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  1. Article ; Online: Constraining the p-Mode-g-Mode Tidal Instability with GW170817.

    Abbott, B P / Abbott, R / Abbott, T D / Acernese, F / Ackley, K / Adams, C / Adams, T / Addesso, P / Adhikari, R X / Adya, V B / Affeldt, C / Agarwal, B / Agathos, M / Agatsuma, K / Aggarwal, N / Aguiar, O D / Aiello, L / Ain, A / Ajith, P /
    Allen, B / Allen, G / Allocca, A / Aloy, M A / Altin, P A / Amato, A / Ananyeva, A / Anderson, S B / Anderson, W G / Angelova, S V / Antier, S / Appert, S / Arai, K / Araya, M C / Areeda, J S / Arène, M / Arnaud, N / Arun, K G / Ascenzi, S / Ashton, G / Ast, M / Aston, S M / Astone, P / Atallah, D V / Aubin, F / Aufmuth, P / Aulbert, C / AultONeal, K / Austin, C / Avila-Alvarez, A / Babak, S / Bacon, P / Badaracco, F / Bader, M K M / Bae, S / Baker, P T / Baldaccini, F / Ballardin, G / Ballmer, S W / Banagiri, S / Barayoga, J C / Barclay, S E / Barish, B C / Barker, D / Barkett, K / Barnum, S / Barone, F / Barr, B / Barsotti, L / Barsuglia, M / Barta, D / Bartlett, J / Bartos, I / Bassiri, R / Basti, A / Batch, J C / Bawaj, M / Bayley, J C / Bazzan, M / Bécsy, B / Beer, C / Bejger, M / Belahcene, I / Bell, A S / Beniwal, D / Bensch, M / Berger, B K / Bergmann, G / Bernuzzi, S / Bero, J J / Berry, C P L / Bersanetti, D / Bertolini, A / Betzwieser, J / Bhandare, R / Bilenko, I A / Bilgili, S A / Billingsley, G / Billman, C R / Birch, J / Birney, R / Birnholtz, O / Biscans, S / Biscoveanu, S / Bisht, A / Bitossi, M / Bizouard, M A / Blackburn, J K / Blackman, J / Blair, C D / Blair, D G / Blair, R M / Bloemen, S / Bock, O / Bode, N / Boer, M / Boetzel, Y / Bogaert, G / Bohe, A / Bondu, F / Bonilla, E / Bonnand, R / Booker, P / Boom, B A / Booth, C D / Bork, R / Boschi, V / Bose, S / Bossie, K / Bossilkov, V / Bosveld, J / Bouffanais, Y / Bozzi, A / Bradaschia, C / Brady, P R / Bramley, A / Branchesi, M / Brau, J E / Briant, T / Brighenti, F / Brillet, A / Brinkmann, M / Brisson, V / Brockill, P / Brooks, A F / Brown, D D / Brunett, S / Buchanan, C C / Buikema, A / Bulik, T / Bulten, H J / Buonanno, A / Buskulic, D / Buy, C / Byer, R L / Cabero, M / Cadonati, L / Cagnoli, G / Cahillane, C / Calderón Bustillo, J / Callister, T A / Calloni, E / Camp, J B / Canepa, M / Canizares, P / Cannon, K C / Cao, H / Cao, J / Capano, C D / Capocasa, E / Carbognani, F / Caride, S / Carney, M F / Casanueva Diaz, J / Casentini, C / Caudill, S / Cavaglià, M / Cavalier, F / Cavalieri, R / Cella, G / Cepeda, C B / Cerdá-Durán, P / Cerretani, G / Cesarini, E / Chaibi, O / Chamberlin, S J / Chan, M / Chao, S / Charlton, P / Chase, E / Chassande-Mottin, E / Chatterjee, D / Chatziioannou, Katerina / Cheeseboro, B D / Chen, H Y / Chen, X / Chen, Y / Cheng, H-P / Chia, H Y / Chincarini, A / Chiummo, A / Chmiel, T / Cho, H S / Cho, M / Chow, J H / Christensen, N / Chu, Q / Chua, A J K / Chua, S / Chung, K W / Chung, S / Ciani, G / Ciobanu, A A / Ciolfi, R / Cipriano, F / Cirelli, C E / Cirone, A / Clara, F / Clark, J A / Clearwater, P / Cleva, F / Cocchieri, C / Coccia, E / Cohadon, P-F / Cohen, D / Colla, A / Collette, C G / Collins, C / Cominsky, L R / Constancio, M / Conti, L / Cooper, S J / Corban, P / Corbitt, T R / Cordero-Carrión, I / Corley, K R / Cornish, N / Corsi, A / Cortese, S / Costa, C A / Cotesta, R / Coughlin, M W / Coughlin, S B / Coulon, J-P / Countryman, S T / Couvares, P / Covas, P B / Cowan, E E / Coward, D M / Cowart, M J / Coyne, D C / Coyne, R / Creighton, J D E / Creighton, T D / Cripe, J / Crowder, S G / Cullen, T J / Cumming, A / Cunningham, L / Cuoco, E / Canton, T Dal / Dálya, G / Danilishin, S L / D'Antonio, S / Danzmann, K / Dasgupta, A / Costa, C F Da Silva / Dattilo, V / Dave, I / Davier, M / Davis, D / Daw, E J / Day, B / DeBra, D / Deenadayalan, M / Degallaix, J / De