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Article ; Online: Home sleep apnea testing for chronic heart failure: time to break the Cheyne?

Thornton, Christina S / Pendharkar, Sachin R

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

2021 Volume 17, Issue 7, Page(s) 1339–1341

MeSH term(s)	Cheyne-Stokes Respiration/complications ; Cheyne-Stokes Respiration/diagnosis ; Heart Failure/complications ; Heart Failure/diagnosis ; Humans ; Sleep Apnea Syndromes/complications ; Sleep Apnea Syndromes/diagnosis
Language	English
Publishing date	2021-04-30
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2397213-0
ISSN	1550-9397 ; 1550-9389
ISSN (online)	1550-9397
ISSN	1550-9389
DOI	10.5664/jcsm.9334
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Article ; Online: Alternative Care Pathways for Obstructive Sleep Apnea and the Impact on Positive Airway Pressure Adherence: Unraveling the Puzzle of Adherence.

Billings, Martha E / Pendharkar, Sachin R

Sleep medicine clinics

2020 Volume 16, Issue 1, Page(s) 61–74

Abstract: The high burden of obstructive sleep apnea (OSA), combined with inadequate supply of sleep specialists and constraints on polysomnography resources, has prompted interest in alternative models of care to improve access and treatment effectiveness. In ... ...

Abstract	The high burden of obstructive sleep apnea (OSA), combined with inadequate supply of sleep specialists and constraints on polysomnography resources, has prompted interest in alternative models of care to improve access and treatment effectiveness. In appropriately selected patients, ambulatory clinical pathways and use of nonphysicians or primary care providers to manage OSA can improve timely access and costs without compromising adherence or other clinical outcomes. Although initial studies show promising results, there are several potential barriers that must be considered before broad implementation, and further implementation research and economic evaluation studies are required.
MeSH term(s)	Continuous Positive Airway Pressure ; Humans ; Patient Compliance/statistics & numerical data ; Randomized Controlled Trials as Topic ; Sleep Apnea, Obstructive/therapy ; Sleep Medicine Specialty/organization & administration
Language	English
Publishing date	2020-12-07
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1556-4088
ISSN (online)	1556-4088
DOI	10.1016/j.jsmc.2020.10.005
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Article ; Online: Screening for Obstructive Sleep Apnea: Important to Find, but How Hard Should We Look?

Pendharkar, Sachin R / Clement, Fiona M

JAMA internal medicine

2017 Volume 177, Issue 4, Page(s) 463–464

MeSH term(s)	Humans ; Primary Health Care ; Sleep Apnea, Obstructive/diagnosis
Language	English
Publishing date	2017-01-24
Publishing country	United States
Document type	Editorial
ZDB-ID	2699338-7
ISSN	2168-6114 ; 2168-6106
ISSN (online)	2168-6114
ISSN	2168-6106
DOI	10.1001/jamainternmed.2016.9538
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Article ; Online: Acceptance of and adherence with long-term positive airway pressure treatment in adults with chronic obstructive pulmonary disease: A systematic review protocol.

Laratta, Cheryl R / Moore, Linn E / Jen, Rachel / Campbell, Sandra M / MacLean, Joanna E / Pendharkar, Sachin R / Rowe, Brian H

PloS one

2023 Volume 18, Issue 7, Page(s) e0287887

Abstract: Background: Long-term noninvasive positive airway pressure (PAP) treatment is effective treatment for sleep-related breathing disorders and chronic hypercarbic respiratory failure secondary to chronic obstructive pulmonary disease (COPD). PAP treatment ... ...

