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  1. Article ; Online: A network pharmacology-based approach to explore the active ingredients and molecular mechanism of Shen-Kui-Tong-Mai granules on a rat model with chronic heart failure.

    Huang, Hong / Xu, Junyao / Zhang, Siqi / Zhao, Jing / Liu, Shun / Tian, Lei / Wang, Haidan / Geng, Zhirong / Yan, Shihai

    The Journal of pharmacy and pharmacology

    2023  Volume 75, Issue 6, Page(s) 764–783

    Abstract: ... therapeutic mechanisms of Shen-Kui-Tong-Mai granule (SKTMG) in the treatment of heart failure.: Methods ...

    Abstract Objectives: This study aimed to comprehensively investigate the potential active components and therapeutic mechanisms of Shen-Kui-Tong-Mai granule (SKTMG) in the treatment of heart failure.
    Methods: Network pharmacology combined with ultra-high performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS), molecular docking, and in vivo validation was performed to identify the active components and the potential targets for SKTMG to improve chronic heart failure (CHF).
    Key findings: The network pharmacology identified 192 active compounds and 307 potential consensus targets for SKTMG. On the other hand, network analysis discovered 10 core target genes related to the MAPK signal pathway. These genes include AKT1, STAT3, MAPK1, P53, SRC, JUN, TNF, APP, MAPK8 and IL6. The molecular docking results revealed that the SKTMG components were luteolin, quercetin, astragaloside IV and kaempferol, which could bind AKT1, MAPK1, P53, JUN, TNF and MAPK8. Additionally, SKTMG inhibited phosphorylation of AKT, P38, P53 and c-JUN, and reduced TNF-α expression in CHF rats.
    Conclusions: The present results demonstrated that network pharmacology combined with UHPLC-MS/MS, molecular docking and in vivo validation can facilitate the identification of active components and the potential targets for SKTMG to improve CHF.
    MeSH term(s) Animals ; Rats ; Molecular Docking Simulation ; Network Pharmacology ; Tandem Mass Spectrometry ; Tumor Suppressor Protein p53 ; Chronic Disease ; Drugs, Chinese Herbal/pharmacology ; Heart Failure/drug therapy
    Chemical Substances Tumor Suppressor Protein p53 ; Drugs, Chinese Herbal
    Language English
    Publishing date 2023-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 3107-0
    ISSN 2042-7158 ; 0022-3573 ; 0373-1022
    ISSN (online) 2042-7158
    ISSN 0022-3573 ; 0373-1022
    DOI 10.1093/jpp/rgad009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Bioactive Components and Potential Mechanism Prediction of Kui Jie Kang against Ulcerative Colitis via Systematic Pharmacology and UPLC-QE-MS Analysis.

    He, Jinbiao / Wan, Chunping / Li, Xiaosi / Zhang, Zishu / Yang, Yu / Wang, Huaning / Qi, Yan

    Evidence-based complementary and alternative medicine : eCAM

    2022  Volume 2022, Page(s) 9122315

    Abstract: Kui Jie Kang (KJK)-a traditional Chinese medicine-has demonstrated clinical therapeutic efficacy ...

    Abstract Kui Jie Kang (KJK)-a traditional Chinese medicine-has demonstrated clinical therapeutic efficacy against ulcerative colitis (UC). However, the active compounds and their underlying mechanisms have not yet been fully characterized. Therefore, the current study sought to identify the volatile compounds in KJK responsible for eliciting the therapeutic effect against UC, while also analyzing key targets and potential mechanisms. To this end, systematic network pharmacology analysis was employed to obtain UC targets by using GeneCards, DisGeNET, OMIM, among others. A total of 145 candidate ingredients, 412 potential targets of KJK (12 herbs), and 1605 UC targets were identified. Of these KJK and UC targets, 205 intersected and further identified AKT1, JUN, MAPK, ESR, and TNF as the core targets and the PI3K/AKT signaling pathway as the top enriched pathway. Moreover, molecular docking and ultra-performance liquid chromatography Q Exactive-mass spectrometry analysis identified quercetin, kaempferol, luteolin, wogonin, and nobiletin as the core effective compounds of KJK.
    Language English
    Publishing date 2022-06-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2022/9122315
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Kui Jie Tong Ameliorates Ulcerative Colitis by Regulating Gut Microbiota and NLRP3/Caspase-1 Classical Pyroptosis Signaling Pathway.

