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  1. Article ; Online: Takuo Aoyagi, inventor of pulse oximetry

    Gianfranco Cervellin

    Emergency Care Journal, Vol 19, Iss

    the great scientist passed away three years ago, in the middle of the first wave of COVID-19 pandemic

    2023  Volume 1

    Abstract: Antoine-Laurent de Lavoisier (1743-1794), the recognized father of modern chemistry, was the discoverer of both oxygen and hydrogen, as well as the first scientist to understand the importance of oxygen in animal respiration. Following his discoveries, ... ...

    Abstract Antoine-Laurent de Lavoisier (1743-1794), the recognized father of modern chemistry, was the discoverer of both oxygen and hydrogen, as well as the first scientist to understand the importance of oxygen in animal respiration. Following his discoveries, researchers have tried to measure oxygenation of both blood and tissues for the next two centuries. [.]
    Keywords pulse oximeter ; pulse oximetry ; oxygen saturation ; Takuo Aoyagi ; COVID-19 ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher PAGEPress Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Updates on Rabies virus disease: is evolution toward "Zombie virus" a tangible threat?

    Lippi, Giuseppe / Cervellin, Gianfranco

    Acta bio-medica : Atenei Parmensis

    2021  Volume 92, Issue 1, Page(s) e2021045

    Abstract: Human rabies disease is caused by Rabies Lyssavirus, a virus belonging to Rhabdoviridae family. The more frequent means of contagion is through bites of infected mammals (especially dogs, but also bats, skunks, foxes, raccoons and wolves) which, ... ...

    Abstract Human rabies disease is caused by Rabies Lyssavirus, a virus belonging to Rhabdoviridae family. The more frequent means of contagion is through bites of infected mammals (especially dogs, but also bats, skunks, foxes, raccoons and wolves) which, lacerating the skin, directly inoculate virus-laden saliva into the underlying tissues. Immediately after inoculation, the Rabies virus enters neural axons and migrates along peripheral nerves towards the central nervous system, where it preferentially localizes and injuries neurons of brainstem, thalamus, basal ganglia and spinal cord. After an initial prodromic period, the infection evolves towards two distinct clinical entities, encompassing encephalitic (i.e., "furious"; ~70-80% of cases) and paralytic (i.e., "dumb"; ~20-30% of cases) rabies disease. The former subtype is characterized by fever, hyperactivity, hydrophobia, hypersalivation, deteriorated consciousness, phobic or inspiratory spasms, autonomic stimulation, irritability, up to aggressive behaviours. The current worldwide incidence and mortality of rabies disease are estimated at 0.175×100,000 and 0.153×100,000, respectively. The incidence is higher in Africa and South-East Asia, nearly double in men than in women, with a higher peak in childhood. Mortality remains as high as ~90%. Since patients with encephalitic rabies remind the traditional image of "Zombies", we need to think out-of-the-box, in that apocalyptic epidemics of mutated Rabies virus may be seen as an imaginable menace for mankind. This would be theoretically possible by either natural or artificial virus engineering, producing viral strains characterized by facilitated human-to-human transmission, faster incubation, enhanced neurotoxicity and predisposition towards developing highly aggressive behaviours.
    MeSH term(s) Africa ; Animals ; Dogs ; Humans ; Mephitidae ; Rabies/epidemiology ; Rabies virus ; Raccoons
    Language English
    Publishing date 2021-02-04
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2114240-3
    ISSN 2531-6745 ; 0392-4203
    ISSN (online) 2531-6745
    ISSN 0392-4203
    DOI 10.23750/abm.v92i1.9153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cardiac troponin T versus cardiac troponin I for mortality risk prediction: Is one biomarker better than the other?

    Lippi, Giuseppe / Cervellin, Gianfranco

    Clinical biochemistry

    2020  Volume 78, Page(s) 40–41

    MeSH term(s) Biomarkers ; Chest Pain ; Humans ; Prognosis ; Troponin I ; Troponin T
    Chemical Substances Biomarkers ; Troponin I ; Troponin T
    Language English
    Publishing date 2020-02-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 390372-2
    ISSN 1873-2933 ; 0009-9120
    ISSN (online) 1873-2933
    ISSN 0009-9120
    DOI 10.1016/j.clinbiochem.2020.02.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Primary Hyperparathyroidism overlapping with Multiple Sclerosis: a catastrophic marriage.

