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  1. Article: Vascular Involvement in Behcet's Disease: An Evaluation of 147 Cases and Literature Review.

    Atalar, Ebru / Erten, Sukran / Dogan, Ismail / Konak, Hatice Ecem

    Sisli Etfal Hastanesi tip bulteni

    2023  Volume 57, Issue 3, Page(s) 380–386

    Abstract: Objectives: Behcet's disease (BD) is characterized by systemic vasculitis with inflammation that can affect various body organs. In BD, vasculitis primarily manifests with venous involvement, distinguishing it from other forms of systemic vasculitis.: ...

    Abstract Objectives: Behcet's disease (BD) is characterized by systemic vasculitis with inflammation that can affect various body organs. In BD, vasculitis primarily manifests with venous involvement, distinguishing it from other forms of systemic vasculitis.
    Methods: We retrospectively analyzed the demographic and clinical characteristics of 147 patients diagnosed with vascular BD in our center.
    Results: Vascular BD cases accounted for 25.0% (147 out of 589) of all BD patients. A statistically significant correlation was found between gender and vascular involvement that was seen predominantly in males (76.9%). In 71 patients, a vascular event developed during follow-up for BD, while in 76 patients the disease was diagnosed after the occurrence of a vascular event (51.7%). The most common vascular event was deep vein thrombosis in the lower extremities (69.4%). Arterial involvement was primarily observed in the pulmonary arteries (12.9%). Patients with lower extremity deep vein thrombosis tended to be younger, while those with pulmonary artery involvement were typically older. Overall, veins were affected 4.5 times more frequently than arteries.
    Conclusion: The prevalent type of venous involvement was deep vein thrombosis in the lower extremities. Thrombotic events in BD cannot be solely attributed to abnormalities in thrombotic factors. The treatment of thrombotic events in BD remains contentious, with anticoagulant efficacy being debated and immunosuppressive therapy representing the primary treatment approach. Behcet's disease should be considered when a young male patient presents with an arterial or venous vascular event, especially if it is recurrent.
    Language English
    Publishing date 2023-09-29
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 3026862-X
    ISSN 1308-5123 ; 1302-7123
    ISSN (online) 1308-5123
    ISSN 1302-7123
    DOI 10.14744/SEMB.2023.89083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The diagnosis of femoroacetabular impingement can be made on pelvis radiographs using deep learning methods.

    Atalar, Ebru / Üreten, Kemal / Kanatlı, Ulunay / Çiçeklidağ, Murat / Kaya, İbrahim / Vural, Abdurrahman / Maraş, Yüksel

    Joint diseases and related surgery

    2023  Volume 34, Issue 2, Page(s) 298–304

    Abstract: Objectives: The aim of this study was to evaluate diagnostic ability of deep learning models, particularly convolutional neural network models used for image classification, for femoroacetabular impingement (FAI) using hip radiographs.: Materials and ... ...

    Abstract Objectives: The aim of this study was to evaluate diagnostic ability of deep learning models, particularly convolutional neural network models used for image classification, for femoroacetabular impingement (FAI) using hip radiographs.
    Materials and methods: Between January 2010 and December 2020, pelvic radiographs of a total of 516 patients (270 males, 246 females; mean age: 39.1±3.8 years; range, 20 to 78 years) with hip pain were retrospectively analyzed. Based on inclusion and exclusion criteria, a total of 888 hip radiographs (308 diagnosed with FAI and 508 considered normal) were evaluated using deep learning methods. Pre-trained VGG-16, ResNet-101, MobileNetV2, and Inceptionv3 models were used for transfer learning.
    Results: As assessed by performance measures such as accuracy, sensitivity, specificity, precision, F-1 score, and area under the curve (AUC), the VGG-16 model outperformed other pre-trained networks in diagnosing FAI. With the pre-trained VGG-16 model, the results showed 86.6% accuracy, 82.5% sensitivity, 89.6% specificity, 85.5% precision, 83.9% F1 score, and 0.92 AUC.
    Conclusion: In patients with suspected FAI, pelvic radiography is the first imaging method to be applied, and deep learning methods can help in the diagnosis of this syndrome.
    MeSH term(s) Male ; Female ; Humans ; Adult ; Femoracetabular Impingement/diagnostic imaging ; Retrospective Studies ; Deep Learning ; Radiography ; Pelvis
    Language English
    Publishing date 2023-04-26
    Publishing country Turkey
    Document type Journal Article
    ISSN 2687-4792
    ISSN (online) 2687-4792
    DOI 10.52312/jdrs.2023.996
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  3. Article ; Online: Choroidal vascularity index in adult patients with familial meditteranean fever.

