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  1. Article ; Online: Linear mixed-effect modeling of organ of Corti vibratory tuning curves.

    Oghalai, John S

    Hearing research

    2023  Volume 435, Page(s) 108820

    Abstract: Optical coherence tomography has become the most popular approach to experimental measures of sound-induced vibrations within the mammalian cochlea. Because it is relatively easy to use and works in the unopened cochlea, the measurement of vibratory ... ...

    Abstract Optical coherence tomography has become the most popular approach to experimental measures of sound-induced vibrations within the mammalian cochlea. Because it is relatively easy to use and works in the unopened cochlea, the measurement of vibratory tuning curves has become highly reliable, and averaging data from multiple animals in different experimental cohorts is now possible. Here I tested a modern statistical approach to compare cohorts for differences in the magnitude and phase of vibration. A linear mixed-effect approach with first, second, third, and fourth-order models to fit the data was tested. The third-order model best fit both the magnitude and phase data without having terms that did not contribute substantively to improving the R
    MeSH term(s) Animals ; Mice ; Vibration ; Acoustic Stimulation/methods ; Cochlea ; Sound ; Mammals ; Organ of Corti
    Language English
    Publishing date 2023-06-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282629-x
    ISSN 1878-5891 ; 0378-5955
    ISSN (online) 1878-5891
    ISSN 0378-5955
    DOI 10.1016/j.heares.2023.108820
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1467: Show issues Location:
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  2. Article ; Online: Rules for Successful Leadership in Otolaryngology-Head and Neck Surgery.

    Oghalai, John S

    The Laryngoscope

    2022  Volume 132, Issue 8, Page(s) 1503–1504

    MeSH term(s) Head/surgery ; Humans ; Leadership ; Neck/surgery ; Nose ; Otolaryngology
    Language English
    Publishing date 2022-02-11
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.30052
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  3. Book: Atlas of neurotologic and lateral sull base surgery

    Oghalai, John S. / Driscoll, Colin L. W.

    2015  

    Author's details John S. Oghalai ; Colin L. W. Driscoll
    Keywords Temporal bone surgery ; Facial nerve surgery ; Skull base surgery ; Fossa approaches ; Cochlear implantation ; Otoneurologie ; Schädelbasis ; Schädelchirurgie ; Operationstechnik
    Subject Operative Technik ; Chirurgisches Verfahren ; Operationsverfahren ; Schädel ; Basis cranii ; Schädelgrund ; Neurootologie
    Language English
    Size X, 325 S. : zahlr. Ill., 279 mm x 210 mm
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT018773483
    ISBN 978-3-662-46693-3 ; 978-3-662-46694-0 ; 3-662-46693-7 ; 3-662-46694-5
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2015 A 3454 available for loan (reading room) Lesesaal EG

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  4. Article ; Online: Editorial Comment on How COVID-19 is Affecting Otolaryngology-Head and Neck Surgery.

    Oghalai, John S

    The Laryngoscope

    2020  Volume 130, Issue 11, Page(s) 2686–2687

    Abstract: Level of evidence: 5 Laryngoscope, 130:2686-2687, 2020. ...

    Abstract Level of evidence: 5 Laryngoscope, 130:2686-2687, 2020.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Cochlear Implants ; Coronavirus Infections/epidemiology ; Humans ; Mastoid ; Otolaryngology ; Pandemics ; Personal Protective Equipment ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-22
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.29032
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  5. Article ; Online: On the Tonotopy of the Low-Frequency Region of the Cochlea.

    Recio-Spinoso, Alberto / Dong, Wei / Oghalai, John S

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2023  Volume 43, Issue 28, Page(s) 5172–5179

    Abstract: It is generally assumed that frequency selectivity varies along the cochlea. For example, at the base of the cochlea, which is a region sensitive to high-frequency sounds, the best frequency of a cochlear location increases toward the most basal end, ... ...

    Abstract It is generally assumed that frequency selectivity varies along the cochlea. For example, at the base of the cochlea, which is a region sensitive to high-frequency sounds, the best frequency of a cochlear location increases toward the most basal end, that is, near the stapes. Response phases also vary along cochlear locations. At any given frequency, there is a decrease in phase lag toward the stapes. This tonotopic arrangement in the cochlea was originally described by Georg von Békésy in a seminal series of experiments on human cadavers and has been confirmed in more recent works on live laboratory animals. Nonetheless, our knowledge of tonotopy at the apex of the cochlea remains incomplete in animals with low-frequency hearing, which is relevant to human speech. The results of our experiments on guinea pig, gerbil, and chinchilla cochleas, regardless of the sex of the animal, show that responses to sound differ at locations across the apex in a pattern consistent with previous studies of the base of the cochlea.
    MeSH term(s) Animals ; Humans ; Guinea Pigs ; Cochlea/physiology ; Hearing/physiology ; Sound ; Gerbillinae ; Chinchilla
    Language English
    Publishing date 2023-05-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.0249-23.2023
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  6. Article ; Online: What makes a great surgeon?

