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  1. Book ; Online: DAN-Net

    Wang, Tao / Xia, Wenjun / Huang, Yongqiang / Sun, Huaiqiang / Liu, Yan / Chen, Hu / Zhou, Jiliu / Zhang, Yi

    Dual-Domain Adaptive-Scaling Non-local Network for CT Metal Artifact Reduction

    2021  

    Abstract: ... performance. In this paper, a novel Dual-domain Adaptive-scaling Non-local network (DAN-Net) for MAR ... module are leveraged in the proposed network model. In the experiments, the proposed DAN-Net demonstrates ...

    Abstract Metal implants can heavily attenuate X-rays in computed tomography (CT) scans, leading to severe artifacts in reconstructed images, which significantly jeopardize image quality and negatively impact subsequent diagnoses and treatment planning. With the rapid development of deep learning in the field of medical imaging, several network models have been proposed for metal artifact reduction (MAR) in CT. Despite the encouraging results achieved by these methods, there is still much room to further improve performance. In this paper, a novel Dual-domain Adaptive-scaling Non-local network (DAN-Net) for MAR. We correct the corrupted sinogram using adaptive scaling first to preserve more tissue and bone details as a more informative input. Then, an end-to-end dual-domain network is adopted to successively process the sinogram and its corresponding reconstructed image generated by the analytical reconstruction layer. In addition, to better suppress the existing artifacts and restrain the potential secondary artifacts caused by inaccurate results of the sinogram-domain network, a novel residual sinogram learning strategy and nonlocal module are leveraged in the proposed network model. In the experiments, the proposed DAN-Net demonstrates performance competitive with several state-of-the-art MAR methods in both qualitative and quantitative aspects.

    Comment: 29 pages, 11 figures
    Keywords Physics - Medical Physics ; Computer Science - Computer Vision and Pattern Recognition
    Subject code 006
    Publishing date 2021-02-16
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Toxicological safety evaluation of Qin-Zhi-Zhu-Dan formula in rats during the treatment and recovery periods.

    Xu, Wenxiu / Chen, Dan / Zhang, Zehan / Liu, Shuling / Chen, Congai / Sun, Chunyan / Ni, Wenchao / Kang, Xiangdong / Shang, Guojiao / Wang, Xueqian / Cheng, Fafeng / Wang, Qingguo

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 987997

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-08-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.987997
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A network pharmacology-based study of the potential targets and mechanisms of action of Qibao Meiran Dan in delaying skin aging.

    Ke, Dan / Zhang, Han / Tian, Li-Ming / Han, Miao / Zhang, Chong / Tian, Dai-Zhi / Chen, Long / Zhan, Li-Rui / Zong, Shi-Qin / Zhang, Ping

    Journal of cosmetic dermatology

    2022  Volume 21, Issue 10, Page(s) 4956–4964

    Abstract: ... and mechanisms of action of Qibao Meiran Dan in relation to delaying skin aging.: Methods ... integrated database, were used to screen the active ingredients and targets of Qibao Meiran Dan ... showed that cell morphology was clearer and more refractive in the Qibao Meiran Dan group ...

    Abstract Objective: The aim of this study was to use network pharmacology to explore the potential targets and mechanisms of action of Qibao Meiran Dan in relation to delaying skin aging.
    Methods: The traditional Chinese medicine systems pharmacology database and analysis platform, and the traditional Chinese medicine integrated database, were used to screen the active ingredients and targets of Qibao Meiran Dan. The human gene database GeneCards and the gene database of the National Center for Biotechnology Information were jointly adopted to obtain skin aging-related target genes. The search tool for the retrieval of interacting genes/proteins (STRING) database was used for core analysis of protein-protein interaction.
    Results: In total, 72 effective active ingredients, 273 action targets, 234 skin aging target genes, and 64 intersecting core targets were identified. GO enrichment analysis provided 393 biological process entries, and the KEGG analysis was represented by the tumor necrosis factor (TNF) signaling pathway, where the core targets of TNF-α and matrix metalloproteinase-1 (MMP-1) were enriched. The experimental results showed that cell morphology was clearer and more refractive in the Qibao Meiran Dan group than in the model group.
    Conclusion: Qibao Meiran Dan may regulate oxidative stress injury and collagen metabolism by downregulating the expression of TNF-α and MMP-1, thus slowing skin aging.
    MeSH term(s) Humans ; Drugs, Chinese Herbal/pharmacology ; Matrix Metalloproteinase 1/genetics ; Skin Aging ; Tumor Necrosis Factor-alpha ; Network Pharmacology
    Chemical Substances Drugs, Chinese Herbal ; Matrix Metalloproteinase 1 (EC 3.4.24.7) ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2022-04-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.14908
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Guan Xin Dan Shen formulation protects