    Timur, İnci Elif Erbahçeci / Atalar, Ebru / Maraş, Yüksel / Dağ Şeker, Esra / Yüzbaşıoğlu, Sema / Uğurlu, Nagihan

    Photodiagnosis and photodynamic therapy

    2023  Volume 42, Page(s) 103350

    Abstract: Purpose: This study aimed to evaluate choroidal vascular status by the choroidal vascularity index (CVI) in adult patients with familial Mediterranean fever (FMF) in remission period.: Materials-methods: 86 patients diagnosed with FMF and 54 healthy ... ...

    Abstract Purpose: This study aimed to evaluate choroidal vascular status by the choroidal vascularity index (CVI) in adult patients with familial Mediterranean fever (FMF) in remission period.
    Materials-methods: 86 patients diagnosed with FMF and 54 healthy controls were recruited in this study. Retinal, ganglion cell complex and peripapillary retinal nerve fibre layer thicknesses were obtained using Spectralis domain-optical coherence (SD-OCT) tomography. Choroid images were obtained with the enhanced depth imaging mode of SD-OCT, and binarization was applied to the images using ImageJ software. CVI was described as the proportion of the luminal area to the total choroidal area. Blood-derived inflammation markers were calculated by the complete blood count.
    Results: The subfoveal choroidal thickness and nasal and temporal directions from fovea centralis at 500 μm, 1000 μm and 1500 μm were reduced in patients with FMF in comparison to healthy controls (p<0.001, each comparison). CVI was significantly decreased in patients with FMF compared to controls (62.28±2.2 and 64.79±4.3, p<0.001).
    Conclusion: We concluded that the choroidal vasculature structure may be affected prior to retinal changes in patients with FMF.
    MeSH term(s) Humans ; Adult ; Photochemotherapy/methods ; Photosensitizing Agents ; Choroid/diagnostic imaging ; Choroid/blood supply ; Retina/diagnostic imaging ; Retinal Vessels/diagnostic imaging ; Tomography, Optical Coherence/methods
    Chemical Substances Photosensitizing Agents
    Language English
    Publishing date 2023-02-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2149918-4
    ISSN 1873-1597 ; 1572-1000
    ISSN (online) 1873-1597
    ISSN 1572-1000
    DOI 10.1016/j.pdpdt.2023.103350
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  4. Article ; Online: Correction to: Long-term follow-up of a large cohort with focal epilepsy of unknown cause: deciphering their clinical and prognostic characteristics.

    Atalar, Arife Çimen / Vanlı-Yavuz, Ebru Nur / Yılmaz, Ebru / Bebek, Nerses / Baykan, Betül

    Journal of neurology

    2019  Volume 267, Issue 3, Page(s) 848

    Abstract: The original version of this article unfortunately contained a mistake. ...

    Abstract The original version of this article unfortunately contained a mistake.
    Language English
    Publishing date 2019-12-25
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-019-09675-5
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  5. Article ; Online: Diagnosis of osteoarthritic changes, loss of cervical lordosis, and disc space narrowing on cervical radiographs with deep learning methods.

    Maraş, Yüksel / Tokdemir, Gül / Üreten, Kemal / Atalar, Ebru / Duran, Semra / Maraş, Hakan

    Joint diseases and related surgery

    2022  Volume 33, Issue 1, Page(s) 93–101

    Abstract: Objectives: In this study, we aimed to differentiate normal cervical graphs and graphs of diseases that cause mechanical neck pain by using deep convolutional neural networks (DCNN) technology.: Materials and methods: In this retrospective study, the ...

