the first time the impact of
    MeSH term(s) Adipocytes/cytology ; Adipose Tissue, White/drug effects ; Animal Feed/microbiology ; Animals ; Biodiversity ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; DNA, Bacterial ; Diet, High-Fat ; Dietary Supplements/microbiology ; Disease Models, Animal ; Feces/microbiology ; Gastrointestinal Microbiome/drug effects ; Gastrointestinal Microbiome/genetics ; Leptin/metabolism ; Lipid Metabolism/drug effects ; Lipoproteins, LDL/drug effects ; Lipoproteins, LDL/metabolism ; Liver/drug effects ; Liver/metabolism ; Male ; Obesity/chemically induced ; Obesity/microbiology ; Probiotics/administration & dosage ; RNA, Ribosomal, 16S ; Rats ; Rats, Sprague-Dawley ; Weight Gain/drug effects
    Chemical Substances Blood Glucose ; DNA, Bacterial ; Leptin ; Lipoproteins, LDL ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2021-10-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms222011171
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Tart Cherry Juice and Seeds Affect Pro-Inflammatory Markers in Visceral Adipose Tissue of High-Fat Diet Obese Rats.

    Moruzzi, Michele / Klöting, Nora / Blüher, Matthias / Martinelli, Ilenia / Tayebati, Seyed Khosrow / Gabrielli, Maria Gabriella / Roy, Proshanta / Micioni Di Bonaventura, Maria Vittoria / Cifani, Carlo / Lupidi, Giulio / Amenta, Francesco / Tomassoni, Daniele

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 5

    Abstract: Background: Tart cherries (: Methods: This study has investigated the potential positive effects of tart cherries on rats with Diet-Induced Obesity (DIO). In particular, the inflammatory status in retroperitoneal (RPW) and perigonadal (PGW) adipose ... ...

    Abstract Background: Tart cherries (
    Methods: This study has investigated the potential positive effects of tart cherries on rats with Diet-Induced Obesity (DIO). In particular, the inflammatory status in retroperitoneal (RPW) and perigonadal (PGW) adipose tissue were studied. Rats were fed
    Results: No differences in the weight of RPW and PGW animals were found between DS and DJS groups compared to DIO rats. However, an increase of inflammatory markers was observed in DIO group in comparison with control lean rats. A modulation of these markers was evident upon tart cherry supplementation.
    Conclusion: Study results suggest that tart cherry enriched-diet did not modify the accumulation of visceral fat, but it decreased inflammatory markers in both tissues. Therefore, this supplementation could be useful, in combination with healthy lifestyles, to modify adipose tissue cell metabolism limiting-obesity related organ damage.
    MeSH term(s) Animals ; Biomarkers/metabolism ; CD36 Antigens/genetics ; CD36 Antigens/metabolism ; Chemokine CCL2/genetics ; Chemokine CCL2/metabolism ; Diet, High-Fat/adverse effects ; Dietary Supplements ; Fruit and Vegetable Juices ; Gene Expression Regulation ; Intra-Abdominal Fat/drug effects ; Intra-Abdominal Fat/metabolism ; Macrophages/drug effects ; Macrophages/pathology ; Male ; Obesity/diet therapy ; Obesity/etiology ; Panniculitis/diet therapy ; Panniculitis/genetics ; Panniculitis/metabolism ; Prunus avium/chemistry ; Rats, Wistar ; Seeds ; Rats
    Chemical Substances Biomarkers ; CD36 Antigens ; Ccl2 protein, rat ; Chemokine CCL2
    Language English
    Publishing date 2021-03-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26051403
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article: Starch-enriched diet modulates the glucidic profile in the rat colonic mucosa

    Gabrielli, MariaGabriella / Daniele Tomassoni

    European journal of nutrition. 2018 Apr., v. 57, no. 3

    2018  

    Abstract: PURPOSE: The protective function of the intestinal mucosa largely depends on carbohydrate moieties that as a part of glycoproteins and glycolipids form the epithelial glycocalyx or are secreted as mucins. Modifications of their expression can be induced ... ...

    Abstract PURPOSE: The protective function of the intestinal mucosa largely depends on carbohydrate moieties that as a part of glycoproteins and glycolipids form the epithelial glycocalyx or are secreted as mucins. Modifications of their expression can be induced by an altered intestinal microenvironment and have been associated with inflammatory disorders and colorectal cancer. Given the influence of dietary factors on the gut ecosystem, here we have investigated whether a long term feeding on a starch-rich diet can modulate the glucidic profile in the colonic mucosa of rats. METHODS: Animals were divided into two groups and maintained for 9 months at different diets: one group was fed a standard diet, the second was fed a starch-enriched diet. Samples of colonic mucosa, divided in proximal and distal portions, were processed for microscopic analysis. Conventional stainings and lectin histochemistry were applied to identify acidic glycoconjugates and specific sugar residues in oligosaccharide chains, respectively. Some lectins were applied on adjacent sections after sialidase/fucosidase digestion, deacetylation, and oxidation to characterize either terminal dimers or sialic acid acetylation. RESULTS: An increase in sulfomucins was found to be associated with the starch-enriched diet that affected also the expression of several sugar residues as well as fucosylated and sialylated sequences in both proximal and distal colon. CONCLUSIONS: Although the mechanisms leading to such a modulation are at present unknown, either an altered intestinal microbiota or a dysregulation of glycosylation patterns might be responsible for the types and distribution of changes in the glucidic profile here observed.
    Keywords acetylation ; colon ; colorectal neoplasms ; diet ; digestion ; ecosystems ; glycolipids ; glycosylation ; histochemistry ; intestinal microorganisms ; intestinal mucosa ; lectins ; moieties ; mucins ; oligosaccharides ; oxidation ; rats ; sialic acid ; sialidase
    Language English
    Dates of publication 2018-04
    Size p. 1109-1121.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    ZDB-ID 1466536-0
    ISSN 1436-6215 ; 1436-6207
    ISSN (online) 1436-6215
    ISSN 1436-6207
    DOI 10.1007/s00394-017-1393-3
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  9. Article ; Online: Supplementation with Lactiplantibacillus plantarum IMC 510 Modifies Microbiota Composition and Prevents Body Weight Gain Induced by Cafeteria Diet in Rats