    Zhang, Bin / Zhang, Chen-Yang / Zhang, Xue-Lian / Sun, Gui-Bo / Sun, Xiao-Bo

    Molecular medicine reports

    2021  Volume 24, Issue 1

    Abstract: Guan Xin Dan Shen formulation (GXDSF) is a widely used treatment for the management ...

    Abstract Guan Xin Dan Shen formulation (GXDSF) is a widely used treatment for the management of coronary heart disease in China and is composed of three primary components:
    MeSH term(s) Animals ; Apoptosis/drug effects ; Body Weight/drug effects ; Cardiomegaly/etiology ; Cardiomegaly/metabolism ; Cardiomegaly/pathology ; Cardiomegaly/prevention & control ; Cardiotonic Agents/pharmacology ; Cardiotonic Agents/therapeutic use ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/metabolism ; Diabetic Cardiomyopathies/etiology ; Diabetic Cardiomyopathies/metabolism ; Diabetic Cardiomyopathies/pathology ; Diabetic Cardiomyopathies/prevention & control ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Insulin Resistance ; Lipids/blood ; Male ; Mice, Inbred Strains ; Mice, Transgenic ; NF-E2-Related Factor 2/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/drug effects ; Mice
    Chemical Substances Cardiotonic Agents ; Drugs, Chinese Herbal ; Lipids ; NF-E2-Related Factor 2 ; Nfe2l2 protein, mouse ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2021-05-26
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2469505-1
    ISSN 1791-3004 ; 1791-2997
    ISSN (online) 1791-3004
    ISSN 1791-2997
    DOI 10.3892/mmr.2021.12170
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Dan-shen Yin promotes bile acid metabolism and excretion to prevent atherosclerosis via activating FXR/BSEP signaling pathway.

    Sheng, Yingkun / Meng, Guibing / Zhang, Min / Chen, Xiaopeng / Chai, Xin / Yu, Haiyang / Han, Lifeng / Wang, Qilong / Wang, Yuefei / Jiang, Miaomiao

    Journal of ethnopharmacology

    2024  Volume 330, Page(s) 118209

    Abstract: Ethnopharmacological relevance: Dan-shen Yin (DSY), a traditional prescription, has been ...

    Abstract Ethnopharmacological relevance: Dan-shen Yin (DSY), a traditional prescription, has been demonstrated to be effective in decreasing hyperlipidemia and preventing atherosclerosis (AS), but its mechanism remains unknown. We hypothesized that DSY activates farnesoid X receptor (FXR) to promote bile acid metabolism and excretion, thereby alleviating AS.
    Aim of the study: This study was designed to explore whether DSY reduces liver lipid accumulation and prevents AS by activating FXR and increasing cholesterol metabolism and bile acid excretion.
    Materials and methods: The comprehensive chemical characterization of DSY was analyzed by UHPLC-MS/MS. The AS models of ApoE
    Results: A total of 36 ingredients in DSY were identified by UPLC-MS/MS analysis. In vivo, high-dose DSY significantly inhibited aortic intimal thickening, improved arrangement disorder, tortuosity, and rupture of elastic fibers, decreased lipid levels, and reduced the number of fat vacuoles and lipid droplets in liver tissue in SD rats and ApoE
    Conclusion: This study demonstrated that DSY promotes bile acid metabolism and excretion to prevent AS by activating FXR. For the prevent of AS and drug discovery provided experimental basis.
    Language English
    Publishing date 2024-04-23
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2024.118209
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Protective effects of Shen Yuan Dan on myocardial ischemia-reperfusion injury via the regulation of mitochondrial quality control.

