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Book ; Online ; E-Book: The maize genome

Bennetzen, Jeffrey L. / Flint-Garcia, Sherry / Hirsch, Candice / Tuberosa, R.

(Compendium of plant genomes)

2018

Author's details	Jeffrey Bennetzen, Sherry Flint-Garcia, Candice Hirsch, Roberto Tuberosa, editors
Series title	Compendium of plant genomes
Keywords	Plant genetics ; Plant breeding ; Agriculture
Language	English
Size	1 Online-Ressource (xiii, 388 Seiten), Illustrationen
Publisher	Springer International Publishing
Publishing place	Cham
Publishing country	Switzerland
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT019931364
ISBN	978-3-319-97427-9 ; 9783319974262 ; 9783319974286 ; 3-319-97427-0 ; 3319974262 ; 3319974289
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Pediatric Keloids and Review of the Efficacy of Current Treatment Modalities.

Hirsch, Yonatan / Waterman, Christy L / Haber, Roger

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

2023 Volume 49, Issue 7, Page(s) 669–674

Abstract: Background: Keloids and hypertrophic scars are the result of excessive fibroblast proliferation and collagen deposition in the wound healing process, leaving patients with irritating and cosmetically displeasing lesions. Despite there being numerous ... ...

Abstract	Background: Keloids and hypertrophic scars are the result of excessive fibroblast proliferation and collagen deposition in the wound healing process, leaving patients with irritating and cosmetically displeasing lesions. Despite there being numerous modalities for treatment, keloids are notoriously recalcitrant to therapy and recurrence rates are high. Objective: Because many keloids begin to develop during childhood and adolescence, it is important to better understand which treatment options may be best suited toward the pediatric population specifically. Methods: We reviewed 13 studies that focus specifically on effectiveness of treatment options for keloids and hypertrophic scars in the pediatric population. These studies cover 545 keloids in 482 patients, all aged 18 and younger. Results: Many treatment modalities were used, with multimodal treatment being the most common (76%). There were 92 instances of recurrence, with a total recurrence rate of 16.9%. Conclusion: Data from the combined studies suggest that keloid development is less common before adolescence and that higher rates of recurrence are observed among patients who have received monotherapy compared with those who received multimodal treatments. More well-designed studies with standardized ways of assessing outcomes are needed to expand our understanding on how to optimally treat keloids in the pediatric population.
MeSH term(s)	Adolescent ; Humans ; Child ; Keloid/surgery ; Cicatrix, Hypertrophic/therapy ; Wound Healing ; Collagen ; Combined Modality Therapy
Chemical Substances	Collagen (9007-34-5)
Language	English
Publishing date	2023-04-26
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	1227586-4
ISSN	1524-4725 ; 1076-0512
ISSN (online)	1524-4725
ISSN	1076-0512
DOI	10.1097/DSS.0000000000003815
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Zs.A 1212: Show issues

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Article ; Online: Chronic sacroiliac joint dysfunction and CT-guided percutaneous fixation: a 6-year experience.

Jedi, F / Krysiak, R / Hirsch, J A / Ventura, F / De Vivo, E / Manfrè, L

Neuroradiology

2023 Volume 65, Issue 10, Page(s) 1527–1534

Abstract: Purpose: Reporting the clinical outcomes, patient satisfaction, and complications following an imaging-guided percutaneous screw fixation in the treatment of sacroiliac joint dysfunction and evaluating the safety and effectiveness of this method.: ... ...

Abstract	Purpose: Reporting the clinical outcomes, patient satisfaction, and complications following an imaging-guided percutaneous screw fixation in the treatment of sacroiliac joint dysfunction and evaluating the safety and effectiveness of this method. Methods: We performed a retrospective study on a prospectively gathered cohort of patients with physiotherapy-resistant pain due to sacroiliac joint incompetence that underwent percutaneous screw fixation, between 2016 and 2022 in our center. A minimum of two screws were used in all patients to obtain fixation of the sacroiliac joint, using percutaneous screw insertion under CT guidance, coupled with a C-arm fluoroscopy unit. Results: The mean visual analog scale significantly improved at 6 months of follow-up (p < 0.05). One hundred percent of the patients reported significant improvement in pain scores at the final follow-up. None of our patients experienced intraoperative or postoperative complications. Conclusion: The use of percutaneous sacroiliac screws provides a safe and effective technique for the treatment of sacroiliac joint dysfunction in patients with chronic resistant pain.
MeSH term(s)	Humans ; Fracture Fixation, Internal/adverse effects ; Fracture Fixation, Internal/methods ; Retrospective Studies ; Sacroiliac Joint/diagnostic imaging ; Sacroiliac Joint/surgery ; Treatment Outcome ; Tomography, X-Ray Computed ; Pain
Language	English
Publishing date	2023-06-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	123305-1
ISSN	1432-1920 ; 0028-3940
ISSN (online)	1432-1920
ISSN	0028-3940
DOI	10.1007/s00234-023-03171-4
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Zs.A 658: Show issues