    Cervellin, Gianfranco / Brianti, Vincenzo / Viani, Lorenzo / Feldmann, Lucia / Rastelli, Gianni

    Acta bio-medica : Atenei Parmensis

    2023  Volume 94, Issue S1, Page(s) e2023128

    Abstract: Primary hyperparathyroidism (PHPT) often leads to neurological or psychiatric disorders, thus mimicking different diseases. Here we present a 77-years old man visited in the Emergency Department complaining for fatigue, multiple falls, nausea, anorexia, ... ...

    Abstract Primary hyperparathyroidism (PHPT) often leads to neurological or psychiatric disorders, thus mimicking different diseases. Here we present a 77-years old man visited in the Emergency Department complaining for fatigue, multiple falls, nausea, anorexia, and constipation. Symptoms were rapidly worsening, and on admission he appeared sleepy, responsive to verbal stimulus, disoriented, dehydrated, unable to maintain upright position. He suffered from mild, relapsing and remitting Multiple Sclerosis (MS) since the age of 45, at that moment not requiring treatment. The laboratory tests displayed severe hypercalcemia (16.8 mg/dL), slightly decreased level of serum phosphorus (2.8 mg/dL), very high levels of parathyroid hormone (PTH) (508 pg/mL). A parathyroid mass (35x21x32 mm) in left paratracheal position was found with Computed Tomography (CT) of the neck. After correcting hypercalcemia, he was operated on day 18, thus confirming the parathyroid adenoma, that was successfully removed. One month later, the patient was completely well, and able to walk without any help, like three months before. The lab tests' values obtained during the control visit showed complete normalization of calcium-phosphate metabolism. Diabetes, too, was going better, allowing a reduction in metformin dosage. At the best of our knowledge this is the first described case of a clinically significant overlapping between symptoms due to a long-lasting mild MS and an unrecognized, severe, PHPT. This case underlines the importance of a thorough metabolic evaluation of each patient presenting worsening of his neuromuscular and/or neuropsychiatric condition, even when previously known to be affected by a defined neurologic or psychiatric disease.
    MeSH term(s) Male ; Humans ; Aged ; Hyperparathyroidism, Primary/complications ; Hyperparathyroidism, Primary/diagnosis ; Hypercalcemia/etiology ; Marriage ; Multiple Sclerosis/complications ; Neoplasm Recurrence, Local
    Language English
    Publishing date 2023-07-24
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2114240-3
    ISSN 2531-6745 ; 0392-4203
    ISSN (online) 2531-6745
    ISSN 0392-4203
    DOI 10.23750/abm.v94iS1.14446
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Can presepsin be used for screening invasive fungal infections?

    Lippi, Giuseppe / Cervellin, Gianfranco

    Annals of translational medicine

    2019  Volume 7, Issue 5, Page(s) 87

    Language English
    Publishing date 2019-03-21
    Publishing country China
    Document type Editorial
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2019.01.40
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Is digital epidemiology reliable?-insight from updated cancer statistics.

    Lippi, Giuseppe / Cervellin, Gianfranco

    Annals of translational medicine

    2019  Volume 7, Issue 1, Page(s) 15

    Language English
    Publishing date 2019-02-06
    Publishing country China
    Document type Editorial
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2018.11.55
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Clinical Interpretation of High-Sensitivity Troponin Testing.

    Lippi, Giuseppe / Cervellin, Gianfranco

    JAMA internal medicine

    2019  Volume 179, Issue 5, Page(s) 725–726

    MeSH term(s) Acute Coronary Syndrome ; Humans ; Medical Overuse ; Troponin I
    Chemical Substances Troponin I
    Language English
    Publishing date 2019-05-06
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2019.0371
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  8. Article ; Online: Acute chest pain and dyspnoea as clinical presentation of primary membranous nephropathy. A case report and literature review.

    Poggiali, Erika / Borio, Giorgia / Magnacavallo, Andrea / Vercelli, Andrea / Cervellin, Gianfranco

    Acta bio-medica : Atenei Parmensis

    2022  Volume 93, Issue 5, Page(s) e2022216

    Abstract: Membranous nephropathy (MN) is the commonest cause of nephrotic syndrome (NS) in adult male patients worldwide. Most of the cases (80%) are idiopathic (primary MN, PMN), whereas about 20% are associated with autoimmune diseases, malignancies or exposures ...

