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  1. Article ; Online: Editorial: Introduction and commentary to the articles.

    Dusinska, Maria

    Mutation research. Genetic toxicology and environmental mutagenesis

    2022  Volume 885, Page(s) 503575

    Language English
    Publishing date 2022-12-06
    Publishing country Netherlands
    Document type Editorial
    ISSN 1879-3592
    ISSN (online) 1879-3592
    DOI 10.1016/j.mrgentox.2022.503575
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: In memory of Dr. Ir. Gudrun Koppen (1969-2024).

    Collins, Andrew R / Azqueta, Amaya / Schoeters, Greet / Slingers, Gitte / Dusinska, Maria / Langie, Sabine A S

    Mutation research. Genetic toxicology and environmental mutagenesis

    2024  Volume 895, Page(s) 503751

    Language English
    Publishing date 2024-03-19
    Publishing country Netherlands
    Document type Editorial
    ISSN 1879-3592
    ISSN (online) 1879-3592
    DOI 10.1016/j.mrgentox.2024.503751
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Thymidine Kinase

    Chen, Tao / Dusinska, Maria / Elespuru, Rosalie

    Frontiers in toxicology

    2022  Volume 4, Page(s) 864753

    Abstract: The methods outlined here are part of a series of papers designed specifically for genotoxicity assessment of nanomaterials (NM). Common Considerations such as NM characterization, sample preparation and dose selection, relevant to all genotoxicity ... ...

    Abstract The methods outlined here are part of a series of papers designed specifically for genotoxicity assessment of nanomaterials (NM). Common Considerations such as NM characterization, sample preparation and dose selection, relevant to all genotoxicity assays, are found in an accompanying paper. The present paper describes methods for evaluation of mutagenicity in the mammalian (mouse)
    Language English
    Publishing date 2022-06-08
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-3080
    ISSN (online) 2673-3080
    DOI 10.3389/ftox.2022.864753
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Correction to: Hazard Assessment of Benchmark Metal-Based Nanomaterials Through a Set of In Vitro Genotoxicity Assays.

    Vital, Nádia / Pinhão, Mariana / Yamani, Naouale El / Rundén-Pran, Elise / Louro, Henriqueta / Dušinská, Maria / Silva, Maria João

    Advances in experimental medicine and biology

    2022  Volume 1357, Page(s) C1

    Language English
    Publishing date 2022-07-25
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-88071-2_18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Different Sensitivity of Advanced Bronchial and Alveolar Mono- and Coculture Models for Hazard Assessment of Nanomaterials.

    Elje, Elisabeth / Mariussen, Espen / McFadden, Erin / Dusinska, Maria / Rundén-Pran, Elise

    Nanomaterials (Basel, Switzerland)

    2023  Volume 13, Issue 3

    Abstract: For the next-generation risk assessment (NGRA) of chemicals and nanomaterials, new approach methodologies (NAMs) are needed for hazard assessment in compliance with the 3R's to reduce, replace and refine animal experiments. This study aimed to establish ... ...

    Abstract For the next-generation risk assessment (NGRA) of chemicals and nanomaterials, new approach methodologies (NAMs) are needed for hazard assessment in compliance with the 3R's to reduce, replace and refine animal experiments. This study aimed to establish and characterize an advanced respiratory model consisting of human epithelial bronchial BEAS-2B cells cultivated at the air-liquid interface (ALI), both as monocultures and in cocultures with human endothelial EA.hy926 cells. The performance of the bronchial models was compared to a commonly used alveolar model consisting of A549 in monoculture and in coculture with EA.hy926 cells. The cells were exposed at the ALI to nanosilver (NM-300K) in the VITROCELL
    Language English
    Publishing date 2023-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano13030407
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Hazard Assessment of Benchmark Metal-Based Nanomaterials Through a Set of In Vitro Genotoxicity Assays.

    Vital, Nádia / Pinhão, Mariana / Yamani, Naouale El / Rundén-Pran, Elise / Louro, Henriqueta / Dušinská, Maria / Silva, Maria João

    Advances in experimental medicine and biology

    2022  Volume 1357, Page(s) 351–375

    Abstract: For safety assessment of nanomaterials (NMs), in vitro genotoxicity data based on well-designed experiments is required. Metal-based NMs are amongst the most used in consumer products. In this chapter, we report results for three metal-based NMs, ... ...

    Abstract For safety assessment of nanomaterials (NMs), in vitro genotoxicity data based on well-designed experiments is required. Metal-based NMs are amongst the most used in consumer products. In this chapter, we report results for three metal-based NMs, titanium dioxide (NM-100), cerium dioxide (NM-212) and silver (NM-302) in V79 cells, using a set of in vitro genotoxicity assays covering different endpoints: the medium-throughput comet assay and its modified version (with the enzyme formamidopyrimidine DNA glycosylase, Fpg), measuring DNA strand beaks (SBs) and oxidized purines, respectively; the micronucleus (MN) assay, assessing chromosomal damage; and the Hprt gene mutation test. The results generated by this test battery showed that all NMs displayed genotoxic potential. NM-100 induced DNA breaks, DNA oxidation damage and point mutations but not chromosome instability. NM-212 increased the level of DNA oxidation damage, point mutations and increased the MN frequency at the highest concentration tested. NM-302 was moderately cytotoxic and induced gene mutations, but not DNA or chromosome damage. In conclusion, the presented in vitro genotoxicity testing strategy allowed the identification of genotoxic effects caused by three different metal-based NMs, raising concern as to their impact on human health. The results support the use of this in vitro test battery for the genotoxicity assessment of NMs, reducing the use of more expensive, time-consuming and ethically demanding in vivo assays, in compliance with the 3 R's.
    MeSH term(s) Animals ; Benchmarking ; Comet Assay/methods ; DNA ; DNA Damage ; Humans ; Mutagenicity Tests/methods ; Nanostructures/toxicity
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2022-05-18
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-88071-2_14
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: In vivo

    Cardoso, Renato / Dusinska, Maria / Collins, Andrew / Manjanatha, Mugimane / Pfuhler, Stefan / Registre, Marilyn / Elespuru, Rosalie

    Frontiers in toxicology

    2022  Volume 4, Page(s) 903896

    Abstract: ... ...

