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  1. Book ; Online ; E-Book: Williams hematology

    Kaushansky, Kenneth

    2020  

    Abstract: To provide the most current concepts of the genetic basis, pathophysiology, diagnosis and treatment of hematological diseases"-- Provided by publisher. ...

    Author's details Kenneth Kaushansky [and five others]
    Abstract "To provide the most current concepts of the genetic basis, pathophysiology, diagnosis and treatment of hematological diseases"-- Provided by publisher.
    Keywords Blood/Diseases ; Hematology
    Subject code 616.15
    Language English
    Size 1 online resource (xxiii, 2664 pages) :, illustrations, maps
    Edition Tenth edition.
    Publisher bMcGraw-Hill Medical
    Publishing place New York, New York
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-260-46413-X ; 1-260-46412-1 ; 978-1-260-46413-9 ; 978-1-260-46412-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Thrombopoietin, the Primary Regulator of Platelet Production: From Mythos to Logos, a Thirty-Year Journey.

    Kaushansky, Kenneth

    Biomolecules

    2024  Volume 14, Issue 4

    Abstract: Thrombopoietin, the primary regulator of blood platelet production, was postulated to exist in 1958, but was only proven to exist when the cDNA for the hormone was cloned in 1994. Since its initial cloning and characterization, the hormone has revealed ... ...

    Abstract Thrombopoietin, the primary regulator of blood platelet production, was postulated to exist in 1958, but was only proven to exist when the cDNA for the hormone was cloned in 1994. Since its initial cloning and characterization, the hormone has revealed many surprises. For example, instead of acting as the postulated differentiation factor for platelet precursors, megakaryocytes, it is the most potent stimulator of megakaryocyte progenitor expansion known. Moreover, it also stimulates the survival, and in combination with stem cell factor leads to the expansion of hematopoietic stem cells. All of these growth-promoting activities have resulted in its clinical use in patients with thrombocytopenia and aplastic anemia, although the clinical development of the native molecule illustrated that "it's not wise to mess with mother nature", as a highly engineered version of the native hormone led to autoantibody formation and severe thrombocytopenia. Finally, another unexpected finding was the role of the thrombopoietin receptor in stem cell biology, including the development of myeloproliferative neoplasms, an important disorder of hematopoietic stem cells. Overall, the past 30 years of clinical and basic research has yielded many important insights, which are reviewed in this paper.
    MeSH term(s) Thrombopoietin/metabolism ; Humans ; Blood Platelets/metabolism ; Animals ; Receptors, Thrombopoietin/metabolism ; Receptors, Thrombopoietin/genetics ; Thrombopoiesis ; Thrombocytopenia/metabolism ; Megakaryocytes/metabolism ; Megakaryocytes/cytology
    Chemical Substances Thrombopoietin (9014-42-0) ; Receptors, Thrombopoietin
    Language English
    Publishing date 2024-04-18
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom14040489
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Williams hematology

    Kaushansky, Kenneth / Williams, William J.

    2016  

    Title variant Hematology
    Author's details Kenneth Kaushansky
    Keywords Hematologic Diseases ; Hematology / methods ; Hematology
    Subject code 616.15
    Language English
    Size XXI, 2505 S. : Ill., graph. Darst.
    Publisher McGraw-Hill
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT018880611
    ISBN 978-0-07-183300-4 ; 0-07-183300-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2016 A 398 available for loan (reading room) Lesesaal EG

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  4. Article ; Online: Hunting for hematopoietic transcriptional networks.

    Kaushansky, Kenneth

    Proceedings of the National Academy of Sciences of the United States of America

    2018  Volume 115, Issue 40, Page(s) 9818–9820

    MeSH term(s) Conservation of Natural Resources ; Gene Regulatory Networks ; Hematopoietic System
    Language English
    Publishing date 2018-09-10
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1813863115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  5. Article: Megakaryocytes as the Regulator of the Hematopoietic Vascular Niche.

    Zhan, Huichun / Kaushansky, Kenneth

    Frontiers in oncology

    2022  Volume 12, Page(s) 912060

    Abstract: Megakaryocytes (MKs) are important components of the hematopoietic niche. Compared to the non-hematopoietic niche cells, MKs serving as part of the hematopoietic niche provides a mechanism for feedback regulation of hematopoietic stem cells (HSCs), in ... ...