Abstract	Background: Long-term noninvasive positive airway pressure (PAP) treatment is effective treatment for sleep-related breathing disorders and chronic hypercarbic respiratory failure secondary to chronic obstructive pulmonary disease (COPD). PAP treatment may be delivered as continuous positive airway pressure or noninvasive ventilation. Success in initiating PAP treatment and barriers to its use in adult patients with COPD are largely unknown. This systematic review aims to identify the acceptance of and adherence to PAP treatment prescribed for long-term use in adult patients with COPD and to summarize variables associated with these measures. Methods: Seven online electronic databases will be searched by an experienced medical librarian to identify records containing the concepts "obstructive airways disease" and "noninvasive positive airway pressure" and "acceptance" or "adherence". Randomized and non-randomized studies of interventions will be included. Citation lists from relevant articles will be reviewed, and experts will be contacted regarding unpublished studies. Abstracts from key conferences between 2018-2023 and Google Scholar search results will be reviewed for inclusion. Titles, abstracts and full texts will be reviewed independently for inclusion by two reviewers. Data extraction will be completed by one author using a pre-established form and primary outcomes confirmed by a second author. Methodological quality will be evaluated. If sufficient data are available for meta-analysis, a pooled summary statistic for the primary outcome will be calculated using a random-effects generic inverse-variance meta-analysis, weighted proportion or weighted medians-based approach. Subgroup analysis will explore clinically meaningful sources of heterogeneity. Variables that are associated with acceptance and adherence will be described. Discussion: Long-term PAP treatment is a complex intervention prescribed to patients with COPD for several indications. Synthesis of the evidence on success with PAP treatment and variables associated with acceptance or adherence will inform program and policy development for supporting patients with COPD who are prescribed this therapy. Trial registration: Systematic review registration: This protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO) on July 13, 2021 (registration number CRD42021259262), with revisions submitted on April 17, 2023.
MeSH term(s)	Humans ; Adult ; Systematic Reviews as Topic ; Pulmonary Disease, Chronic Obstructive/therapy ; Noninvasive Ventilation ; Hypercapnia ; Respiration ; Meta-Analysis as Topic
Language	English
Publishing date	2023-07-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0287887
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Article ; Online: Temporal and Regional Trends in Obstructive Sleep Apnea Using Administrative Health Data in Alberta, Canada.

Pendharkar, Sachin R / Sharpe, Heather / Rosychuk, Rhonda J / Laratta, Cheryl R / Fong, Andrew / Duan, Qiuli M / Ronksley, Paul E / MacLean, Joanna E

Annals of the American Thoracic Society

2022 Volume 20, Issue 3, Page(s) 433–439

Abstract: Rationale: ...

Abstract	Rationale:
MeSH term(s)	Female ; Male ; Child ; Humans ; Aged ; Child, Preschool ; Alberta/epidemiology ; Sleep Apnea, Obstructive/diagnosis ; Databases, Factual ; Prevalence
Language	English
Publishing date	2022-12-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2717461-X
ISSN	2325-6621 ; 1943-5665 ; 2325-6621
ISSN (online)	2325-6621 ; 1943-5665
ISSN	2325-6621
DOI	10.1513/AnnalsATS.202209-789OC
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Article ; Online: Addressing challenges with current therapies for obstructive sleep apnea.

Laratta, Cheryl R / Ayas, Najib T / Povitz, Marcus / Pendharkar, Sachin R

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

2018 Volume 190, Issue 18, Page(s) E573

MeSH term(s)	Adult ; Humans ; Risk Factors ; Sleep Apnea, Obstructive
Language	English
Publishing date	2018-04-30
Publishing country	Canada
Document type	Letter ; Comment
ZDB-ID	215506-0
ISSN	1488-2329 ; 0008-4409 ; 0820-3946
ISSN (online)	1488-2329
ISSN	0008-4409 ; 0820-3946
DOI	10.1503/cmaj.69278
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Article ; Online: Association of clinically significant obstructive sleep apnoea with risks of contracting COVID-19 and serious COVID-19 complications: a retrospective population-based study of health administrative data.

Kendzerska, Tetyana / Povitz, Marcus / Gershon, Andrea S / Ryan, Clodagh M / Talarico, Robert / Franco Avecilla, Dennys Andrea / Robillard, Rebecca / Ayas, Najib T / Pendharkar, Sachin R

Thorax

2023 Volume 78, Issue 9, Page(s) 933–941

Abstract: Rationale/objectives: Despite plausible pathophysiological mechanisms, more research is needed to confirm the relationship between obstructive sleep apnoea (OSA) and the risk of COVID-19 infection or COVID-19-related serious complications.: Methods: ... ...

