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  1. Article ; Online: Impact with equity: EDCTP and equitable research partnerships.

    Makanga, Michael / Beattie, Pauline / Jajkowicz, Dominika / Nyirenda, Thomas / Tanner, Marcel / Hankins, Catherine

    The Lancet. Global health

    2024  Volume 12, Issue 4, Page(s) e552–e554

    MeSH term(s) Humans ; International Cooperation ; Developing Countries
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2723488-5
    ISSN 2214-109X ; 2214-109X
    ISSN (online) 2214-109X
    ISSN 2214-109X
    DOI 10.1016/S2214-109X(24)00002-0
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  2. Article ; Online: The African Medicines Agency: the key to unlocking clinical research in Africa.

    Hwenda, Lenias / Sidibe, Michel / Makanga, Michael

    The Lancet. Global health

    2022  Volume 10, Issue 8, Page(s) e1088–e1089

    MeSH term(s) Africa ; Humans ; Research ; South Africa
    Language English
    Publishing date 2022-06-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2723488-5
    ISSN 2214-109X ; 2214-109X
    ISSN (online) 2214-109X
    ISSN 2214-109X
    DOI 10.1016/S2214-109X(22)00243-1
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  3. Article ; Online: The abiding, hidden, and pervasive centrality of the health research workforce.

    Ferrinho, Paulo / Makanga, Michael / Sarfraz, Shabnum / Poz, Mario Dal

    Human resources for health

    2023  Volume 21, Issue 1, Page(s) 39

    Abstract: Research for health and development (R4HD) acknowledges that many of the determinants of health lie outside the boundaries of the health system. The size and quality of the health and care workforce (HCWF) are key drivers towards the future trajectory of ...

    Abstract Research for health and development (R4HD) acknowledges that many of the determinants of health lie outside the boundaries of the health system. The size and quality of the health and care workforce (HCWF) are key drivers towards the future trajectory of many of these factors. We consider researchers for health and development an abiding, pervasive but neglected constituent part of this HCWF. This workforce straddles many professional groups and sectors. The diversity of occupations, lack of standardization in occupational cadres, the complexity and gendered aspects of the labour market, and the variable demographic, epidemiological, socio-economic and health systems' contexts in the global south and the global north, led to a kaleidoscopic perception of the health research workforce that have kept it hidden from public opinion. This led to neglect by science as well as health policymakers and created an orphan sub-set of the HCWF. Understanding the health researchers' labour market will help to identify means to develop, retain and utilize the health research workforce, addressing size, composition, role, skills transferability, careers and social impact through building, enabling or sustaining its research functions, capacity, employment opportunities and career tracks, among other issues. This thematic series of the Human Resources for Health Journal, calls for papers that go beyond narrow conceptual approaches and professional understandings of health care workers and the health research workforce, and requests that contributors examine important workforce issues through the broad lens of R4HD within a sustainable development goals framework.
    MeSH term(s) Humans ; Health Workforce ; Health Personnel ; Workforce ; Occupations
    Language English
    Publishing date 2023-05-11
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2126923-3
    ISSN 1478-4491 ; 1478-4491
    ISSN (online) 1478-4491
    ISSN 1478-4491
    DOI 10.1186/s12960-023-00821-9
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  4. Article ; Online: A review of the effects of artemether-lumefantrine on gametocyte carriage and disease transmission.

    Makanga, Michael

    Malaria journal

    2014  Volume 13, Page(s) 291

    Abstract: While significant advances have been made in the prevention and treatment of malaria in recent years, these successes continue to fall short of the World Health Organization (WHO) goals for malaria control and elimination. For elimination strategies to ... ...

