LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 95

Search options

  1. Article ; Online: SARS-CoV-2 the ASIA virus (Autoimmune/autoinflammatory Syndrome Induced by Adjuvants), the risk of infertility and vaccine hesitancy.

    Ameratunga, Rohan

    Expert review of vaccines

    2022  Volume 21, Issue 9, Page(s) 1177–1184

    Abstract: Introduction: COVID-19 has had a catastrophic impact on the world. The current death toll far exceeds 6 million and large numbers of patients are experiencing long-term medical and psychiatric morbidity from the infection. The immunopathology of severe ... ...

    Abstract Introduction: COVID-19 has had a catastrophic impact on the world. The current death toll far exceeds 6 million and large numbers of patients are experiencing long-term medical and psychiatric morbidity from the infection. The immunopathology of severe COVID-19 is now better understood. In severely affected patients, there is a chaotic, destructive immune response triggered by SARS-CoV-2, where autoimmunity features prominently.
    Areas covered: COVID-19 vaccines ensure a coordinated, balanced immune response to future SARS-CoV-2 infection. The rapid global deployment of effective COVID-19 vaccines has been hindered by financial, logistical and political barriers. Of concern is increasing vaccine hesitancy caused by unfounded conspiracy theories of vaccine adverse effects, often fueled by misinformation and disinformation on social media.
    Expert opinion: This perspective discusses the potential impact of the so-called Autoimmune/autoinflammatory Syndrome Induced by Adjuvants (ASIA) on COVID-19 vaccine uptake. Proponents of the ASIA syndrome have inappropriately linked infertility to HPV vaccines and have recently suggested antigenic cross-reactivity between SARS-CoV-2 and ovarian follicles. COVID-19 vaccines have also been linked to ASIA and unfounded fear of infertility is a leading cause of vaccine hesitancy. Vaccine hesitancy caused by spurious disorders such as ASIA are likely to harm individuals and delay global vaccination efforts leading to emergence of vaccine and monoclonal antibody-resistant SARS-CoV-2 variants, thereby prolonging the COVID-19 pandemic.
    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Female ; Humans ; Infertility/chemically induced ; Pandemics/prevention & control ; SARS-CoV-2 ; Vaccination/adverse effects ; Vaccination Hesitancy ; Viral Vaccines/adverse effects
    Chemical Substances COVID-19 Vaccines ; Viral Vaccines
    Language English
    Publishing date 2022-07-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2181284-6
    ISSN 1744-8395 ; 1476-0584
    ISSN (online) 1744-8395
    ISSN 1476-0584
    DOI 10.1080/14760584.2022.2089120
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6077: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: An Antisense Oligonucleotide for Hereditary Angioedema.

    Longhurst, Hilary J / Ameratunga, Rohan

    The New England journal of medicine

    2022  Volume 386, Issue 11, Page(s) 1083–1085

    MeSH term(s) Angioedemas, Hereditary/genetics ; Complement C1 Inhibitor Protein ; Humans ; Oligonucleotides/therapeutic use ; Oligonucleotides, Antisense/therapeutic use
    Chemical Substances Complement C1 Inhibitor Protein ; Oligonucleotides ; Oligonucleotides, Antisense
    Language English
    Publishing date 2022-03-16
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe2201729
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.34: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Improved prospects for food allergy prevention.

    Ameratunga, Rohan

    Journal of primary health care

    2018  Volume 9, Issue 4, Page(s) 254–257

    Abstract: Three recent publications from Professor Gideon Lack have fundamentally changed our understanding of how to prevent food allergy. His team has shown that early introduction of allergenic foods may prevent food allergy in most but not all high-risk ... ...

    Abstract Three recent publications from Professor Gideon Lack have fundamentally changed our understanding of how to prevent food allergy. His team has shown that early introduction of allergenic foods may prevent food allergy in most but not all high-risk children. Various allergy and paediatric societies around the world are changing their recommendations based on these three studies. It appears there is a window of opportunity to safely introduce allergenic foods to high-risk children. This has resource implications, as some of these children will need testing and food challenges.
    MeSH term(s) Food Hypersensitivity/prevention & control ; Humans ; Immunoglobulin E/immunology ; Peanut Hypersensitivity/prevention & control ; Primary Prevention/methods ; Risk Factors ; Secondary Prevention/methods ; Tertiary Prevention/methods
    Chemical Substances Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2018-03-12
    Publishing country Australia
    Document type Journal Article
    ISSN 1172-6156
    ISSN (online) 1172-6156
    DOI 10.1071/HC17042
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Assessing Disease Severity in Common Variable Immunodeficiency Disorders (CVID) and CVID-Like Disorders.

