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  1. Book: Controversies in total knee replacement

    Laskin, Richard S.

    (Controversies in orthopaedic surgery)

    2001  

    Author's details ed. by Richard S. Laskin
    Series title Controversies in orthopaedic surgery
    Language English
    Size XIII, 401 S. : Ill., graph. Darst.
    Edition 1. publ.
    Publisher Oxford University Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT013063908
    ISBN 0-19-263072-5 ; 978-0-19-263072-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2002 A 3291 order for loan Magazin

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  2. Book: Total knee replacement

    Laskin, Richard S.

    1991  

    Author's details Richard S. Laskin (ed.)
    Keywords Knee Prosthesis ; Kniegelenkprothese
    Subject Kniegelenksendoprothese ; Knieendoprothese ; Kniegelenk ; Kniegelenkendoprothese
    Language English
    Size XVI, 268 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT003884682
    ISBN 3-540-19644-7 ; 0-387-19644-7 ; 978-3-540-19644-0 ; 978-0-387-19644-2
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: Exploration of Germline Correlates and Risk of Immune-Related Adverse Events in Advanced Cancer Patients Treated with Immune Checkpoint Inhibitors.

    Titmuss, Emma / Yu, Irene S / Pleasance, Erin D / Williamson, Laura M / Mungall, Karen / Mungall, Andrew J / Renouf, Daniel J / Moore, Richard / Jones, Steven J M / Marra, Marco A / Laskin, Janessa J / Savage, Kerry J

    Current oncology (Toronto, Ont.)

    2024  Volume 31, Issue 4, Page(s) 1865–1875

    Abstract: Immune checkpoint inhibitors (ICIs) are increasingly used in the treatment of many tumor types, and durable responses can be observed in select populations. However, patients may exhibit significant immune-related adverse events (irAEs) that may lead to ... ...

    Abstract Immune checkpoint inhibitors (ICIs) are increasingly used in the treatment of many tumor types, and durable responses can be observed in select populations. However, patients may exhibit significant immune-related adverse events (irAEs) that may lead to morbidity. There is limited information on whether the presence of specific germline mutations may highlight those at elevated risk of irAEs. We evaluated 117 patients with metastatic solid tumors or hematologic malignancies who underwent genomic analysis through the ongoing Personalized OncoGenomics (POG) program at BC Cancer and received an ICI during their treatment history. Charts were reviewed for irAEs. Whole genome sequencing of a fresh biopsy and matched normal specimens (blood) was performed at the time of POG enrollment. Notably, we found that MHC class I alleles in the HLA-B27 family, which have been previously associated with autoimmune conditions, were associated with grade 3 hepatitis and pneumonitis (q = 0.007) in patients treated with combination PD-1/PD-L1 and CTLA-4 inhibitors, and PD-1 inhibitors in combination with IDO-1 inhibitors. These data highlight that some patients may have a genetic predisposition to developing irAEs.
    MeSH term(s) Humans ; Immune Checkpoint Inhibitors/adverse effects ; Immune Checkpoint Inhibitors/therapeutic use ; Male ; Neoplasms/drug therapy ; Female ; Middle Aged ; Aged ; Germ-Line Mutation ; Adult ; Aged, 80 and over
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2024-03-30
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol31040140
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Conference proceedings: Symposium on Disorders of the Knee Joint

    Laskin, Richard S.

    (The orthopedic clinics of North America ; 10,1)

    1979  

    Institution Symposium on Disorders of the Knee Joint
    Author's details RICHARD S. LASKIN, GUEST ED
    Series title The orthopedic clinics of North America ; 10,1
    Collection
    Keywords JOINT DISEASES ; KNEE JOINT
    Size VI, 284 S. ; 24 CM
    Publisher Saunders
    Publishing place PHILADELPHIA U.A
    Document type Book ; Conference proceedings
    HBZ-ID HT001080257
    Database Catalogue ZB MED Medicine, Health

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    SE 118 -10,1- verfügbar in Königswinter Königswinter

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  5. Article ; Online: The classic: modular total knee-replacement arthroplasty. A review of eighty-nine patients. 1976.

