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  1. Book ; Thesis: Die Rolle von Interleukin-10 im murinen Schlaganfall

    Piepke, Marius / Mittrücker, Hans-Willi / Gelderblom, Mathias

    2022  

    Institution Universität Hamburg
    Universität Hamburg / Medizinische Fakultät
    Author's details vorgelegt von: Marius Piepke ; Prüfungsausschuss, der/die Vorsitzende: Prof. Dr. Hans Willi Mittrücker, Prüfungsausschuss, zweite/r Gutachter/in: PD Dr. Mathias Gelderblom
    Language German ; English
    Size 37 Blätter, Illustrationen, Diagramme
    Publishing place Hamburg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Hamburg, 2023
    Note Text in deutsch, Zeitschriftenartikel in englisch ; Dissertation angenommen von der Medizinischen Fakultät der Universität Hamburg ; Enthält 1 Zeitschriftenartikel
    HBZ-ID HT030346327
    Database Catalogue ZB MED Medicine, Health

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    2023 E 1236 order for loan Magazin

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  2. Article ; Online: No need for H

    Gelderblom, Hans / Zwaveling, Juliette

    British journal of cancer

    2021  Volume 124, Issue 10, Page(s) 1613–1614

    Abstract: The theoretical basis for use of histamine 2 ( ... ...

    Abstract The theoretical basis for use of histamine 2 (H
    MeSH term(s) Drug Hypersensitivity ; Histamine H2 Antagonists ; Humans ; Paclitaxel ; Premedication ; Ranitidine
    Chemical Substances Histamine H2 Antagonists ; Ranitidine (884KT10YB7) ; Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2021-03-24
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-021-01316-x
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  3. Article ; Online: Denosumab in Giant Cell Rich Tumors of Bone: An Open-Label Multicenter Phase II Study.

    Lipplaa, Astrid / Schreuder, Willem H / Pichardo, Sarina E C / Gelderblom, Hans

    The oncologist

    2023  Volume 28, Issue 11, Page(s) 1005–e1104

    Abstract: Background: Since giant cell tumors of bone (GCTB) and other giant cell rich tumors of bone (GCRTB) share the histological presence of osteoclastic giant cells and expression of RANK/RANKL, we hypothesized that GCRTB will respond similarly to denosumab ... ...

    Abstract Background: Since giant cell tumors of bone (GCTB) and other giant cell rich tumors of bone (GCRTB) share the histological presence of osteoclastic giant cells and expression of RANK/RANKL, we hypothesized that GCRTB will respond similarly to denosumab as GCTB. The primary objective of this study was to determine the efficacy of denosumab in patients with GCRTB that have recurred or require morbid surgery.
    Methods: In this open-label, multicenter, phase II trial, patients with GCRTB were included (June 2018-March 2020). Recruitment was stopped because of low accrual. Patients received denosumab (120 mg) subcutaneously (SC) on day 1 of every 4-week cycle with a loading dose of 120 mg SC on days 8 and 15.
    Results: Three patients were enrolled. One withdrew consent before start of study. The remaining patients had central giant cell granuloma of the jawbone (CGCG). Median treatment duration was 15 cycles (range 12-18). In both subjects, improvement in ossification of lesions was seen. Median follow-up was 28.5 months (range 20-37). One patient developed a recurrence for which surgery was performed.
    Conclusion: Due to critical emerging real-world data of denosumab in GCRTBs, the study was prematurely stopped and not supportive of use of denosumab for this indication. (ClinicalTrials.gov Identifier: NCT03605199).
    MeSH term(s) Humans ; Denosumab ; Bone Density Conservation Agents/therapeutic use ; Bone Neoplasms/drug therapy ; Giant Cell Tumor of Bone/drug therapy ; Giant Cells/pathology
    Chemical Substances Denosumab (4EQZ6YO2HI) ; Bone Density Conservation Agents
    Language English
    Publishing date 2023-07-10
    Publishing country England
    Document type Clinical Trial, Phase II ; Multicenter Study ; Journal Article
    ZDB-ID 1409038-7
    ISSN 1549-490X ; 1083-7159
    ISSN (online) 1549-490X
    ISSN 1083-7159
    DOI 10.1093/oncolo/oyad196
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  4. Article ; Online: Systemic therapy of advanced/metastatic gastrointestinal stromal tumors: an update on progress beyond imatinib, sunitinib, and regorafenib.