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Article ; Online: Fosfomycin Disk Diffusion Testing among Klebsiella pneumoniae Results in Frequent Inner Colonies and Categorical Disagreement Based on Conflicting Breakpoint Organization Recommendations.

Bixby, Morgan L / Salay, Jenna M / Krueger, Amanda R / Mathers, Amy J / Hirsch, Elizabeth B

Microbiology spectrum

2023 , Page(s) e0336322

Abstract: Recent studies indicate that discrete inner colonies (ICs) arise during fosfomycin disk diffusion (DD) testing. CLSI and EUCAST have contradicting recommendations on the interpretation of ICs; CLSI recommends considering them while EUCAST recommends ... ...

Abstract	Recent studies indicate that discrete inner colonies (ICs) arise during fosfomycin disk diffusion (DD) testing. CLSI and EUCAST have contradicting recommendations on the interpretation of ICs; CLSI recommends considering them while EUCAST recommends ignoring them when interpreting DD results. We sought to compare the categorical agreement of DD and agar dilution (AD) MIC and to assess the implications of ICs interpretation on zone diameter readings. A convenience sample of 80 Klebsiella pneumoniae clinical isolates with varied phenotypic profiles collected from 3 United States locations was included. Susceptibility was determined in duplicate, using both organization recommendations and interpretations for
Language	English
Publishing date	2023-03-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.03363-22
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Article ; Online: Compliance and Documentation for Evaluation and Management Services in Interventional Pain Management Practice.

Manchikanti, Laxmaiah / Sanapati, Mahendra R / Pampati, Vidyasagar / Hirsch, Joshua A

Pain physician

2023 Volume 26, Issue 7, Page(s) 503–525

Abstract: Evaluation of new and established patients is an integral part of interventional pain management. Over the last 3 decades, there has been significant confusion over the proper documentation for evaluation and management (E/M) services in general and for ... ...

Abstract	Evaluation of new and established patients is an integral part of interventional pain management. Over the last 3 decades, there has been significant confusion over the proper documentation for evaluation and management (E/M) services in general and for interventional pain management in particular. Interventional pain physicians have learned how to evaluate patients presenting with pain on the basis of their specialty training. Although modern training programs are introducing residents and fellows to the intricacies of E/M services and federal regulations, this has not always been the case. Multiple textbooks about pain management, physiatry, and neurology, and numerous journal articles have described the evaluation of pain patients, but they have not been specific to chronic pain patients and may not meet the regulatory perspective.A multitude of these issues led to the development of guidelines in 1995 and 1997, which were highly complicated and difficult to follow. These also led to significant criticism from clinicians. Consequently, further guidance was developed to be effective January 2021.The crucial concept in the present system of coding for E/M services is medical decision making, which includes 3 elements since 2021: 1.The number and complexity of problems addressed. 2. Amount or complexity of data to be reviewed and analyzed. 3. Risk of complications and/or morbidity or mortality of patient management. In order to select a level of E/M service, 2 of the 3 elements of medical decision making (MDM) must be met or exceeded. This is in contrast to prior guidelines wherein for new patients, all 3 elements with history, physical examination and MDM , and for established patients have been met. For ease of appreciation, an algorithmic approach created by the American Medical Association (AMA), and Centers for Medicare and Medicaid Services (CMS) approved a new MDM table outlining all of the appropriate criteria.This review systematically describes the changes and provides an algorithmic approach for application in interventional pain management practices.
MeSH term(s)	Aged ; Humans ; United States ; Pain Management ; Medicare ; Chronic Pain/diagnosis ; Chronic Pain/therapy ; Documentation ; Centers for Medicare and Medicaid Services, U.S.
Language	English
Publishing date	2023-11-17
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	2146393-1
ISSN	2150-1149 ; 1533-3159
ISSN (online)	2150-1149
ISSN	1533-3159
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Zs.A 5930: Show issues

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Article ; Online: Adeno-Associated Virus Vector Mobilization, Risk Versus Reality.

