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Article ; Online: Changes in Expression and Function of Placental and Intestinal P-gp and BCRP Transporters during Pregnancy.

Szatmári, Péter / Ducza, Eszter

International journal of molecular sciences

2023 Volume 24, Issue 17

Abstract: ... the pharmacokinetic and pharmacologic properties of drugs. P-gp and BCRP transporters are the best-characterized ... absorption and distribution. Placental and intestinal P-gp and BCRP show gestational-age-dependent expression ...

Abstract	ABC transporters are ubiquitous in the human body and are responsible for the efflux of drugs. They are present in the placenta, intestine, liver and kidney, which are the major organs that can affect the pharmacokinetic and pharmacologic properties of drugs. P-gp and BCRP transporters are the best-characterized transporters in the ABC superfamily, and they have a pivotal role in the barrier tissues due to their efflux mechanism. Moreover, during pregnancy, drug efflux is even more important because of the developing fetus. Recent studies have shown that placental and intestinal ABC transporters have great importance in drug absorption and distribution. Placental and intestinal P-gp and BCRP show gestational-age-dependent expression changes, which determine the drug concentration both in the mother and the fetus during pregnancy. They may have an impact on the efficacy of antibiotic, antiviral, antihistamine, antiemetic and oral antidiabetic therapies. In this review, we would like to provide an overview of the pharmacokinetically relevant expression alterations of placental and intestinal ABC transporters during pregnancy.
MeSH term(s)	Female ; Humans ; Pregnancy ; ATP Binding Cassette Transporter, Subfamily G, Member 2/genetics ; ATP-Binding Cassette Transporters/genetics ; Intestines ; Membrane Transport Proteins ; Neoplasm Proteins ; Placenta
Chemical Substances	ATP Binding Cassette Transporter, Subfamily G, Member 2 ; ATP-Binding Cassette Transporters ; Membrane Transport Proteins ; Neoplasm Proteins ; ABCB5 protein, human
Language	English
Publishing date	2023-08-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241713089
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: "P" and "DP:" Examining Symptom-Level Bifactor Models of Psychopathology and Dysregulation in Clinically Referred Children and Adolescents.

Haltigan, John D / Aitken, Madison / Skilling, Tracey / Henderson, Joanna / Hawke, Lisa / Battaglia, Marco / Strauss, John / Szatmari, Peter / Andrade, Brendan F

Journal of the American Academy of Child and Adolescent Psychiatry

2018 Volume 57, Issue 6, Page(s) 384–396

Abstract: ... P") and a narrower, clinically oriented dysregulation general factor based on the Dysregulation ... Profile ("DP") in a large clinical sample of children and adolescents. We also compared the magnitude of P ... Self Report data (N = 2,395).: Results: General P and DP bifactor models fit the data better than single ...

Abstract	Objective: This study examined cross-informant evidence for a general factor of psychopathology ("P") and a narrower, clinically oriented dysregulation general factor based on the Dysregulation Profile ("DP") in a large clinical sample of children and adolescents. We also compared the magnitude of P and DP general factor associations with self-harm and suicidal ideation as an indicator of criterion validity. Method: Itemwise data from the Child Behavior Checklist (N = 2,934; 4-18 years of age) were analyzed using confirmatory bifactor modeling and replicated in a supplementary analysis using Youth Self Report data (N = 2,395). Results: General P and DP bifactor models fit the data better than single-factor and correlated factor models. Cross-informant criterion analyses on a subset of youth (n = 1,552) suggested that whether modeled as latent P or DP, associations with a brief composite index of self-harm and suicidal ideation are essentially of the same magnitude. Conclusion: Our findings provide novel, large-sample support for the existence of general factors of psychopathology and dysregulation in clinically referred children and adolescents using a standardized rating system of psychopathology symptoms. Moreover, our results provide preliminary evidence that general psychopathology and dysregulation factors are clinically meaningful constructs. In addition, our findings raise the possibility that the DP general factor may serve as an efficient proxy for the general psychopathology factor in future clinical applications. Further efforts are necessary to understand the core empirical meaning of the P factor and to determine how it can be applied to clinical assessment and intervention.
MeSH term(s)	Adolescent ; Checklist/methods ; Child ; Child Behavior Disorders/diagnosis ; Female ; Humans ; Male ; Models, Statistical ; Psychiatric Status Rating Scales ; Psychopathology ; Self Report ; Self-Injurious Behavior ; Suicidal Ideation
Language	English
Publishing date	2018-04-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	392535-3
ISSN	1527-5418 ; 0890-8567
ISSN (online)	1527-5418
ISSN	0890-8567
DOI	10.1016/j.jaac.2018.03.010
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Article ; Online: Editorial: The Importance of Screening for Developmental Disorders and Demonstrating Improved Health Outcomes.