    Zhang, Zhuhua / Zhou, Mingxue / Liu, Hongxu / Liu, Wei / Chen, Jiaping

    Cardiovascular diagnosis and therapy

    2023  Volume 13, Issue 2, Page(s) 395–407

    Abstract: ... of Shen Yuan Dan (SYD) on cardiomyocytes hypoxia-reoxygenation (H/R) injury via the regulation ...

    Abstract Background: Myocardial cell death resulting from ischemia-reperfusion (I/R) injury has been a predominant contributor to morbidity and mortality globally. The mitochondria-centered mechanism plays an important role in the formation of I/R injury. This study intended to discuss the protective mechanism of Shen Yuan Dan (SYD) on cardiomyocytes hypoxia-reoxygenation (H/R) injury via the regulation of mitochondrial quality control (MQC). Additionally, this study clarified the mechanism by which SYD suppressed mitophagy activity through the suppression of the PTEN-induced kinase 1 (PINK1)/Parkin pathway.
    Methods: To induce cellular injury, H9c2 cardiomyocytes were exposed to H/R stimulation. Following the pretreatment with SYD, cardiomyocytes were subjected to H/R stimulation. Mitochondrial membrane potential (MMP), adenosine triphosphate (ATP), superoxide dismutase (SOD), and methane dicarboxylic aldehyde (MDA) were detected to evaluate the degree of cardiomyocyte mitochondrial damage. Laser confocal microscopy was applied to observe the mitochondrial quality, and the messenger (mRNA) levels of mitofusin 1 (Mfn1), mitofusin 2 (Mfn2), optic atrophy protein 1 (Opa1), dynamin-related protein 1 (Drp1), fission 1 (Fis1), and peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) in cardiomyocytes were assessed using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Western blotting was employed for the estimation of light chain 3 (LC3)-I, LC3-II, PINK1, and Parkin in cardiomyocytes.
    Results: It was discovered that SYD pretreatment elevated MMP in H/R injury cardiomyocytes, enhanced ATP content, activated SOD activity, and reduced MDA level. SYD treatment increased the mRNA levels of Mfn1, Mfn2, Opa1 and PGC-1α decreased the mRNA levels of Drp1 and Fis1, and reduced the protein levels of LC3, PINK1, and Parkin.
    Conclusions: SYD plays a protective role in H/R injury to cardiomyocytes by regulating mitochondrial quality. Meanwhile, SYD may inhibit mitophagy activity through inhibiting the PINK1/Parkin pathway. This study provides insights into the underlying mechanism of SYD in alleviating myocardial I/R injury.
    Language English
    Publishing date 2023-04-24
    Publishing country China
    Document type Journal Article
    ZDB-ID 2685043-6
    ISSN 2223-3660 ; 2223-3652
    ISSN (online) 2223-3660
    ISSN 2223-3652
    DOI 10.21037/cdt-23-86
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Neuroprotective potential of phytochemicals isolated from Paeonia ostii ‘Feng Dan’ stamen

    Peng, Xiao-Na / Zhou, Yang / Liu, Yan-Xiang / Huo, Yi-Lin / Ren, Jie-Yi / Bai, Zhang-Zhen / Zhang, Yan-Long / Tang, Jiang-Jiang

    Industrial Crops & Products. 2023 Sept., v. 200 p.116808-

    2023  

    Abstract: Paeonia ostii ‘Feng Dan’, traditionally known as an important medicinal and ornamental plant, is ...