    Abstract While significant advances have been made in the prevention and treatment of malaria in recent years, these successes continue to fall short of the World Health Organization (WHO) goals for malaria control and elimination. For elimination strategies to be effective, limited disease transmission, achieved through rapid reduction in the infectious parasite reservoir and decreased gametocyte carriage, will be critical. Artemisinin-based combination therapy (ACT) forms the cornerstone of WHO-recommended treatment for uncomplicated Plasmodium falciparum malaria, and in combination with other effective interventions will undoubtedly play a vital role in elimination programmes. The gametocytocidal properties of artemisinins are a bonus attribute; there is epidemiological evidence of reductions in malaria incidence and transmission in African regions since the introduction of these agents. Many studies and analyses have specifically investigated the effects of the ACT, artemether-lumefantrine (AL) on gametocyte carriage. In this systematic review of 62 articles published between 1998 and January 2014, the effects of AL on gametocyte carriage and malaria transmission are compared with other artemisinin-based anti-malarials and non-ACT. The impact of AL treatment of asymptomatic carriers on population gametocyte carriage, and the potential future role of AL in malaria elimination initiatives are also considered. Despite the inherent difficulties in comparing data from a range of different studies that also utilized different diagnostic approaches to assess baseline gametocyte counts, the gametocytocidal effect of AL was proportionately consistent across the studies reviewed, suggesting that AL will continue to play a vital role in the treatment of malaria and contribute to clearing the path towards malaria elimination. However, the specific place of AL is the subject of much ongoing research and will undoubtedly be dependent on different demographic and geographical scenarios. Utilizing ACT, such as AL, within malaria elimination strategies is also associated with a number of other challenges, such as balancing potential increased use of ACT (e g, treatment of asymptomatic carriers and home-based treatment) with rational use and avoidance of drug resistance development.
    MeSH term(s) Antimalarials/pharmacology ; Artemether, Lumefantrine Drug Combination ; Artemisinins/pharmacology ; Drug Combinations ; Ethanolamines/pharmacology ; Fluorenes/pharmacology ; Humans ; Malaria, Falciparum/parasitology ; Plasmodium falciparum/cytology ; Plasmodium falciparum/drug effects ; Plasmodium falciparum/genetics ; Trophozoites/cytology ; Trophozoites/drug effects
    Chemical Substances Antimalarials ; Artemether, Lumefantrine Drug Combination ; Artemisinins ; Drug Combinations ; Ethanolamines ; Fluorenes ; artemisinin (9RMU91N5K2)
    Language English
    Publishing date 2014-07-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
    ISSN 1475-2875
    ISSN (online) 1475-2875
    DOI 10.1186/1475-2875-13-291
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  5. Article ; Online: Funders' Perspectives on Supporting Implementation Research in Low- and Middle-Income Countries.

    Cardoso-Weinberg, Ana / Alley, Chris / Kupfer, Linda E / Aslanyan, Garry / Makanga, Michael / Zicker, Fabio / Olesen, Ole F

    Global health, science and practice

    2022  Volume 10, Issue 2

    MeSH term(s) Developing Countries ; Global Health ; Humans ; Income
    Language English
    Publishing date 2022-04-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2710875-2
    ISSN 2169-575X ; 2169-575X
    ISSN (online) 2169-575X
    ISSN 2169-575X
    DOI 10.9745/GHSP-D-21-00497
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Accelerating research and development of new vaccines against tuberculosis: a global roadmap.

    Cobelens, Frank / Suri, Rajinder Kumar / Helinski, Michelle / Makanga, Michael / Weinberg, Ana Lúcia / Schaffmeister, Britta / Deege, Frank / Hatherill, Mark

    The Lancet. Infectious diseases

    2022  Volume 22, Issue 4, Page(s) e108–e120

    Abstract: To eliminate tuberculosis globally, a new, effective, and affordable vaccine is urgently needed, particularly for use in adults and adolescents in low-income and middle-income countries. We have created a roadmap that lists the actions needed to ... ...