    Abstract Megakaryocytes (MKs) are important components of the hematopoietic niche. Compared to the non-hematopoietic niche cells, MKs serving as part of the hematopoietic niche provides a mechanism for feedback regulation of hematopoietic stem cells (HSCs), in which HSC progeny (MKs) can modulate HSC adaptation to hematopoietic demands during both steady-state and stress hematopoiesis. MKs are often located adjacent to marrow sinusoids. Considering that most HSCs reside close to a marrow vascular sinusoid, as do MKs, the interactions between MKs and vascular endothelial cells are positioned to play important roles in modulating HSC function, and by extrapolation, might be dysregulated in various disease states. In this review, we discuss the interactions between MKs and the vascular niche in both normal and neoplastic hematopoiesis.
    Language English
    Publishing date 2022-06-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.912060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Blood's 70th anniversary: the elusive von Willebrand factor-cleaving protease.

    Kaushansky, Kenneth

    Blood

    2016  Volume 127, Issue 18, Page(s) 2163–2164

    MeSH term(s) ADAMTS13 Protein/metabolism ; Anniversaries and Special Events ; Blood Platelets/metabolism ; Humans ; Proteolysis ; Purpura, Thrombotic Thrombocytopenic/metabolism ; von Willebrand Factor/metabolism
    Chemical Substances von Willebrand Factor ; ADAMTS13 Protein (EC 3.4.24.87) ; ADAMTS13 protein, human (EC 3.4.24.87)
    Language English
    Publishing date 2016-05-04
    Publishing country United States
    Document type Editorial
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2015-09-636779
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 364: Show issues

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  7. Article: Thrombopoietin and its receptor in normal and neoplastic hematopoiesis.

    Kaushansky, Kenneth

    Thrombosis journal

    2016  Volume 14, Issue Suppl 1, Page(s) 40

    Abstract: Thrombopoietin was posited to exist in 1958 and cloned in 1994, and in the ensuing two decades we have learned a great deal about the physiology and pathology of the primary regulator of thrombopoiesis. This paper will review the role of the hormone and ... ...

    Abstract Thrombopoietin was posited to exist in 1958 and cloned in 1994, and in the ensuing two decades we have learned a great deal about the physiology and pathology of the primary regulator of thrombopoiesis. This paper will review the role of the hormone and its receptor, the product of the c-Mpl proto-oncogene, in health and disease, including many unexpected effects in both normal and neoplastic hematopoiesis. Amongst these unexpected properties are a non-redundant effect on hematopoietic stem cells, a critical role in all three of the acquired, chronic myeloproliferative neoplasms, as well as both gain-of-function and loss-of-function mutations in congenital and acquired states of thrombocytopenia and thrombocythemia.
    Language English
    Publishing date 2016-10-04
    Publishing country England
    Document type Journal Article
    ISSN 1477-9560
    ISSN 1477-9560
    DOI 10.1186/s12959-016-0095-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book: Williams hematology

    Kaushansky, Kenneth / Williams, William J.

    2010  

    Title variant Hematology
    Author's details Kenneth Kaushansky
    Keywords Hematologic Diseases
    Language English
    Size XXIII, 2439 S. : Ill., graph. Darst., 29 cm
    Edition 8. ed.
    Publisher McGraw Hill Medical
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    Note Systemvoraussetzungen der CD-ROM-Beil.: Windows Vista or XP. - Mac OSX 10.4.11 or higher
    Accompanying material 1 CD-ROM (12 cm)
    HBZ-ID HT016509356
    ISBN 978-0-07-162144-1 ; 0-07-162144-X ; 978-0-07-162151-9 ; 0-07-162151-2 ; 978-0-07-162145-8 ; 0-07-162145-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 A 4559 order for loan Magazin
    2010 MO 478 <<[Begleitmaterial]>> order for loan Magazin

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  9. Article ; Online: Thrombopoiesis.