    Abstract Paeonia ostii ‘Feng Dan’, traditionally known as an important medicinal and ornamental plant, is an emerging oilseed crop widely cultivated in China. As a byproduct, its stamens showed promising anti-neuroinflammation potential in our previous study. In this work, an in-depth phytochemical investigation was firstly conducted through comprehensive spectra to elucidate the neuroprotective components. Two new compounds (+)-oxylactiflorin (1), (+)-3′′-methoxy-oxylactiflorin (2), and twenty-two known compounds were isolated and identified. In lipopolysaccharides-induced BV-2 cells, compound 2 exhibited excellent inhibitory property in inhibiting nitric oxide (NO) production with the lowest EC₅₀ value of 3.02 ± 1.60 µM among all tested compounds. Western blotting and molecular docking results demonstrated the feasible mechanism that 2 exerted anti-inflammatory activity mainly by binding with the key protein cyclooxygenase-2 (COX-2). Additionally, compound 2 showed potent protective effects on the oxidative damages of H₂O₂ or 6-Hydroxydopamine (6-OHDA)-treated PC12 cells. This work provides a theoretical basis of P. ostii stamens for developing into a promising functional tea or neuroprotective drug.
    Keywords Paeonia ostii ; anti-inflammatory activity ; byproducts ; drugs ; neuroprotective effect ; nitric oxide ; oilseed crops ; ornamental plants ; phytochemicals ; prostaglandin synthase ; tea ; China ; Paeonia ostii stamen ; Anti-neuroinflammation ; Cyclooxygenase-2 ; Neuroprotection
    Language English
    Dates of publication 2023-09
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 1132158-1
    ISSN 1872-633X ; 0926-6690
    ISSN (online) 1872-633X
    ISSN 0926-6690
    DOI 10.1016/j.indcrop.2023.116808
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: [Action mechanism of Professor Xu Fusong's Shuilu Erxian Dan in the treatment of premature ejaculation: An exploration based on network pharmacology and molecular docking technology].

    Zhang, Xing / Han, Zi-Yang / Nie, Pan / Wang, Heng / Chen, Jian-Huai / Chen, Yun

    Zhonghua nan ke xue = National journal of andrology

    2023  Volume 28, Issue 2, Page(s) 149–156

    Abstract: Objective: To analyze the potential action mechanism of Shuilu Erxian Dan in the treatment ... constituents of Euryale and golden cherry, the core components of Shuilu Erxian Dan. Oral bioavailability and ... the potential action mechanism of Shuilu Erxian Dan in the treatment of premature ejaculation, which has paved ...

    Abstract Objective: To analyze the potential action mechanism of Shuilu Erxian Dan in the treatment of premature ejaculation based on network pharmacology.
    Methods: The TCMSP database was searched for the main chemical constituents of Euryale and golden cherry, the core components of Shuilu Erxian Dan. Oral bioavailability and medicinal properties were set as the parameters for screening active components, premature ejaculation-related disease targets retrieved from the DisGeNET, GeneCards, OMIM and TTD databases, the common targets of drug pairs and diseases identified with the Wayne diagram, and a drug-active ingredient-target-disease network map constructed with the software Cytoscape. A PPI network map designed through the STRING platform, the website Metascape used for GO and KEGG analyses of the common targets, and the protein receptors and small molecular ligands of the core genes employed for molecular docking and PyMOL visualization.
    Results: A total of 7 chemical constituents and 171 predictive targets, 1 918 premature ejaculation targets and 113 common targets were identified. GO analysis showed significant enrichment of BP in response to toxic substances and inorganic substances, CC in membrane raft and plasma membrane protein complex, and MF in transcription factor binding and kinase binding. KEGG analysis manifested markedly enriched TNF signaling pathway, JAK-STAT signaling pathway and Cocaine addiction. The results of molecular docking exhibited a good binding energy between the core gene and the component.
    Conclusion: Network pharmacology has revealed the potential action mechanism of Shuilu Erxian Dan in the treatment of premature ejaculation, which has paved the theoretical ground for verification of the effectiveness of Shuilu Erxian Dan in the treatment of premature ejaculation via animals and cells.
    MeSH term(s) Animals ; Male ; Humans ; Network Pharmacology ; Molecular Docking Simulation ; Premature Ejaculation/drug therapy ; Signal Transduction ; Drugs, Chinese Herbal/pharmacology
    Chemical Substances Drugs, Chinese Herbal
    Language Chinese
    Publishing date 2023-07-18
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2267480-9
    ISSN 1009-3591
    ISSN 1009-3591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Babao Dan decreases hepatocarcinogenesis by inhibiting hepatic progenitor cells malignant transformation via down-regulating toll-like receptor 4.

    Liang, Lei / Zhang, Lu-Yao / Liu, Wen-Ting / Zong, Chen / Gao, Lu / Li, Rong / Zhao, Qiu-Dong / Zhao, Na-Ping / Wei, Li-Xin / Zhang, Li / Han, Zhi-Peng

    Frontiers in oncology

    2023  Volume 13, Page(s) 1073859

    Abstract: Background: Babao Dan (BBD) is a traditional Chinese medicine that has been widely used ...