    Ameratunga, Rohan

    Frontiers in immunology

    2018  Volume 9, Page(s) 2130

    MeSH term(s) Adult ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Cohort Studies ; Common Variable Immunodeficiency/complications ; Common Variable Immunodeficiency/diagnosis ; Common Variable Immunodeficiency/epidemiology ; Common Variable Immunodeficiency/genetics ; Delayed Diagnosis ; Epistasis, Genetic ; Health Impact Assessment/methods ; Humans ; Mutation ; NF-kappa B p50 Subunit/genetics ; Organ Dysfunction Scores ; Prevalence ; Severity of Illness Index ; Transmembrane Activator and CAML Interactor Protein/genetics
    Chemical Substances Basic Helix-Loop-Helix Transcription Factors ; NF-kappa B p50 Subunit ; NFKB1 protein, human ; TCF3 protein, human ; TNFRSF13B protein, human ; Transmembrane Activator and CAML Interactor Protein
    Language English
    Publishing date 2018-09-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2018.02130
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Initial intravenous immunoglobulin doses should be based on adjusted body weight in obese patients with primary immunodeficiency disorders.

    Ameratunga, Rohan

    Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology

    2017  Volume 13, Page(s) 47

    Abstract: Background: Immunoglobulin therapy plays a critical role in the treatment of immunodeficiency disorders as well as autoimmune and inflammatory conditions. In immunodeficient patients, there has been controversy whether initial loading doses of ... ...

    Abstract Background: Immunoglobulin therapy plays a critical role in the treatment of immunodeficiency disorders as well as autoimmune and inflammatory conditions. In immunodeficient patients, there has been controversy whether initial loading doses of intravenous (IVIG) should be based on actual body weight or a calculated parameter such as adjusted body weight in obese patients.
    Case presentation: I describe a patient with Common Variable Immunodeficiency disorder (CVID) who underwent bariatric surgery for morbid obesity. Her weight decreased by 50% to below her calculated ideal body weight (IBW) while her immunoglobulin requirement fell by approximately 20%. Her steady state serum IgG increased from approximately 7 g/l to 11.7 g/l concomitant with weight loss.
    Conclusions: I present this observation as support for the recommendation that initial loading doses of SCIG/IVIG in immunodeficiency should be based on adjusted body weight (AjBW) and not actual body weight in obese patients. This has important fiscal implications for treating obese patients with immunodeficiency disorders.
    Language English
    Publishing date 2017-12-06
    Publishing country England
    Document type Case Reports
    ZDB-ID 2434973-2
    ISSN 1710-1492 ; 1710-1484
    ISSN (online) 1710-1492
    ISSN 1710-1484
    DOI 10.1186/s13223-017-0220-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6713: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Resolution of extensive vulvovaginal condylomatosis following immunoglobulin replacement in primary immunodeficiency disorders.

    Ameratunga, Rohan V

    The journal of allergy and clinical immunology. In practice

    2017  Volume 6, Issue 3, Page(s) 1053–1055

    MeSH term(s) Adolescent ; Adult ; Agammaglobulinemia/diagnosis ; Agammaglobulinemia/therapy ; Condylomata Acuminata/pathology ; Female ; Genital Diseases, Female/diagnosis ; Genital Diseases, Female/pathology ; Genital Diseases, Female/therapy ; Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18/immunology ; Human papillomavirus 6/physiology ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Immunologic Deficiency Syndromes/diagnosis ; Immunologic Deficiency Syndromes/therapy ; Papillomavirus Infections/diagnosis ; Papillomavirus Infections/therapy ; T-Lymphocytes/pathology ; Treatment Outcome
    Chemical Substances Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18 ; Immunoglobulins, Intravenous
    Language English
    Publishing date 2017-11-14
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2017.10.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 7086: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Editorial: Contemporary challenges in diagnosis and treatment of predominantly antibody deficiency.

    Ameratunga, Rohan / Abolhassani, Hassan / Maglione, Paul J / Edwards, Emily S J

    Frontiers in immunology

    2022  Volume 13, Page(s) 959720

    MeSH term(s) Humans ; IgA Deficiency ; Immunologic Deficiency Syndromes/diagnosis ; Immunologic Deficiency Syndromes/therapy ; Primary Immunodeficiency Diseases
    Language English
    Publishing date 2022-08-15
    Publishing country Switzerland
    Document type Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.959720
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: Phenotypic spectrum in a family with a novel

    Ashby, Louisa / Chan, Lydia / Winterbourn, Christine / Woon, See-Tarn / Keating, Paula / Heller, Raoul / Ameratunga, Rohan / Chua, Ignatius / Hsiao, Kuang-Chih

    Clinical & translational immunology

    2024  Volume 13, Issue 2, Page(s) e1493

    Abstract: Objectives: Dominant-activating (DA) lesions in : Methods: Clinical and immunological information was collated for seven living individuals from the same kindred with : Results: Patient 1 (P1, aged 11, male) has a history of bacterial suppurative ... ...