    Abstract Objectives: In this study, we aimed to differentiate normal cervical graphs and graphs of diseases that cause mechanical neck pain by using deep convolutional neural networks (DCNN) technology.
    Materials and methods: In this retrospective study, the convolutional neural networks were used and transfer learning method was applied with the pre-trained VGG-16, VGG-19, Resnet-101, and DenseNet-201 networks. Our data set consisted of 161 normal lateral cervical radiographs and 170 lateral cervical radiographs with osteoarthritis and cervical degenerative disc disease.
    Results: We compared the performances of the classification models in terms of performance metrics such as accuracy, sensitivity, specificity, and precision metrics. Pre-trained VGG-16 network outperformed other models in terms of accuracy (93.9%), sensitivity (95.8%), specificity (92.0%), and precision (92.0%) results.
    Conclusion: The results of this study suggest that the deep learning methods are promising support tool in automated control of cervical graphs using the DCNN and the exclusion of normal graphs. Such a supportive tool may reduce the diagnosis time and provide radiologists or clinicians to have more time to interpret abnormal graphs.
    MeSH term(s) Deep Learning ; Humans ; Intervertebral Disc Degeneration/diagnostic imaging ; Lordosis ; Radiography ; Retrospective Studies
    Language English
    Publishing date 2022-03-28
    Publishing country Turkey
    Document type Journal Article
    ISSN 2687-4792
    ISSN (online) 2687-4792
    DOI 10.52312/jdrs.2022.445
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  6. Article: Neurological Involvement in Patients with Primary Sjögren's Syndrome: A Retrospective Cross-Sectional Study.

    Konak, Hatice Ecem / Gök, Kevser / Armağan, Berkan / Güven, Serdar Can / Atalar, Ebru / Apaydın, Hakan / Maraş, Yüksel / Erten, Şükran

    Annals of Indian Academy of Neurology

    2023  Volume 26, Issue 4, Page(s) 424–430

    Abstract: Background: To determine the rate and types of neurological involvement in patients with primary Sjögren's syndrome (pSS) and to evaluate predictive clinical and immunologic features of neurological involvement.: Methods: We retrospectively assessed ... ...

    Abstract Background: To determine the rate and types of neurological involvement in patients with primary Sjögren's syndrome (pSS) and to evaluate predictive clinical and immunologic features of neurological involvement.
    Methods: We retrospectively assessed 2127 patients with an ICD-10 code for Sjögren recorded in the hospital database. Among these patients, those meeting the pSS classification criteria and having neurological symptoms and an objective evaluation accordingly were enrolled. After comparing the patients with and without neurological involvement, peripheral and central involvement subtypes were also compared within themselves.
    Results: A total of 199 pSS patients were enrolled and neurological involvement was found in 31.6%. Peripheral nervous system (PNS) involvement was found in 23.5% of the patients, and central nervous system (CNS) involvement was found in 34.3%. Patients with neurological involvement had a higher frequency of Schirmer's test, anti-Ro/SS-A and anti-La/SS-B positivity and the presence of interstitial lung disease, articular involvement, lymphadenopathy, anemia and hypocomplementemia than patients without those. In multivariate regression analysis, only articular involvement had a higher risk for the development of neurologic involvement [OR 10.01 (4.18-23.97),
    Conclusions: In our study, it was shown that one third of the symptomatic pSS patients had objective neurological involvement. The presence of neurological symptoms should be considered, especially in patients with articular involvement in pSS.
    Language English
    Publishing date 2023-08-08
    Publishing country India
    Document type Journal Article
    ZDB-ID 2240174-X
    ISSN 1998-3549 ; 0972-2327
    ISSN (online) 1998-3549
    ISSN 0972-2327
    DOI 10.4103/aian.aian_138_23
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  7. Article ; Online: 14-3-3 η ETA protein as a potential marker of joint damage in gout.

    Doğan, İsmail / Kor, Ahmet / Güven, Serdar Can / Fırat Oğuz, Esra / Başer, Salih / Atalar, Ebru / Maraş, Yüksel / Erel, Özcan / Erten, Şükran

    Clinical biochemistry

    2023  Volume 118, Page(s) 110611

    Abstract: Introduction: The aim of the study is to investigate serum levels of 14-3-3 η (ETA) protein in patients with gout and possible relations with joint damage.: Method: This cross-sectional study included 43 gout patients and 30 control patients.: ... ...