Laurentis, M / Deléglise, S / Del Pozzo, W / Demos, N / Denker, T / Dent, T / De Pietri, R / Derby, J / Dergachev, V / De Rosa, R / De Rossi, C / DeSalvo, R / de Varona, O / Dhurandhar, S / Díaz, M C / Di Fiore, L / Di Giovanni, M / Di Girolamo, T / Di Lieto, A / Ding, B / Di Pace, S / Di Palma, I / Di Renzo, F / Dmitriev, A / Doctor, Z / Dolique, V / Donovan, F / Dooley, K L / Doravari, S / Dorrington, I / Dovale Álvarez, M / Downes, T P / Drago, M / Dreissigacker, C / Driggers, J C / Du, Z / Dupej, P / Dwyer, S E / Easter, P J / Edo, T B / Edwards, M C / Effler, A / Eggenstein, H-B / Ehrens, P / Eichholz, J / Eikenberry, S S / Eisenmann, M / Eisenstein, R A / Essick, R C / Estelles, H / Estevez, D / Etienne, Z B / Etzel, T / Evans, M / Evans, T M / Fafone, V / Fair, H / Fairhurst, S / Fan, X / Farinon, S / Farr, B / Farr, W M / Fauchon-Jones, E J / Favata, M / Fays, M / Fee, C / Fehrmann, H / Feicht, J / Fejer, M M / Feng, F / Fernandez-Galiana, A / Ferrante, I / Ferreira, E C / Ferrini, F / Fidecaro, F / Fiori, I / Fiorucci, D / Fishbach, M / Fisher, R P / Fishner, J M / Fitz-Axen, M / Flaminio, R / Fletcher, M / Fong, H / Font, J A / Forsyth, P W F / Forsyth, S S / Fournier, J-D / Frasca, S / Frasconi, F / Frei, Z / Freise, A / Frey, R / Frey, V / Fritschel, P / Frolov, V V / Fulda, P / Fyffe, M / Gabbard, H A / Gadre, B U / Gaebel, S M / Gair, J R / Gammaitoni, L / Ganija, M R / Gaonkar, S G / Garcia, A / García-Quirós, C / Garufi, F / Gateley, B / Gaudio, S / Gaur, G / Gayathri, V / Gemme, G / Genin, E / Gennai, A / George, D / George, J / Gergely, L / Germain, V / Ghonge, S / Ghosh, Abhirup / Ghosh, Archisman / Ghosh, S / Giacomazzo, B / Giaime, J A / Giardina, K D / Giazotto, A / Gill, K / Giordano, G / Glover, L / Goetz, E / Goetz, R / Goncharov, B / González, G / Gonzalez Castro, J M / Gopakumar, A / Gorodetsky, M L / Gossan, S E / Gosselin, M / Gouaty, R / Grado, A / Graef, C / Granata, M / Grant, A / Gras, S / Gray, C / Greco, G / Green, A C / Green, R / Gretarsson, E M / Groot, P / Grote, H / Grunewald, S / Gruning, P / Guidi, G M / Gulati, H K / Guo, X / Gupta, A / Gupta, M K / Gushwa, K E / Gustafson, E K / Gustafson, R / Halim, O / Hall, B R / Hall, E D / Hamilton, E Z / Hamilton, H F / Hammond, G / Haney, M / Hanke, M M / Hanks, J / Hanna, C / Hannam, M D / Hannuksela, O A / Hanson, J / Hardwick, T / Harms, J / Harry, G M / Harry, I W / Hart, M J / Haster, C-J / Haughian, K / Healy, J / Heidmann, A / Heintze, M C / Heitmann, H / Hello, P / Hemming, G / Hendry, M / Heng, I S / Hennig, J / Heptonstall, A W / Hernandez, F J / Heurs, M / Hild, S / Hinderer, T / Hoak, D / Hochheim, S / Hofman, D / Holland, N A / Holt, K / Holz, D E / Hopkins, P / Horst, C / Hough, J / Houston, E A / Howell, E J / Hreibi, A / Huerta, E A / Huet, D / Hughey, B / Hulko, M / Husa, S / Huttner, S H / Huynh-Dinh, T / Iess, A / Indik, N / Ingram, C / Inta, R / Intini, G / Isa, H N / Isac, J-M / Isi, M / Iyer, B R / Izumi, K / Jacqmin, T / Jani, K / Jaranowski, P / Johnson, D S / Johnson, W W / Jones, D I / Jones, R / Jonker, R J G / Ju, L / Junker, J / Kalaghatgi, C V / Kalogera, V / Kamai, B / Kandhasamy, S / Kang, G / Kanner, J B / Kapadia, S J / Karki, S / Karvinen, K S / Kasprzack, M / Katolik, M / Katsanevas, S / Katsavounidis, E / Katzman, W / Kaufer, S / Kawabe, K / Keerthana, N V / Kéfélian, F / Keitel, D / Kemball, A J / Kennedy, R / Key, J S / Khalili, F Y / Khamesra, B / Khan, H / Khan, I / Khan, S / Khan, Z / Khazanov, E A / Kijbunchoo, N / Kim, Chunglee / Kim, J C / Kim, K / Kim, W / Kim, W S / Kim, Y-M / King, E J / King, P J / Kinley-Hanlon, M / Kirchhoff, R / Kissel, J S / Kleybolte, L / Klimenko, S / Knowles, T D / Koch, P / Koehlenbeck, S M / Koley, S / Kondrashov, V / Kontos, A / Korobko, M / Korth, W Z / Kowalska, I / Kozak, D B / Krämer, C / Kringel, V / Krishnan, B / Królak, A / Kuehn, G / Kumar, P / Kumar, R / Kumar, S / Kuo, L / Kutynia, A / Kwang, S / Lackey, B D / Lai, K H / Landry, M / Lang, R N / Lange, J / Lantz, B / Lanza, R K / Lartaux-Vollard, A / Lasky, P D / Laxen, M / Lazzarini, A / Lazzaro, C / Leaci, P / Leavey, S / Lee, C H / Lee, H K / Lee, H M / Lee, H W / Lee, K / Lehmann, J / Lenon, A / Leonardi, M / Leroy, N / Letendre, N / Levin, Y / Li, J / Li, T G F / Li, X / Linker, S D / Littenberg, T B / Liu, J / Liu, X / Lo, R K L / Lockerbie, N A / London, L T / Longo, A / Lorenzini, M / Loriette, V / Lormand, M / Losurdo, G / Lough, J D / Lovelace, G / Lück, H / Lumaca, D / Lundgren, A P / Lynch, R / Ma, Y / Macas, R / Macfoy, S / Machenschalk, B / MacInnis, M / Macleod, D M / Magaña Hernandez, I / Magaña-Sandoval, F / Magaña Zertuche, L / Magee, R M / Majorana, E / Maksimovic, I / Man, N / Mandic, V / Mangano, V / Mansell, G L / Manske, M / Mantovani, M / Marchesoni, F / Marion, F / Márka, S / Márka, Z / Markakis, C / Markosyan, A S / Markowitz, A / Maros, E / Marquina, A / Martelli, F / Martellini, L / Martin, I W / Martin, R M / Martynov, D V / Mason, K / Massera, E / Masserot, A / Massinger, T J / Masso-Reid, M / Mastrogiovanni, S / Matas, A / Matichard, F / Matone, L / Mavalvala, N / Mazumder, N / McCann, J J / McCarthy, R / McClelland, D E / McCormick, S / McCuller, L / McGuire, S C / McIver, J / McManus, D J / McRae, T / McWilliams, S T / Meacher, D / Meadors, G D / Mehmet, M / Meidam, J / Mejuto-Villa, E / Melatos, A / Mendell, G / Mendoza-Gandara, D / Mercer, R A / Mereni, L / Merilh, E L / Merzougui, M / Meshkov, S / Messenger, C / Messick, C / Metzdorff, R / Meyers, P M / Miao, H / Michel, C / Middleton, H / Mikhailov, E E / Milano, L / Miller, A L / Miller, A / Miller, B B / Miller, J / Millhouse, M / Mills, J / Milovich-Goff, M C / Minazzoli, O / Minenkov, Y / Ming, J / Mishra, C / Mitra, S / Mitrofanov, V P / Mitselmakher, G / Mittleman, R / Moffa, D / Mogushi, K / Mohan, M / Mohapatra, S R P / Montani, M / Moore, C J / Moraru, D / Moreno, G / Morisaki, S / Mours, B / Mow-Lowry, C M / Mueller, G / Muir, A W / Mukherjee, Arunava / Mukherjee, D / Mukherjee, S / Mukund, N / Mullavey, A / Munch, J / Muñiz, E A / Muratore, M / Murray, P G / Nagar, A / Napier, K / Nardecchia, I / Naticchioni, L / Nayak, R K / Neilson, J / Nelemans, G / Nelson, T J N / Nery, M / Neunzert, A / Nevin, L / Newport, J M / Ng, K Y / Ng, S / Nguyen, P / Nguyen, T T / Nichols, D / Nielsen, A B / Nissanke, S / Nitz, A / Nocera, F / Nolting, D / North, C / Nuttall, L K / Obergaulinger, M / Oberling, J / O'Brien, B D / O'Dea, G D / Ogin, G H / Oh, J J / Oh, S H / Ohme, F / Ohta, H / Okada, M A / Oliver, M / Oppermann, P / Oram, Richard J / O'Reilly, B / Ormiston, R / Ortega, L F / O'Shaughnessy, R / Ossokine, S / Ottaway, D J / Overmier, H / Owen, B J / Pace, A E / Pagano, G / Page, J / Page, M A / Pai, A / Pai, S A / Palamos, J R / Palashov, O / Palomba, C / Pal-Singh, A / Pan, Howard / Pan, Huang-Wei / Pang, B / Pang, P T H / Pankow, C / Pannarale, F / Pant, B C / Paoletti, F / Paoli, A / Papa, M A / Parida, A / Parker, W / Pascucci, D / Pasqualetti, A / Passaquieti, R / Passuello, D / Patil, M / Patricelli, B / Pearlstone, B L / Pedersen, C / Pedraza, M / Pedurand, R / Pekowsky, L / Pele, A / Penn, S / Perez, C J / Perreca, A / Perri, L M / Pfeiffer, H P / Phelps, M / Phukon, K S / Piccinni, O J / Pichot, M / Piergiovanni, F / Pierro, V / Pillant, G / Pinard, L / Pinto, I M / Pirello, M / Pitkin, M / Poggiani, R / Popolizio, P / Porter, E K / Possenti, L / Post, A / Powell, J / Prasad, J / Pratt, J W W / Pratten, G / Predoi, V / Prestegard, T / Principe, M / Privitera, S / Prodi, G A / Prokhorov, L G / Puncken, O / Punturo, M / Puppo, P / Pürrer, M / Qi, H / Quetschke, V / Quintero, E A / Quitzow-James, R / Rabeling, D