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Article ; Online: Reply from P. Dominelli, C. Wiggins, S. E. Baker, J. R. A. Shepherd, S. Roberts, T. K. Roy, T. Curry, J. Hoyer, J. L. Oliveira and M. J. Joyner.

Dominelli, Paolo / Wiggins, Chad / Baker, Sarah E / Shepherd, John R A / Roberts, Shelly / Roy, Tuhin K / Curry, Timothy / Hoyer, James / Oliveira, Jennifer L / Joyner, Michael J

The Journal of physiology

2020 Volume 598, Issue 16, Page(s) 3533–3534

MeSH term(s)	Hemoglobins ; Humans ; Hypoxia
Chemical Substances	Hemoglobins
Language	English
Publishing date	2020-06-08
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	3115-x
ISSN	1469-7793 ; 0022-3751
ISSN (online)	1469-7793
ISSN	0022-3751
DOI	10.1113/JP280124
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Article: Genomic regions, cellular components and gene regulatory basis underlying pod length variations in cowpea (V.Â unguiculata L. Walp)

Xu, Pei / BaoâLam Huynh / Baogen Wang / Guojing Li / MarÃa MuÃ±ozâAmatriaÃn / Philip A. Roberts / Timothy J. Close / Wen Zhou / Xiaohua Wu / Xinyi Wu / Yaowen Hu / Zhongfu Lu

Plant biotechnology journal. 2017 May, v. 15, no. 5

2017

Abstract: Cowpea (V.Â unguiculata L. Walp) is a climate resilient legume crop important for food security ... Cultivated cowpea (V.Â unguiculata L) generally comprises the bushy, shortâpodded grain cowpea dominant ...

Abstract	Cowpea (V.Â unguiculata L. Walp) is a climate resilient legume crop important for food security. Cultivated cowpea (V.Â unguiculata L) generally comprises the bushy, shortâpodded grain cowpea dominant in Africa and the climbing, longâpodded vegetable cowpea popular in Asia. How selection has contributed to the diversification of the two types of cowpea remains largely unknown. In the current study, a novel genotyping assay for over 50Â 000 SNPs was employed to delineate genomic regions governing pod length. Major, minor and epistatic QTLs were identified through QTL mapping. Seventyâtwo SNPs associated with pod length were detected by genomeâwide association studies (GWAS). Population stratification analysis revealed subdivision among a cowpea germplasm collection consisting of 299 accessions, which is consistent with pod length groups. Genomic scan for selective signals suggested that domestication of vegetable cowpea was accompanied by selection of multiple traits including pod length, while the further improvement process was featured by selection of pod length primarily. Pod growth kinetics assay demonstrated that more durable cell proliferation rather than cell elongation or enlargement was the main reason for longer pods. Transcriptomic analysis suggested the involvement of sugar, gibberellin and nutritional signalling in regulation of pod length. This study establishes the basis for mapâbased cloning of pod length genes in cowpea and for markerâassisted selection of this trait in breeding programmes.
Keywords	breeding programs ; cell growth ; cell proliferation ; climate ; cowpeas ; domestication ; epistasis ; genes ; genome-wide association study ; genomics ; genotyping ; germplasm conservation ; gibberellins ; growth models ; marker-assisted selection ; molecular cloning ; pods ; quantitative trait loci ; single nucleotide polymorphism ; sugars ; transcriptomics ; vegetables ; Vigna unguiculata
Language	English
Dates of publication	2017-05
Size	p. 547-557.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2136367-5
ISSN	1467-7652 ; 1467-7644
ISSN (online)	1467-7652
ISSN	1467-7644
DOI	10.1111/pbi.12639
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Neostigmine and Postoperative Cognitive Dysfunction in the Elderly: Teaching an Old Dog a New Trick?

Okada, Hisako / Butt, Amir L / Roberts, Pamela R / Tanaka, Kenichi A

Anesthesia and analgesia

2024 Volume 138, Issue 5, Page(s) e27–e28

MeSH term(s)	Humans ; Aged ; Neostigmine/adverse effects ; Postoperative Cognitive Complications ; Sugammadex ; Neuromuscular Blockade
Chemical Substances	Neostigmine (3982TWQ96G) ; Sugammadex (361LPM2T56)
Language	English
Publishing date	2024-04-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	80032-6
ISSN	1526-7598 ; 0003-2999
ISSN (online)	1526-7598
ISSN	0003-2999
DOI	10.1213/ANE.0000000000006935
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Book ; Online: Perception and Cognition: Interactions in the Ageing Brain

Allen, Harriet A. / Roberts, Katherine L.

