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Article ; Online: Development of a Web-Based Oxygenation Dashboard for Preterm Neonates: A Quality Improvement Initiative.

Poppe, J A / Smorenburg, R S / Goos, T G / Taal, H R / Reiss, I K M / Simons, S H P

2024 Volume 48, Issue 1, Page(s) 46

Abstract: Background: Preterm neonates are extensively monitored to require strict oxygen target attainment for optimal outcomes. In daily practice, detailed oxygenation data are hardly used and crucial patterns may be missed due to the snapshot presentations and ...

Abstract	Background: Preterm neonates are extensively monitored to require strict oxygen target attainment for optimal outcomes. In daily practice, detailed oxygenation data are hardly used and crucial patterns may be missed due to the snapshot presentations and subjective observations. This study aimed to develop a web-based dashboard with both detailed and summarized oxygenation data in real-time and to test its feasibility to support clinical decision making. Methods: Data from pulse oximeters and ventilators were synchronized and stored to enable real-time and retrospective trend visualizations in a web-based viewer. The dashboard was designed based on interviews with clinicians. A preliminary version was evaluated during daily clinical rounds. The routine evaluation of the respiratory condition of neonates (gestational age < 32 weeks) with respiratory support at the NICU was compared to an assessment with the assistance of the dashboard. Results: The web-based dashboard included data on the oxygen saturation (SpO Conclusions: A web-based customized oxygenation dashboard for preterm neonates at the NICU was developed and found feasible during evaluation. More clear and objective information was found supportive for clinicians during the daily rounds in tailoring treatment strategies.
MeSH term(s)	Humans ; Infant, Newborn ; Infant, Premature ; Quality Improvement/organization & administration ; Oximetry/methods ; Internet ; Oxygen Saturation ; Intensive Care Units, Neonatal ; Monitoring, Physiologic/methods
Language	English
Publishing date	2024-04-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	423488-1
ISSN	1573-689X ; 0148-5598
ISSN (online)	1573-689X
ISSN	0148-5598
DOI	10.1007/s10916-024-02064-0
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Article ; Online: The impact of health symptoms on health-related quality of life in early-stage breast cancer survivors.

de Ligt, K M / Heins, M / Verloop, J / Ezendam, N P M / Smorenburg, C H / Korevaar, J C / Siesling, S

Breast cancer research and treatment

2019 Volume 178, Issue 3, Page(s) 703–711

Abstract: Purpose: In breast cancer patients, treatment-related health symptoms can occur that may affect their health-related quality of life (HRQoL). This study aimed to determine the impact of health symptoms on HRQoL in breast cancer patients up to 5 years ... ...

Abstract	Purpose: In breast cancer patients, treatment-related health symptoms can occur that may affect their health-related quality of life (HRQoL). This study aimed to determine the impact of health symptoms on HRQoL in breast cancer patients up to 5 years after diagnosis. Methods: Females surgically treated for early-stage breast cancer diagnosed between 2012 and 2016 (n = 876) were selected from the Netherlands Cancer Registry and invited for a survey about current health symptoms ('Symptoms and Perceptions questionnaire', SaP) and HRQoL ('EORTC-QLQ-C30'). From the latter, functioning and global health were included. Mean scores were compared to norm population scores (T test). Multivariable linear regression analyses were performed to determine the association between health symptoms and global health and functioning. Results: 404 patients (46%) responded. The median age was 62.2 ± 10.9 years. Respondents had significantly lower mean scores for role, cognitive, emotional, and social functioning than the general population. The most frequently reported health symptoms were musculoskeletal (including pain/complaints in lower/upper extremities/back/neck; 71%) and central nervous system symptoms (including concentration impairment, dizziness, neuralgia; 66%), and fatigue (63%). While most symptoms affected functioning, irrespective of time since diagnosis, especially fatigue, musculoskeletal, central nervous system, and gastrointestinal symptoms were significantly associated (p < 0.05) with lower functioning. Conclusions: The majority of health symptoms that occur after breast cancer treatment were associated with lower functioning of patients in daily life. This paper urges healthcare providers to support breast cancer patients in alleviating or coping with health symptoms, even years after end of treatment, to improve their functioning.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Breast Neoplasms/pathology ; Breast Neoplasms/physiopathology ; Breast Neoplasms/psychology ; Breast Neoplasms/therapy ; Cancer Survivors/psychology ; Cancer Survivors/statistics & numerical data ; Cross-Sectional Studies ; Female ; Health Status ; Health Surveys ; Humans ; Middle Aged ; Netherlands/epidemiology ; Quality of Life ; Registries ; Survivorship
Language	English
Publishing date	2019-09-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	604563-7
ISSN	1573-7217 ; 0167-6806
ISSN (online)	1573-7217
ISSN	0167-6806
DOI	10.1007/s10549-019-05433-3
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Article ; Online: Patient-reported health problems and healthcare use after treatment for early-stage breast cancer.