S / Radkins, H / Raffai, P / Raja, S / Rajan, C / Rajbhandari, B / Rakhmanov, M / Ramirez, K E / Ramos-Buades, A / Rana, Javed / Rapagnani, P / Raymond, V / Razzano, M / Read, J / Regimbau, T / Rei, L / Reid, S / Reitze, D H / Ren, W / Ricci, F / Ricker, P M / Riles, K / Rizzo, M / Robertson, N A / Robie, R / Robinet, F / Robson, T / Rocchi, A / Rolland, L / Rollins, J G / Roma, V J / Romano, R / Romel, C L / Romie, J H / Rosińska, D / Ross, M P / Rowan, S / Rüdiger, A / Ruggi, P / Rutins, G / Ryan, K / Sachdev, S / Sadecki, T / Sakellariadou, M / Salconi, L / Saleem, M / Salemi, F / Samajdar, A / Sammut, L / Sampson, L M / Sanchez, E J / Sanchez, L E / Sanchis-Gual, N / Sandberg, V / Sanders, J R / Sarin, N / Sassolas, B / Saulson, P R / Sauter, O / Savage, R L / Sawadsky, A / Schale, P / Scheel, M / Scheuer, J / Schmidt, P / Schnabel, R / Schofield, R M S / Schönbeck, A / Schreiber, E / Schuette, D / Schulte, B W / Schutz, B F / Schwalbe, S G / Scott, J / Scott, S M / Seidel, E / Sellers, D / Sengupta, A S / Sentenac, D / Sequino, V / Sergeev, A / Setyawati, Y / Shaddock, D A / Shaffer, T J / Shah, A A / Shahriar, M S / Shaner, M B / Shao, L / Shapiro, B / Shawhan, P / Shen, H / Shoemaker, D H / Shoemaker, D M / Siellez, K / Siemens, X / Sieniawska, M / Sigg, D / Silva, A D / Singer, L P / Singh, A / Singhal, A / Sintes, A M / Slagmolen, B J J / Slaven-Blair, T J / Smith, B / Smith, J R / Smith, R J E / Somala, S / Son, E J / Sorazu, B / Sorrentino, F / Souradeep, T / Spencer, A P / Srivastava, A K / Staats, K / Steinke, M / Steinlechner, J / Steinlechner, S / Steinmeyer, D / Steltner, B / Stevenson, S P / Stocks, D / Stone, R / Stops, D J / Strain, K A / Stratta, G / Strigin, S E / Strunk, A / Sturani, R / Stuver, A L / Summerscales, T Z / Sun, L / Sunil, S / Suresh, J / Sutton, P J / Swinkels, B L / Szczepańczyk, M J / Tacca, M / Tait, S C / Talbot, C / Talukder, D / Tanner, D B / Tápai, M / Taracchini, A / Tasson, J D / Taylor, J A / Taylor, R / Tewari, S V / Theeg, T / Thies, F / Thomas, E G / Thomas, M / Thomas, P / Thorne, K A / Thrane, E / Tiwari, S / Tiwari, V / Tokmakov, K V / Toland, K / Tonelli, M / Tornasi, Z / Torres-Forné, A / Torrie, C I / Töyrä, D / Travasso, F / Traylor, G / Trinastic, J / Tringali, M C / Trozzo, L / Tsang, K W / Tse, M / Tso, R / Tsuna, D / Tsukada, L / Tuyenbayev, D / Ueno, K / Ugolini, D / Urban, A L / Usman, S A / Vahlbruch, H / Vajente, G / Valdes, G / van Bakel, N / van Beuzekom, M / van den Brand, J F J / Van Den Broeck, C / Vander-Hyde, D C / van der Schaaf, L / van Heijningen, J V / van Veggel, A A / Vardaro, M / Varma, V / Vass, S / Vasúth, M / Vecchio, A / Vedovato, G / Veitch, J / Veitch, P J / Venkateswara, K / Venugopalan, G / Verkindt, D / Vetrano, F / Viceré, A / Viets, A D / Vinciguerra, S / Vine, D J / Vinet, J-Y / Vitale, S / Vo, T / Vocca, H / Vorvick, C / Vyatchanin, S P / Wade, A R / Wade, L E / Wade, M / Walet, R / Walker, M / Wallace, L / Walsh, S / Wang, G / Wang, H / Wang, J Z / Wang, W H / Wang, Y F / Ward, R L / Warner, J / Was, M / Watchi, J / Weaver, B / Wei, L-W / Weinert, M / Weinstein, A J / Weiss, R / Wellmann, F / Wen, L / Wessel, E K / Weßels, P / Westerweck, J / Wette, K / Whelan, J T / Whiting, B F / Whittle, C / Wilken, D / Williams, D / Williams, R D / Williamson, A R / Willis, J L / Willke, B / Wimmer, M H / Winkler, W / Wipf, C C / Wittel, H / Woan, G / Woehler, J / Wofford, J K / Wong, W K / Worden, J / Wright, J L / Wu, D S / Wysocki, D M / Xiao, S / Yam, W / Yamamoto, H / Yancey, C C / Yang, L / Yap, M J / Yazback, M / Yu, Hang / Yu, Haocun / Yvert, M / Zadrożny, A / Zanolin, M / Zelenova, T / Zendri, J-P / Zevin, M / Zhang, J / Zhang, L / Zhang, M / Zhang, T / Zhang, Y-H / Zhao, C / Zhou, M / Zhou, Z / Zhu, S J / Zhu, X J / Zimmerman, A B / Zucker, M E / Zweizig, J / Weinberg, N N

