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Article: A rare case of gestational trophoblastic neoplasia following an ectopic molar pregnancy.

Dollinger, Sarah / Yeoshoua, Effi / Eitan, Ram

2021 Volume 37, Page(s) 100798

Abstract: Ectopic molar pregnancies are a rare gynecological occurrence.•Gestational trophoblastic neoplasia (GTN) can arise following an ectopic molar pregnancy.•Histopathology should be sought and hCG levels should be monitored after surgical treatment of ... ...

Abstract	•Ectopic molar pregnancies are a rare gynecological occurrence.•Gestational trophoblastic neoplasia (GTN) can arise following an ectopic molar pregnancy.•Histopathology should be sought and hCG levels should be monitored after surgical treatment of ectopic pregnancies.•The combination of histopathology and serum hCG is gold standard for diagnosis of molar pregnancy and GTN.
Language	English
Publishing date	2021-05-30
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2818505-5
ISSN	2352-5789
ISSN	2352-5789
DOI	10.1016/j.gore.2021.100798
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Article ; Online: Long-term risk of adnexal operation after vaginal hysterectomy for pelvic organs prolapse repair.

Geron, Yossi / From, Anat / Matot, Ran / Peled, Yoav / Eitan, Ram / Krissi, Haim

European journal of obstetrics, gynecology, and reproductive biology

2023 Volume 294, Page(s) 1–3

Abstract: Objective: To determine if women who undergo vaginal hysterectomy for pelvic floor prolapse repair without concomitant opportunistic bilateral salpingo-oophorectomy are at increased risk of further complications related to the remaining adnexa later in ... ...

Abstract	Objective: To determine if women who undergo vaginal hysterectomy for pelvic floor prolapse repair without concomitant opportunistic bilateral salpingo-oophorectomy are at increased risk of further complications related to the remaining adnexa later in life. Study design: The database of a tertiary university medical center was searched for all women who underwent vaginal hysterectomy as part of the treatment for pelvic organ prolapse, without opportunistic adnexectomy, from 2006 to 2015 to provide adequate time for long-term evaluation. Demographic and clinical data including surgeries performed during the long-term follow-up were collected from all medical insurer electronic medical records. Results: The cohort included 427 women of mean age 63 ± 9.3 years; 90.9 % were postmenopausal. Mean duration of follow-up was 10.7 ± 2.6 years. During the follow-up period, only 3 patients (0.7 %) were re-operated for left adnexal pathology, non-malignant in all cases. Conclusion: In women undergoing vaginal hysterectomy for pelvic organ prolapse without opportunistic adnexectomy, preservation of the adnexa poses only a very low risk for adnexal pathology or need for reoperation later in life.
MeSH term(s)	Humans ; Female ; Middle Aged ; Aged ; Hysterectomy, Vaginal/adverse effects ; Salpingo-oophorectomy ; Pelvic Organ Prolapse/surgery ; Pelvic Organ Prolapse/etiology ; Adnexa Uteri ; Reoperation/adverse effects ; Hysterectomy/adverse effects
Language	English
Publishing date	2023-12-17
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	190605-7
ISSN	1872-7654 ; 0301-2115 ; 0028-2243
ISSN (online)	1872-7654
ISSN	0301-2115 ; 0028-2243
DOI	10.1016/j.ejogrb.2023.12.026
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Article ; Online: Early tracheostomy after cardiac surgery improves intermediate- and long-term survival.

Keizman, Eitan / Frogel, Jonathan K / Ram, Eilon / Volvovitch, David / Jamal, Tamer / Levin, Shany / Raanani, Ehud / Sternik, Leonid / Kogan, Alexander

Medicina intensiva

2023 Volume 47, Issue 9, Page(s) 516–525

Abstract: Objective: Complicated post-cardiac surgery course, can lead to both prolonged ICU stay and ventilation, and may require a tracheostomy. This study represents the single-center experience with post-cardiac surgery tracheostomy. The aim of this study was ...