    Xue, Shigui / Xue, Yan / Dou, Danbo / Wu, Huan / Zhang, Ping / Gao, Yang / Tang, Yini / Xia, Zehua / Yang, Sen / Gu, Sizhen

    Disease markers

    2022  Volume 2022, Page(s) 2782112

    Abstract: Ulcerative colitis (UC) is one of the most refractory digestive diseases in the world. Kui jie tong ...

    Abstract Ulcerative colitis (UC) is one of the most refractory digestive diseases in the world. Kui jie tong (KJT) is an effective traditional Chinese medicine used clinically to treat UC. This study observed the regulatory effects of KJT on NIMA-related kinase 7- (NEK7-) activated nod-like receptor protein-3 (NLRP3)/caspase-1 classical pyroptosis pathway and intestinal flora in UC model rats. KJT components were analyzed using an ultraperformance liquid chromatography-tandem mass spectrometer (UPLC-MS/MS). A UC Sprague Dawley (SD) rat model was established using sodium dextran sulfate (DSS). Rats were randomly divided into four groups: control group (CG), UC model group (UG), KJT group (KG), and sulfasalazine (SASP) group (SG). After seven days of intervention, each group's body weight, disease activity index (DAI) scores, and colon length were recorded. Intestinal mucosal injury to each group was observed using hematoxylin-eosin staining. Additionally, we investigated the expression levels of NEK7, NLRP3, ASC, caspase-1, and GSDMD in intestinal mucosa, as well as serum interleukin- (IL-) 1
    MeSH term(s) Animals ; Caspase 1/metabolism ; Caspase 1/pharmacology ; Chromatography, Liquid ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/metabolism ; Colon/pathology ; Disease Models, Animal ; Gastrointestinal Microbiome ; Interleukin-18/metabolism ; Interleukin-33/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Pyroptosis ; RNA, Ribosomal, 16S ; Rats ; Rats, Sprague-Dawley ; Signal Transduction ; Tandem Mass Spectrometry
    Chemical Substances Interleukin-18 ; Interleukin-33 ; NLR Family, Pyrin Domain-Containing 3 Protein ; Nlrp3 protein, rat ; RNA, Ribosomal, 16S ; Caspase 1 (EC 3.4.22.36)
    Language English
    Publishing date 2022-07-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604951-5
    ISSN 1875-8630 ; 0278-0240
    ISSN (online) 1875-8630
    ISSN 0278-0240
    DOI 10.1155/2022/2782112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Bioactive Components and Potential Mechanism Prediction of Kui Jie Kang against Ulcerative Colitis via Systematic Pharmacology and UPLC-QE-MS Analysis

    Jinbiao He / Chunping Wan / Xiaosi Li / Zishu Zhang / Yu Yang / Huaning Wang / Yan Qi

    Evidence-Based Complementary and Alternative Medicine, Vol

    2022  Volume 2022

    Abstract: Kui Jie Kang (KJK)—a traditional Chinese medicine—has demonstrated clinical therapeutic efficacy ...

    Abstract Kui Jie Kang (KJK)—a traditional Chinese medicine—has demonstrated clinical therapeutic efficacy against ulcerative colitis (UC). However, the active compounds and their underlying mechanisms have not yet been fully characterized. Therefore, the current study sought to identify the volatile compounds in KJK responsible for eliciting the therapeutic effect against UC, while also analyzing key targets and potential mechanisms. To this end, systematic network pharmacology analysis was employed to obtain UC targets by using GeneCards, DisGeNET, OMIM, among others. A total of 145 candidate ingredients, 412 potential targets of KJK (12 herbs), and 1605 UC targets were identified. Of these KJK and UC targets, 205 intersected and further identified AKT1, JUN, MAPK, ESR, and TNF as the core targets and the PI3K/AKT signaling pathway as the top enriched pathway. Moreover, molecular docking and ultra-performance liquid chromatography Q Exactive-mass spectrometry analysis identified quercetin, kaempferol, luteolin, wogonin, and nobiletin as the core effective compounds of KJK. In vivo murine studies revealed that KJK exposure increases the body weight and colon length, while reducing colonic epithelial injury, and the expression of inflammatory factors in colitis tissues such as TNF-α, IL-6, and IL-1β. Furthermore, KJK treatment downregulates the expression of pi3k and akt genes, as well as p-PI3K/PI3K and p-AKT/AKT proteins. Collectively, these findings describe the therapeutic effects and mechanisms of KJK in UC and highlight KJK as a potentially valuable therapeutic option for UC via modulation of the PI3K/AKT signaling pathway, thus providing a theoretical reference for the broader application of KJK in the clinical management of UC.
    Keywords Other systems of medicine ; RZ201-999
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Three types of gut bacteria collaborating to improve Kui Jie'an enema treat DSS-induced colitis in mice.