    Abstract Background: Babao Dan (BBD) is a traditional Chinese medicine that has been widely used as a complementary and alternative medicine to treat chronic liver diseases. In this study, we aimed to observe the effect of BBD on the incidence of diethylnitrosamine (DEN)-initiated hepatocellular carcinoma formation in rats and explored its possible mechanism.
    Methods: To verify this hypothesis, BBD was administrated to rats at a dose of 0.5g/kg body weight per two days from the 9th to 12th week in HCC-induced by DEN. Liver injury biomarkers and hepatic inflammatory parameters were evaluated by histopathology as well as serum and hepatic content analysis. We applied immunohistochemical analysis to investigate the expression of CK-19 and SOX-9 in liver tissues. The expression of TLR4 was determined by immunohistochemical, RT-PCR, and western blot analysis. Furthermore, we also detected the efficacy of BBD against primary HPCs neoplastic transformation induced by LPS.
    Results: We observed that DEN could induce hepatocarcinogenesis, and BBD could obviously decrease the incidence. The biochemical and histopathological examination results confirmed that BBD could protect against liver injury and decrease inflammatory infiltration. Immunohistochemistry staining results showed that BBD could effectively inhibit the ductal reaction and the expression of TLR4. The results showed that BBD-serumcould obviously inhibit primary HPCs neoplastic transformation induced by regulating the TLR4/Ras/ERK signaling pathway.
    Conclusion: In summary, our results indicate that BBD has potential applications in the prevention and treatment of HCC, which may be related to its effect on hepatic progenitor cells malignant transformation via inhibiting the TLR4/Ras/ERK signaling pathway.
    Language English
    Publishing date 2023-05-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1073859
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: UPLC-QTOF-MS with a chemical profiling approach for holistic quality evaluation between a material reference of Wen Dan decoction and its commercial preparations.

    Yang, Siyu / Chen, Gan / Yuan, Man / Zou, Yan / Zhang, Hongmei / Xu, Hongxi

    Chinese medicine

    2023  Volume 18, Issue 1, Page(s) 63

    Abstract: Background: Wen Dan decoction (WDD) has been a famous classic formula for resolving phlegm ...

    Abstract Background: Wen Dan decoction (WDD) has been a famous classic formula for resolving phlegm since ancient times in China. Currently, there are many types of WDD commercial preparations produced through modern technology. However, it is not known whether the holistic quality of WDD commercial preparations is consistent with the traditional decocting method to exert its proper effects. Therefore, the WDD material reference was studied and prepared, which can represent the traditional Chinese formulation WDD.
    Methods: A method based on UPLC-QTOF-MS was developed to evaluate the quality of WDD material reference and commercial prescriptions. At the same time, the multivariate statistical method was used to compare the differences between the material reference and the commercial prescription by principal component analysis (PCA) and heatmap. Finally, the UPLC-QTOF-MS method was established to quantitatively study 11 representative components, including naringin, hesperidin, neohesperidin, liquiritin, glycyrrhizic acid, adenosine, liquiritigenin, tangeretin, eriocitrin, naringenin and synephrine.
    Results: A total of 107 compounds were identified in the WDD material reference by comparing the retention time and fragment ion characteristics, including 54 flavonoids, 14 triterpenes, 10 organic acids, 7 alkaloids, 7 coumarins and 15 other components. The samples were almost evenly split into two groups, indicating a difference in quality between the WDD material reference and its commercial preparations in multivariate statistical analysis. Eleven major components of linearity, precision, repeatability, stability and recovery rate met the requirements, which were clearly different in commercial preparations and WDD material references. In terms of the content of 11 components in the commercial preparation, only CP8 is close to the material reference, which is in agreement with the statistical analysis of the heatmap. The concentrations of naringin and neohesperidin from the WDD material reference were higher than those from the commercial preparations.
    Conclusions: The quality evaluation method established in this study can be used to identify different sources of WDD but also proves that the WDD material reference contains higher naringin. Furthermore, this study confirmed that the preparation technology of WDD commercial prescriptions should be optimized on the basis of WDD material references, producing the closest possible clinical basis for the substance.
    Language English
    Publishing date 2023-05-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2260322-0
    ISSN 1749-8546
    ISSN 1749-8546
    DOI 10.1186/s13020-023-00767-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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