2016

Abstract: Healthy ageing can lead to declines in both perceptual and cognitive functions. Impaired perception, such as that resulting from hearing loss or reduced visual or tactile resolution, increases demands on 'higher-level' cognitive functions to cope or ... ...

Abstract	Healthy ageing can lead to declines in both perceptual and cognitive functions. Impaired perception, such as that resulting from hearing loss or reduced visual or tactile resolution, increases demands on 'higher-level' cognitive functions to cope or compensate. It is possible, for example, to use focused attention to overcome perceptual limitations. Unfortunately, cognitive functions also decline in old age. This can mean that perceptual impairments are exacerbated by cognitive decline, and vice versa, but also means that interventions aimed at one type of decline can lead to improvements in the other. Just as improved cognition can ameliorate perceptual deficits, improving the stimulus can help offset cognitive deficits. For example, making directions and routes easy to follow can help compensate for declines in navigation abilities. In this Topic, we bring together papers from both auditory and visual researchers that address the interaction between perception and cognition in the ageing brain. Many of the studies demonstrate that a broadening of representations or increased reliance on gist underlie perceptual and cognitive age-related declines. There is also clear evidence that impaired perception is associated with poor cognition although, encouragingly, it can also be seen that good perception is associated with better cognition. Compensatory cognitive strategies were less successful in improving perception than might be expected. We also present papers which highlight important methodological considerations that are required when studying the older brain
Keywords	Science (General) ; Neurosciences. Biological psychiatry. Neuropsychiatry
Size	1 electronic resource (204 p.)
Publisher	Frontiers Media SA
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT020090657
ISBN	9782889199372 ; 2889199371
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Fat malabsorption in pancreatic cancer: Pathophysiology and management.

Murray, Gretchen / Ramsey, Mitchell L / Hart, Phil A / Roberts, Kristen M

Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition

2024 Volume 39 Suppl 1, Page(s) S46–S56

Abstract: Exocrine pancreatic insufficiency (EPI) is common in pancreatic ductal adenocarcinoma (PDAC) and may lead to significant nutrition compromise. In the setting of cancer cachexia and gastrointestinal toxicities of cancer treatments, untreated (or ... ...

Abstract	Exocrine pancreatic insufficiency (EPI) is common in pancreatic ductal adenocarcinoma (PDAC) and may lead to significant nutrition compromise. In the setting of cancer cachexia and gastrointestinal toxicities of cancer treatments, untreated (or undertreated) EPI exacerbates weight loss, sarcopenia, micronutrient deficiencies, and malnutrition. Together, these complications contribute to poor tolerance of oncologic therapies and negatively impact survival. Treatment of EPI in PDAC involves the addition of pancreatic enzyme replacement therapy, with titration to improve gastrointestinal symptoms. Medical nutrition therapies may also be applicable and may include fat-soluble vitamin replacement, medium-chain triglycerides, and, in some cases, enteral nutrition. Optimizing nutrition status is an important adjunct treatment approach to improve quality of life and may also improve overall survival.
MeSH term(s)	Humans ; Quality of Life ; Pancreas ; Exocrine Pancreatic Insufficiency/etiology ; Exocrine Pancreatic Insufficiency/therapy ; Pancreatic Neoplasms/complications ; Pancreatic Neoplasms/therapy ; Malnutrition/etiology ; Enteral Nutrition/adverse effects ; Gastrointestinal Diseases ; Enzyme Replacement Therapy
Language	English
Publishing date	2024-03-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	645074-x
ISSN	1941-2452 ; 0884-5336
ISSN (online)	1941-2452
ISSN	0884-5336
DOI	10.1002/ncp.11129
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Article ; Online: Current and Emerging Issues in Wilson's Disease.

Roberts, Eve A / Schilsky, Michael L

The New England journal of medicine

2023 Volume 389, Issue 10, Page(s) 922–938

MeSH term(s)	Humans ; Hepatolenticular Degeneration/complications
Language	English
Publishing date	2023-09-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMra1903585
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Article ; Online: Phosphorylation of hnRNP A1-Serine 199 Is Not Required for T Cell Differentiation and Function.

White, Tristan L A / Jin, Ye / Roberts, Sean D A / Gable, Matthew J / Morel, Penelope A

ImmunoHorizons

2024 Volume 8, Issue 2, Page(s) 136–146

Abstract: hnRNP A1 is an important RNA-binding protein that influences many stages of RNA processing, including transcription, alternative splicing, mRNA nuclear export, and RNA stability. However, the role of hnRNP A1 in immune cells, specifically CD4+ T cells, ... ...