Szatmari, Peter

Journal of the American Academy of Child and Adolescent Psychiatry

2023 Volume 62, Issue 10, Page(s) 1086–1088

Abstract: Screening for emotional, behavioral, and developmental disorders is generally considered to be a valuable activity in the child and youth developmental and mental health service sectors. The premise is that screening allows for early identification, ... ...

Abstract	Screening for emotional, behavioral, and developmental disorders is generally considered to be a valuable activity in the child and youth developmental and mental health service sectors. The premise is that screening allows for early identification, which in turn allows for early intervention, which in turn leads to better long-term outcomes. While the hypothesized causal chain from screening to outcomes may seem long, the evidence base to support this aspiration is growing. In this issue of the Journal, the article by Rah et al.
MeSH term(s)	Child ; Adolescent ; Humans ; Child, Preschool ; Developmental Disabilities/diagnosis ; Emotions ; Outcome Assessment, Health Care
Language	English
Publishing date	2023-03-21
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	392535-3
ISSN	1527-5418 ; 0890-8567
ISSN (online)	1527-5418
ISSN	0890-8567
DOI	10.1016/j.jaac.2023.03.009
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Article ; Online: Validation of the Hungarian version of the Prolapse and Incontinence Knowledge Questionnaire (PIKQ).

Szatmári, Éva / Makai, Alexandra / Ambrus, Eszter / Hock, Márta

European journal of obstetrics & gynecology and reproductive biology: X

2024 Volume 22, Page(s) 100296

Abstract: ... pelvic organ prolapse (p < 0.001) compared to women who had not worked in a medical field. The Hungarian PIKQ had ...

Abstract	Objective: The Prolapse and Incontinence Knowledge Questionnaire (PIKQ) is a self-administered, reliable and valid instrument which assess knowledge regarding urinary incontinence and pelvic organ prolapse. There is no validated Hungarian version of this questionnaire; therefore the aim of this study was to develop a reliable, valid and culturally sensitive Hungarian version of the PIKQ. Study design: A cross-sectional study was conducted from March to October 2022 with a sample of 459 women. The PIKQ, which consists of the urinary incontinence and pelvic organ prolapse scales, was translated into Hungarian in accordance with international guidelines. The validity and reliability of the final version of the Hungarian PIKQ was evaluated using construct validity, comparison with known-groups, internal consistency and test-retest reliability. Results: Regarding construct validity, all fit indices were found acceptable. Healthcare workers had significantly higher knowledge about urinary incontinence and pelvic organ prolapse (p < 0.001) compared to women who had not worked in a medical field. The Hungarian PIKQ had an adequate internal consistency with Cronbach alpha of 0.785 for the urinary incontinence scale and 0.826 for the pelvic organ prolapse scale. The correlation coeffcients between the test and retest was 0.931 for the urinary incontinence scale and 0.964 for the pelvic organ prolapse scale. Conclusion: The Hungarian version of the PIKQ is a reliable and valid tool to measure the level of knowledge about urinary incontinence and pelvic organ prolapse among Hungarian speaking women.
Language	English
Publishing date	2024-03-02
Publishing country	Netherlands
Document type	Journal Article
ISSN	2590-1613
ISSN (online)	2590-1613
DOI	10.1016/j.eurox.2024.100296
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Article ; Online: Novel Eco-friendly, One-Pot Method for the Synthesis of Kynurenic Acid Ethyl Esters.