    Physical review letters

    2019  Volume 122, Issue 6, Page(s) 61104

    Abstract: We analyze the impact of a proposed tidal instability coupling p modes and g modes within neutron ... we compute the Bayes factor (lnB_{!pg}^{pg}) comparing our p-g model to a standard one. We find ... that the observed signal is consistent with waveform models that neglect p-g effects, with lnB_{!pg}^{pg}=0.03_{-0 ...

    Abstract We analyze the impact of a proposed tidal instability coupling p modes and g modes within neutron stars on GW170817. This nonresonant instability transfers energy from the orbit of the binary to internal modes of the stars, accelerating the gravitational-wave driven inspiral. We model the impact of this instability on the phasing of the gravitational wave signal using three parameters per star: an overall amplitude, a saturation frequency, and a spectral index. Incorporating these additional parameters, we compute the Bayes factor (lnB_{!pg}^{pg}) comparing our p-g model to a standard one. We find that the observed signal is consistent with waveform models that neglect p-g effects, with lnB_{!pg}^{pg}=0.03_{-0.58}^{+0.70} (maximum a posteriori and 90% credible region). By injecting simulated signals that do not include p-g effects and recovering them with the p-g model, we show that there is a ≃50% probability of obtaining similar lnB_{!pg}^{pg} even when p-g effects are absent. We find that the p-g amplitude for 1.4  M_{⊙} neutron stars is constrained to less than a few tenths of the theoretical maximum, with maxima a posteriori near one-tenth this maximum and p-g saturation frequency ∼70  Hz. This suggests that there are less than a few hundred excited modes, assuming they all saturate by wave breaking. For comparison, theoretical upper bounds suggest ≲10^{3} modes saturate by wave breaking. Thus, the measured constraints only rule out extreme values of the p-g parameters. They also imply that the instability dissipates ≲10^{51}  erg over the entire inspiral, i.e., less than a few percent of the energy radiated as gravitational waves.
    Language English
    Publishing date 2019-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.122.061104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Serum anti-Spike immunoglobulin G levels in random blood donors in Italy: High-titre convalescent plasma is easier than ever to procure.

    Focosi, Daniele / Meschi, Silvia / Coen, Sabrina / Iorio, Maria Carla / Franchini, Massimo / Lanza, Maria / Maggi, Fabrizio

    Vox sanguinis

    2023  Volume 118, Issue 9, Page(s) 794–797

    Abstract: ... in November 2022 and 299 in February 2023) using the Abbott Alinity® anti-Spike immunoglobulin G assay ...

    Abstract Background and objectives: COVID-19 convalescent plasma (CCP) has retained potency and clinical efficacy against SARS-CoV-2 and is currently of utmost value for seronegative immunocompromised patients. Since most of the effect is due to the vaccine boost of infection-elicited antibodies, there is a theoretical concern that the frequency of suitable donors is declining.
    Materials and methods: In this single-institution serosurvey, we screened 599 consecutive donors attending our area in two different seasons (300 in November 2022 and 299 in February 2023) using the Abbott Alinity® anti-Spike immunoglobulin G assay.
    Results: More than 80% of random donors qualify according to the FDA criteria for high-titre CCP (>4350 AU/mL), with a stable trend.
    Conclusion: Despite reduced anti-Spike vaccine boost deployment in the general population, we have shown here that high-titre CCP units are easier than ever to procure. This finding also has implications for the derivation of standard immunoglobulins, which are finally approaching the potency of hyperimmune serum and could soon represent an alternative to CCP.
    MeSH term(s) Humans ; Blood Donors ; COVID-19/therapy ; COVID-19 Serotherapy ; SARS-CoV-2 ; Cancer Vaccines ; Italy ; Immunoglobulin G ; Antibodies, Viral/therapeutic use ; Immunization, Passive ; Antibodies, Neutralizing
    Chemical Substances Cancer Vaccines ; Immunoglobulin G ; Antibodies, Viral ; Antibodies, Neutralizing
    Language English
    Publishing date 2023-07-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 80313-3
    ISSN 1423-0410 ; 0042-9007
    ISSN (online) 1423-0410
    ISSN 0042-9007
    DOI 10.1111/vox.13498
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Immunogenicity and protective efficacy of RSV G central conserved domain vaccine with a prefusion nanoparticle.

    Rainho-Tomko, Jennifer N / Pavot, Vincent / Kishko, Michael / Swanson, Kurt / Edwards, Darin / Yoon, Heesik / Lanza, Lilibeth / Alamares-Sapuay, Judith / Osei-Bonsu, Robert / Mundle, Sophia T / Murison, Dave A / Gallichan, Scott / Delagrave, Simon / Wei, Chih-Jen / Zhang, Linong / Nabel, Gary J

    NPJ vaccines

    2022  Volume 7, Issue 1, Page(s) 74

    Abstract: Respiratory syncytial virus (RSV) G glycoprotein has recently reemerged as a vaccine antigen due ... three constructs to display the G central conserved domain (Gcc) focused on inducing broad and potent ...

    Abstract Respiratory syncytial virus (RSV) G glycoprotein has recently reemerged as a vaccine antigen due to its ability to elicit potent neutralizing antibodies and ameliorate disease in animal models. Here we designed three constructs to display the G central conserved domain (Gcc) focused on inducing broad and potent neutralizing antibodies. One construct displaying Gcc from both RSV subgroups trimerized via a C-terminal foldon (Gcc-Foldon) was highly immunogenic in mice and in MIMIC, a pre-immune human in vitro model. To explore an optimal RSV vaccine, we combined the Gcc-Foldon antigen with a stabilized pre-fusion-F nanoparticle (pre-F-NP) as a bivalent vaccine and detected no antigenic interference between the two antigens in the MIMIC model. In RSV-primed macaques, the bivalent vaccine elicited potent humoral responses. Furthermore, both Gcc-Foldon and the bivalent vaccine conferred effective protection against RSV challenge in mice. This two-component vaccine could potentially provide effective protection against RSV infection in humans and warrants further clinical evaluation.
    Language English
    Publishing date 2022-06-30
    Publishing country England
    Document type Journal Article
    ISSN 2059-0105
    ISSN (online) 2059-0105
    DOI 10.1038/s41541-022-00487-9
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  4. Article ; Online: Measurement of the Q^{2} Dependence of the Deuteron Spin Structure Function g_{1} and its Moments at Low Q^{2} with CLAS.