    Maria Vittoria Micioni Di Bonaventura / Maria Magdalena Coman / Daniele Tomassoni / Emanuela Micioni Di Bonaventura / Luca Botticelli / Maria Gabriella Gabrielli / Gian Maria Rossolini / Vincenzo Di Pilato / Cinzia Cecchini / Amedeo Amedei / Stefania Silvi / Maria Cristina Verdenelli / Carlo Cifani

    International Journal of Molecular Sciences, Vol 22, Iss 11171, p

    2021  Volume 11171

    Abstract: Changes in functionality and composition of gut microbiota (GM) have been associated and may contribute to the development and maintenance of obesity and related diseases. The aim of our study was to investigate for the first time the impact of ... ...

    Abstract Changes in functionality and composition of gut microbiota (GM) have been associated and may contribute to the development and maintenance of obesity and related diseases. The aim of our study was to investigate for the first time the impact of Lactiplantibacillus (L.) plantarum IMC 510 in a rat model of diet-induced obesity, specifically in the cafeteria (CAF) diet. This diet provides a strong motivation to voluntary overeat, due to the palatability and variety of selected energy-dense foods. The oral administration for 84 days of this probiotic strain, added to the CAF diet, decreased food intake and body weight gain. Accordingly, it ameliorated body mass index, liver and white adipose tissue weight, hepatic lipid accumulation, adipocyte size, serum parameters, including glycemia and low-density lipoprotein levels, in CAF fed rats, potentially through leptin control. In this scenario, L. plantarum IMC 510 showed also beneficial effects on GM, limiting the microbial imbalance established by long exposure to CAF diet and preserving the proportion of different bacterial taxa. Further research is necessary to better elucidate the relationship between GM and overweight and then the mechanism of action by which L. plantarum IMC 510 modifies weight. However, these promising results prompt a clear advantage of probiotic supplementation and identify a new potential probiotic as a novel and safe therapeutic approach in obesity prevention and management.
    Keywords microbiota ; 16S ; obesity ; cafeteria (CAF) diet ; Lactiplantibacillus (L.) plantarum IMC 510 ; leptin ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 630
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  10. Article ; Online: Tart Cherry Juice and Seeds Affect Pro-Inflammatory Markers in Visceral Adipose Tissue of High-Fat Diet Obese Rats

    Michele Moruzzi / Nora Klöting / Matthias Blüher / Ilenia Martinelli / Seyed Khosrow Tayebati / Maria Gabriella Gabrielli / Proshanta Roy / Maria Vittoria Micioni Di Bonaventura / Carlo Cifani / Giulio Lupidi / Francesco Amenta / Daniele Tomassoni

    Molecules, Vol 26, Iss 5, p

    2021  Volume 1403

    Abstract: Background: Tart cherries ( Prunus cerasus L.) are a rich source of anthocyanins. They are phytochemical flavonoids found in red and blue fruits, and vegetables that can reduce hyperlipidemia. Visceral Adipose Tissue (VAT) has emerged as a major player ... ...

    Abstract Background: Tart cherries ( Prunus cerasus L.) are a rich source of anthocyanins. They are phytochemical flavonoids found in red and blue fruits, and vegetables that can reduce hyperlipidemia. Visceral Adipose Tissue (VAT) has emerged as a major player in driving obesity-related inflammatory response. Methods: This study has investigated the potential positive effects of tart cherries on rats with Diet-Induced Obesity (DIO). In particular, the inflammatory status in retroperitoneal (RPW) and perigonadal (PGW) adipose tissue were studied. Rats were fed ad libitum for 17 weeks with a hypercaloric diet with the supplementation of tart cherries seeds powder (DS) and seeds powder plus tart cherries juice containing 1mg of anthocyanins (DJS). In RPW and PGW, expression of CRP, IL-1 β, TNF-α, CCL2 and CD36, were measured by qRT-PCR, Western blot and immunohistochemistry techniques. Results: No differences in the weight of RPW and PGW animals were found between DS and DJS groups compared to DIO rats. However, an increase of inflammatory markers was observed in DIO group in comparison with control lean rats. A modulation of these markers was evident upon tart cherry supplementation. Conclusion: Study results suggest that tart cherry enriched-diet did not modify the accumulation of visceral fat, but it decreased inflammatory markers in both tissues. Therefore, this supplementation could be useful, in combination with healthy lifestyles, to modify adipose tissue cell metabolism limiting-obesity related organ damage.
    Keywords obesity ; visceral adipose tissue ; inflammation ; tart cherries ; Organic chemistry ; QD241-441
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

To top