de Ligt, K M / Heins, M / Verloop, J / Smorenburg, C H / Korevaar, J C / Siesling, S

Breast (Edinburgh, Scotland)

2019 Volume 46, Page(s) 4–11

Abstract: Background: A clear picture of treatment-related health problems following breast cancer treatment is useful in anticipating the informational and other needs of patients during follow-up. This study aimed to identify treatment-related health problems ... ...

Abstract	Background: A clear picture of treatment-related health problems following breast cancer treatment is useful in anticipating the informational and other needs of patients during follow-up. This study aimed to identify treatment-related health problems in breast cancer patients up to five years after diagnosis. Secondly, the use of care associated with these health problems was identified. Methods: 876 surgically-treated female patients diagnosed between 2012 and 2016 with early-stage breast cancer were asked to complete an online survey about their current health problems and use of care. Multivariate logistic regression analyses were applied to determine the effect of patient and treatment characteristics on health problems. Results: 404 patients responded (46%). The median age was 62.0 years (SD:10.9). Apart from breast surgery, patients had been treated with radiotherapy (72%), chemotherapy (49%), anti-hormonal therapy (57%), and axillary dissection (21%). Ninety-three percent experienced one or more health problems. Over 50% of respondents experienced fatigue, psychological problems, and health problems regarding the breast, and/or musculoskeletal, central nervous, and reproductive system. Treatment with chemotherapy was significantly associated (p < 0.05) with an increased risk of health problems, respectively fatigue (OR:2.00), respiratory (OR:1.81), gastrointestinal (OR:1.87), central nervous (OR:3.40), and skin problems (OR:2.62). Use of healthcare for one or more health problems was reported by 64% of respondents. Discussion: Almost all patients experienced health problems up to five years after breast cancer diagnosis, with a range of complaints that were consistently present over time. Factors associated with the development of health problems are useful for better informing patients beforehand and targeting follow-up care.
MeSH term(s)	Adult ; Aged ; Breast Neoplasms/therapy ; Cancer Survivors/statistics & numerical data ; Facilities and Services Utilization/statistics & numerical data ; Female ; Humans ; Mastectomy/adverse effects ; Middle Aged ; Patient Acceptance of Health Care/statistics & numerical data ; Patient Reported Outcome Measures ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Postoperative Period
Language	English
Publishing date	2019-04-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1143210-x
ISSN	1532-3080 ; 0960-9776
ISSN (online)	1532-3080
ISSN	0960-9776
DOI	10.1016/j.breast.2019.03.010
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Zs.A 3620: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: The effect of trastuzumab on cardiac function in patients with HER2-positive metastatic breast cancer and reduced baseline left ventricular ejection fraction.

Bouwer, Nathalie I / Steenbruggen, Tessa G / Rier, Hánah N / Kitzen, Jos J E M / Smorenburg, Carolien H / van Bekkum, Marlies L / de Jong, Paul C / Drooger, Jan C / Holterhues, Cynthia / Kofflard, Marcel J M / Boersma, Eric / Sonke, Gabe S / Levin, Mark-David / Jager, Agnes

International journal of cancer

2022 Volume 151, Issue 4, Page(s) 616–622

Abstract: We investigated the effect of trastuzumab on cardiac function in a real-world historic cohort of patients with HER2-positive metastatic breast cancer (MBC) with reduced baseline left ventricular ejection fraction (LVEF). Thirty-seven patients with HER2- ... ...