    Abstract To eliminate tuberculosis globally, a new, effective, and affordable vaccine is urgently needed, particularly for use in adults and adolescents in low-income and middle-income countries. We have created a roadmap that lists the actions needed to accelerate tuberculosis vaccine research and development using a participatory process. The vaccine pipeline needs more diverse immunological approaches, antigens, and platforms. Clinical development can be accelerated by validated preclinical models, agreed laboratory correlates of protection, efficient trial designs, and validated endpoints. Determining the public health impact of new tuberculosis vaccines requires understanding of a country's demand for a new tuberculosis vaccine, how to integrate vaccine implementation with ongoing tuberculosis prevention efforts, cost, and national and global demand to stimulate vaccine production. Investments in tuberculosis vaccine research and development need to be increased, with more diversity of funding sources and coordination between these funders. Open science is important to enhance the efficiency of tuberculosis vaccine research and development including early and freely available publication of study findings and effective mechanisms for sharing datasets and specimens. There is a need for increased engagement of industry vaccine developers, for increased political commitment for new tuberculosis vaccines, and to address stigma and vaccine hesitancy. The unprecedented speed by which COVID-19 vaccines have been developed and introduced provides important insight for tuberculosis vaccine research and development.
    MeSH term(s) Adolescent ; Adult ; COVID-19 ; COVID-19 Vaccines ; Humans ; Research ; Tuberculosis/prevention & control ; Tuberculosis Vaccines ; Vaccines
    Chemical Substances COVID-19 Vaccines ; Tuberculosis Vaccines ; Vaccines
    Language English
    Publishing date 2022-02-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(21)00810-0
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    In stock of ZB MED Cologne/Königswinter

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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  7. Article ; Online: The European & Developing Countries Clinical Trials Partnership (EDCTP) Knowledge Hub: developing an open platform for facilitating high-quality clinical research.

    Driver, Samuel / Gray, Shan / Sikhondze, Welile / Awuonda, Ken / Wilcox, Helena / Segrt, Alexis / Pandya, Lara / Roth, Johanna / Makanga, Michael / Lang, Trudie

    Trials

    2022  Volume 23, Issue 1, Page(s) 374

    Abstract: There is stark global inequity in health research in terms of where studies happen, who leads the research and the ultimate beneficiaries of the results generated. Despite significant efforts made, limited research ideas are conceptualised and ... ...

    Abstract There is stark global inequity in health research in terms of where studies happen, who leads the research and the ultimate beneficiaries of the results generated. Despite significant efforts made, limited research ideas are conceptualised and implemented in low-resource settings to tackle diseases of poverty, and this is especially true in sub-Saharan Africa. There is strong evidence to show that the barriers to locally led research do not vary largely between disease, study type and location and can be largely solved by addressing these common gaps. The European & Developing Countries Clinical Trials Partnership (EDCTP) was established in 2003 as a European response to the global health crisis caused by the three main poverty-related diseases HIV, tuberculosis and malaria. EDCTP has established a model of long-term sustainable capacity development integrated into clinical trials which addresses this lack of locally led research in sub-Saharan Africa, supporting the development of individual and institutional capacity and research outputs that change the management, prevention and treatment of poverty-related and neglected infectious diseases across Africa. In recognition of emergent data on what the barriers and enablers are to long-term, sustainable capabilities to run studies, EDCTP formed a new collaboration with The Global Health Network (TGHN) in September 2017, with the aim to make a set of cross-cutting tools and resources to support the planning, writing and delivery of high-quality clinical trials available to research staff wherever they are in the world, especially those in low- and middle-income countries (LMICs) via TGHN platform. These new resources developed on the 'EDCTP Knowledge Hub' are those identified in the mixed method study described in this commentary as being key to addressing the gaps that the research community report as the most limiting elements in their ability to design and implement studies. The Knowledge Hub aims to make these tools freely available to any potential health research team in need of support and guidance in designing and running their own studies, particularly in low-resource settings. The purpose is to provide open access to the specific guidance, information and tools these teams cannot otherwise access freely. Ultimately, this will enable them to design and lead their own high-quality studies addressing local priorities with global alignment, generating new data that can change health outcomes in their communities.
    MeSH term(s) Africa South of the Sahara ; Clinical Trials as Topic ; Developing Countries ; Humans ; Malaria/diagnosis ; Malaria/prevention & control ; Poverty ; Tuberculosis/diagnosis ; Tuberculosis/therapy
    Language English
    Publishing date 2022-05-07
    Publishing country England
    Document type Letter
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1745-6215
    ISSN (online) 1745-6215
    ISSN 1468-6694 ; 1745-6215
    DOI 10.1186/s13063-022-06311-y
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  8. Article ; Online: Translating evidence into global impact: lessons for HIV research and policy development from the AMBITION trial.