    Adhikari, K P / Deur, A / El Fassi, L / Kang, H / Kuhn, S E / Ripani, M / Slifer, K / Zheng, X / Adhikari, S / Akbar, Z / Amaryan, M J / Avakian, H / Ball, J / Balossino, I / Barion, L / Battaglieri, M / Bedlinskiy, I / Biselli, A S / Bosted, P /
    Briscoe, W J / Brock, J / Bültmann, S / Burkert, V D / Thanh Cao, F / Carlin, C / Carman, D S / Celentano, A / Charles, G / Chen, J-P / Chetry, T / Choi, S / Ciullo, G / Clark, L / Cole, P L / Contalbrigo, M / Crede, V / D'Angelo, A / Dashyan, N / De Vita, R / De Sanctis, E / Defurne, M / Djalali, C / Dodge, G E / Drozdov, V / Dupre, R / Egiyan, H / El Alaoui, A / Elouadrhiri, L / Eugenio, P / Fedotov, G / Filippi, A / Ghandilyan, Y / Gilfoyle, G P / Golovatch, E / Gothe, R W / Griffioen, K A / Guidal, M / Guler, N / Guo, L / Hafidi, K / Hakobyan, H / Hanretty, C / Harrison, N / Hattawy, M / Heddle, D / Hicks, K / Holtrop, M / Hyde, C E / Ilieva, Y / Ireland, D G / Isupov, E L / Jenkins, D / Jo, H S / Johnston, S C / Joo, K / Joosten, S / Kabir, M L / Keith, C D / Keller, D / Khachatryan, G / Khachatryan, M / Khandaker, M / Kim, W / Klein, A / Klein, F J / Konczykowski, P / Kovacs, K / Kubarovsky, V / Lanza, L / Lenisa, P / Livingston, K / Long, E / MacGregor, I J D / Markov, N / Mayer, M / McKinnon, B / Meekins, D G / Meyer, C A / Mineeva, T / Mirazita, M / Mokeev, V / Movsisyan, A / Munoz Camacho, C / Nadel-Turonski, P / Niculescu, G / Niccolai, S / Osipenko, M / Ostrovidov, A I / Paolone, M / Pappalardo, L / Paremuzyan, R / Park, K / Pasyuk, E / Payette, D / Phelps, W / Phillips, S K / Pierce, J / Pogorelko, O / Poudel, J / Price, J W / Prok, Y / Protopopescu, D / Raue, B A / Rizzo, A / Rosner, G / Rossi, P / Sabatié, F / Salgado, C / Schumacher, R A / Sharabian, Y G / Shigeyuki, T / Simonyan, A / Skorodumina, Iu / Smith, G D / Sparveris, N / Sokhan, D / Stepanyan, S / Strakovsky, I I / Strauch, S / Sulkosky, V / Taiuti, M / Tan, J A / Ungaro, M / Voutier, E / Wei, X / Weinstein, L B / Zhang, J / Zhao, Z W

    Physical review letters

    2018  Volume 120, Issue 6, Page(s) 62501

    Abstract: We measured the g_{1} spin structure function of the deuteron at low Q^{2}, where QCD can be ...

    Abstract We measured the g_{1} spin structure function of the deuteron at low Q^{2}, where QCD can be approximated with chiral perturbation theory (χPT). The data cover the resonance region, up to an invariant mass of W≈1.9  GeV. The generalized Gerasimov-Drell-Hearn sum, the moment Γ_{1}^{d} and the spin polarizability γ_{0}^{d} are precisely determined down to a minimum Q^{2} of 0.02  GeV^{2} for the first time, about 2.5 times lower than that of previous data. We compare them to several χPT calculations and models. These results are the first in a program of benchmark measurements of polarization observables in the χPT domain.
    Language English
    Publishing date 2018-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.120.062501
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  5. Article ; Online: A functional role for soluble HLA-G antigens in immune modulation mediated by mesenchymal stromal cells.

    Rizzo, R / Campioni, D / Stignani, M / Melchiorri, L / Bagnara, G P / Bonsi, L / Alviano, F / Lanzoni, G / Moretti, S / Cuneo, A / Lanza, F / Baricordi, O R

    Cytotherapy

    2008  Volume 10, Issue 4, Page(s) 364–375

    Abstract: ... mesenchymal stromal cells (MSC) play a fundamental role in mediating immune modulation. HLA-G antigens (Ag) are ... of the main up-modulators of soluble HLA-G Ag (sHLA-G) production by CD14+ peripheral blood monocyte cells and ... We investigated, by specific enzyme-linked immunosorbent assay (ELISA), the possible role of sHLA-G molecules ...

    Abstract Background: It has been suggested that soluble factors produced by bone marrow (BM) mesenchymal stromal cells (MSC) play a fundamental role in mediating immune modulation. HLA-G antigens (Ag) are major histocompatibility complex (MHC) class Ib molecules characterized by a limited polymorphism and a splicing mechanism that regulates the production of membrane-bound and soluble isoforms. Interleukin-10 (IL-10) cytokine is one of the main up-modulators of soluble HLA-G Ag (sHLA-G) production by CD14+ peripheral blood monocyte cells and increased IL-10 levels are reported to be associated with MSC immune modulation.
    Methods: We investigated, by specific enzyme-linked immunosorbent assay (ELISA), the possible role of sHLA-G molecules in the inhibition of the peripheral blood mononuclear cell (PBMC) response to phytohemagglutinin (PHA) mediated by MSC from different sources.
    Results: There was a significant correlation between the presence of increased levels of sHLA-G and IL-10 in the MSC/PBMC/PHA culture supernatants and lymphoproliferative inhibition. Neutralizing experiments performed with monoclonal Ab directed against HLA-G and IL-10 molecules confirmed the inhibitory ability of sHLA-G Ag. Furthermore, exogenous IL-10 induced sHLA-G molecule secretion by MSC alone in a polymorphic way, while a longitudinal analysis confirmed the loss of MSC inhibitory functions in relation to in vitro MSC aging.
    Discussion: Overall the results obtained suggest a functional role for sHLA-G molecules in inhibiting the PBMC response mediated by MSC. Moreover, the ability of IL-10 to induce sHLA-G Ag production by MSC alone could be proposed as a marker of MSC functional ability.
    MeSH term(s) Adult ; Animals ; Antibodies/immunology ; Antigens, CD/metabolism ; Biomarkers/metabolism ; Bone Marrow Cells/cytology ; Bone Marrow Cells/immunology ; Cells, Cultured ; Coculture Techniques ; Female ; HLA Antigens/immunology ; HLA-G Antigens ; Histocompatibility Antigens Class I/immunology ; Humans ; Immunity/physiology ; Immunophenotyping ; Interleukin-10/immunology ; Leukocytes, Mononuclear/cytology ; Leukocytes, Mononuclear/immunology ; Mesoderm/cytology ; Middle Aged ; Stromal Cells/cytology ; Stromal Cells/immunology
    Chemical Substances Antibodies ; Antigens, CD ; Biomarkers ; HLA Antigens ; HLA-G Antigens ; Histocompatibility Antigens Class I ; Interleukin-10 (130068-27-8)
    Language English
    Publishing date 2008
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2039821-9
    ISSN 1477-2566 ; 1465-3249
    ISSN (online) 1477-2566
    ISSN 1465-3249
    DOI 10.1080/14653240802105299
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  6. Book ; Online ; E-Book: Principles of regenerative medicine