Song, Liujiang / Samulski, R Jude / Hirsch, Matthew L

Human gene therapy

2020 Volume 31, Issue 19-20, Page(s) 1054–1067

Abstract: Recombinant adeno-associated viral (rAAV) vector mobilization is a largely theoretical process in which intact AAV vectors spread or "mobilize" from transduced cells and infect additional cells within, or external of, the initial host. This process can ... ...

Abstract	Recombinant adeno-associated viral (rAAV) vector mobilization is a largely theoretical process in which intact AAV vectors spread or "mobilize" from transduced cells and infect additional cells within, or external of, the initial host. This process can be helper virus-independent (vector alone) or helper virus-dependent (
MeSH term(s)	Adenoviridae/genetics ; DNA Replication ; DNA, Viral/genetics ; Dependovirus/physiology ; Genetic Vectors/administration & dosage ; Genetic Vectors/genetics ; HeLa Cells ; Humans ; Recombination, Genetic ; Virus Assembly
Chemical Substances	DNA, Viral
Language	English
Publishing date	2020-08-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1028152-6
ISSN	1557-7422 ; 1043-0342
ISSN (online)	1557-7422
ISSN	1043-0342
DOI	10.1089/hum.2020.118
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Zs.A 2988: Show issues

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Article ; Online: Wither Vulnerability? The Over/Under Protection Dilemma and Research Equity.

Barwise, Amelia K / Allyse, Megan A / Hirsch, Jessica R / McGowan, Michelle L / Meaghar, Karen M / Riggan, Kirsten A

The American journal of bioethics : AJOB

2023 Volume 23, Issue 6, Page(s) 113–116

MeSH term(s)	Humans ; Ethics Committees, Research
Language	English
Publishing date	2023-05-24
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2060433-6
ISSN	1536-0075 ; 1526-5161
ISSN (online)	1536-0075
ISSN	1526-5161
DOI	10.1080/15265161.2023.2201201
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Zs.A 6814: Show issues

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Article ; Online: Opportunities for antibiotic stewardship in emergency department or hospitalized patients with asymptomatic bacteriuria: identifying risk factors for antibiotic treatment.

Bixby, Morgan L / Raux, Brian R / Bhalla, Aakansha / McCoy, Christopher / Hirsch, Elizabeth B

Antimicrobial stewardship & healthcare epidemiology : ASHE

2022 Volume 2, Issue 1, Page(s) e16

Abstract: Antibiotic treatment of asymptomatic bacteriuria (ASB) is considered inappropriate and may lead to adverse events. This 2-center, retrospective cohort study including emergency department or inpatient adults identified pyuria (odds ratio, 2.43; 95% ... ...

Abstract	Antibiotic treatment of asymptomatic bacteriuria (ASB) is considered inappropriate and may lead to adverse events. This 2-center, retrospective cohort study including emergency department or inpatient adults identified pyuria (odds ratio, 2.43; 95% confidence interval, 1.17-5.01;
Language	English
Publishing date	2022-01-31
Publishing country	England
Document type	Journal Article
ISSN	2732-494X
ISSN (online)	2732-494X
DOI	10.1017/ash.2022.4
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Article ; Online: Extending the vision of adaptive point-of-care platform trials to improve targeted use of drug therapy regimens: An agile approach in the learning healthcare system toolkit.

Hirsch, Gigi / Velentgas, Priscilla / Curtis, Jeffrey R / Larholt, Kay / Park, Jay J H / Pashos, Chris L / Trinquart, Ludovic

Contemporary clinical trials

2023 Volume 133, Page(s) 107327

Abstract: Objectives: Improving the targeted use of drug regimens requires robust real-world evidence (RWE) to address the uncertainties that remain regarding their real-world performance following market entry. However, challenges in the current state of RWE ... ...