Abstract	We investigated the effect of trastuzumab on cardiac function in a real-world historic cohort of patients with HER2-positive metastatic breast cancer (MBC) with reduced baseline left ventricular ejection fraction (LVEF). Thirty-seven patients with HER2-positive MBC and baseline LVEF of 40% to 49% were included. Median LVEF was 46% (interquartile range [IQR] 44%-48%) and median follow-up was 18 months (IQR 9-34 months). During this period, the LVEF did not worsen in 24/37 (65%) patients, while 13/37 (35%) patients developed severe cardiotoxicity defined as LVEF <40% with median time to severe cardiotoxicity of 7 months (IQR 4-10 months) after beginning trastuzumab. Severe cardiotoxicity was reversible (defined as LVEF increase to a value <5%-points below baseline value) in 7/13 (54%) patients, partly reversible (defined as absolute LVEF increase ≥10%-points from nadir to a value >5%-points below baseline) in 3/13 (23%) patients and irreversible (defined as absolute LVEF increase <10%-points from nadir and to a value >5%-points below baseline) in 3/13 (23%) patients. Likelihood of reversibility was numerically higher in patients who received cardio-protective medications (CPM), including ACE-inhibitors, beta-blockers and angiotensine-2 inhibitors, compared to those who did not receive any CPM (71% vs 13%, P = .091). Sixty-five percent of patients who received trastuzumab for HER2-positive MBC did not develop severe cardiotoxicity during a median follow-up of 18 months, despite having a compromised baseline LVEF. If severe cardiotoxicity occurred, it was at least partly reversible in more than two-thirds of the cases. Risks and benefits of trastuzumab use should be balanced carefully in this vulnerable population.
MeSH term(s)	Breast Neoplasms/pathology ; Cardiotoxicity/drug therapy ; Cardiotoxicity/epidemiology ; Cardiotoxicity/etiology ; Female ; Humans ; Neoplasms, Second Primary/chemically induced ; Receptor, ErbB-2 ; Stroke Volume ; Trastuzumab/adverse effects ; Ventricular Function, Left
Chemical Substances	Receptor, ErbB-2 (EC 2.7.10.1) ; Trastuzumab (P188ANX8CK)
Language	English
Publishing date	2022-04-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218257-9
ISSN	1097-0215 ; 0020-7136
ISSN (online)	1097-0215
ISSN	0020-7136
DOI	10.1002/ijc.34024
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Zs.A 478: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 576: Show issues

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Article: Inhibition of angiogenesis with heparin?

Smorenburg, S M

Haemostasis

2001 Volume 31 Suppl 1, Page(s) 25–29

MeSH term(s)	Animals ; Antineoplastic Agents/therapeutic use ; Cells, Cultured ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/growth & development ; Heparin/metabolism ; Heparin/therapeutic use ; Humans ; Mice ; Neoplasms, Experimental/therapy ; Neovascularization, Pathologic/prevention & control
Chemical Substances	Antineoplastic Agents ; Heparin (9005-49-6)
Language	English
Publishing date	2001-10-25
Publishing country	Switzerland
Document type	Lecture
ZDB-ID	185252-8
ISSN	1423-0038 ; 0301-0147
ISSN (online)	1423-0038
ISSN	0301-0147
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Article ; Online: Chromatic aberrations correction of attosecond high-order harmonic beams by flat-top spatial shaping of the fundamental beam

K Veyrinas / M Plach / J Peschel / M Hoflund / F Catoire / C Valentin / P Smorenburg / H Dacasa / S Maclot / C Guo / H Wikmark / A Zaïr / V Strelkov / C Picot / C Arnold / P Eng-Johnsson / A L’Huillier / E Mével / E Constant

New Journal of Physics, Vol 25, Iss 2, p

2023 Volume 023017

Abstract: Attosecond pulses created by high-order harmonic generation in gases often exhibit strong chromatic aberrations, arising from the broad bandwidth and wavelength-dependent nonlinear light–matter interaction. When the driving laser intensity varies ... ...