    Mohammadi, Mahmoud / Gelderblom, Hans

    Expert opinion on investigational drugs

    2020  Volume 30, Issue 2, Page(s) 143–152

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Animals ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Drug Resistance, Neoplasm ; Gastrointestinal Neoplasms/drug therapy ; Gastrointestinal Neoplasms/enzymology ; Gastrointestinal Neoplasms/genetics ; Gastrointestinal Neoplasms/mortality ; Gastrointestinal Stromal Tumors/drug therapy ; Gastrointestinal Stromal Tumors/enzymology ; Gastrointestinal Stromal Tumors/genetics ; Gastrointestinal Stromal Tumors/mortality ; Humans ; Imatinib Mesylate/adverse effects ; Imatinib Mesylate/therapeutic use ; Molecular Targeted Therapy ; Mutation ; Phenylurea Compounds/adverse effects ; Phenylurea Compounds/therapeutic use ; Protein Kinase Inhibitors/adverse effects ; Protein Kinase Inhibitors/therapeutic use ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Protein-Tyrosine Kinases/genetics ; Protein-Tyrosine Kinases/metabolism ; Pyridines/adverse effects ; Pyridines/therapeutic use ; Signal Transduction ; Sunitinib/adverse effects ; Sunitinib/therapeutic use ; Treatment Outcome
    Chemical Substances Antineoplastic Agents ; Phenylurea Compounds ; Protein Kinase Inhibitors ; Pyridines ; regorafenib (24T2A1DOYB) ; Imatinib Mesylate (8A1O1M485B) ; Protein-Tyrosine Kinases (EC 2.7.10.1) ; Sunitinib (V99T50803M)
    Language English
    Publishing date 2020-12-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1182884-5
    ISSN 1744-7658 ; 0967-8298 ; 1354-3784
    ISSN (online) 1744-7658
    ISSN 0967-8298 ; 1354-3784
    DOI 10.1080/13543784.2021.1857363
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  5. Article ; Online: Characteristics and Survival Outcomes of Patients With Metastatic

    Hackshaw, Allan / Fajardo, Otto / Dafni, Urania / Gelderblom, Hans / Garrido, Pilar / Siena, Salvatore / Taylor, Matthew H / Bordogna, Walter / Nikolaidis, Christos

    JCO precision oncology

    2024  Volume 8, Page(s) e2300334

    Abstract: Purpose: RET: Methods: Data for RET TKI-naïve patients with metastatic solid tumors (excluding NSCLC) who had ≥one Foundation Medicine comprehensive genomic profiling test (January 1, 2011-March 31, 2022) were obtained from a deidentified nationwide ( ...

    Abstract Purpose: RET
    Methods: Data for RET TKI-naïve patients with metastatic solid tumors (excluding NSCLC) who had ≥one Foundation Medicine comprehensive genomic profiling test (January 1, 2011-March 31, 2022) were obtained from a deidentified nationwide (US-based) clinicogenomic database. The primary objective of this study was to compare the overall survival (OS) of patients with
    Results: The study population included 26 patients in the
    Conclusion: These data suggest that
    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Proto-Oncogene Proteins c-ret/genetics ; Standard of Care ; Prognosis
    Chemical Substances Proto-Oncogene Proteins c-ret (EC 2.7.10.1) ; RET protein, human (EC 2.7.10.1)
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Journal Article
    ISSN 2473-4284
    ISSN (online) 2473-4284
    DOI 10.1200/PO.23.00334
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  6. Article ; Online: A Genome-Wide Association Study of Endoxifen Serum Concentrations and Adjuvant Tamoxifen Efficacy in Early-Stage Breast Cancer Patients.

    Sanchez-Spitman, Anabel Beatriz / Böhringer, Stefan / Dezentjé, Vincent Olaf / Gelderblom, Hans / Swen, Jesse Joachim / Guchelaar, Henk-Jan

    Clinical pharmacology and therapeutics

    2024  

    Abstract: Tamoxifen is part of the standard of care of endocrine therapy for adjuvant treatment of breast cancer. However, survival outcomes with tamoxifen are highly variable. The concentration of endoxifen, the 30-100 times more potent metabolite of tamoxifen ... ...

    Abstract Tamoxifen is part of the standard of care of endocrine therapy for adjuvant treatment of breast cancer. However, survival outcomes with tamoxifen are highly variable. The concentration of endoxifen, the 30-100 times more potent metabolite of tamoxifen and bioactivated by the CYP2D6 enzyme, has been described as the most relevant metabolite of tamoxifen metabolism. A genome-wide association study (GWAS) was performed with the objective to identify genetic polymorphisms associated with endoxifen serum concentration levels and clinical outcome in early-stage breast cancer patients receiving tamoxifen. A GWAS was conducted in 608 women of the CYPTAM study (NTR1509/PMID: 30120701). Germline DNA and clinical and survival characteristics were readily available. Genotyping was performed on Infinium Global Screening Array (686,082 markers) and single nucleotide polymorphism (SNP) imputation by using 1000 Genomes. Relapse-free survival during tamoxifen (RFSt) was defined the primary clinical outcome. Endoxifen serum concentration was analyzed as a continuous variable. Several genetic variants reached genome-wide significance (P value: ≤5 × 10
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123793-7
    ISSN 1532-6535 ; 0009-9236
    ISSN (online) 1532-6535
    ISSN 0009-9236
    DOI 10.1002/cpt.3255
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  7. Article ; Online: Pharmacokinetic profile of irinotecan in patients with chronic kidney disease: Two cases and literature review.

