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  1. Article ; Online: After PCI and 6 to 18 mo of DAPT, clopidogrel reduced a composite of clinical events vs. aspirin at 6 y.

    Lader, Ellis W

    Annals of internal medicine

    2023  Volume 176, Issue 4, Page(s) JC38

    Abstract: Source citation: Kang J, Park KW, Lee H, et al. ...

    Abstract Source citation: Kang J, Park KW, Lee H, et al.
    MeSH term(s) Humans ; Aspirin/therapeutic use ; Clopidogrel/therapeutic use ; Platelet Aggregation Inhibitors/therapeutic use ; Percutaneous Coronary Intervention ; Treatment Outcome ; Drug Therapy, Combination
    Chemical Substances Aspirin (R16CO5Y76E) ; Clopidogrel (A74586SNO7) ; Platelet Aggregation Inhibitors
    Language English
    Publishing date 2023-04-04
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/J23-0019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: In rheumatic heart disease-associated AF, rivaroxaban increased adverse vascular outcomes vs. VKA at 3 y.

    Lader, Ellis W

    Annals of internal medicine

    2023  Volume 176, Issue 1, Page(s) JC2

    Abstract: Source citation: Connolly SJ, Karthikeyan G, Ntsekhe M, et al. ...

    Abstract Source citation: Connolly SJ, Karthikeyan G, Ntsekhe M, et al.
    MeSH term(s) Humans ; Rivaroxaban/adverse effects ; Anticoagulants/adverse effects ; Rheumatic Heart Disease/complications ; Rheumatic Heart Disease/chemically induced ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Stroke/prevention & control ; Stroke/chemically induced ; Factor Xa Inhibitors/adverse effects ; Vitamin K ; Treatment Outcome
    Chemical Substances Rivaroxaban (9NDF7JZ4M3) ; Anticoagulants ; Factor Xa Inhibitors ; Vitamin K (12001-79-5)
    Language English
    Publishing date 2023-01-03
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/J22-0102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Type 2 Myocardial Infarction: Trying to Fit a Square Peg Into a Round Hole?

    Lader, Ellis W

    The American journal of cardiology

    2019  Volume 124, Issue 3, Page(s) 460–461

    MeSH term(s) Biomarkers/blood ; Cardiology/standards ; Humans ; Myocardial Infarction/classification ; Myocardial Infarction/diagnosis ; Terminology as Topic ; Troponin/blood
    Chemical Substances Biomarkers ; Troponin
    Language English
    Publishing date 2019-05-09
    Publishing country United States
    Document type Letter
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2019.04.040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Field guide to the arrhythmias

    Lader, Ellis W

    2013  

    Author's details Ellis W. Lader, MD, FACC, FAHA, FACP, Mid Valley Cardiology, adjunct assistant professor of clinical medicine, New York University School of Medicine, New York, NY, USA
    MeSH term(s) Arrhythmias, Cardiac ; Problems and Exercises
    Language English
    Size 164 pages :, illustrations ;, 22 cm
    Document type Book
    ISBN 9781118386095 ; 1118386094
    Database Catalogue of the US National Library of Medicine (NLM)

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  5. Article: Acronym mania.

    Lader, Ellis W

    Lancet (London, England)

    2002  Volume 360, Issue 9332, Page(s) 576

    MeSH term(s) Abbreviations as Topic
    Language English
    Publishing date 2002-08-17
    Publishing country England
    Document type Letter
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0140-6736 ; 0023-7507
    ISSN (online) 1474-547X
    ISSN 0140-6736 ; 0023-7507
    DOI 10.1016/S0140-6736(02)09737-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: How to join a clinical trial.

    Lader, Ellis W / Cannon, Christopher P

    Critical pathways in cardiology

    2005  Volume 4, Issue 1, Page(s) 26–29

    Language English
    Publishing date 2005-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2079676-6
    ISSN 1535-2811 ; 1535-282X
    ISSN (online) 1535-2811
    ISSN 1535-282X
    DOI 10.1097/01.hpc.0000153394.65699.23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The clinician as investigator: participating in clinical trials in the practice setting: Appendix 2: statistical concepts in study design and analysis.

    Lader, Ellis W / Cannon, Christopher P / Ohman, E Magnus / Newby, L Kristin / Sulmasy, Daniel P / Barst, Robyn J / Fair, Joan M / Flather, Marcus / Freedman, Jane E / Frye, Robert L / Hand, Mary M / Jesse, Robert L / Van de Werf, Frans / Costa, Fernando

    Circulation

    2004  Volume 109, Issue 21, Page(s) e305–7

    MeSH term(s) Biomarkers ; Clinical Medicine ; Clinical Trials as Topic/methods ; Clinical Trials as Topic/standards ; Clinical Trials as Topic/statistics & numerical data ; Endpoint Determination/statistics & numerical data ; Evidence-Based Medicine ; Humans ; Probability ; Randomized Controlled Trials as Topic/methods ; Randomized Controlled Trials as Topic/standards ; Randomized Controlled Trials as Topic/statistics & numerical data ; Regression Analysis ; Research Design/standards ; Research Design/statistics & numerical data ; Research Personnel ; Risk ; Sample Size ; Survival Analysis
    Chemical Substances Biomarkers
    Language English
    Publishing date 2004-06-01
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/01.CIR.0000129020.43304.A7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The clinician as investigator: participating in clinical trials in the practice setting: Appendix 1: fundamentals of study design.