Abstract	hnRNP A1 is an important RNA-binding protein that influences many stages of RNA processing, including transcription, alternative splicing, mRNA nuclear export, and RNA stability. However, the role of hnRNP A1 in immune cells, specifically CD4+ T cells, remains unclear. We previously showed that Akt phosphorylation of hnRNP A1 was dependent on TCR signal strength and was associated with Treg differentiation. To explore the impact of hnRNP A1 phosphorylation by Akt on CD4+ T cell differentiation, our laboratory generated a mutant mouse model, hnRNP A1-S199A (A1-MUT) in which the major Akt phosphorylation site on hnRNP A1 was mutated to alanine using CRISPR Cas9 technology. Immune profiling of A1-MUT mice revealed changes in the numbers of Tregs in the mesenteric lymph node. We found no significant differences in naive CD4+ T cell differentiation into Th1, Th2, Th17, or T regulatory cells (Tregs) in vitro. In vivo, Treg differentiation assays using OTII-A1-Mut CD4+ T cells exposed to OVA food revealed migration and homing defects in the A1-MUT but no change in Treg induction. A1-MUT mice were immunized with NP- keyhole limpet hemocyanin, and normal germinal center development, normal numbers of NP-specific B cells, and no change in Tfh numbers were observed. In conclusion, Akt phosphorylation of hnRNP A1 S199 does not play a role in CD4+ T cell fate or function in the models tested. This hnRNP A1-S199A mouse model should be a valuable tool to study the role of Akt phosphorylation of hnRNP A1-S199 in different cell types or other mouse models of human disease.
MeSH term(s)	Animals ; Mice ; Cell Differentiation ; Heterogeneous Nuclear Ribonucleoprotein A1/metabolism ; Phosphorylation ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Receptors, Antigen, T-Cell/metabolism ; Serine/metabolism ; Signal Transduction ; T-Lymphocytes/cytology
Chemical Substances	Heterogeneous Nuclear Ribonucleoprotein A1 ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Receptors, Antigen, T-Cell ; Serine (452VLY9402)
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article
ISSN	2573-7732
ISSN (online)	2573-7732
DOI	10.4049/immunohorizons.2300074
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: Plant Organ Abscission: From Models to Crops

Roberts, Jeremy A. / Tucker, Mark L. / Tranbarger, Timothy J. / Meir, Shimon

2017

Abstract: Plant organ abscission is a developmental process regulated by the environment, stress, pathogens and the physiological status of the plant. In particular, seed and fruit abscission play an important role in seed dispersion and plant reproductive success ...

Abstract	Plant organ abscission is a developmental process regulated by the environment, stress, pathogens and the physiological status of the plant. In particular, seed and fruit abscission play an important role in seed dispersion and plant reproductive success and are common domestication traits with important agronomic consequences for many crop species. Indeed, in natural populations, shedding of the seed or fruit at the correct time is essential for reproductive success, while for crop species the premature or lack of abscission may be either beneficial or detrimental to crop productivity. The use of model plants, in particular Arabidopsis and tomato, have led to major advances in our understanding of the molecular and cellular mechanisms underlying organ abscission, and now many workers pursue the translation of these advances to crop species.- Organ abscission involves specialized cell layers called the abscission zone (AZ), where abscission signals are perceived and cell separation takes place for the organ to be shed. A general model for plant organ abscission includes (1) the differentiation of the AZ, (2) the acquisition of AZ cells to become competent to respond to various abscission signals, (3) response to signals and the activation of the molecular and cellular processes that lead to cell separation in the AZ and (4) the post-abscission events related to protection of exposed cells after the organ has been shed. While this simple four-phase framework is helpful to describe the abscission process, the exact mechanisms of each stage, the differences between organ types and amongst diverse species, and in response to different abscission inducing signals are far from elucidated.- For an organ to be shed, AZ cells must transduce a multitude of both endogenous and exogenous signals that lead to transcriptional and cellular and ultimately cell wall modifications necessary for adjacent cells to separate. How these key processes have been adapted during evolution to allow for organ abscission to take place in different locations and under different conditions is unknown. The aim of the current collection of articles is to present and be able to compare recent results on our understanding of organ abscission from model and crop species, and to provide a basis to understand both the evolution of abscission in plants and the translation of advances with model plants for applications in crop species
Keywords	Science (General) ; Botany
Size	1 electronic resource (271 p.)
Publisher	Frontiers Media SA
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT020097460
ISBN	9782889453283 ; 2889453286
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Age Deficits in Associative Memory are not Alleviated by Multisensory Paradigms.