Simon, Péter / Lőrinczi, Bálint / Hetényi, Anasztázia / Szatmári, István

ACS omega

2023 Volume 8, Issue 20, Page(s) 17966–17975

Abstract: The synthesis of kynurenic acid derivatives with potential biological effect was investigated and optimized for one-batch, two-step microwave-assisted reactions. Utilizing both chemically and biologically representative non-, methyl-, methoxy-, and ... ...

Abstract	The synthesis of kynurenic acid derivatives with potential biological effect was investigated and optimized for one-batch, two-step microwave-assisted reactions. Utilizing both chemically and biologically representative non-, methyl-, methoxy-, and chlorosubstituted aniline derivatives, in catalyst-free conditions, syntheses of seven kynurenic acid derivatives were achieved in a time frame of 2-3.5 h. In place of halogenated reaction media, tuneable green solvents were introduced for each analogue. The potential of green solvent mixtures to replace traditional solvents and to alter the regioisomeric ratio regarding the Conrad-Limpach method was highlighted. The advantages of the fast, eco-friendly, inexpensive analytic technique of TLC densitometry were emphasized for reaction monitoring and conversion determination in comparison to quantitative NMR. Moreover, the developed 2-3.5 h syntheses were scaled-up to achieve gram-scale products of KYNA derivatives, without altering the reaction time in the halogenated solvent DCB and more importantly in its green substitutes.
Language	English
Publishing date	2023-05-11
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c01170
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Article ; Online: Synthesis of Indole-Coupled KYNA Derivatives via C-N Bond Cleavage of Mannich Bases.

Lőrinczi, Bálint / Simon, Péter / Szatmári, István

International journal of molecular sciences

2022 Volume 23, Issue 13

Abstract: KYNAs, a compound with endogenous neuroprotective functions and an indole that is a building block of many biologically active compounds, such as a variety of neurotransmitters, are reacted in a transformation building upon Mannich bases. The reaction ... ...

Abstract	KYNAs, a compound with endogenous neuroprotective functions and an indole that is a building block of many biologically active compounds, such as a variety of neurotransmitters, are reacted in a transformation building upon Mannich bases. The reaction yields triarylmethane derivatives containing two biologically potent skeletons, and it may contribute to the synthesis of new, specialised neuroprotective compounds. The synthesis has been investigated via two procedures and the results were compared to those of previous studies. A possible alternative reaction route through acid catalysis has been established.
MeSH term(s)	Catalysis ; Indoles ; Mannich Bases/chemistry
Chemical Substances	Indoles ; Mannich Bases
Language	English
Publishing date	2022-06-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23137152
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Article ; Online: Fine-Tuned Reactivity of

Csuvik, Oszkár / Barta, Petra / Csámpai, Antal / Szatmári, István

International journal of molecular sciences

2022 Volume 23, Issue 20

Abstract: 6-Hydroxyquinoline and 3-hydroxyisoquinoline ... ...

Abstract	6-Hydroxyquinoline and 3-hydroxyisoquinoline as
MeSH term(s)	Mannich Bases/chemistry ; Naphthols ; Methanol ; Water/chemistry ; Morpholines ; Aldehydes
Chemical Substances	Mannich Bases ; Naphthols ; Methanol (Y4S76JWI15) ; Water (059QF0KO0R) ; Morpholines ; Aldehydes
Language	English
Publishing date	2022-10-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms232012329
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Article ; Online: Paramedical counselling in infertility treatment: its effects on anxio-depressive symptom severity, perceived stress and self-esteem

Szatmári, Angelika / Helembai, Kornélia / Zádori, János / Kovács, Ildikó

Heliyon. 2022 July, v. 8, no. 7 p.e09827-

2022

Abstract: The importance of contributing psychological factors and stress-control in female infertility is well documented, but research on their role in male infertility is scarce. The present study aimed to evaluate the effects of a novel paramedical counselling ...