Abstract	Rationale/objectives: Despite plausible pathophysiological mechanisms, more research is needed to confirm the relationship between obstructive sleep apnoea (OSA) and the risk of COVID-19 infection or COVID-19-related serious complications. Methods: We conducted a retrospective population-based cohort study using provincial health administrative data (Ontario, Canada). Adults with physician-diagnosed OSA who received positive airway pressure therapy in the 5 years prepandemic ( Results: We identified and matched 324 029 individuals in the OSA group to 4 588 200 individuals in the non-OSA group. Compared with the non-OSA group, those in the OSA group were at a greater hazard of testing positive for COVID-19 (HR=1.17, 95% CI 1.13 to 1.21), having a COVID-19-related ED visit (HR=1.62, 95% CI 1.51 to 1.73), hospitalisation (HR=1.50, 95% CI 1.37 to 1.65) or ICU admission (HR=1.53, 95% CI 1.27 to 1.84). COVID-19-related 30-day mortality was not different (HR=0.98, 95% CI 0.82 to 1.16).We found that for the OSA group, comorbid airways disease but not cardiometabolic conditions increased the hazards of COVID-19-related outcomes, including mortality. Conclusion: In this large population-based study, we demonstrated that a recent diagnosis of OSA requiring treatment was associated with an increased hazard of testing positive for COVID-19 and serious COVID-19-related complications, particularly in those with co-existing chronic airways disease.
MeSH term(s)	Adult ; Humans ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/epidemiology ; Sleep Apnea, Obstructive/therapy ; Retrospective Studies ; Cohort Studies ; Routinely Collected Health Data ; COVID-19/complications ; COVID-19/epidemiology ; Ontario/epidemiology ; Pulmonary Disease, Chronic Obstructive/complications
Language	English
Publishing date	2023-01-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	204353-1
ISSN	1468-3296 ; 0040-6376
ISSN (online)	1468-3296
ISSN	0040-6376
DOI	10.1136/thorax-2022-219574
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Article ; Online: The association between sleep quality and obstructive sleep apnea with health-related quality of life in children with obesity.

Xiao, Lena / Voutsas, Giorge / Ryan, Clodagh M / Katz, Sherri Lynne / Narang, Indra / Ayas, Najib / Carrier, Julie / Hanly, Patrick / Peever, John / Pendharkar, Sachin / Skomro, Roberto

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

2023 Volume 19, Issue 11, Page(s) 1877–1883

Abstract: Study objectives: Obstructive sleep apnea (OSA) and poor sleep quality are highly prevalent in children with obesity, but their individual associations with health-related quality of life (HRQOL) are unknown in this population. The primary objective was ...

Abstract	Study objectives: Obstructive sleep apnea (OSA) and poor sleep quality are highly prevalent in children with obesity, but their individual associations with health-related quality of life (HRQOL) are unknown in this population. The primary objective was to describe the independent association of OSA and sleep quality with HRQOL in children with obesity. Methods: This was a cross-sectional study of children with obesity at 2 tertiary care centers. Sleep quality and HRQOL were measured with the Pittsburgh Sleep Quality Index and Pediatric Quality of Life Inventory questionnaires, respectively. Multivariable regression models were created to evaluate associations between OSA and sleep quality with HRQOL. Results: There were 98 children (median age 15.0 years, median body mass index z-score 3.8, 44% females). Among the study population, 49/98 (50%) children reported poor sleep quality, 41/98 (42%) children had OSA, and 52/98 (53%) children reported impaired HRQOL. Self-reported poor sleep quality was independently associated with reduced HRQOL, whereas the presence of OSA was not. Children with poor sleep quality had a reduced Pediatric Quality of Life Inventory score by 8.8 compared to children with good sleep quality (95% confidence interval, 2.6-14.9; Conclusions: In the current study of children with obesity, we found that HRQOL was more strongly associated with the self-reported experience of sleep than the presence of OSA. Clinicians should assess and optimize sleep quality as part of the evaluation for OSA in children with obesity. Citation: Xiao L, Voutsas G, Ryan CM, Katz SL, Narang I. The association between sleep quality and obstructive sleep apnea with health-related quality of life in children with obesity.
MeSH term(s)	Female ; Humans ; Child ; Adolescent ; Male ; Sleep Quality ; Quality of Life ; Cross-Sectional Studies ; Polysomnography ; Obesity/complications ; Obesity/epidemiology ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/epidemiology ; Sleep Initiation and Maintenance Disorders/complications
Language	English
Publishing date	2023-07-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2397213-0
ISSN	1550-9397 ; 1550-9389
ISSN (online)	1550-9397
ISSN	1550-9389
DOI	10.5664/jcsm.10706
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Article ; Online: Patient-reported Differences in Obstructive Sleep Apnea Care between Jurisdictions with and without Government Funding for Continuous Positive Airway Pressure.