    Abstract Introduction: The aim of the study is to investigate serum levels of 14-3-3 η (ETA) protein in patients with gout and possible relations with joint damage.
    Method: This cross-sectional study included 43 gout patients and 30 control patients.
    Results: Serum 14-3-3 η protein levels were significantly higher in gout patients (median [IQR], 3.1 [2.0] vs 2.2 [1.0], p = 0.007). In subgroup analyses of gout patients, serum 14-3-3 η protein levels did not differ between patients with and without a flare, tophaceous disease, elevated CRP and serum uric acid levels and a history of chronic kidney disease; however, were significantly higher in the patients with erosions (Median [IQR], 4.1 [2.7] vs 2.7 [1.5], p = 0.002). According to ROC curve, serum 14-3-3 η protein had 86.0% sensitivity and 30% specifity at a cut-off point of 1.7 ng/mL and had 74.7% sensitivity and 43.3% specifity at a cut-off point of 2.0 ng/mL.
    Conclusion: Our results demonstrated elevated levels of 14-3-3 η protein in gout patients which is more prominent in patients with erosive changes, implying role of 14-3-3 η protein in inflammatory and structural damage related pathways and suggesting a potential as a marker for disease severity.
    MeSH term(s) Humans ; Uric Acid ; 14-3-3 Proteins ; Cross-Sectional Studies ; Gout/diagnosis ; ROC Curve
    Chemical Substances Uric Acid (268B43MJ25) ; 14-3-3 Proteins
    Language English
    Publishing date 2023-07-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390372-2
    ISSN 1873-2933 ; 0009-9120
    ISSN (online) 1873-2933
    ISSN 0009-9120
    DOI 10.1016/j.clinbiochem.2023.110611
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    Zs.A 624: Show issues Location:
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  8. Article ; Online: 14-3-3η Proteins as a Diagnostic Marker, Disease Activation Indicator, and Lymphoma Predictor in Patients with Primary Sjögren Syndrome.

    Kor, Ahmet / Yalçın, Merve / Erten, Şükran / Maraş, Yüksel / Oğuz, Esra Fırat / Doğan, İsmail / Atalar, Ebru / Başer, Salih / Erel, Özcan

    Archives of Iranian medicine

    2023  Volume 26, Issue 10, Page(s) 582–591

    Abstract: Background: Primary Sjögren syndrome (PSS) is a chronic, autoimmune, and lymphoproliferative disease of the connective tissue. In patients with PSS, the risk of developing B-cell non-Hodgkin lymphoma (NHL) increases dramatically, with a prevalence of ... ...

    Abstract Background: Primary Sjögren syndrome (PSS) is a chronic, autoimmune, and lymphoproliferative disease of the connective tissue. In patients with PSS, the risk of developing B-cell non-Hodgkin lymphoma (NHL) increases dramatically, with a prevalence of approximately 5%. The 14-3-3 protein isoforms are phospho-serin/phospho-threonine binding proteins associated with many malignant diseases. This study aimed to evaluate the relationship between disease activity parameters and markers predicting lymphoma development in patients with PSS and 14-3-3η proteins.
    Methods: This study was designed as an analytical case-control study. A total of 57 PSS patients and 54 healthy volunteers were included in the study. The European League Against Rheumatism (EULAR) Sjögren syndrome disease activity index (ESSDAI) was used to assess systemic disease activity in PSS. Receiver operating characteristic (ROC) analysis was used to test the diagnostic accuracy measures of the analytical results. Multivariable linear regression analysis was used to evaluate the effects of independent variables on the 14-3-3η protein.
    Results: The 14-3-3η protein serum levels were found to be significantly higher in PSS (2.72 [2.04-4.07]) than healthy controls (1.73 [1.41-2.43]) (
    Conclusion: 14-3-3η proteins are potential candidates for diagnostic marker, marker of disease activity, and predictor of lymphoma in PSS patients.
    MeSH term(s) Humans ; Sjogren's Syndrome/complications ; Sjogren's Syndrome/diagnosis ; Case-Control Studies ; 14-3-3 Proteins ; Lymphoma/diagnosis ; Lymphoma/epidemiology
    Chemical Substances 14-3-3 Proteins
    Language English
    Publishing date 2023-10-01
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2204979-4
    ISSN 1735-3947 ; 1029-2977
    ISSN (online) 1735-3947
    ISSN 1029-2977
    DOI 10.34172/aim.2023.85
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  9. Article ; Online: Effects of intrauterine device use on attack frequency and severity ın woman of reproductive age with familial Mediterranean fever.

    Özdemir Ulusoy, Bahar / Güven, Serdar Can / Babaoğlu, Hakan / Ulusoy, Can Ozan / Armağan, Berkan / Kayacan Erdoğan, Esra / Maraş, Yüksel / Doğan, İsmail / Orhan, Kevser / Koçak Ulucaköy, Rezan / Atalar, Ebru / Omma, Ahmet / Küçükşahin, Orhan / Erten, Şükran

    Archives of gynecology and obstetrics

    2024  Volume 309, Issue 5, Page(s) 2041–2046

    Abstract: Aim: Familial Mediterranean fever (FMF) is the most common inherited autoinflammatory disease in the world. There are known triggers to initiate an FMF attack, yet potential effects of intrauterine devices (IUD) in women of reproductive age have not ... ...