Abstract	Objective: Complicated post-cardiac surgery course, can lead to both prolonged ICU stay and ventilation, and may require a tracheostomy. This study represents the single-center experience with post-cardiac surgery tracheostomy. The aim of this study was to assess the timing of tracheostomy as a risk factor for early, intermediate, and late mortality. The study's second aim was to assess the incidence of both superficial and deep sternal wound infections. Design: Retrospective study of prospectively collected data. Setting: Tertiary hospital. Patients: Patients were divided into 3 groups, according to the timing of tracheostomy; early (4-10 days); intermediate (11-20 days) and late (≥21 days). Interventions: None. Main variables of interest: The primary outcomes were early, intermediate, and long-term mortality. The secondary outcome was the incidence of sternal wound infection. Results: During the 17-year study period, 12,782 patients underwent cardiac surgery, of whom 407 (3.18%) required postoperative tracheostomy. 147 (36.1%) had early, 195 (47.9%) intermediate, and 65 (16%) had a late tracheostomy. Early, 30-day, and in-hospital mortality was similar for all groups. However, patients, who underwent early- and intermediate tracheostomy, demonstrated statistically significant lower mortality after 1- and 5-year (42.8%; 57.4%; 64.6%; and 55.8%; 68.7%; 75.4%, respectively; P < .001). Cox model demonstrated age [1.025 (1.014-1.036)] and timing of tracheostomy [0.315 (0.159-0.757)] had significant impacts on mortality. Conclusions: This study demonstrates a relationship between the timing of tracheostomy after cardiac surgery and mortality: early tracheostomy (within 4-10 days of mechanical ventilation) is associated with better intermediate- and long-term survival.
MeSH term(s)	Humans ; Retrospective Studies ; Tracheostomy ; Cardiac Surgical Procedures ; Respiration, Artificial ; Risk Factors
Language	English
Publishing date	2023-03-01
Publishing country	Spain
Document type	Journal Article
ISSN	2173-5727
ISSN (online)	2173-5727
DOI	10.1016/j.medine.2023.02.003
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Article ; Online: Laser Tooth Preparation for Pit and Fissure Sealing.

Schwimmer, Yair / Beyth, Nurit / Ram, Diana / Mijiritsky, Eitan / Davidovich, Esti

International journal of environmental research and public health

2020 Volume 17, Issue 21

Abstract: Objectives: ...

Abstract	Objectives:
MeSH term(s)	Acid Etching, Dental ; Lasers ; Pit and Fissure Sealants ; Tooth Preparation
Chemical Substances	Pit and Fissure Sealants
Language	English
Publishing date	2020-10-26
Publishing country	Switzerland
Document type	Journal Article
ISSN	1660-4601
ISSN (online)	1660-4601
DOI	10.3390/ijerph17217813
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Article ; Online: The impact of COVID-19 pandemic on cardiac surgery in Israel.

Keizman, Eitan / Ram, Eilon / Kachel, Erez / Sternik, Leonid / Raanani, Ehud

Journal of cardiothoracic surgery

2020 Volume 15, Issue 1, Page(s) 294

Abstract: Background: Ever since the coronavirus disease 2019 (COVID-19) has become a pandemic, worldwide efforts are being made to "flatten the curve". Israel was amongst the first countries to impose significant restrictions. As a result, cardiac surgeons have ... ...

Abstract	Background: Ever since the coronavirus disease 2019 (COVID-19) has become a pandemic, worldwide efforts are being made to "flatten the curve". Israel was amongst the first countries to impose significant restrictions. As a result, cardiac surgeons have been required to scale down their routine practice, resulting in a significant reduction in the number of cardiac surgeries. The aim of this study is to characterize the impact of COVID-19 on cardiac surgery in Israel. Methods: This is a retrospective observational study performed in two cardiac surgery departments in Israel and includes all patients who underwent cardiac surgery in March and April during the years 2019 and 2020. The patient cohort was divided into two groups based on the year of operation. Analysis of the patients' baseline characteristics, operative data, and postoperative outcome, was performed. Results: The 2019 group (n = 173), and the 2020 group (n = 108) were similar regarding their baseline characteristics, previous medical history, and rates of previous revascularization interventions. However, compared to the 2019 group, patients in the 2020 group were found to be more symptomatic (NYHA class IV; 2.4% vs. 6.2%, p = 0.007). While all patients underwent similar procedures, patients in the 2020 group had significantly longer procedural time (p < 0.001). In-hospital mortality rate was found to be significantly higher in group 2020 (13% vs. 5.2%, p = 0.037). Conclusions: While the number of patients undergoing cardiac surgery declined during the outbreak period, the rate of surgical mortality increased. One explanation for this might be delayed hospital arrival.
MeSH term(s)	Aged ; Betacoronavirus ; COVID-19 ; Cardiac Surgical Procedures/mortality ; Coronavirus Infections ; Female ; Hospital Mortality ; Humans ; Israel ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral ; Postoperative Period ; Retrospective Studies ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-10-02
Publishing country	England
Document type	Journal Article ; Observational Study
ISSN	1749-8090
ISSN (online)	1749-8090
DOI	10.1186/s13019-020-01342-5
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Article: The germline regulates longevity and somatic repair in a sex-specific manner.

Moses, Eitan / Atlan, Tehila / Sun, Xue / Franek, Roman / Siddiqui, Atif / Marinov, Georgi K / Shifman, Sagiv / Zucker, David M / Oron-Gottesman, Adi / Greenleaf, William J / Cohen, Ehud / Ram, Oren / Harel, Itamar

bioRxiv : the preprint server for biology

2023

Abstract: Classical evolutionary theories propose tradeoffs between reproduction, damage repair, and lifespan. However, the specific role of the germline in shaping vertebrate aging remains largely unknown. Here, we use the turquoise killifish ( ...