Abstract	Attosecond pulses created by high-order harmonic generation in gases often exhibit strong chromatic aberrations, arising from the broad bandwidth and wavelength-dependent nonlinear light–matter interaction. When the driving laser intensity varies spatially, as for Gaussian driving beams, the apparent source position of the harmonics differs significantly from one order to the next, thus affecting the achievable intensity and duration of the attosecond pulses when they are focused on a target. We show that these chromatic aberrations can be reduced by spatially shaping the fundamental beam to generate high-order harmonics with a driver having a flat-top profile inside the gas medium. By measuring both the intensity profile and wavefront for each harmonic in a plane, we access the extreme ultra-violet (XUV) beam properties and investigate these properties near focus. We observe that controlling chromatic aberrations by flat-top spatial shaping strongly reduces the variation of the XUV spectrum on the beam axis during propagation and, in return, the longitudinal sensitivity of both the temporal profiles and the temporal shifts of the focused attosecond pulses.
Keywords	attosecond pulses ; high-order harmonics ; chromatic aberration ; flat-top ; spatial shaping ; Science ; Q ; Physics ; QC1-999
Subject code	535
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	IOP Publishing
Document type	Article ; Online
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Article ; Online: Current decisions on neoadjuvant chemotherapy for early breast cancer: Experts' experiences in the Netherlands.

Spronk, P E R / de Ligt, K M / van Bommel, A C M / Siesling, S / Smorenburg, C H / Vrancken Peeters, M T F D

Patient education and counseling

2018 Volume 101, Issue 12, Page(s) 2111–2115

Abstract: Purpose: To evaluate the opinion of surgical and medical oncologists on neoadjuvant chemotherapy (NAC) for early breast cancer.: Methods: Surgical and medical oncologists (N = 292) participating in breast cancer care in the Netherlands were invited ... ...

Abstract	Purpose: To evaluate the opinion of surgical and medical oncologists on neoadjuvant chemotherapy (NAC) for early breast cancer. Methods: Surgical and medical oncologists (N = 292) participating in breast cancer care in the Netherlands were invited for a 20-question survey on the influence of patient, disease, and management related factors on their decisions towards NAC. Results: A total of 138 surgical and medical oncologists from 64 out of 89 different Dutch hospitals completed the survey. NAC was recommended for locally advanced breast cancer (94%) and for downstaging to enable breast conserving surgery (BCS) (75%). Despite willingness to downstage, 64% of clinicians routinely recommended NAC when systemic therapy was indicated preoperatively. Reported reasons to refrain from NAC are comorbidities (68%), age >70 years (52%), and WHO-performance status ≥2 (93%). Opinions on NAC and surgical management were inconclusive; while 75% recommends NAC to enable BCS, some stated that BCS after NAC increases the risk of a non-radical resection (21%), surgical complications (9%) and recurrence of disease (5%). Conclusion: This article emphasizes the need for more consensus among specialists on the indications for NAC in early BC patients. Unambiguous and evidence-based treatment information could improve doctor-patient communication, supporting the patient in chemotherapy timing decision-making.
MeSH term(s)	Antineoplastic Agents/administration & dosage ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Chemotherapy, Adjuvant/methods ; Decision Making ; Female ; Health Care Surveys ; Humans ; Middle Aged ; Neoadjuvant Therapy/methods ; Netherlands ; Oncologists ; Treatment Outcome
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2018-07-18
Publishing country	Ireland
Document type	Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605590-4
ISSN	1873-5134 ; 0738-3991
ISSN (online)	1873-5134
ISSN	0738-3991
DOI	10.1016/j.pec.2018.07.012
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Article ; Online: Patients' experiences with decisions on timing of chemotherapy for breast cancer.

de Ligt, K M / Spronk, P E R / van Bommel, A C M / Vrancken Peeters, M T F D / Siesling, S / Smorenburg, C H

Breast (Edinburgh, Scotland)

2018 Volume 37, Page(s) 99–106

Abstract: Introduction: Despite potential advantages, application of chemotherapy in the neo-adjuvant (NAC) instead of adjuvant (AC) setting for breast cancer (BC) patients varies among hospitals. The aim of this study was to gain insight in patients' experiences ...

