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  1. Article ; Online: COVID-19 travel policies for people from China and discrimination.

    He, Guiqing / Jones, Jeffery A / Sun, Wenjie

    The Lancet. Infectious diseases

    2023  Volume 23, Issue 3, Page(s) 282–283

    MeSH term(s) Humans ; COVID-19 ; Travel ; SARS-CoV-2 ; Policy ; China
    Language English
    Publishing date 2023-01-30
    Publishing country United States
    Document type Letter
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(23)00052-X
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    Zs.A 5743: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Twenty years of Gendicine® rAd-p53 cancer gene therapy: The first-in-class human cancer gene therapy in the era of personalized oncology.

    Qi, Li / Li, Guiqing / Li, Peipei / Wang, Hongwei / Fang, Xiaolong / He, Tongchuan / Li, Jingjing

    Genes & diseases

    2023  Volume 11, Issue 4, Page(s) 101155

    Abstract: Genetic mutations ... ...

    Abstract Genetic mutations in
    Language English
    Publishing date 2023-10-31
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2821806-1
    ISSN 2352-3042 ; 2352-3042
    ISSN (online) 2352-3042
    ISSN 2352-3042
    DOI 10.1016/j.gendis.2023.101155
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  3. Article ; Online: A novel objective for improving the sustainability of water supply system regarding hydrological response.

    Moudi, Mahdi / Gai, Qiuyan / Yuan, He / Guiqing, Li / Basirialmahjough, Mahdi / Motamedi, Artemis / Galoie, Majid

    PloS one

    2023  Volume 18, Issue 11, Page(s) e0294578

    Abstract: In general, the sustainability of the water supply system is indicative of an adaptive operational approach, wherein the decision-maker adjusts the system's performance based on the availability of water resources in a given time frame. In light of this, ...

    Abstract In general, the sustainability of the water supply system is indicative of an adaptive operational approach, wherein the decision-maker adjusts the system's performance based on the availability of water resources in a given time frame. In light of this, a novel framework is proposed in this study to evaluate sustainability, including three key indicators: resilience, reliability, and vulnerability. To address stressors that may lead to system failure, a multisectoral water allocation optimization is undertaken. In order to account for the future implications of climate change on the hydrological cycle, a simulation step, is incorporated, utilizing the Soil and Water Assessment Tool (SWAT) under various emission scenarios (RCP4.5 and RCP8.5), prior to integrating the streamflow data into our proposed optimal framework. To calibrate and validate historical data (2014-2019) and simulate future streamflow patterns (2025-2085), the Sistan Basin, located in an arid region of Iran, is analyzed as a case study. In light of the anticipated adverse impacts on the water supply system, certain adaptation measures, such as demand shrinkage scenarios, are considered to further appraise the proposed framework. Based on the final output, it is evident that the agricultural and industrial sectors, being the primary water consumers, are more susceptible to negative impacts resulting from the reduction in system sustainability. This susceptibility is primarily attributed to their highest vulnerability and comparatively lower reliability.
    MeSH term(s) Water ; Reproducibility of Results ; Water Supply ; Agriculture/methods ; Soil ; Climate Change
    Chemical Substances Water (059QF0KO0R) ; Soil
    Language English
    Publishing date 2023-11-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0294578
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  4. Article ; Online: A novel objective for improving the sustainability of water supply system regarding hydrological response

    Mahdi Moudi / Qiuyan Gai / He Yuan / Li Guiqing / Mahdi Basirialmahjough / Artemis Motamedi / Majid Galoie

    PLoS ONE, Vol 18, Iss

    2023  Volume 11

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
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  5. Article ; Online: Microsatellite instability evaluation by a novel PCR-based 8-loci test kit in colorectal cancer.

    Xiao, Gaofang / Li, Jing / Deng, Lijun / Gao, Shuangquan / Tan, Caiyun / He, Guiqing / Du, Richang

    Biotechnology and applied biochemistry

    2024  

    Abstract: Microsatellite instability (MSI) assessment is strongly recommended for colorectal cancer patients, as MSI status is crucial in determining optimal treatment and predicting prognosis. This study evaluated the reliability and accuracy of a novel ... ...