    Yu, Wei / Su, Xing / Chen, Wen / Tian, Xing / Zhang, Ke / Guo, Gang / Zhou, Liangxue / Zeng, Tao / Han, Bo

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2019  Volume 113, Page(s) 108751

    Abstract: A rising amount of evidences show that gut microbiota is an important factor in mediating the growth of ulcerative colitis (UC), the major product of colon bacteria fermentation butyrate as mediator have effects on the mucosal immune system by expanding ... ...

    Abstract A rising amount of evidences show that gut microbiota is an important factor in mediating the growth of ulcerative colitis (UC), the major product of colon bacteria fermentation butyrate as mediator have effects on the mucosal immune system by expanding regulatory T cells (Treg) in the colon. Turkish galls, an insect gall parasitized on the tree branches of Quercus infectoria Oliv., exhibiting the promising prospect in treating the remedy of UC by regulating the bacteria, whereas its mechanism remains unclear. Here, this work found that three types of gut bacteria collaborating to improve DSS-induced UC in mice after Turkish galls intervention, including putative SCFAs-producing bacteria (PCPB), anti-inflammatory bacteria and harmful bacteria. The Helicobacter, Bilophila, Acinetobacter and Odoribacter, which belong to the harmful bacteria were dramatically increased in UC group, whereas the harmful bacteria were reduced after treatment with Turkish galls. The Allobaculum, Bacteriodes, Blautia, Butyricimonas, belonging to PCPB, were significantly increased after Turkish galls and butyrate intervention, and we also observed that the concentration of butyrate increased with the grows of PCPB. The Bifidobacterium, Lactococcus, which belong to the anti-inflammatory bacteria, were also significantly increased after Turkish galls intervention. Meanwhile, rectal administration of Turkish galls and butyrate could increase mucosa inflammation and diarrhea. The expression of cytokines in the colon was improved by butyrate and Turkish galls treatment group. The percentage of Treg out of CD4
    MeSH term(s) Animals ; Butyrates/metabolism ; Colitis, Ulcerative/immunology ; Colitis, Ulcerative/pathology ; Colitis, Ulcerative/therapy ; Dextran Sulfate/toxicity ; Diarrhea/pathology ; Diarrhea/therapy ; Disease Models, Animal ; Enema ; Female ; Flow Cytometry ; Gastrointestinal Microbiome ; Inflammation/pathology ; Inflammation/therapy ; Insecta ; Male ; Medicine, Chinese Traditional/methods ; Mice ; Polyphenols/isolation & purification ; Polyphenols/pharmacology ; Quercus/parasitology ; T-Lymphocytes, Regulatory/immunology
    Chemical Substances Butyrates ; Polyphenols ; Dextran Sulfate (9042-14-2)
    Language English
    Publishing date 2019-03-11
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2019.108751
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Evaluation of surface water and groundwater interactions in the upstream of Kui river and Yunlong lake, Xuzhou, China

    Yang, Jing / Yu, Zhongbo / Yi, Peng / Frape, Shaun K / Gong, Meng / Zhang, Yuting

    Journal of hydrology. 2020 Apr., v. 583

    2020  

    Abstract: ... of Kui river and Yunlong lake. The exchange fluxes of Kui river, Yunlong lake and groundwater were ...