Abstract	Introduction: Despite potential advantages, application of chemotherapy in the neo-adjuvant (NAC) instead of adjuvant (AC) setting for breast cancer (BC) patients varies among hospitals. The aim of this study was to gain insight in patients' experiences with decisions on the timing of chemotherapy for stage II and III BC. Materials and methods: A 35-item online questionnaire was distributed among female patients (age>18) treated with either NAC or AC for clinical stage II/III invasive BC in 2013-2014 in the Netherlands. Outcome measures were the experienced exchange of information on the possible choice between both options and patients' involvement in the final decision on chemotherapy timing. Chemotherapy treatment experience was measured with the Cancer Therapy Satisfaction Questionnaire (CTSQ). Results: Of 805 invited patients, 49% responded (179 NAC, 215 AC). NAC-treated patients were younger and more often treated in teaching/academic hospitals and high-volume hospitals. Information on the possibility of NAC was given to a minority of AC-treated patients (AC, stage II:14%, stage III: 31%). Information on pros and cons of both NAC and AC was rated sufficient in about three fourth of respondents. Respondents not always felt having a choice in the timing of chemotherapy (stage II: 54% NAC vs 36% AC; stage III: 26% NAC, 54% AC). Conclusion: The need to make a treatment decision on NAC was found to be made explicit in only a small number of adjuvant treated patients, in particular in BC stage II. Less than half of the respondents felt they had a real choice.
MeSH term(s)	Adult ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Chemotherapy, Adjuvant/adverse effects ; Clinical Decision-Making ; Female ; Humans ; Middle Aged ; Neoadjuvant Therapy/adverse effects ; Neoplasm Invasiveness ; Neoplasm Staging ; Patient Education as Topic ; Patient Participation ; Patient Preference ; Surveys and Questionnaires ; Time Factors
Language	English
Publishing date	2018-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1143210-x
ISSN	1532-3080 ; 0960-9776
ISSN (online)	1532-3080
ISSN	0960-9776
DOI	10.1016/j.breast.2017.10.016
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Article ; Online: The daily updated Dutch national database on COVID-19 epidemiology, vaccination and sewage surveillance.

Geubbels, E L P E / Backer, J A / Bakhshi-Raiez, F / van der Beek, R F H J / van Benthem, B H B / van den Boogaard, J / Broekman, E H / Dongelmans, D A / Eggink, D / van Gaalen, R D / van Gageldonk, A / Hahné, S / Hajji, K / Hofhuis, A / van Hoek, A J / Kooijman, M N / Kroneman, A / Lodder, W / van Rooijen, M /

Roorda, W / Smorenburg, N / Zwagemaker, F / de Keizer, N F / van Walle, I / de Roda Husman, A M / Ruijs, C / van den Hof, S

Scientific data

2023 Volume 10, Issue 1, Page(s) 469

Abstract: The Dutch national open database on COVID-19 has been incrementally expanded since its start on 30 April 2020 and now includes datasets on symptoms, tests performed, individual-level positive cases and deaths, cases and deaths among vulnerable ... ...