    Chui, Chang Yue / Moes, Dirk Jan A R / Koolen, Stijn L W / Swen, Jesse J / Gelderblom, Hans

    British journal of clinical pharmacology

    2023  Volume 89, Issue 9, Page(s) 2920–2925

    Abstract: Aims: There are limited pharmacokinetic data on the use of irinotecan in patients with reduced glomerular filtration rate (GFR) and no haemodialysis. In this case report, we present 2 cases and review the current literature.: Methods: The dose of ... ...

    Abstract Aims: There are limited pharmacokinetic data on the use of irinotecan in patients with reduced glomerular filtration rate (GFR) and no haemodialysis. In this case report, we present 2 cases and review the current literature.
    Methods: The dose of irinotecan in both patients was reduced pre-emptively due to reduced GFR. The first patient had her irinotecan dose reduced to 50%, but was nevertheless admitted to hospital because of irinotecan-induced toxicity, including gastrointestinal toxicity and neutropenic fever. The dose was reduced further to 40% for the second cycle; however, the patient was again admitted to the hospital, and irinotecan was stopped indefinitely. The second patient also had his irinotecan dose reduced to 50% and was admitted to the emergency department for gastrointestinal toxicity after the first cycle. However, irinotecan could be administered in the same dose in later cycles.
    Results: The area under the curve to infinity of irinotecan and SN-38 in the first patient were comparable to those of an individual receiving 100% dose intensity. The area under the curve to infinity of irinotecan and SN-38 in patient 2 in both cycles were slightly less than reference values. Furthermore, clearance values of irinotecan and SN-38 in our patients were comparable to those without renal impairment.
    Conclusion: Our case report suggests that reduced GFR may not significantly affect the clearance of irinotecan and SN-38, but can still result in clinical toxicity. Reduced initial dosing seems indicated in this patient population. Further research is needed to fully understand the relationship between reduced GFR, pharmacokinetics, and toxicity of irinotecan and SN-38.
    Language English
    Publishing date 2023-07-17
    Publishing country England
    Document type Case Reports
    ZDB-ID 188974-6
    ISSN 1365-2125 ; 0306-5251 ; 0264-3774
    ISSN (online) 1365-2125
    ISSN 0306-5251 ; 0264-3774
    DOI 10.1111/bcp.15833
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  8. Article ; Online: COVID-19 and systemic anticancer therapy: exploiting uncertainty.

    Gelderblom, Hans / Veelken, Hendrik / Stiggelbout, Anne M

    The Lancet. Oncology

    2020  Volume 22, Issue 1, Page(s) 3–5

    MeSH term(s) COVID-19 ; Clinical Decision-Making ; England ; Humans ; Pandemics ; Retrospective Studies ; SARS-CoV-2 ; Uncertainty
    Language English
    Publishing date 2020-11-27
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(20)30700-2
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  9. Article ; Online: UGT1A1

    Peeters, Sofía Lj / Deenen, Maarten J / Thijs, Anna Mj / Hulshof, Emma C / Mathijssen, Ron Hj / Gelderblom, Hans / Guchelaar, Henk-Jan / Swen, Jesse J

    Pharmacogenomics

    2023  Volume 24, Issue 8, Page(s) 435–439

    Abstract: Tweetable abstract ... ...

    Abstract Tweetable abstract Pretreatment
    MeSH term(s) Humans ; Irinotecan/adverse effects ; Camptothecin/adverse effects ; Patient Safety ; Genotype ; Neoplasms/drug therapy ; Glucuronosyltransferase/genetics
    Chemical Substances Irinotecan (7673326042) ; Camptothecin (XT3Z54Z28A) ; Glucuronosyltransferase (EC 2.4.1.17)
    Language English
    Publishing date 2023-07-20
    Publishing country England
    Document type Editorial
    ZDB-ID 2019513-8
    ISSN 1744-8042 ; 1462-2416
    ISSN (online) 1744-8042
    ISSN 1462-2416
    DOI 10.2217/pgs-2023-0096
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    Zs.A 5247: Show issues Location:
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  10. Article ; Online: Adjuvant immune checkpoint blockade revisited.

    van Waalwijk van Doorn-Khosrovani, Sahar Barjesteh / Huisman, Atse / Roy, Anke Pisters-van / Koole, Simone / Timmers, Lonneke / Blank, Christian / Gelderblom, Hans

    The Lancet. Oncology

    2023  Volume 24, Issue 7, Page(s) 717–719

    MeSH term(s) Humans ; Immune Checkpoint Inhibitors ; Antibodies, Monoclonal ; Immunotherapy/adverse effects
    Chemical Substances Immune Checkpoint Inhibitors ; Antibodies, Monoclonal
    Language English
    Publishing date 2023-07-07
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(23)00233-4
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