Badham, Stephen P / Atkin, Christopher / Stacey, Jemaine E / Henshaw, Helen / Allen, Harriet A / Roberts, Katherine L

The journals of gerontology. Series B, Psychological sciences and social sciences

2024

Abstract: Objectives: Age deficits in memory are widespread, this impacts individuals at a personal level, and investigating memory has been a key focus in cognitive ageing research. Age deficits occur in memory for an episode, where information from the ... ...

Abstract	Objectives: Age deficits in memory are widespread, this impacts individuals at a personal level, and investigating memory has been a key focus in cognitive ageing research. Age deficits occur in memory for an episode, where information from the environment is integrated through the senses into an episodic event via associative memory. Associating items in memory has been shown to be particularly difficult for older adults but can often be alleviated by providing support from the external environment. The current investigation explored the potential for increased sensory input (multimodal stimuli) to alleviate age deficits in associative memory. Here, we present compelling evidence, supported by Bayesian analysis, for a null age-by-modality interaction. Methods: Across three pre-registered studies, young and older adults (n = 860) completed associative memory tasks either in single modalities or in multimodal formats. Study 1 used either visual text (unimodal) or video introductions (multimodal) to test memory for name-face associations. Studies 2 and 3 tested memory for paired associates. Study 2 used unimodal visual presentation or cross modal visual-auditory word pairs in a cued recall paradigm. Study 3 presented word pairs as visual only, auditory only or audiovisual and tested memory separately for items (individual words) or associations (word pairings). Results: Typical age deficits in associative memory emerged, but these were not alleviated by multimodal presentation. Discussion: The lack of multimodal support for associative memory indicates that perceptual manipulations are less effective than other forms of environmental support at alleviating age deficits in associative memory.
Language	English
Publishing date	2024-04-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	1223664-0
ISSN	1758-5368 ; 1079-5014
ISSN (online)	1758-5368
ISSN	1079-5014
DOI	10.1093/geronb/gbae063
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Article ; Online: Clinical and epidemiologic features of persons accessing emergency departments for dog and cat bite injuries in California (2005-2019).

Campagna, Rebecca A / Roberts, Elizabeth / Porco, Alice / Fritz, Curtis L

Journal of the American Veterinary Medical Association

2023 Volume 261, Issue 5, Page(s) 723–732

Abstract: Objective: To describe the clinical and epidemiologic features of persons with dog and cat bite injuries who presented to emergency departments.: Sample: Records of 648,492 dog and cat bite-related emergency department visits in California from 2005 ... ...

Abstract	Objective: To describe the clinical and epidemiologic features of persons with dog and cat bite injuries who presented to emergency departments. Sample: Records of 648,492 dog and cat bite-related emergency department visits in California from 2005 to 2019. Procedures: Visits were selected by standardized International Classification of Diseases, Ninth or Tenth Revision, Clinical Modification codes that indicated a bite as an external cause of injury in the medical record. Incidence rates were calculated for patient demographics, location and month of bite incident, characteristics of bite injury, infection, patient outcome/disposition, and expected source of payment. Cross-sectional descriptive analysis was performed. Results: The average annual incidence of dog bites was highest in children aged < 10 years and males, while that of cat bites was highest in adults aged ≥ 80 years and females. Bites were more likely to occur in rural settings, in private residences, and during the summer. The median household income for zip codes in which animal bite patients resided was lower than the statewide median household income. Both dog and cat bite injuries were more likely to occur to upper limbs. Bacteria were isolated from 3% of dog bite injuries and 21.5% of cat bite injuries at initial presentation. Clinical relevance: Epidemiologic findings about persons presenting to emergency departments for animal bite injuries can inform bite prevention efforts by identifying at-risk populations. Effective animal bite prevention demands an ongoing multisectoral program of veterinarians and other health professionals, collaborating with community and governmental organizations, to develop and implement integrated strategies within the context of other socially contributory factors.
MeSH term(s)	Male ; Female ; Animals ; Dogs ; Cats ; Cross-Sectional Studies ; Cat Diseases/epidemiology ; Dog Diseases/epidemiology ; Bites and Stings/epidemiology ; Bites and Stings/veterinary ; California/epidemiology ; Emergency Service, Hospital
Language	English
Publishing date	2023-02-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	390811-2
ISSN	1943-569X ; 0003-1488
ISSN (online)	1943-569X
ISSN	0003-1488
DOI	10.2460/javma.22.11.0494
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