    Abstract Microsatellite instability (MSI) assessment is strongly recommended for colorectal cancer patients, as MSI status is crucial in determining optimal treatment and predicting prognosis. This study evaluated the reliability and accuracy of a novel polymerase chain reaction (PCR)-based 8-loci MSI test kit, a rapid test kit designed to detect MSI, by comparing its performance with immunohistochemistry (IHC) and the National Cancer Institute (NCI) 2B3D Panel. MSI status was determined in 186 formalin-fixed paraffin-embedded (FFPE) colorectal cancer tissue samples with known mismatch repair (MMR) status by IHC using the novel PCR-based 8-loci MSI test kit. Additionally, the consistency between the NCI 2B3D Panel and the novel PCR-based 8-loci panel was compared using 69 FFPE tumor tissues paired with adjacent non-cancerous tissue. The novel PCR-based 8-loci MSI test kit and IHC demonstrated high concordance (overall agreement: 97.8%). However, four samples displayed discordant results, exhibiting MMR deficiency using IHC and microsatellite stability using the novel PCR-based 8-loci MSI test kit. Of the 69 samples reanalyzed using the NCI 2B3D Panel, high concordance with the novel PCR-based 8-loci MSI test kit was observed in 67 of 69 cases (overall agreement: 97.1%). The novel PCR-based 8-loci MSI test kit is a rapid and reliable tool for accurately detecting MSI status in colorectal cancer.
    Language English
    Publishing date 2024-03-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 883433-7
    ISSN 1470-8744 ; 0885-4513
    ISSN (online) 1470-8744
    ISSN 0885-4513
    DOI 10.1002/bab.2582
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    Zs.A 1865: Show issues Location:
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  6. Article ; Online: Long non-coding RNA KCNQ10T1/miR-19a-3p/SMAD5 axis promotes osteogenic differentiation of mouse bone mesenchymal stem cells.

    Lin, He / Nie, Lanjun / Lu, Guiqing / Wu, Haixia / Xu, Tao

    Journal of orthopaedic surgery and research

    2023  Volume 18, Issue 1, Page(s) 929

    Abstract: Background: Bone fracture is a common orthopedic disease that needs over 3 months to recover. Promoting the osteogenic differentiation of bone mesenchymal stem cells (BMSCs) is beneficial for fracture healing. Therefore, this research aimed to study the ...

    Abstract Background: Bone fracture is a common orthopedic disease that needs over 3 months to recover. Promoting the osteogenic differentiation of bone mesenchymal stem cells (BMSCs) is beneficial for fracture healing. Therefore, this research aimed to study the roles of long non-coding RNA (lncRNA) KCNQ10T1 in osteogenic differentiation of BMSCs.
    Methods: BMSCs were treated with osteogenic medium and assessed by CCK-8 and flow cytometry assays. Alkaline phosphatase (ALP) staining, alizarin red staining (ARS), as well as concentration of osteoblast markers were measured to evaluate osteogenic differentiation of BMSCs. Western blot was employed to detect proteins; while, qRT-PCR was for mRNA levels. Additionally, targeted relationships between KCNQ10T1 and miR-19a-3p, as well as miR-19a-3p and SMAD5 were verified by dual luciferase reporter gene assay along with RNA pull-down method.
    Results: Upregulation of KCNQ10T1 promoted the ALP staining and ARS intensity, increased the cell viability and decreased the apoptosis rate of BMSCs. Besides, KCNQ10T1 overexpression increased the ALP, OPG, OCN and OPN protein levels. KCNQ10T1 sponges miR-19a-3p, which targets Smad5. Upregulated miR-19a-3p reversed the overexpressed KCNQ10T1-induced effects, and depletion of SMAD5 reversed the miR-19a-3p inhibitor-induced effects on osteogenic medium-treated BMSCs.
    Conclusions: Upregulation of KCNQ10T1 promoted osteogenic differentiation of BMSCs through miR-19a-3p/SMAD5 axis in bone fracture.
    MeSH term(s) Animals ; Mice ; Cell Differentiation/genetics ; Cells, Cultured ; Fractures, Bone/metabolism ; Mesenchymal Stem Cells/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Osteogenesis/genetics ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism
    Chemical Substances MicroRNAs ; RNA, Long Noncoding ; Smad5 protein, mouse
    Language English
    Publishing date 2023-12-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2252548-8
    ISSN 1749-799X ; 1749-799X
    ISSN (online) 1749-799X
    ISSN 1749-799X
    DOI 10.1186/s13018-023-04425-w
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  7. Article: RNA Sequencing Analysis and Verification of