    Jarvis, Joseph N / Chou, Roger / Harrison, Thomas S / Lawrence, David S / Muthoga, Charles / Mupeli, Kennedy / Meya, David B / Mwandumba, Henry C / Kanyama, Cecilia / Meintjes, Graeme / Leeme, Tshepo B / Ndhlovu, Chiratidzo E / Beattie, Pauline / Sued, Omar / Pérez Casas, Carmen / Makanga, Michael / Ford, Nathan

    The Lancet. Global health

    2023  Volume 11, Issue 11, Page(s) e1688–e1690

    MeSH term(s) Humans ; Policy Making ; Health Policy ; HIV Infections/prevention & control
    Language English
    Publishing date 2023-10-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2723488-5
    ISSN 2214-109X ; 2214-109X
    ISSN (online) 2214-109X
    ISSN 2214-109X
    DOI 10.1016/S2214-109X(23)00412-6
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  9. Article ; Online: The European & Developing Countries Clinical Trials Partnership (EDCTP) Knowledge Hub

    Samuel Driver / Shan Gray / Welile Sikhondze / Ken Awuonda / Helena Wilcox / Alexis Segrt / Lara Pandya / Johanna Roth / Michael Makanga / Trudie Lang

    Trials, Vol 23, Iss 1, Pp 1-

    developing an open platform for facilitating high-quality clinical research

    2022  Volume 7

    Abstract: Abstract There is stark global inequity in health research in terms of where studies happen, who leads the research and the ultimate beneficiaries of the results generated. Despite significant efforts made, limited research ideas are conceptualised and ... ...

    Abstract Abstract There is stark global inequity in health research in terms of where studies happen, who leads the research and the ultimate beneficiaries of the results generated. Despite significant efforts made, limited research ideas are conceptualised and implemented in low-resource settings to tackle diseases of poverty, and this is especially true in sub-Saharan Africa. There is strong evidence to show that the barriers to locally led research do not vary largely between disease, study type and location and can be largely solved by addressing these common gaps. The European & Developing Countries Clinical Trials Partnership (EDCTP) was established in 2003 as a European response to the global health crisis caused by the three main poverty-related diseases HIV, tuberculosis and malaria. EDCTP has established a model of long-term sustainable capacity development integrated into clinical trials which addresses this lack of locally led research in sub-Saharan Africa, supporting the development of individual and institutional capacity and research outputs that change the management, prevention and treatment of poverty-related and neglected infectious diseases across Africa. In recognition of emergent data on what the barriers and enablers are to long-term, sustainable capabilities to run studies, EDCTP formed a new collaboration with The Global Health Network (TGHN) in September 2017, with the aim to make a set of cross-cutting tools and resources to support the planning, writing and delivery of high-quality clinical trials available to research staff wherever they are in the world, especially those in low- and middle-income countries (LMICs) via TGHN platform. These new resources developed on the ‘EDCTP Knowledge Hub’ are those identified in the mixed method study described in this commentary as being key to addressing the gaps that the research community report as the most limiting elements in their ability to design and implement studies. The Knowledge Hub aims to make these tools freely available to any ...
    Keywords Capacity development ; Research resources ; Research methodology ; Research leadership ; African research leaders ; Medicine (General) ; R5-920
    Subject code 306
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Parasitic and parachute research in global health.

    Bockarie, Moses / Machingaidze, Shingai / Nyirenda, Thomas / Olesen, Ole F / Makanga, Michael

    The Lancet. Global health

    2018  Volume 6, Issue 9, Page(s) e964

    MeSH term(s) Animals ; Global Health ; Parasites ; Research
    Language English
    Publishing date 2018-08-14
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2723488-5
    ISSN 2214-109X ; 2214-109X
    ISSN (online) 2214-109X
    ISSN 2214-109X
    DOI 10.1016/S2214-109X(18)30342-5
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