    Atala, Anthony / Lanza, Robert P. / Mikos, Antonios G. / Nerem, Robert M.

    2019  

    Title variant Regenerative medicine
    Author's details edited by Anthony Atala, Robert Lanza, Anthony G. Mikos, Robert Nerem
    Language English
    Size 1 Online-Ressource (xxv, 1428 Seiten), Illustrationen, Diagramme
    Edition Third edition
    Publisher Elsevier AP
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019805983
    ISBN 978-0-12-809893-6 ; 9780128098806 ; 0-12-809893-7 ; 0128098805
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  7. Article ; Online: Umbilical cord blood CD34(+)cell-derived progeny produces human leukocyte antigen-G molecules with immuno-modulatory functions.

    Buzzi, Marina / Alviano, Francesco / Campioni, Diana / Stignani, Marina / Melchiorri, Loredana / Rotola, Antonella / Tazzari, Pierluigi / Ricci, Francesca / Vaselli, Cristiana / Terzi, Adriana / Pagliaro, Pasquale P / Cuneo, Antonio / Lanza, Francesco / Bontadini, Andrea / Baricordi, Olavio R / Rizzo, Roberta

    Human immunology

    2012  Volume 73, Issue 2, Page(s) 150–155

    Abstract: ... stem-cell transplantation. Human leukocyte antigen (HLA)-G is a tolerogenic molecule with a possible implication in UCB ... immunoregulatory effect. HLA-G expression was observed in UCB myeloid and plasmacytoid dendritic cells; in contrast ... transplantation needs further evaluation of HLA-G expression in CD34(+) cells and their hematopoietic progeny ...

    Abstract Human umbilical cord blood units (UCBs) are an alternative source in allogeneic-stem-cell transplantation. Human leukocyte antigen (HLA)-G is a tolerogenic molecule with a possible implication in UCB immunoregulatory effect. HLA-G expression was observed in UCB myeloid and plasmacytoid dendritic cells; in contrast, CD34(+) cells did not produce this molecule. CD34(+) cells are primitive hematopoietic progenitor cells that are present in UCB and are necessary for long-term engraftment via production of immunoregulatory molecules and a hematopoietic progeny that supports cellular recovery. The role of these cells in UCB transplantation needs further evaluation of HLA-G expression in CD34(+) cells and their hematopoietic progeny. We confirmed the absence of HLA-G expression in CD34(+) cells, whereas CD34(+)-derived progeny secreted HLA-G molecules and expressed HLA-G mRNA in in vitro cultures. Furthermore, soluble HLA (sHLA)-G molecules purified from the culture supernatants of CD34(+)-derived progeny were able to suppress lymphoproliferative response in an HLA-G dose-dependent manner. Overall these results identify CD34(+)-derived hematopoietic progeny as producers of HLA-G molecules and support a role of this antigen as an immuno-modulatory factor in UCB.
    MeSH term(s) Adult ; Antigens, CD34/immunology ; Cell Proliferation/drug effects ; Cells, Cultured ; Electrophoresis, Polyacrylamide Gel ; Enzyme-Linked Immunosorbent Assay ; Female ; Fetal Blood/cytology ; Fetal Blood/immunology ; Gene Expression Regulation ; HLA-G Antigens/immunology ; HLA-G Antigens/isolation & purification ; HLA-G Antigens/pharmacology ; Humans ; Immunologic Factors/pharmacology ; Pregnancy
    Chemical Substances Antigens, CD34 ; HLA-G Antigens ; Immunologic Factors
    Language English
    Publishing date 2012-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 801524-7
    ISSN 1879-1166 ; 0198-8859
    ISSN (online) 1879-1166
    ISSN 0198-8859
    DOI 10.1016/j.humimm.2011.12.003
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  8. Book ; Online ; E-Book: Current Microbiological Research in Africa

    Abia, Akebe Luther King / Lanza, Guy R.

    Selected Applications for Sustainable Environmental Management

    2020  

    Abstract: ... highlighted. Microbial involvement in different common indoor (e.g., household kitchens, latrines, and ...