    Abstract Membranous nephropathy (MN) is the commonest cause of nephrotic syndrome (NS) in adult male patients worldwide. Most of the cases (80%) are idiopathic (primary MN, PMN), whereas about 20% are associated with autoimmune diseases, malignancies or exposures (secondary MN). PMN is a kidney-specific autoimmune glomerular disease mediated by antibodies to the M-type phospholipase A2 receptor (anti-PLA2R) (85%), thrombospondin type 1 domain containing 7A (THSD7A) (3-5%), or by other still unidentified mechanisms (10%). Most of the patients with PMN present with NS (80%). Clinical course of PMN is characterised by spontaneous remissions (40%) and relapses (15-30%). One third develop end-stage renal disease (ESRD) within 5 to 15 years from the onset. Anti-PLA2R/THSD7A antibodies levels correlate with proteinuria, clinical course, and outcomes. The treatment still remains matter of debate. Hypertension, proteinuria, and hyperlipidaemia must be treated in all patients. Immunosuppressive therapy is indicated in patients with elevated anti-PLA2R/THSD7A levels and proteinuria >3.5 g/d at diagnosis. With proper management, only 10% or less will develop ESRD over the subsequent 10 years. Here we report a case of a 34-year-old male patient with a ten-year history of asymptomatic PMN, treated with ACE-inhibitors, who presented to our emergency room for acute chest pain and exertional dyspnoea due to ESRD that required urgent dialysis. (www.actabiomedica.it).
    MeSH term(s) Adult ; Humans ; Male ; Receptors, Phospholipase A2 ; Glomerulonephritis, Membranous/complications ; Glomerulonephritis, Membranous/diagnosis ; Thrombospondins ; Autoantibodies ; Neoplasm Recurrence, Local ; Proteinuria ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/therapy ; Chest Pain/etiology ; Dyspnea/etiology
    Chemical Substances Receptors, Phospholipase A2 ; Thrombospondins ; Autoantibodies
    Language English
    Publishing date 2022-10-26
    Publishing country Italy
    Document type Review ; Case Reports ; Journal Article
    ZDB-ID 2114240-3
    ISSN 2531-6745 ; 0392-4203
    ISSN (online) 2531-6745
    ISSN 0392-4203
    DOI 10.23750/abm.v93i5.12782
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Salernitan Medical School or Langobardic Medical School?

    Longobardi, Ugo / Mitaritonno, Michele / Cervellin, Gianfranco

    Acta bio-medica : Atenei Parmensis

    2021  Volume 92, Issue 2, Page(s) e2021015

    Abstract: Already famous since the high Middle Ages, the Salernitan Medical School reached its whole scientific role between the 11th and 12th century, declining later due to the rising of modern universities. Information on the earliest period of the School is ... ...

    Abstract Already famous since the high Middle Ages, the Salernitan Medical School reached its whole scientific role between the 11th and 12th century, declining later due to the rising of modern universities. Information on the earliest period of the School is very poor but, starting from the 10th century, we know that Salernitan physicians were widely recognized as researchers and healers. This paper is focused on the heavy role recognized to the Langobards (first) and Normans (later) on development of the Salernitan Medical School. A special role must be recognized to Alfanus I, Gariopontus and Trotula de Ruggiero: they left memories on their enterprises and many manuscripts of great relevance for the development of Middle Ages and Renaissance Medicine. Their multicultural experience dragged the Salernitan School to become the greatest expression of medical science of its age. This role was expressed in the "Regimen Sanitatis Salernitanum" or "Flos Medicinae Salerni", a book that resumes the highest knowledges on general hygiene, dietetics, physiotherapy, comparative anatomy and surgery. The book had a tremendous success, having more than 300 editions in many languages up to 1846. It was an essential reference for western medical literature up to Renaissance. Furthermore, Langobards took care of health laws, mainly in the Rotari edict, which included laws on medical practice and on the physicians' role. (www.actabiomedica.it).
    MeSH term(s) Humans ; Hygiene ; Language ; Physician's Role ; Physicians ; Schools, Medical
    Language English
    Publishing date 2021-05-12
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2114240-3
    ISSN 2531-6745 ; 0392-4203
    ISSN (online) 2531-6745
    ISSN 0392-4203
    DOI 10.23750/abm.v92i2.9109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Birth of a new Journal section on Emergency Medicine.

    Cervellin, Gianfranco / Meschi, Tiziana

    Acta bio-medica : Atenei Parmensis

    2018  Volume 88, Issue 4, Page(s) 391–392

    Abstract: Not available. ...

    Abstract Not available.
    MeSH term(s) Emergency Medicine ; Emergency Service, Hospital ; Humans ; Periodicals as Topic
    Language English
    Publishing date 2018-01-16
    Publishing country Italy
    Document type Editorial
    ZDB-ID 2114240-3
    ISSN 0392-4203
    ISSN 0392-4203
    DOI 10.23750/abm.v88i4.7001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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