    Oghalai, John S

    The Laryngoscope

    2018  Volume 129, Issue 3, Page(s) 533–534

    MeSH term(s) General Surgery/standards
    Language English
    Publishing date 2018-12-24
    Publishing country United States
    Document type Editorial
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.27774
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  8. Article ; Online: Editorial Comment on How COVID ‐19 is Affecting Otolaryngology–Head and Neck Surgery

    Oghalai, John S.

    The Laryngoscope

    2020  Volume 130, Issue 11, Page(s) 2686–2687

    Keywords Otorhinolaryngology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.29032
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  9. Article ; Online: Review of blast noise and the auditory system.

    Paik, Connie B / Pei, Michelle / Oghalai, John S

    Hearing research

    2022  Volume 425, Page(s) 108459

    Abstract: The auditory system is particularly vulnerable to blast injury due to the ear's role as a highly sensitive pressure transducer. Over the past several decades, studies have used a variety of animal models and experimental procedures to recreate blast- ... ...

    Abstract The auditory system is particularly vulnerable to blast injury due to the ear's role as a highly sensitive pressure transducer. Over the past several decades, studies have used a variety of animal models and experimental procedures to recreate blast-induced acoustic trauma. Given the developing nature of this field and our incomplete understanding of molecular mechanisms underlying blast-related auditory disturbances, an updated discussion about these studies is warranted. Here, we comprehensively review well-established blast-related auditory pathology including tympanic membrane perforation and hair cell loss. In addition, we discuss important mechanistic studies that aim to bridge gaps in our current understanding of the molecular and microstructural events underlying blast-induced cochlear, auditory nerve, brainstem, and central auditory system damage. Key findings from the recent literature include the association between endolymphatic hydrops and cochlear synaptic loss, blast-induced neuroinflammatory markers in the peripheral and central auditory system, and therapeutic approaches targeting biochemical markers of blast injury. We conclude that blast is an extreme form of noise exposure. Blast waves produce cochlear damage that appears similar to, but more extreme than, the standard noise exposure protocols used in auditory research. However, experimental variations in studies of blast-induced acoustic trauma make it challenging to compare and interpret data across studies.
    MeSH term(s) Animals ; Auditory Threshold ; Biomarkers ; Blast Injuries/etiology ; Blast Injuries/pathology ; Cochlea/pathology ; Evoked Potentials, Auditory, Brain Stem/physiology ; Hearing Loss, Noise-Induced/etiology ; Hearing Loss, Noise-Induced/pathology
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-02-08
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 282629-x
    ISSN 1878-5891 ; 0378-5955
    ISSN (online) 1878-5891
    ISSN 0378-5955
    DOI 10.1016/j.heares.2022.108459
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    Zs.A 1467: Show issues Location:
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  10. Article ; Online: In Vivo Cochlear imaging provides a tool to study endolymphatic hydrops.

    Badash, Ido / Applegate, Brian E / Oghalai, John S

    Journal of vestibular research : equilibrium & orientation

    2021  Volume 31, Issue 4, Page(s) 269–276

    Abstract: Exposure to noise trauma, such as that from improvised explosive devices, can lead to sensorineural hearing loss and a reduced quality of life. In order to elucidate the mechanisms underlying noise-induced hearing loss, we have adapted optical coherence ... ...

    Abstract Exposure to noise trauma, such as that from improvised explosive devices, can lead to sensorineural hearing loss and a reduced quality of life. In order to elucidate the mechanisms underlying noise-induced hearing loss, we have adapted optical coherence tomography (OCT) for real-time cochlear visualization in live mice after blast exposure. We demonstrated that endolymphatic hydrops develops following blast injury, and that this phenomenon may be associated with glutamate excitotoxicity and cochlear synaptopathy. Additionally, osmotic stabilization of endolymphatic hydrops partially rescues cochlear synapses after blast trauma. OCT is thus a valuable research tool for investigating the mechanisms underlying acoustic trauma and dynamic changes in endolymph volume. It may also help with the diagnosis and treatment of human hearing loss and/or vertigo in the near future.
    MeSH term(s) Animals ; Endolymphatic Hydrops/diagnostic imaging ; Hearing Loss, Sensorineural/diagnostic imaging ; Humans ; Mice ; Quality of Life ; Vertigo
    Language English
    Publishing date 2021-01-22
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1051840-x
    ISSN 1878-6464 ; 0957-4271
    ISSN (online) 1878-6464
    ISSN 0957-4271
    DOI 10.3233/VES-200718
    Database MEDical Literature Analysis and Retrieval System OnLINE

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