    Abstract Objectives: Dominant-activating (DA) lesions in
    Methods: Clinical and immunological information was collated for seven living individuals from the same kindred with
    Results: Patient 1 (P1, aged 11, male) has a history of bacterial suppurative otitis media, viral and bacterial cutaneous infections. P1's siblings (P2, P3), mother (P4), maternal aunt (P5) and uncle (P6) have similar infection histories. P1's maternal cousin (P7) presented with Burkitt's lymphoma at age 9. All affected individuals are alive and none has required HSCT to date. They have chronic lymphopenia affecting the CD4
    Conclusion: RAC2
    Language English
    Publishing date 2024-02-26
    Publishing country Australia
    Document type Case Reports
    ZDB-ID 2694482-0
    ISSN 2050-0068
    ISSN 2050-0068
    DOI 10.1002/cti2.1493
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Perspective: Evolving Concepts in the Diagnosis and Understanding of Common Variable Immunodeficiency Disorders (CVID).

    Ameratunga, Rohan / Woon, See-Tarn

    Clinical reviews in allergy & immunology

    2019  Volume 59, Issue 1, Page(s) 109–121

    Abstract: Common variable immunodeficiency disorders (CVID) are the most frequent symptomatic primary immune deficiency in adults. At this time, the causes of these conditions are unknown. Patients with CVID experience immune system failure consequent to late ... ...

    Abstract Common variable immunodeficiency disorders (CVID) are the most frequent symptomatic primary immune deficiency in adults. At this time, the causes of these conditions are unknown. Patients with CVID experience immune system failure consequent to late onset antibody failure. They have increased susceptibility to infections and are also at risk of severe autoimmune and inflammatory disorders as a result of immune dysregulation. An increasing number of monogenic causes as well as a digenic disorder have been described in patients with a CVID phenotype. If a causative mutation is identified, patients are removed from the umbrella diagnosis of CVID and are reclassified as having a CVID-like disorder, resulting from a specific mutation. In non-consanguineous populations, next-generation sequencing (NGS) identifies a genetic cause in approximately 25% of patients with a CVID phenotype. It is six years since we published our diagnostic criteria for CVID. There is ongoing debate about diagnostic criteria, the role of vaccine responses and genetic analysis in the diagnosis of CVID. There have been several recent studies, which have addressed some of these uncertainties. Here we review this new evidence from the perspective of our CVID diagnostic criteria and speculate on future approaches, which may assist in identifying and assessing this group of enigmatic disorders.
    MeSH term(s) Common Variable Immunodeficiency/diagnosis ; Common Variable Immunodeficiency/genetics ; Genetic Association Studies ; Genetic Predisposition to Disease ; High-Throughput Nucleotide Sequencing ; Humans ; Mutation/genetics
    Language English
    Publishing date 2019-11-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1239045-8
    ISSN 1559-0267 ; 1080-0549
    ISSN (online) 1559-0267
    ISSN 1080-0549
    DOI 10.1007/s12016-019-08765-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1844: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: Gluteal subcutaneous atrophy after depot steroid injection for allergic rhinitis.

    Ameratunga, Rohan

    The World Allergy Organization journal

    2012  Volume 5, Issue 11, Page(s) 168–169

    Abstract: Allergic rhinitis is a common and often distressing condition. Currently, treatment with nonsedating antihistamines, topical therapy, and immunotherapy are very effective. Despite this, intramuscular depot steroids are commonly used in clinical ... ...

    Abstract : Allergic rhinitis is a common and often distressing condition. Currently, treatment with nonsedating antihistamines, topical therapy, and immunotherapy are very effective. Despite this, intramuscular depot steroids are commonly used in clinical practice. Here, we present the case of a young woman who developed disfiguring scarring after a depot steroid injection. This case highlights the risks of this form of treatment for allergic rhinitis.
    Language English
    Publishing date 2012-05-15
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2581968-9
    ISSN 1939-4551
    ISSN 1939-4551
    DOI 10.1097/WOX.0b013e3182758d80
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top