    Author's details edited by Akebe Luther King Abia, Guy R. Lanza
    Abstract Scientific output in low- and middle-income countries is greatly challenged by numerous factors. This is particularly pronounced in sub-Saharan African countries, despite the continent being the world’s second largest and second most-populous continent, currently undergoing rapid economic growth. Financial constraints and unclear areas of focus when funding is available, are among the limiting factors, with the consequence being the development of inadequate policies, especially those relating to environmental protection and conservation. This 13-chapter book is a unique piece in the field of microbiology, designed to stimulate some research areas in Africa by illustrating interesting and informative examples of the current applied research agenda in environmental microbiology in selected countries within the continent. With authors from the North, South, East and West of Africa, the book touches diverse applied methods and approaches to meet the pragmatic needs faced by environmental microbiologists in Africa. Also included are topics on viruses, bacteria (including cyanobacteria), and protozoa, and their importance in disease. Sustainable agriculture and aquaculture, and eco-friendly oil and hydrocarbon bioremediation and degradation approaches are highlighted. Microbial involvement in different common indoor (e.g., household kitchens, latrines, and hospitals) and outdoor settings including air, soil, and water habitats, and their resistance to commonly used antibiotics, are described. Hopefully, the work presented here will stimulate the need for increasing modern training and funding initiatives to prepare African microbiologists to meet the challenges they face in African universities and research laboratories.
    Keywords Microbial ecology ; Environmental management ; Environmental health ; Microbial genetics ; Microbial genomics ; Microbiology ; Microbial Ecology ; Environmental Management ; Water and Health ; Microbial Genetics and Genomics
    Subject code 579.16
    Language English
    Size 1 online resource (XII, 359 p. 28 illus., 24 illus. in color.)
    Edition 1st ed. 2020.
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-35296-X ; 3-030-35295-1 ; 978-3-030-35296-7 ; 978-3-030-35295-0
    DOI 10.1007/978-3-030-35296-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  9. Article: Soluble HLA-G molecules in follicular fluid: a tool for oocyte selection in IVF?

    Rizzo, R / Fuzzi, B / Stignani, M / Criscuoli, L / Melchiorri, L / Dabizzi, S / Campioni, D / Lanza, F / Marzola, A / Branconi, F / Noci, I / Baricordi, O R

    Journal of reproductive immunology

    2007  Volume 74, Issue 1-2, Page(s) 133–142

    Abstract: ... Since several studies have proposed the expression of HLA-G antigens in early embryos to be a possible marker ... of elevated implantation rate, we have investigated the presence of soluble HLA-G molecules in 50 ... follicular fluids (FFs). The results have shown soluble HLA-G antigens (sHLA-G) in 19/50 (38%) FFs. Furthermore ...

    Abstract Currently, different approaches are used to select oocytes for in vitro fertilization (IVF) procedures, but they do not assure a significant association with the pregnancy outcome. Since several studies have proposed the expression of HLA-G antigens in early embryos to be a possible marker of elevated implantation rate, we have investigated the presence of soluble HLA-G molecules in 50 follicular fluids (FFs). The results have shown soluble HLA-G antigens (sHLA-G) in 19/50 (38%) FFs. Furthermore, we have related the presence of sHLA-G molecules in FFs to detection of the soluble antigens in culture supernatants of the corresponding fertilized oocyte, evidencing a significant relationship (p=1.3 x 10(-6); Fisher exact p-test). Specific ELISA and Western blot approaches identified both HLA-G5 and soluble HLA-G1 molecules in FFs while immunocytochemical analysis indicated polymorphonuclear-like and granulosa cells as responsible for production of sHLA-G1 and HLA-G5 molecules. In contrast, only sHLA-G1 antigens were detected in culture supernatants of fertilized oocytes. Overall, these results suggest a role for sHLA-G molecules in the ovulatory process and propose the FFs analysis for sHLA-G molecule presence as a useful tool for oocyte selection in IVF.
    MeSH term(s) Blotting, Western ; Embryo Implantation ; Enzyme-Linked Immunosorbent Assay ; Female ; Fertilization in Vitro/methods ; Follicular Fluid/immunology ; HLA Antigens/analysis ; HLA Antigens/physiology ; HLA-G Antigens ; Histocompatibility Antigens Class I/analysis ; Histocompatibility Antigens Class I/physiology ; Humans ; Immunohistochemistry ; Male ; Pregnancy ; Sperm Injections, Intracytoplasmic ; Zygote/immunology
    Chemical Substances HLA Antigens ; HLA-G Antigens ; Histocompatibility Antigens Class I
    Language English
    Publishing date 2007-06
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 424421-7
    ISSN 1872-7603 ; 0165-0378
    ISSN (online) 1872-7603
    ISSN 0165-0378
    DOI 10.1016/j.jri.2007.02.005
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  10. Article ; Online: Higher BMI is not a barrier to stem cell mobilization with standard doses of plerixafor and G-CSF.

    Basak, G W / Wiktor-Jedrzejczak, W / Apperley, J F / Douglas, K W / Gabriel, I H / Geraldes, C / Hübel, K / Jaksic, O / Koristek, Z / Lanza, F / Lemoli, R / Mikala, G / Selleslag, D / Worel, N / Mohty, M / Duarte, R F

    Bone marrow transplantation

    2011  Volume 47, Issue 7, Page(s) 1003–1005

    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Benzylamines ; Body Mass Index ; Contraindications ; Cyclams ; Female ; Granulocyte Colony-Stimulating Factor/administration & dosage ; Hematopoietic Stem Cell Mobilization/methods ; Heterocyclic Compounds/administration & dosage ; Hodgkin Disease/pathology ; Humans ; Lymphoma, Non-Hodgkin/pathology ; Male ; Middle Aged ; Multiple Myeloma/pathology ; Obesity/physiopathology ; Overweight/physiopathology ; Retrospective Studies ; Thinness/physiopathology ; Young Adult
    Chemical Substances Benzylamines ; Cyclams ; Heterocyclic Compounds ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; plerixafor (S915P5499N)
    Language English
    Publishing date 2011-10-10
    Publishing country England
    Document type Letter
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/bmt.2011.199
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