    Wang, Jiange / Song, Yinglong / Wang, Zheng / Shi, Liyun / Yu, Shuiyan / Xu, Yufeng / Wang, Guiqing / He, Dan / Jiang, Liwei / Shang, Wenqian / He, Songlin

    Plants (Basel, Switzerland)

    2024  Volume 13, Issue 3

    Abstract: Tree peony ( ...

    Abstract Tree peony (
    Language English
    Publishing date 2024-01-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants13030421
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  8. Article ; Online: Antimicrobial susceptibility and minimum inhibitory concentration distribution of common clinically relevant non-tuberculous mycobacterial isolates from the respiratory tract.

    He, Guiqing / Wu, Lianpeng / Zheng, Qingyong / Jiang, Xiangao

    Annals of medicine

    2022  Volume 54, Issue 1, Page(s) 2500–2510

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Amikacin/pharmacology ; Amikacin/therapeutic use ; Amoxicillin ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Cefoxitin/pharmacology ; Cefoxitin/therapeutic use ; Ciprofloxacin/pharmacology ; Ciprofloxacin/therapeutic use ; Clarithromycin/pharmacology ; Clavulanic Acid/pharmacology ; Clavulanic Acid/therapeutic use ; Doxycycline/pharmacology ; Doxycycline/therapeutic use ; Humans ; Imipenem/pharmacology ; Imipenem/therapeutic use ; Linezolid/pharmacology ; Linezolid/therapeutic use ; Lung Diseases ; Microbial Sensitivity Tests ; Moxifloxacin/pharmacology ; Moxifloxacin/therapeutic use ; Mycobacterium Infections, Nontuberculous/drug therapy ; Mycobacterium Infections, Nontuberculous/microbiology ; Nontuberculous Mycobacteria ; Respiratory System ; Rifabutin/pharmacology ; Rifabutin/therapeutic use ; Rifampin/pharmacology ; Rifampin/therapeutic use ; Sulfamethoxazole/pharmacology ; Sulfamethoxazole/therapeutic use ; Tigecycline/pharmacology ; Tigecycline/therapeutic use ; Tobramycin/pharmacology ; Tobramycin/therapeutic use ; Trimethoprim/pharmacology ; Trimethoprim/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Rifabutin (1W306TDA6S) ; Clavulanic Acid (23521W1S24) ; Ciprofloxacin (5E8K9I0O4U) ; Cefoxitin (6OEV9DX57Y) ; Tigecycline (70JE2N95KR) ; Imipenem (71OTZ9ZE0A) ; Amoxicillin (804826J2HU) ; Amikacin (84319SGC3C) ; Trimethoprim (AN164J8Y0X) ; Clarithromycin (H1250JIK0A) ; Linezolid (ISQ9I6J12J) ; Sulfamethoxazole (JE42381TNV) ; Doxycycline (N12000U13O) ; Moxifloxacin (U188XYD42P) ; Rifampin (VJT6J7R4TR) ; Tobramycin (VZ8RRZ51VK)
    Language English
    Publishing date 2022-08-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1004226-x
    ISSN 1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
    ISSN (online) 1365-2060 ; 1651-2219
    ISSN 0785-3890 ; 1743-1387
    DOI 10.1080/07853890.2022.2121984
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    Zs.A 680: Show issues Location:
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  9. Article ; Online: A novel objective for improving the sustainability of water supply system regarding hydrological response.