Chiu, Judy / Fenton, Mark / Ayas, Najib T / Povitz, Marcus / Almeida, Fernanda / Huynh, Nelly / Kendzerska, Tetyana / Ratycz, Diana / Bansback, Nick / Pendharkar, Sachin R

Annals of the American Thoracic Society

2022 Volume 20, Issue 1, Page(s) 110–117

Abstract: Rationale: ...

Abstract	Rationale:
MeSH term(s)	Adult ; Humans ; Male ; Middle Aged ; Aged ; Female ; Continuous Positive Airway Pressure ; Canada ; Sleep Apnea, Obstructive/therapy ; Patient Reported Outcome Measures ; Government
Language	English
Publishing date	2022-09-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2717461-X
ISSN	2325-6621 ; 1943-5665 ; 2325-6621
ISSN (online)	2325-6621 ; 1943-5665
ISSN	2325-6621
DOI	10.1513/AnnalsATS.202205-390OC
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Article ; Online: Predicting CPAP failure in patients with suspected sleep hypoventilation identified on ambulatory testing.

Braganza, Michael V / Hanly, Patrick J / Fraser, Kristin L / Tsai, Willis H / Pendharkar, Sachin R

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

2020 Volume 16, Issue 9, Page(s) 1555–1565

Abstract: Study objectives: Home sleep apnea testing (HSAT) is commonly used to diagnose obstructive sleep apnea, but its role in identifying patients with suspected hypoventilation or predicting their response to continuous positive airway pressure (CPAP) ... ...

Abstract	Study objectives: Home sleep apnea testing (HSAT) is commonly used to diagnose obstructive sleep apnea, but its role in identifying patients with suspected hypoventilation or predicting their response to continuous positive airway pressure (CPAP) therapy has not been assessed. The primary objective was to determine if HSAT, combined with clinical variables, could predict the failure of CPAP to correct nocturnal hypoxemia during polysomnography in a population with suspected hypoventilation. Secondary objectives were to determine if HSAT and clinical parameters could predict awake or sleep hypoventilation. Methods: A retrospective review was performed of 142 consecutive patients who underwent split-night polysomnography for suspected hypoventilation after clinical assessment by a sleep physician and review of HSAT. We collected quantitative indices of nocturnal hypoxemia, patient demographics, medications, pulmonary function tests, as well as arterial blood gas data from the night of the polysomnography . CPAP failure was defined as persistent obstructive sleep apnea, hypoxemia (oxygen saturation measured by pulse oximetry < 85%), or hypercapnia despite maximal CPAP. Results: Failure of CPAP was predicted by awake oxygen saturation and arterial blood gas results but not by HSAT indices of nocturnal hypoxemia. Awake oxygen saturation ≥ 94% ruled out CPAP failure, and partial pressure of oxygen measured by arterial blood gas ≥ 68 mmHg decreased the likelihood of CPAP failure significantly. Conclusions: In patients with suspected hypoventilation based on clinical review and HSAT interpretation by a sleep physician, awake oxygen saturation measured by pulse oximetry and partial pressure of oxygen measured by arterial blood gas can reliably identify patients in whom CPAP is likely to fail. Additional research is required to determine the role of HSAT in the identification and treatment of patients with hypoventilation.
MeSH term(s)	Continuous Positive Airway Pressure ; Humans ; Hypoventilation/diagnosis ; Hypoventilation/therapy ; Polysomnography ; Retrospective Studies ; Sleep
Language	English
Publishing date	2020-06-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2397213-0
ISSN	1550-9397 ; 1550-9389
ISSN (online)	1550-9397
ISSN	1550-9389
DOI	10.5664/jcsm.8616
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