    Abstract Aim: Familial Mediterranean fever (FMF) is the most common inherited autoinflammatory disease in the world. There are known triggers to initiate an FMF attack, yet potential effects of intrauterine devices (IUD) in women of reproductive age have not been evaluated before.
    Method: Consecutive female patients with FMF who ever used IUD over the age of 18 were enrolled. Female patients with FMF were sub grouped according to the type of IUD they use. FMF attack frequency, severity, duration, presence of dysmenorrhea, severity of dysmenorrhea, having attacks during menstruation before and after IUD use were questioned. Demographic and clinical data were collected from hospital database.
    Results: When all patients with IUD use were evaluated, it was found that the frequency of attacks increased after IUD insertion at 3rd and 12th months (median [min-max] attack frequency at 3rd month, 1 (0-3) vs 1 (0-6), p = 0.002, median [min-max] attack frequency at 12th month, 2 (0-12) vs 3.5 (0-18), p = 0.028). Attack severity measured by VAS pain was also significantly increased. Attack duration and menstrual pain was similar before and after IUD use. Attack frequency at 3rd and 12th months, attack severity and menstrual pain was all increased significantly in Cu-IUD users, whereas none of these parameters deteriorated in LNG-IUD group.
    Conclusion: IUD use, especially Cu-IUD, may increase the frequency and severity of attacks in female patients with FMF. Clinicians may benefit from considering LGN-IUD if IUDs are preferred as contraception in women of childbearing age with FMF.
    MeSH term(s) Female ; Humans ; Adult ; Middle Aged ; Dysmenorrhea/etiology ; Familial Mediterranean Fever/complications ; Intrauterine Devices/adverse effects ; Contraceptive Agents, Female ; Contraception ; Intrauterine Devices, Copper/adverse effects
    Chemical Substances Contraceptive Agents, Female
    Language English
    Publishing date 2024-03-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 896455-5
    ISSN 1432-0711 ; 0932-0067
    ISSN (online) 1432-0711
    ISSN 0932-0067
    DOI 10.1007/s00404-024-07413-5
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  10. Article ; Online: Investigation of Generalized EEG Paroxysms Accompanying Focal Epilepsies.

    Atalar, Arife Çimen / Vanlı-Yavuz, Ebru Nur / Yılmaz, Ebru / Bebek, Nerses / Baykan, Betül

    Clinical EEG and neuroscience

    2019  Volume 50, Issue 6, Page(s) 413–422

    Abstract: Interictal focal EEG features were frequently observed in generalized, epilepsies, but there is limited information about interictal, epileptiform/nonepileptiform generalized paroxysms in focal epilepsies. We aimed to report the frequency and associated ... ...

    Abstract Interictal focal EEG features were frequently observed in generalized, epilepsies, but there is limited information about interictal, epileptiform/nonepileptiform generalized paroxysms in focal epilepsies. We aimed to report the frequency and associated factors of generalized EEG discharges in focal epilepsy with unknown cause (FEUC) and mesial, temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). A total of 200 patients (FEUC in 90 patients; MTLE-HS in 110 patients) were included. Generalized epileptiform (spike/sharp waves simultaneously in all regions) and nonspecific generalized discharges (paroxysmal slow waves) were investigated. All clinical and laboratory findings of 2 groups were compared with each other and with remaining control group, without generalized paroxysms, statistically. Generalized EEG features were present in 22 (11%; 4 males) patients; 9 in the FEUC group (10%; 2) and 13 in the MTLE-HS group (11.8%). Female gender (
    MeSH term(s) Adult ; Brain/physiopathology ; Electroencephalography ; Epilepsies, Partial/physiopathology ; Epilepsy, Generalized/physiopathology ; Epilepsy, Temporal Lobe/physiopathology ; Female ; Hippocampus/pathology ; Hippocampus/physiopathology ; Humans ; Male ; Middle Aged ; Retrospective Studies
    Language English
    Publishing date 2019-06-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2140201-2
    ISSN 2169-5202 ; 0009-9155 ; 1550-0594
    ISSN (online) 2169-5202
    ISSN 0009-9155 ; 1550-0594
    DOI 10.1177/1550059419841837
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