    Mahdi Moudi / Qiuyan Gai / He Yuan / Li Guiqing / Mahdi Basirialmahjough / Artemis Motamedi / Majid Galoie

    PLoS ONE, Vol 18, Iss 11, p e

    2023  Volume 0294578

    Abstract: In general, the sustainability of the water supply system is indicative of an adaptive operational approach, wherein the decision-maker adjusts the system's performance based on the availability of water resources in a given time frame. In light of this, ...

    Abstract In general, the sustainability of the water supply system is indicative of an adaptive operational approach, wherein the decision-maker adjusts the system's performance based on the availability of water resources in a given time frame. In light of this, a novel framework is proposed in this study to evaluate sustainability, including three key indicators: resilience, reliability, and vulnerability. To address stressors that may lead to system failure, a multisectoral water allocation optimization is undertaken. In order to account for the future implications of climate change on the hydrological cycle, a simulation step, is incorporated, utilizing the Soil and Water Assessment Tool (SWAT) under various emission scenarios (RCP4.5 and RCP8.5), prior to integrating the streamflow data into our proposed optimal framework. To calibrate and validate historical data (2014-2019) and simulate future streamflow patterns (2025-2085), the Sistan Basin, located in an arid region of Iran, is analyzed as a case study. In light of the anticipated adverse impacts on the water supply system, certain adaptation measures, such as demand shrinkage scenarios, are considered to further appraise the proposed framework. Based on the final output, it is evident that the agricultural and industrial sectors, being the primary water consumers, are more susceptible to negative impacts resulting from the reduction in system sustainability. This susceptibility is primarily attributed to their highest vulnerability and comparatively lower reliability.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Clinical application of a three-dimensional-printed model in the treatment of intracranial and extracranial communicating tumors: a pilot study.

    Zhang, Xiang-Heng / Li, Jiahao / He, Zhenqiang / Wang, Dikan / Liao, Guiqing / Zhang, Si-En / Duan, Hao / Mou, Yonggao / Liang, Yujie

    3D printing in medicine

    2024  Volume 10, Issue 1, Page(s) 2

    Abstract: Background: Surgical management for intracranial and extracranial communicating tumors is difficult due to the complex anatomical structures. Therefore, assisting methods are urgently needed. Accordingly, this study aimed to investigate the utility of a ...

    Abstract Background: Surgical management for intracranial and extracranial communicating tumors is difficult due to the complex anatomical structures. Therefore, assisting methods are urgently needed. Accordingly, this study aimed to investigate the utility of a three-dimensional (3D)-printed model in the treatment of intracranial and extracranial communicating tumors as well as its applicability in surgical planning and resident education.
    Methods: Individualized 3D-printed models were created for eight patients with intracranial and extracranial communicating tumors. Based on these 3D-printed models, a comprehensive surgical plan was made for each patient, after which the patients underwent surgery. The clinicopathological data of patients were collected and retrospectively analyzed to determine surgical outcomes. To examine the educational capability of the 3D-printed models, specialists and resident doctors were invited to review three of these cases and then rate the clinical utility of the models using a questionnaire.
    Results: The 3D-printed models accurately replicated anatomical structures, including the tumor, surrounding structures, and the skull. Based on these models, customized surgical approaches, including the orbitozygomatic approach and transcervical approach, were designed for the patients. Although parameters such as operation time and blood loss varied among the patients, satisfactory surgical outcomes were achieved, with only one patient developing a postoperative complication. Regarding the educational applicability of the 3D-printed model, the mean agreement for all eight questionnaire items was above six (seven being complete agreement). Moreover, no significant difference was noted in the agreement scores between specialists and residents.
    Conclusion: The results revealed that 3D-printed models have good structural accuracy and are potentially beneficial in developing surgical approaches and educating residents. Further research is needed to test the true applicability of these models in the treatment of intracranial and extracranial communicating tumors.
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article
    ISSN 2365-6271
    ISSN (online) 2365-6271
    DOI 10.1186/s41205-024-00202-5
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