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  1. Article ; Online: The combination of bromelain and curcumin as an immune-boosting nutraceutical in the prevention of severe COVID-19.

    Kritis, Panagiotis / Karampela, Irene / Kokoris, Styliani / Dalamaga, Maria

    Metabolism open

    2020  Volume 8, Page(s) 100066

    Abstract: The coronavirus disease 2019 (COVID-19) pandemic is still ongoing, while no treatment has been proven effective. COVID-19 pathophysiology involves the activation of three main pathways: the inflammatory, the coagulation and the bradykinin cascades. Here, ...

    Abstract The coronavirus disease 2019 (COVID-19) pandemic is still ongoing, while no treatment has been proven effective. COVID-19 pathophysiology involves the activation of three main pathways: the inflammatory, the coagulation and the bradykinin cascades. Here, we highlight for the first time the joint potential therapeutic role of bromelain and curcumin, two well-known nutraceuticals, in the prevention of severe COVID-19. Bromelain (a cysteine protease isolated from the pineapple stem) and curcumin (a natural phenol found in turmeric) exert important immunomodulatory actions interfering in the crucial steps of COVID-19 pathophysiology. Their anti-inflammatory properties include inhibition of transcription factors and subsequent downregulation of proinflammatory mediators. They also present fibrinolytic and anticoagulant properties. Additionally, bromelain inhibits cyclooxygenase and modulates prostaglandins and thromboxane, affecting both inflammation and coagulation, and also hydrolyzes bradykinin. Interestingly, curcumin has been shown in
    Keywords covid19
    Language English
    Publishing date 2020-11-13
    Publishing country England
    Document type Journal Article
    ISSN 2589-9368
    ISSN (online) 2589-9368
    DOI 10.1016/j.metop.2020.100066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The combination of bromelain and curcumin as an immune-boosting nutraceutical in the prevention of severe COVID-19

    Kritis, Panagiotis / Karampela, Irene / Kokoris, Styliani / Dalamaga, Maria

    Metabolism Open

    2020  , Page(s) 100066

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2589-9368
    DOI 10.1016/j.metop.2020.100066
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

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  3. Article: The combination of bromelain and curcumin as an immune-boosting nutraceutical in the prevention of severe COVID-19

    Kritis, Panagiotis / Karampela, Irene / Kokoris, Styliani / Dalamaga, Maria

    Metabol Open

    Abstract: The coronavirus disease 2019 (COVID-19) pandemic is still ongoing, while no treatment has been proved effective. COVID-19 pathophysiology involves the activation of three main pathways: the inflammatory, the coagulation and the bradykinin cascades. Here, ...

    Abstract The coronavirus disease 2019 (COVID-19) pandemic is still ongoing, while no treatment has been proved effective. COVID-19 pathophysiology involves the activation of three main pathways: the inflammatory, the coagulation and the bradykinin cascades. Here, we highlight for the first time the joint potential therapeutic role of bromelain and curcumin, two well-known nutraceuticals, in the prevention of severe COVID-19. Bromelain (a cysteine protease isolated from the pineapple stem) and curcumin (a natural phenol found in turmeric) exert important immunomodulatory actions interfering in the crucial steps of COVID-19 pathophysiology. Their anti-inflammatory properties include inhibition of transcription factors and subsequent downregulation of proinflammatory mediators. They also present fibrinolytic and anticoagulant properties. Additionally, bromelain inhibits cyclooxygenase and modulates prostaglandins and thromboxane, affecting both inflammation and coagulation, and also hydrolyzes bradykinin. Interestingly, curcumin has been shown in in silico studies to prevent entry of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into cells as well as viral replication, while a recent experimental study has demonstrated that bromelain may also inhibit viral entry into cells. Notably, bromelain substantially increases the absorption of curcumin after oral administration. To the best of our knowledge, this is the first report highlighting the significance of bromelain and, most importantly, the potential preventive value of the synergistic effects of bromelain and curcumin against severe COVID-19.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #922096
    Database COVID19

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  4. Article: Atomic Force Microscope Nanoindentation Analysis of Diffuse Astrocytic Tumor Elasticity: Relation with Tumor Histopathology.

    Tsitlakidis, Abraham / Tsingotjidou, Anastasia S / Kritis, Aristeidis / Cheva, Angeliki / Selviaridis, Panagiotis / Aifantis, Elias C / Foroglou, Nicolas

    Cancers

    2021  Volume 13, Issue 18

    Abstract: This study aims to investigate the influence of isocitrate dehydrogenase gene family (IDH) mutations, World Health Organization (WHO) grade, and mechanical preconditioning on glioma and adjacent brain elasticity through standard monotonic and repetitive ... ...

    Abstract This study aims to investigate the influence of isocitrate dehydrogenase gene family (IDH) mutations, World Health Organization (WHO) grade, and mechanical preconditioning on glioma and adjacent brain elasticity through standard monotonic and repetitive atomic force microscope (AFM) nanoindentation. The elastic modulus was measured ex vivo on fresh tissue specimens acquired during craniotomy from the tumor and the peritumoral white matter of 16 diffuse glioma patients. Linear mixed-effects models examined the impact of tumor traits and preconditioning on tissue elasticity. Tissues from IDH-mutant cases were stiffer than those from IDH-wildtype ones among anaplastic astrocytoma patients (
    Language English
    Publishing date 2021-09-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13184539
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Mechanical properties of human glioma.

    Tsitlakidis, Abraham / Aifantis, Elias C / Kritis, Aristeidis / Tsingotjidou, Anastasia S / Cheva, Angeliki / Selviaridis, Panagiotis / Foroglou, Nicolas

    Neurological research

    2020  Volume 42, Issue 12, Page(s) 1018–1026

    Abstract: Brain gliomas represent some of the most aggressive tumors encountered by modern medicine and, despite major efforts to optimize early diagnosis and treatment, the prognosis remains poor. Due to the complex structure of the brain and the unique ... ...

    Abstract Brain gliomas represent some of the most aggressive tumors encountered by modern medicine and, despite major efforts to optimize early diagnosis and treatment, the prognosis remains poor. Due to the complex structure of the brain and the unique mechanical properties of the extracellular matrix, gliomas invade and expand into the brain parenchyma, along white matter tracts and within perivascular spaces, usually sparing normal vessels. Different methods have been developed to study the mechanical properties of gliomas in a wide range of scales, from cells and the microscale to tissues and the macroscale. In this review, the current view on glioma mechanics is presented and the methods used to determine glioma mechanical properties are outlined. Their principles and current state of affairs are discussed.
    MeSH term(s) Brain/pathology ; Brain Neoplasms/pathology ; Elasticity Imaging Techniques/methods ; Glioma/diagnosis ; Glioma/pathology ; Humans ; Microscopy, Atomic Force/methods ; Prognosis
    Language English
    Publishing date 2020-07-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 424428-x
    ISSN 1743-1328 ; 0161-6412
    ISSN (online) 1743-1328
    ISSN 0161-6412
    DOI 10.1080/01616412.2020.1796381
    Database MEDical Literature Analysis and Retrieval System OnLINE

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