    Abstract Understanding the interaction between groundwater and surface water is of great significance to the rational development and utilization of water resources and the protection of ecological environment. Here we present a combination of several methods (radon balance method, EC conservation method and flow balance method) for evaluating the hydraulic exchange of groundwater and surface water in a small watershed of Kui river and Yunlong lake. The exchange fluxes of Kui river, Yunlong lake and groundwater were estimated by one-dimensional steady state model and box model. The results indicate that the lake water is mainly recharged by groundwater from the surrounding mountains and the lake renewal time is approximately 26 days. Meanwhile, multiple transformations occur between groundwater and river water, and river water leakage is dominant. The existence of several tributaries complicates the hydraulic exchange, and groundwater discharge is also evident. Furthermore, the advantages and disadvantages of these three methods were analyzed. This study successfully demonstrated that radon and EC as tracers can be used to estimate the exchange flux between groundwater and surface water, particularly in areas lacking conventional hydrological data. Combining these three methods, the hydraulic exchange between groundwater and surface water can be evaluated more effectively. The analysis of hydraulic exchange is also crucial for Xuzhou area where water resources are extraordinary scarce and polluted.
    Keywords electrical conductivity ; groundwater ; hydrologic data ; lakes ; models ; mountains ; radon ; river water ; rivers ; surface water ; tracer techniques ; watersheds ; China
    Language English
    Dates of publication 2020-04
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1473173-3
    ISSN 1879-2707 ; 0022-1694
    ISSN (online) 1879-2707
    ISSN 0022-1694
    DOI 10.1016/j.jhydrol.2020.124549
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Pursue the truth, devote to education: Chen Hua-Kui, a respectable educator and pioneer of China's soil microbiology.

    Chen, Doudou / Zhang, Han / Liu, Huan

    Protein & cell

    2016  Volume 7, Issue 6, Page(s) 389–390

    MeSH term(s) Agriculture ; Bibliography as Topic ; China ; Humans ; Rhizobium/growth & development ; Rhizobium/metabolism ; Soil Microbiology
    Language English
    Publishing date 2016
    Publishing country Germany
    Document type Journal Article
    ISSN 1674-8018
    ISSN (online) 1674-8018
    DOI 10.1007/s13238-016-0270-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Ntf3 hypermethylation in antenatal PTSD and preventive effect of the Chinese herbal medicine Jin Kui Shen Qi Wan

    Zhang, Hui / Peng, Si Han / Liang, Xiao Li / Wang, Hong Yan / Zhang, Xian Geng / Jiang, Xiao Jing

    Biotechnology, biotechnological equipment. 2018 May 4, v. 32, no. 3

    2018  

    Abstract: ... behavioural disorders. This study investigated the epigenetic mechanism of the effects of Jin Kui Shen Qi Wan (JKSQW ...

    Abstract Antenatal post-traumatic stress disorder (PTSD can leave offspring with life-long mental and behavioural disorders. This study investigated the epigenetic mechanism of the effects of Jin Kui Shen Qi Wan (JKSQW) in preventing antenatal PTSD. Thirty-six pregnant rats were randomized into Control, PTSD and JKSQW. Offspring characteristics were investigated with open-field test (OFT), elevated pull maze (EPM), gene expression profile chip test and methylated DNA immunoprecipitation sequencing. In the OFT test, the PTSD offspring showed lower OFT scores than the Control and JKSQW groups (p < 0.05). The PTSD group's EPM performance, OE (open arm entry) + CE (closed arm entry), OE% and OT% (open arm time) were also lower than those of either the Control or the JKSQW group (p < 0.05). In the gene expression profile chip test, 54 genes showed dysregulation through PTSD intervention and were normalized by JKSQW. Endocytosis (Epn3, Folr1 and Hspa1l) and MAPK signaling (Fgf17, Hspa1l, Ntf3 and Pla2g5) pathways were annotated. Combining those genes and methylation sequencing, Ntf3 was identified in both tests. Compared with the Control, the PTSD offspring showed Ntf3 hypermethylation (Log₂FC = 1.022) at 225679501∼225680000 on Chromosome 4 and downregulation in the gene expression profile. The Ntf3 methylation level in JKSQW was restored nearly to the Control level (Log₂FC = −1.082 in JKSQW vs. PTSD). In conclusion, the reduction in the offspring's behavioural performance might constitute experimental evidence of kidney deficiency due to Ntf3 hypermethylation, which could be prevented by JKSQW.
    Keywords DNA methylation ; biotechnology ; chromosomes ; endocytosis ; epigenetics ; equipment ; gene expression ; herbal medicines ; kidneys ; precipitin tests ; progeny
    Language English
    Dates of publication 2018-0504
    Size p. 663-670.
    Publishing place Taylor & Francis
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 1214963-9
    ISSN 1314-3530 ; 0205-2067 ; 1310-2818
    ISSN (online) 1314-3530
    ISSN 0205-2067 ; 1310-2818
    DOI 10.1080/13102818.2017.1421101
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Uygur medicine Xipayi Kui Jie'an affects gene expression profiles in intestinal tissue lesions in a rat model of ulcerative colitis.