Abstract	Classical evolutionary theories propose tradeoffs between reproduction, damage repair, and lifespan. However, the specific role of the germline in shaping vertebrate aging remains largely unknown. Here, we use the turquoise killifish (
Language	English
Publishing date	2023-12-18
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.12.18.572041
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Article ; Online: Normothermic Versus Hypothermic Norwood Procedure.

Keizman, Eitan / Mishaly, David / Ram, Eilon / Urtaev, Soslan / Tejman-Yarden, Shai / Tirosh Wagner, Tal / Serraf, Alain E

World journal for pediatric & congenital heart surgery

2022 Volume 14, Issue 2, Page(s) 125–132

Abstract: Background: Either deep hypothermia with circulatory arrest or hypothermic perfusion with antegrade selective cerebral perfusion is used during the Norwood procedure for hypoplastic left heart syndrome. Normothermic perfusion has been described for ... ...

Abstract	Background: Either deep hypothermia with circulatory arrest or hypothermic perfusion with antegrade selective cerebral perfusion is used during the Norwood procedure for hypoplastic left heart syndrome. Normothermic perfusion has been described for pediatric patients. The aim of this study was to compare the early outcomes of patients undergoing the Norwood procedure with antegrade selective cerebral perfusion under hypothermia with the procedure under normothermia. Methods: From 2005 to 2020, 117 consecutive patients with hypoplastic left heart syndrome underwent the Norwood procedure: 68 (58.2%) under hypothermia and 49 (41.8%) under normothermia. Antegrade selective cerebral perfusion flow was adjusted to maintain right radial arterial pressure above 50 mm Hg, and a flow rate of 40 to 50 mL kg Results: The baseline characteristics and cardiovascular diagnosis were similar in both groups. The normothermic group had a significantly shorter bypass time (in minutes) of 90.31 (±31.60) versus 123.63 (±25.33), a cross-clamp time of 45.24 (±16.35) versus 81.93 (±16.34), and an antegrade selective cerebral perfusion time of 25.61 (±13.84) versus 47.30 (±14.35) ( Conclusion: The normothermic Norwood procedure with selective cerebral perfusion is feasible and safe in terms of in-hospital mortality and short-term outcomes. It is comparable to the standard hypothermic Norwood with selective cerebral perfusion.
MeSH term(s)	Humans ; Child ; Hypoplastic Left Heart Syndrome/surgery ; Hypothermia/etiology ; Perfusion/methods ; Circulatory Arrest, Deep Hypothermia Induced/methods ; Norwood Procedures ; Cerebrovascular Circulation ; Hypothermia, Induced ; Treatment Outcome
Language	English
Publishing date	2022-12-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2550261-X
ISSN	2150-136X ; 2150-1351
ISSN (online)	2150-136X
ISSN	2150-1351
DOI	10.1177/21501351221140330
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Article ; Online: Acute Adnexal Torsion: Is Immediate Surgical Intervention Associated with a Better Outcome?

Yaakov, Odelia / Ashwal, Eran / Gemer, Ofer / Peled, Yoav / Kapustian, Victoria / Namazov, Ahmet / Eitan, Ram / Krissi, Haim

Gynecologic and obstetric investigation

2022 Volume 87, Issue 2, Page(s) 100–104

Abstract: Objectives: We aimed to investigate whether surgery for adnexal detorsion within 6 h from admission to the hospital was associated with less adnexal ischemia.: Design: This is a retrospective cohort study.: Participants/materials, setting, and ... ...

Abstract	Objectives: We aimed to investigate whether surgery for adnexal detorsion within 6 h from admission to the hospital was associated with less adnexal ischemia. Design: This is a retrospective cohort study. Participants/materials, setting, and methods: This retrospective study was conducted at two university-affiliated medical centers and assessed women aged 18-45 years with adnexal torsion who were hospitalized within 12 h from the pain onset and underwent surgery for detorsion within 24 h. The study group was divided into 2 groups: early, surgical intervention within less than 6 h and late, surgical intervention between 6 and 24 h. The primary outcome was the rate of macroscopic appearance of ischemic adnexa. Results: Two hundred and twenty women fulfilled the inclusion criteria. In 101 women, the adnexa with the torsion appeared macroscopically ischemic. There was no difference in ischemic adnexa between the early and late intervention groups (48% vs. 40%; p = 0.269). No significant association was found between the physical examination or ultrasonographic findings and the rate of ischemic adnexa within each group. Limitations: The main limitations of our study are its retrospective nature. Much of the clinical and ultrasonographic data are subjective and operator-dependent. The decision to operate may vary from one surgeon to another. Conclusion: Immediate surgical intervention in patients with adnexal torsion is not associated with a lower rate of adnexal ischemia. These findings suggest that in acute adnexal torsion, there is a wider time window for a thorough evaluation before surgery.
MeSH term(s)	Adnexal Diseases/surgery ; Female ; Humans ; Ischemia/complications ; Ovarian Torsion ; Retrospective Studies ; Torsion Abnormality/complications ; Torsion Abnormality/surgery
Language	English
Publishing date	2022-02-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	800003-7
ISSN	1423-002X ; 0378-7346
ISSN (online)	1423-002X
ISSN	0378-7346
DOI	10.1159/000522501
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Article ; Online: Laser Tooth Preparation for Pit and Fissure Sealing