Abstract	The Dutch national open database on COVID-19 has been incrementally expanded since its start on 30 April 2020 and now includes datasets on symptoms, tests performed, individual-level positive cases and deaths, cases and deaths among vulnerable populations, settings of transmission, hospital and ICU admissions, SARS-CoV-2 variants, viral loads in sewage, vaccinations and the effective reproduction number. This data is collected by municipal health services, laboratories, hospitals, sewage treatment plants, vaccination providers and citizens and is cleaned, analysed and published, mostly daily, by the National Institute for Public Health and the Environment (RIVM) in the Netherlands, using automated scripts. Because these datasets cover the key aspects of the pandemic and are available at detailed geographical level, they are essential to gain a thorough understanding of the past and current COVID-19 epidemiology in the Netherlands. Future purposes of these datasets include country-level comparative analysis on the effect of non-pharmaceutical interventions against COVID-19 in different contexts, such as different cultural values or levels of socio-economic disparity, and studies on COVID-19 and weather factors.
MeSH term(s)	Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; SARS-CoV-2 ; Sewage ; Vaccination ; Wastewater-Based Epidemiological Monitoring ; Netherlands
Chemical Substances	Sewage
Language	English
Publishing date	2023-07-20
Publishing country	England
Document type	Dataset ; Journal Article
ZDB-ID	2775191-0
ISSN	2052-4463 ; 2052-4463
ISSN (online)	2052-4463
ISSN	2052-4463
DOI	10.1038/s41597-023-02232-w
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Article ; Online: Breast-Contour-Preserving Procedure as a Multidisciplinary Parameter of Esthetic Outcome in Breast Cancer Treatment in The Netherlands.

van Bommel, Annnelotte / Spronk, Pauline / Mureau, Marc / Siesling, Sabine / Smorenburg, Carolien / Tollenaar, Rob / Vrancken Peeters, Marie-Jeanne / van Dalen, Thijs

Annals of surgical oncology

2019 Volume 26, Issue 6, Page(s) 1704–1711

Abstract: Background: The rate of breast-conserving surgery (BCS) is used as an esthetic outcome parameter, while other treatments contribute also, such as neoadjuvant chemotherapy (NAC) enabling BCS or immediate breast reconstruction (IBR). This study explores ... ...

Abstract	Background: The rate of breast-conserving surgery (BCS) is used as an esthetic outcome parameter, while other treatments contribute also, such as neoadjuvant chemotherapy (NAC) enabling BCS or immediate breast reconstruction (IBR). This study explores these efforts to preserve the patient's breast contour. Patients and methods: All patients who underwent surgery for invasive breast cancer in The Netherlands between January 2011 and December 2015 were selected from the Dutch national breast cancer audit (n = 61,309). The breast-contour-preserving procedures (BCPP) rate was defined as the rate of primary BCS, BCS after NAC, or mastectomy with IBR. BCPP rates were calculated and compared by year of diagnosis, age categories, and individual hospitals. Results: The rate of primary BCS remained stable (53%) while the BCPP rate increased from 63% in 2011 to 71% in 2015 due to an increase in patients receiving BCS after NAC and mastectomy with IBR. Primary BCS rates increased with age (from 17% in patients aged < 30 years to 63% in patients aged 60-69 years), while the proportion of patients undergoing mastectomy with IBR decreased from 44% in patients < 30 years to 1% in patients ≥ 70 years. The BCPP rate was similar for all age groups except for patients > 70 years. BCPP rates varied between the different hospitals in The Netherlands, ranging from 47 to 88%. Conclusions: The chance of preserving the breast contour for patients with breast cancer has increased substantially over recent years. BCPP provides a comprehensive parameter of esthetic outcome of breast cancer surgery.
MeSH term(s)	Adult ; Aged ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Carcinoma, Ductal, Breast/pathology ; Carcinoma, Ductal, Breast/surgery ; Carcinoma, Lobular/pathology ; Carcinoma, Lobular/surgery ; Chemotherapy, Adjuvant ; Esthetics ; Female ; Follow-Up Studies ; Humans ; Mammaplasty ; Mastectomy, Segmental ; Middle Aged ; Neoadjuvant Therapy ; Neoplasm Invasiveness ; Netherlands ; Organ Sparing Treatments/methods ; Prognosis
Language	English
Publishing date	2019-03-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-019-07265-3
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