    Yunusi, Kurexi / Zhang, Jingping / Zhong, Li / Mosha, Gulinisha / Nuermaimaiti, Ajiguli / Abudula, Mairipaiti / Upur, Halmurat

    BMC complementary and alternative medicine

    2015  Volume 15, Page(s) 152

    Abstract: Background: The aim of this study was to investigate the mechanisms underlying the therapeutic effect of Uygur medicine KJA on UC in a rat model.: Methods: UC was induced in Wistar rats by application of 2, 4-dinitrochlorobenzene and acetic acid and ... ...

    Abstract Background: The aim of this study was to investigate the mechanisms underlying the therapeutic effect of Uygur medicine KJA on UC in a rat model.
    Methods: UC was induced in Wistar rats by application of 2, 4-dinitrochlorobenzene and acetic acid and were then treated with three different doses of KJA, and normal saline as control. After treatment for 20 days, the gene expression profile of colonic tissue was analyzed by microarray and verified by quantitative real-time RT-PCR.
    Results: Animals treated with the three different doses of KJA were compared with normal saline controls, wherein microarray analysis identified 1991, 2163, and 1677 differentially expressed genes respectively, of which 444 genes were raised and 670 genes were decrease spliced together in the three doses tested. The KEGG pathway analyses found commonly raised genes related to several different biological functions. Interesting genes included TRL2, IL-1β, TGF-β1, and NF-κB were confirmed by quantitative PCR.
    Conclusions: The therapeutic effect of KJA on UC is likely explained by specific effects on the expression of genes, which are the effector molecules known to be involved in the development of UC. Further studies on differentially expressed genes will help explain the mechanism of action of Uygur medicine KJA.
    MeSH term(s) Animals ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/genetics ; Colitis, Ulcerative/metabolism ; Colitis, Ulcerative/pathology ; Cytokines/genetics ; Cytokines/metabolism ; Gallic Acid/pharmacology ; Gallic Acid/therapeutic use ; Interleukin-1beta/genetics ; Interleukin-1beta/metabolism ; Intestines/drug effects ; Intestines/metabolism ; Intestines/pathology ; Male ; Medicine, Traditional ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Phytotherapy ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Rats ; Rats, Wistar ; Real-Time Polymerase Chain Reaction ; Transcriptome/drug effects ; Transforming Growth Factor beta1/genetics ; Transforming Growth Factor beta1/metabolism
    Chemical Substances Cytokines ; Interleukin-1beta ; NF-kappa B ; Plant Extracts ; Transforming Growth Factor beta1 ; Gallic Acid (632XD903SP)
    Language English
    Publishing date 2015-05-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2050429-9
    ISSN 1472-6882 ; 1472-6882
    ISSN (online) 1472-6882
    ISSN 1472-6882
    DOI 10.1186/s12906-015-0672-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Audio / Video: Xiang ri kui

    Zhang, Yang

    Sunflower

    2005  

    Author's details [Regie: Zhang Yang]
    Language Chinese
    Size 2 DVDs (Region 1-6, 8), 127 Min
    Publishing place China
    Document type Book ; Audio / Video
    Note Audiosprache: Chinesisch ; Untertitel: Chinesisch (Kurzzeichen)
    Database Former special subject collection: coastal and deep sea fishing

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