    Laskin, Richard S

    Clinical orthopaedics and related research

    2008  Volume 466, Issue 11, Page(s) 2581–2588

    Abstract: Fifty-eight osteoarthritic and thirty-one rheumatoid patients underwent modular total knee-replacement arthroplasty. The major indication for the operation was relief of pain. Contraindications to this resurfacing arthroplasty included varus-valgus ... ...

    Abstract Fifty-eight osteoarthritic and thirty-one rheumatoid patients underwent modular total knee-replacement arthroplasty. The major indication for the operation was relief of pain. Contraindications to this resurfacing arthroplasty included varus-valgus instability of over 20 degrees, combined varus-valgus instability with flexion contracture of over 40 degrees, marked recurvatum, and predominant patellofemoral symptoms. In 59 per cent of the osteoarthritic and 58 per cent of the rheumatoid patients, complete relief of pain was evident when they were evaluated twenty-four months after surgery, while another 35 per cent of each group had only mild pain related to inclement weather. Their ability to walk long distances without support or limp was increased. Range of motion and ability to climb stairs were not significantly improved.
    MeSH term(s) Arthroplasty, Replacement, Knee/history ; History, 20th Century ; Humans ; Osteoarthritis, Knee/history ; United States
    Language English
    Publishing date 2008-09-16
    Publishing country United States
    Document type Biography ; Classical Article ; Historical Article ; Journal Article
    ZDB-ID 80301-7
    ISSN 1528-1132 ; 0009-921X
    ISSN (online) 1528-1132
    ISSN 0009-921X
    DOI 10.1007/s11999-008-0461-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The classic: total condylar knee replacement in patients who have rheumatoid arthritis. A ten-year follow-up study. 1990.

    Laskin, Richard S

    Clinical orthopaedics and related research

    2008  Volume 466, Issue 11, Page(s) 2589–2596

    Abstract: Eighty knee replacements with a total condylar prosthesis in patients who had rheumatoid arthritis were followed for ten years. At ten years, nineteen knees needed revision and sixty-one prostheses were still functioning. The major reasons for revision ... ...

    Abstract Eighty knee replacements with a total condylar prosthesis in patients who had rheumatoid arthritis were followed for ten years. At ten years, nineteen knees needed revision and sixty-one prostheses were still functioning. The major reasons for revision were loosening of the tibial component or late bacteremic seeding from another site. Radiolucency at the bone-cement interface adjacent to the tibial component was statistically related to malposition of the tibial component. According to the system of The Hospital for Special Surgery, the mean scores were 64 points preoperatively and 85 points postoperatively. Synovitis recurred in only 3 per cent of the knees. When revision, pain, or radiographic evidence of loosening were considered an indication of failure, the ten-year cumulative survival was 75 per cent.
    MeSH term(s) Arthritis, Rheumatoid/history ; Arthritis, Rheumatoid/surgery ; Arthroplasty, Replacement, Knee/history ; History, 20th Century ; Humans ; Osteoarthritis, Knee/history ; Osteoarthritis, Knee/surgery
    Language English
    Publishing date 2008-09-16
    Publishing country United States
    Document type Biography ; Classical Article ; Historical Article ; Journal Article
    ZDB-ID 80301-7
    ISSN 1528-1132 ; 0009-921X
    ISSN (online) 1528-1132
    ISSN 0009-921X
    DOI 10.1007/s11999-008-0462-6
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  7. Article: The effect of a high-flex implant on postoperative flexion after primary total knee arthroplasty.

    Laskin, Richard S

    Orthopedics

    2007  Volume 30, Issue 8 Suppl, Page(s) 86–88

    Abstract: Compared to a statistically similar cohort, patients implanted with a high-flex poster-stabilized prosthesis achieved greater return of flexion than that with a standard posterior stabilized implant. In addition, patients with a high flexion arc ... ...