Yair Schwimmer / Nurit Beyth / Diana Ram / Eitan Mijiritsky / Esti Davidovich

International Journal of Environmental Research and Public Health, Vol 17, Iss 7813, p

2020 Volume 7813

Abstract: Objectives: Various approaches are available for pit and fissure sealing, including: the use of sealants, with or without mechanical preparation; the use of etching, with or without bonding; and the use of lasers as an alternative to mechanical ... ...

Abstract	Objectives: Various approaches are available for pit and fissure sealing, including: the use of sealants, with or without mechanical preparation; the use of etching, with or without bonding; and the use of lasers as an alternative to mechanical preparation. The objective of this study is to evaluate pit and fissure sealing by comparing the retention and microleakage of sealants, between mechanical and Er:Yag laser enamel preparation. Methods: Sixty extracted sound third molars are classified into six groups: A, bur mechanical preparation and sealant application; B, bur mechanical preparation, etching and sealant; C, bur mechanical preparation, etching, bonding and sealant; D, laser mechanical preparation and sealant; E, laser mechanical preparation, etching and sealant application; F, laser mechanical preparation, etching, bonding, and sealant. Statistical analysis methods include Fisher’s exact test, a general linear model for one-way analysis of variance (ANOVA) of multiple comparisons, and Bonferroni multiple comparison tests. Results: All the groups showed dye microleakage beneath the sealants. Less microleakage was observed for those that used bur rather than laser, 41 versus 44 specimens, respectively. The number of specimens without microleakage decreased as follows: group E (24), group A (18), groups B and F (17), group C (14), and group D (5). Retention was 100% in all groups except group D. Conclusion: Mechanical preparation increases retention of sealants, especially when etching material is used; additionally, bonding can help the retention. The best technique is mechanical preparation via laser and subsequent use of etching, without bonding prior to application of the dental sealant.
Keywords	pits ; fissures ; sealants ; lasers ; Medicine ; R
Subject code	670
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: The impact of COVID-19 pandemic on cardiac surgery in Israel

Eitan Keizman / Eilon Ram / Erez Kachel / Leonid Sternik / Ehud Raanani

Journal of Cardiothoracic Surgery, Vol 15, Iss 1, Pp 1-

2020 Volume 6

Abstract: Abstract Background Ever since the coronavirus disease 2019 (COVID-19) has become a pandemic, worldwide efforts are being made to “flatten the curve”. Israel was amongst the first countries to impose significant restrictions. As a result, cardiac ... ...

Abstract	Abstract Background Ever since the coronavirus disease 2019 (COVID-19) has become a pandemic, worldwide efforts are being made to “flatten the curve”. Israel was amongst the first countries to impose significant restrictions. As a result, cardiac surgeons have been required to scale down their routine practice, resulting in a significant reduction in the number of cardiac surgeries. The aim of this study is to characterize the impact of COVID-19 on cardiac surgery in Israel. Methods This is a retrospective observational study performed in two cardiac surgery departments in Israel and includes all patients who underwent cardiac surgery in March and April during the years 2019 and 2020. The patient cohort was divided into two groups based on the year of operation. Analysis of the patients’ baseline characteristics, operative data, and postoperative outcome, was performed. Results The 2019 group (n = 173), and the 2020 group (n = 108) were similar regarding their baseline characteristics, previous medical history, and rates of previous revascularization interventions. However, compared to the 2019 group, patients in the 2020 group were found to be more symptomatic (NYHA class IV; 2.4% vs. 6.2%, p = 0.007). While all patients underwent similar procedures, patients in the 2020 group had significantly longer procedural time (p < 0.001). In-hospital mortality rate was found to be significantly higher in group 2020 (13% vs. 5.2%, p = 0.037). Conclusions While the number of patients undergoing cardiac surgery declined during the outbreak period, the rate of surgical mortality increased. One explanation for this might be delayed hospital arrival.
Keywords	Cardiac surgery ; COVID-19 ; Surgery ; RD1-811 ; Anesthesiology ; RD78.3-87.3 ; covid19
Subject code	610
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
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