    Abstract The
    Language English
    Publishing date 2022-05-30
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-3080
    ISSN (online) 2673-3080
    DOI 10.3389/ftox.2022.903896
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Do cytotoxicity and cell death cause false positive results in the in vitro comet assay?

    Azqueta, Amaya / Stopper, Helga / Zegura, Bojana / Dusinska, Maria / Møller, Peter

    Mutation research. Genetic toxicology and environmental mutagenesis

    2022  Volume 881, Page(s) 503520

    Abstract: The comet assay is used to measure DNA damage induced by chemical and physical agents. High concentrations of test agents may cause cytotoxicity or cell death, which may give rise to false positive results in the comet assay. Systematic studies on ... ...

    Abstract The comet assay is used to measure DNA damage induced by chemical and physical agents. High concentrations of test agents may cause cytotoxicity or cell death, which may give rise to false positive results in the comet assay. Systematic studies on genotoxins and cytotoxins (i.e. non-genotoxic poisons) have attempted to establish a threshold of cytotoxicity or cell death by which DNA damage results measured by the comet assay could be regarded as a false positive result. Thresholds of cytotoxicity/cell death range from 20% to 50% in various publications. Curiously, a survey of the latest literature on comet assay results from cell culture studies suggests that one-third of publications did not assess cytotoxicity or cell death. We recommend that it should be mandatory to include results from at least one type of assay on cytotoxicity, cell death or cell proliferation in publications on comet assay results. A combination of cytotoxicity (or cell death) and proliferation (or colony forming efficiency assay) is preferable in actively proliferating cells because it covers more mechanisms of action. Applying a general threshold of cytotoxicity/cell death to all types of agents may not be applicable; however, 25% compared to the concurrent negative control seems to be a good starting value to avoid false positive comet assay results. Further research is needed to establish a threshold value to distinguish between true and potentially false positive genotoxic effects detected by the comet assay.
    MeSH term(s) Cause of Death ; Cell Death ; Comet Assay ; DNA Damage ; Mutagens
    Chemical Substances Mutagens
    Language English
    Publishing date 2022-06-23
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1879-3592
    ISSN (online) 1879-3592
    DOI 10.1016/j.mrgentox.2022.503520
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The alamar blue assay in the context of safety testing of nanomaterials.

    Longhin, Eleonora Marta / El Yamani, Naouale / Rundén-Pran, Elise / Dusinska, Maria

    Frontiers in toxicology

    2022  Volume 4, Page(s) 981701

    Abstract: The Alamar Blue (AB) assay is widely used to investigate cytotoxicity, cell proliferation and cellular metabolic activity within different fields of toxicology. The use of the assay with nanomaterials (NMs) entails specific aspects including the ... ...

    Abstract The Alamar Blue (AB) assay is widely used to investigate cytotoxicity, cell proliferation and cellular metabolic activity within different fields of toxicology. The use of the assay with nanomaterials (NMs) entails specific aspects including the potential interference of NMs with the test. The procedure of the AB assay applied for testing NMs is described in detail and step-by-step, from NM preparation, cell exposure, inclusion of interference controls, to the analysis and interpretation of the results. Provided that the proper procedure is followed, and relevant controls are included, the AB assay is a reliable and high throughput test to evaluate the cytotoxicity/proliferation/metabolic response of cells exposed to NMs.
    Language English
    Publishing date 2022-09-28
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-3080
    ISSN (online) 2673-3080
    DOI 10.3389/ftox.2022.981701
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Do Carbon Nanotubes and Asbestos Fibers Exhibit Common Toxicity Mechanisms?

    Gupta, Suchi Smita / Singh, Krishna P / Gupta, Shailendra / Dusinska, Maria / Rahman, Qamar

    Nanomaterials (Basel, Switzerland)

    2022  Volume 12, Issue 10

    Abstract: During the last two decades several nanoscale materials were engineered for industrial and medical applications. Among them carbon nanotubes (CNTs) are the most exploited nanomaterials with global production of around 1000 tons/year. Besides several ... ...

    Abstract During the last two decades several nanoscale materials were engineered for industrial and medical applications. Among them carbon nanotubes (CNTs) are the most exploited nanomaterials with global production of around 1000 tons/year. Besides several commercial benefits of CNTs, the fiber-like structures and their bio-persistency in lung tissues raise serious concerns about the possible adverse human health effects resembling those of asbestos fibers. In this review, we present a comparative analysis between CNTs and asbestos fibers using the following four parameters: (1) fibrous needle-like shape, (2) bio-persistent nature, (3) high surface to volume ratio and (4) capacity to adsorb toxicants/pollutants on the surface. We also compare mechanisms underlying the toxicity caused by certain diameters and lengths of CNTs and asbestos fibers using downstream pathways associated with altered gene expression data from both asbestos and CNT exposure. Our results suggest that indeed certain types of CNTs are emulating asbestos fiber as far as associated toxicity is concerned.
    Language English
    Publishing date 2022-05-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano12101708
    Database MEDical Literature Analysis and Retrieval System OnLINE

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