    Abstract Compared to a statistically similar cohort, patients implanted with a high-flex poster-stabilized prosthesis achieved greater return of flexion than that with a standard posterior stabilized implant. In addition, patients with a high flexion arc preoperatively retained this high arc of flexion after surgery. Finally, there was an increase in the range of flexion seen after surgery in both groups of patients, but larger in the group in which the modified high-flexion implant was used.
    MeSH term(s) Arthroplasty, Replacement, Knee/instrumentation ; Biomechanical Phenomena ; Female ; Finite Element Analysis ; Humans ; Knee Joint/physiology ; Knee Prosthesis ; Male ; Range of Motion, Articular
    Language English
    Publishing date 2007-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 424447-3
    ISSN 0147-7447
    ISSN 0147-7447
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Surgical exposure for total knee arthroplasty: for everything there is a season.

    Laskin, Richard S

    The Journal of arthroplasty

    2007  Volume 22, Issue 4 Suppl 1, Page(s) 12–14

    Abstract: The author has used a mini midvastus lesser-invasive knee approach for 5 years for patients undergoing a primary total knee arthroplasty. The approach involves a modified capsular and muscular incision, displacement but not eversion of the patella, and ... ...

    Abstract The author has used a mini midvastus lesser-invasive knee approach for 5 years for patients undergoing a primary total knee arthroplasty. The approach involves a modified capsular and muscular incision, displacement but not eversion of the patella, and avoidance of anterior dislocation of the tibia before bony resections. This has resulted in a more rapid return of flexion and functional ability with a lesser amount of postoperative pain as compared with previous larger median parapatellar approaches with patellar eversion. The approach is indicated for patients who preoperatively have good knee flexion, a mild to moderate coronal deformity, and no prior open procedures on the joint. It is difficult to use in patients who have large, heavy and/or muscular thighs; those with severe angular or flexion deformities; those with limited flexion; and those with severe inflammatory arthritis of the knee.
    MeSH term(s) Arthroplasty, Replacement, Knee/instrumentation ; Arthroplasty, Replacement, Knee/methods ; Humans ; Minimally Invasive Surgical Procedures/instrumentation
    Language English
    Publishing date 2007-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632770-9
    ISSN 0883-5403
    ISSN 0883-5403
    DOI 10.1016/j.arth.2007.02.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Risk of infection extends beyond two years.

    Laskin, Richard S

    The New York state dental journal

    2006  Volume 72, Issue 4, Page(s) 8–9; author reply 9

    MeSH term(s) American Dental Association ; Antibiotic Prophylaxis ; Dental Care for Chronically Ill ; Hip Prosthesis ; Humans ; Knee Prosthesis ; Orthopedics ; Prosthesis-Related Infections/prevention & control ; Societies, Medical ; United States
    Language English
    Publishing date 2006-06
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 415686-9
    ISSN 0028-7571
    ISSN 0028-7571
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Reduced-incision total knee replacement through a mini-midvastus technique.

    Laskin, Richard S

    The journal of knee surgery

    2006  Volume 19, Issue 1, Page(s) 52–57

    MeSH term(s) Arthroplasty, Replacement, Knee/methods ; Humans ; Minimally Invasive Surgical Procedures/methods ; Muscle, Skeletal/blood supply ; Muscle, Skeletal/innervation ; Muscle, Skeletal/surgery ; Pain, Postoperative/prevention & control ; Range of Motion, Articular ; Treatment Outcome
    Language English
    Publishing date 2006-02-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2075354-8
    ISSN 1938-2480 ; 1538-8506 ; 0899-7403
    ISSN (online) 1938-2480
    ISSN 1538-8506 ; 0899-7403
    DOI 10.1055/s-0030-1248079
    Database MEDical Literature Analysis and Retrieval System OnLINE

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