Abstract	Objectives: Improving the targeted use of drug regimens requires robust real-world evidence (RWE) to address the uncertainties that remain regarding their real-world performance following market entry. However, challenges in the current state of RWE production limit its impact on clinical decisions, as well as its operational scalability and sustainability. We propose an adaptive point-of-care (APoC) platform trial as an approach to RWE production that improves both clinical and operational efficiencies. Methods and findings: We explored design innovations, operational challenges, and infrastructure needs within a multi-stakeholder consortium to evaluate the potential of an APoC platform trial for studying chronic disease treatment regimens using rheumatoid arthritis as a case study. The concept integrates elements from adaptive clinical trials (dynamic treatment regimen strategies) and point-of-care trials (research embedded into routine clinical care) under a perpetual platform infrastructure. The necessary components to implement an APoC platform trial within outpatient settings exist, and present an opportunity for a cross-disciplinary, multi-stakeholder approach. Effective engagement of key stakeholders involved in and impacted by the platform is critical to success. Our collaborative design process identified three high-impact stakeholder-engagement areas: (1) focus on research question(s), (2) design and implementation planning such that it is feasible and fit-for-purpose, and (3) measurement, or meaningful metrics for both clinical (patient outcomes) and system (operational efficiencies) impact. Conclusions: An APoC platform trial for rheumatoid arthritis integrating innovative design elements in a scalable infrastructure has the potential to reduce important uncertainties about the real-world performance of biomedical innovations and improve clinical decisions.
Language	English
Publishing date	2023-08-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2182176-8
ISSN	1559-2030 ; 1551-7144
ISSN (online)	1559-2030
ISSN	1551-7144
DOI	10.1016/j.cct.2023.107327
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Zs.A 1581: Show issues

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Article ; Online: Comorbid alcohol use disorder and posttraumatic stress disorder: A proof-of-concept randomized placebo-controlled trial of buprenorphine and naltrexone combination treatment.

Davis, Lori L / Petrakis, Ismene L / Pilkinton, Patricia D / Nolen, Tracy / Vandergrift, Nathan / Hirsch, Shawn / Norrholm, Seth D / Kosten, Thomas R

Alcohol, clinical & experimental research

2023 Volume 47, Issue 9, Page(s) 1756–1772

Abstract: Background: Effective pharmacologic treatments for comorbid alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) are lacking. Kappa (κ) opioid receptor antagonists may address this unmet need. Buprenorphine is a κ-opioid antagonist and a ... ...

Abstract	Background: Effective pharmacologic treatments for comorbid alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) are lacking. Kappa (κ) opioid receptor antagonists may address this unmet need. Buprenorphine is a κ-opioid antagonist and a partial agonist of mu (μ) opioid receptors. Whereas naltrexone blocks all μ-mediated effects combining it with buprenorphine yields a pharmacologic net effect of opioid receptor antagonism. Because no κ-opioid receptor antagonist it available for clinical use, we tested this combination in a proof-of-concept study. Methods: Consenting participants were enrolled in a Phase II, multisite, double-blind, randomized, placebo-controlled trial evaluating the effectiveness of sublingual (SL) buprenorphine combined with extended-release (XR) injectable naltrexone for the treatment of comorbid AUD and PTSD. Eligible participants (n = 75) were randomized (1:1:1) to receive either buprenorphine 2 mg/day plus naltrexone-XR (n = 35), buprenorphine 8 mg/day plus naltrexone-XR (n = 6) or SL plus injectable placebo (n = 34) for 12 weeks. The buprenorphine 8 mg/day plus naltrexone-XR arm was dropped early in the trial due to the negative impact of COVID-19 on enrollment. A binary primary outcome of response at week 8 was defined as a decrease from baseline of ≥10 points on the past week Clinician-Administered PTSD Scale (CAPS-5) and a reduction of ≥1 of past month alcohol risk level, as defined by the World Health Organization (WHO) and measured by the Timeline Follow-Back. Results: Based on the results of a futility analysis, enrollment was stopped prior to reaching the initial goal of 90 participants. At the week eight primary timepoint, there were no statistically significant differences between buprenorphine plus naltrexone-XR and placebo group for the primary composite outcome (OR = 0.63; p-value = 0.52), or the subcomponents of the PTSD outcome (OR = 0.76; p-value = 0.69) and AUD outcome (OR = 0.17; p-value = 0.08). The placebo arm had a significantly higher proportion of participants with ≥1 WHO risk level reduction than the buprenorphine plus naltrexone-XR arm (OR = 0.18, p value = 0.02). Conclusions: This is the first study to evaluate the potential of κ-opioid receptor antagonism for the treatment of comorbid AUD and PTSD. The combination of buprenorphine and naltrexone-XR showed no significant improvement over placebo for the composite, PTSD, or alcohol measures.
Language	English
Publishing date	2023-08-30
Publishing country	United States
Document type	Journal Article
ISSN	2993-7175
ISSN (online)	2993-7175
DOI	10.1111/acer.15155
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