Abstract	The importance of contributing psychological factors and stress-control in female infertility is well documented, but research on their role in male infertility is scarce. The present study aimed to evaluate the effects of a novel paramedical counselling on anxio-depressive symptom severity, perceived stress and self-esteem in infertile men participating in an infertility treatment programme. Patients were recruited from clinics of University of Szeged, Hungary between 2019 May and 2020 December, and were sorted into control (n = 51) and experimental (n = 57) groups, where patients in the experimental group received a 5-session paramedical counselling in extension to their medical treatment. The levels of anxio-depressive symptom severity, perceived stress and self-esteem were measured prior to and after receiving paramedical counselling. The control group scored lower in regards of the severity of depressive symptom, and showed an increase of self-esteem, while the experimental group resulted in a significant decrease of anxio-depressive scores with the elevation of the level of self-esteem. Our results indicate that joining an infertility treatment programme alone had a positive role in reducing depressive symptoms and in the increase of self-esteem among infertile men, but receiving additional paramedical counselling throughout the treatment programme resulted in the decrease of anxio-depressive symptoms, besides the elevation of the level of self-esteem, with a significantly higher decrease in the state anxiety compared to not receiving this additional paramedical counselling. Thus, it would be advisable for infertility treatment programmes to incorporate screening for psychological vulnerability and implement additional paramedical counselling to alleviate these confounding symptoms detrimental to conceiving.
Keywords	anxiety ; female fertility ; male sterility ; medical treatment ; self-esteem ; Hungary ; Male infertility ; Paramedical counselling ; Anxio-depressive symptoms ; Perceived stress
Language	English
Dates of publication	2022-07
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2022.e09827
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Being Precise About Precision Mental Health.

Szatmari, Peter / Susser, Ezra

JAMA psychiatry

2022 Volume 79, Issue 12, Page(s) 1149–1150

MeSH term(s)	Humans ; Mental Health
Language	English
Publishing date	2022-11-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2701203-7
ISSN	2168-6238 ; 2168-622X
ISSN (online)	2168-6238
ISSN	2168-622X
DOI	10.1001/jamapsychiatry.2022.3391
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Article ; Online: Progressive Right Ventricular Obstruction Caused by a Double-Chambered Right Ventricle Resulting in Shunt-Reversal via a Concomitant Congenital Ventricular Septal Defect and Subsequent Erythrocytosis in a Dog

Viktor Szatmári / Mark Dirven / Heike Aupperle-Lellbach

Veterinary Sciences, Vol 10, Iss 174, p

2023 Volume 174

Abstract: A 3-year-old Chihuahua was presented because of exercise intolerance, respiratory distress, and syncopal episodes. At the age of 10 weeks, the dog was diagnosed with a congenital small left-to-right shunting ventricular septal defect and a mild right ... ...

Abstract	A 3-year-old Chihuahua was presented because of exercise intolerance, respiratory distress, and syncopal episodes. At the age of 10 weeks, the dog was diagnosed with a congenital small left-to-right shunting ventricular septal defect and a mild right ventricular outflow tract obstruction via echocardiography. At that time, the dog was asymptomatic, but the breeder’s veterinarian heard a murmur. Both cardiac defects were judged to be clinically non-relevant at that time. However, at 3 years of age, echocardiography revealed a severe right ventricular obstruction, known as a double-chambered right ventricle, along with right-to-left shunting via the ventricular septal defect. Because of chronic hypoxemia due to the right-to-left shunting, erythrocytosis developed. Flow reversal via the shunt was caused by a progressively worsening right ventricular obstruction leading to a supra-systemic right ventricular systolic pressure. Because of the poor prognosis, the dog was euthanized, and the heart was submitted for post-mortem examination. Gross pathologic findings revealed the close proximity of the right ventricular obstructive lesion to the ventricular septal defect. Histopathology revealed localized muscular hypertrophy and severe endocardial fibrosis. The suspected pathogenesis of the progressive obstruction was infiltrative myocardial fibrosis due to turbulent blood flow from the left-to-right shunting ventricular septal defect, as described in humans.
Keywords	cyanosis ; endothelial-to-mesenchymal transition ; Gasul phenomenon ; endocardial fibrosis ; hypoxemia ; murmur ; Veterinary medicine ; SF600-1100
Subject code	610
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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