    Kaushansky, Kenneth

    Seminars in hematology

    2015  Volume 52, Issue 1, Page(s) 4–11

    Abstract: The production of platelets is a complex process that involves hematopoietic stem cells (HSCs), their differentiated progeny, the marrow microenvironment and hematopoietic cytokines. Much has been learned in the 110 years since James Homer Wright ... ...

    Abstract The production of platelets is a complex process that involves hematopoietic stem cells (HSCs), their differentiated progeny, the marrow microenvironment and hematopoietic cytokines. Much has been learned in the 110 years since James Homer Wright postulated that marrow megakaryocytes were responsible for blood platelet production, at a time when platelets were termed the "dust of the blood". In the 1980s a number of in vitro culture systems were developed that could produce megakaryocytes, followed by the identification of several cytokines that could stimulate the process in vitro. However, none of these cytokines produced a substantial thrombocytosis when injected into animals or people, nor were blood levels inversely related to platelet count, the sine qua non of a physiological regulator. A major milestone in our understanding of thrombopoiesis occurred in 1994 when thrombopoietin, the primary regulator of platelet production was cloned and initially characterized. Since that time many of the molecular mechanisms of thrombopoiesis have been identified, including the effects of thrombopoietin on the survival, proliferation, and differentiation of hematopoietic stem and progenitor cells, the development of polyploidy and proplatelet formation, the final fragmentation of megakaryocyte cytoplasm to yield blood platelets, and the regulation of this process. While much progress has been made, several outstanding questions remain, such as the nature of the signals for final platelet formation, the molecular nature of the regulation of marrow stromal thrombopoietin production, and the role of these physiological processes in malignant hematopoiesis.
    MeSH term(s) Animals ; Bone Marrow ; Bone Marrow Cells/cytology ; Bone Marrow Cells/drug effects ; Cytokines/metabolism ; Humans ; Thrombopoiesis/drug effects ; Thrombopoietin/pharmacology
    Chemical Substances Cytokines ; Thrombopoietin (9014-42-0)
    Language English
    Publishing date 2015-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 206923-4
    ISSN 1532-8686 ; 0037-1963
    ISSN (online) 1532-8686
    ISSN 0037-1963
    DOI 10.1053/j.seminhematol.2014.10.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 328: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: The Hematopoietic Microenvironment in Myeloproliferative Neoplasms: The Interplay Between Nature (Stem Cells) and Nurture (the Niche).

    Zhan, Huichun / Kaushansky, Kenneth

    Advances in experimental medicine and biology

    2020  Volume 1273, Page(s) 135–145

    Abstract: Hematopoietic stem cells (HSCs) rely on instructive cues from the marrow microenvironment for their maintenance and function. Accumulating evidence indicates that the survival and proliferation of hematopoietic neoplasms are dependent not only on cell- ... ...

    Abstract Hematopoietic stem cells (HSCs) rely on instructive cues from the marrow microenvironment for their maintenance and function. Accumulating evidence indicates that the survival and proliferation of hematopoietic neoplasms are dependent not only on cell-intrinsic, genetic mutations, and other molecular alterations present within neoplastic stem cells, but also on the ability of the surrounding microenvironmental cells to nurture and promote the malignancy. It is anticipated that a better understanding of the molecular and cellular events responsible for these microenvironmental features of neoplastic hematopoiesis will lead to improved treatment for patients. This review will focus on the myeloproliferative neoplasms (MPNs), polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), in which an acquired signaling kinase mutation (JAK2V617F) plays a central, pathogenetic role in 50-100% of patients with these disorders. Evidence is presented that the development of an MPN requires both an abnormal, mutation-bearing (i.e., neoplastic) HSC and an abnormal, mutation-bearing microenvironment.
    MeSH term(s) Hematopoietic Stem Cells/cytology ; Humans ; Janus Kinase 2/genetics ; Mutation ; Myeloproliferative Disorders/genetics ; Myeloproliferative Disorders/pathology ; Neoplasms/genetics ; Neoplasms/pathology ; Stem Cell Niche ; Tumor Microenvironment
    Chemical Substances JAK2 protein, human (EC 2.7.10.2) ; Janus Kinase 2 (EC 2.7.10.2)
    Language English
    Publishing date 2020-10-29
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-49270-0_7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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