    Lader, Ellis W / Cannon, Christopher P / Ohman, E Magnus / Newby, L Kristin / Sulmasy, Daniel P / Barst, Robyn J / Fair, Joan M / Flather, Marcus / Freedman, Jane E / Frye, Robert L / Hand, Mary M / Jesse, Robert L / Van de Werf, Frans / Costa, Fernando

    Circulation

    2004  Volume 109, Issue 21, Page(s) e302–4

    MeSH term(s) Biomarkers ; Clinical Medicine ; Clinical Trials as Topic/classification ; Clinical Trials as Topic/methods ; Clinical Trials as Topic/standards ; Clinical Trials as Topic/statistics & numerical data ; Double-Blind Method ; Endpoint Determination ; Evidence-Based Medicine ; Follow-Up Studies ; Humans ; Randomized Controlled Trials as Topic/methods ; Randomized Controlled Trials as Topic/standards ; Randomized Controlled Trials as Topic/statistics & numerical data ; Registries ; Research Design/standards ; Research Personnel ; Sample Size ; Single-Blind Method
    Chemical Substances Biomarkers
    Language English
    Publishing date 2004-06-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/01.CIR.0000128807.57602.61
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The clinician as investigator: participating in clinical trials in the practice setting.

    Lader, Ellis W / Cannon, Christopher P / Ohman, E Magnus / Newby, L Kristin / Sulmasy, Daniel P / Barst, Robyn J / Fair, Joan M / Flather, Marcus / Freedman, Jane E / Frye, Robert L / Hand, Mary M / Jesse, Robert L / Van de Werf, Frans / Costa, Fernando

    Circulation

    2004  Volume 109, Issue 21, Page(s) 2672–2679

    Abstract: The rapid development of new drugs, therapies, and devices has created a dramatic increase in the number of trials needed to properly evaluate them. The majority of patients treated today, many of whom could be eligible for participation in these studies, ...

    Abstract The rapid development of new drugs, therapies, and devices has created a dramatic increase in the number of trials needed to properly evaluate them. The majority of patients treated today, many of whom could be eligible for participation in these studies, are seen in community hospitals and medical practices that are not affiliated with an academic medical center. Thus, there is a demonstrable need for physicians in private practice to enlist as investigators in these trials. This article is intended to encourage those physicians by describing the need and providing the rationale for their participation. It covers basic requirements for participating in clinical trials and outlines ethical, regulatory, financial, and other logistical issues of importance for the potential investigator and provides an algorithm for selecting a study for participation. Finally, the appendices review basic elements of study design and statistical principles, which may be of interest to a potential investigator.
    MeSH term(s) Choice Behavior ; Clinical Medicine/legislation & jurisprudence ; Clinical Medicine/manpower ; Clinical Medicine/organization & administration ; Clinical Trials as Topic/economics ; Clinical Trials as Topic/legislation & jurisprudence ; Evidence-Based Medicine ; Humans ; Physician's Role ; Private Practice ; Randomized Controlled Trials as Topic ; Research Personnel/legislation & jurisprudence ; Research Personnel/statistics & numerical data ; Research Personnel/supply & distribution
    Language English
    Publishing date 2004-06-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/01.CIR.0000128702.16441.75
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Impact of invasive management versus noninvasive management on functional status and quality of life following non-Q-wave myocardial infarction: a randomized clinical trial.

    Eisenberg, Mark J / Teng, Flora F / Chaudhry, Muhammad R / Ortiz, Jose / Sobkowski, Wojciech / Ebrahim, Iftikhar / Saligrama, Ramesh S / Serio, Kerala / Lader, Ellis / Pilote, Louise

    American heart journal

    2005  Volume 149, Issue 5, Page(s) 813–819

    Abstract: Background: Multiple studies have examined whether clinical outcomes are improved by invasive management following non-Q-wave myocardial infarction (NQWMI). However, it remains unclear whether functional status and quality of life are affected by an ... ...

    Abstract Background: Multiple studies have examined whether clinical outcomes are improved by invasive management following non-Q-wave myocardial infarction (NQWMI). However, it remains unclear whether functional status and quality of life are affected by an invasive strategy.
    Methods: Following NQWMI, we randomized 88 patients to invasive management vs noninvasive management. The primary end point was functional status assessed at 12 months using maximal endurance exercise treadmill testing measured in metabolic equivalents. Secondary end points included changes in scores between baseline and 12 months on the Duke Activity Status Index, the Seattle Angina Questionnaire, and the Medical Outcomes Study 36-Item Short-Form Survey.
    Results: Of the 42 patients in the invasive arm, 83% underwent initial angiography. Of the 46 patients in the noninvasive arm, 91% underwent initial stress testing. Inhospital and 12-month revascularization rates were similar in the 2 arms (24% vs 22%, P > or = .99; 31% vs 30%, P > or = .99). Maximal endurance exercise treadmill testing was also similar at 12 months (7.8 vs 6.7 metabolic equivalents, P = .24). Patients in the invasive arm showed improved functional status by mean difference in their Duke Activity Status Index scores (4.3 vs -3.5, P = .04). Improvements in angina-specific quality of life for patients in the invasive arm were demonstrated by the Seattle Angina Questionnaire measures of anginal stability (21.6 vs -5.3, P = .02), anginal frequency (22.9 vs 2.3, P = .02), treatment satisfaction (11.2 vs -10.3, P = .02), and disease perception (24.7% vs 10.9%, P = .07).
    Conclusions: Compared with patients undergoing noninvasive management of NQWMI, patients undergoing invasive management have some measures indicative of improved functional status.
    MeSH term(s) Coronary Angiography ; Electrocardiography ; Exercise Test ; Female ; Humans ; Male ; Middle Aged ; Myocardial Infarction/diagnosis ; Myocardial Infarction/physiopathology ; Myocardial Infarction/therapy ; Quality of Life
    Language English
    Publishing date 2005-05
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 80026-0
    ISSN 1097-6744 ; 0002-8703
    ISSN (online) 1097-6744
    ISSN 0002-8703
    DOI 10.1016/j.ahj.2004.08.040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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