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  1. Article ; Online: Genome doubling - twice the same is not the same.

    Storchová, Zuzana

    Nature reviews. Molecular cell biology

    2023  Volume 24, Issue 9, Page(s) 605

    Language English
    Publishing date 2023-05-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2031313-5
    ISSN 1471-0080 ; 1471-0072
    ISSN (online) 1471-0080
    ISSN 1471-0072
    DOI 10.1038/s41580-023-00618-7
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    Zs.A 5446: Show issues Location:
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  2. Article ; Online: The adaptive strategies of cells in the face of CIN.

    Storchová, Zuzana

    The EMBO journal

    2023  Volume 42, Issue 8, Page(s) e113766

    Abstract: An increased frequency of chromosome segregation errors, known as chromosomal instability (CIN), leads to accumulation of aneuploid cells with abnormal chromosomal numbers, which impairs viability through negative effects on survival and proliferation ... ...

    Abstract An increased frequency of chromosome segregation errors, known as chromosomal instability (CIN), leads to accumulation of aneuploid cells with abnormal chromosomal numbers, which impairs viability through negative effects on survival and proliferation under most conditions. Two recent papers find by independent approaches that the key to surviving high levels of CIN is reducing the instability itself, showcasing the remarkable adaptability of the chromosome segregation machinery, in particular the microtubule-kinetochore interface, and highlighting the crucial role that maintaining chromosomal stability plays in cell proliferation.
    MeSH term(s) Humans ; Chromosomal Instability ; Microtubules ; Kinetochores ; Aneuploidy ; Chromosome Segregation ; Neoplasms/genetics
    Language English
    Publishing date 2023-03-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 586044-1
    ISSN 1460-2075 ; 0261-4189
    ISSN (online) 1460-2075
    ISSN 0261-4189
    DOI 10.15252/embj.2023113766
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  3. Book ; Online: Aneuploidy in Health and Disease

    Storchova, Zuzana

    2012  

    Keywords Medical genetics
    Size 1 electronic resource (258 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021049328
    ISBN 9789535152965 ; 9535152963
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Consequences of mitotic failure - The penalties and the rewards.

    Storchova, Zuzana

    Seminars in cell & developmental biology

    2021  Volume 117, Page(s) 149–158

    Abstract: Eukaryotic cells are usually diploid, meaning they contain two copies of each chromosome. However, aberrant chromosome numbers due to both, chromosome gains and losses, are often observed in nature. They can occur as a planned developmental step, but are ...

    Abstract Eukaryotic cells are usually diploid, meaning they contain two copies of each chromosome. However, aberrant chromosome numbers due to both, chromosome gains and losses, are often observed in nature. They can occur as a planned developmental step, but are more often an uninvited result of mitotic failure. Recent discoveries have improved our understanding of the cellular effects of aneuploidy - uneven chromosome numbers, and polyploidy - multiplication of entire sets of chromosomes - in eukaryotic cells. The results show that mitotic errors lead to rapid and extensive modifications of many cellular processes and affect proliferation, proteome balance, genome stability and more. The findings picture the cellular response to aneuploidy and polyploidy as a complex, tissue and context dependent network of events. Here I review the latest discoveries, with an emphasis on pathological aspects of aneuploidy and polyploidy in human cells.
    MeSH term(s) Aneuploidy ; Chromosomal Instability/physiology ; Humans ; Mitosis/physiology
    Language English
    Publishing date 2021-04-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1312473-0
    ISSN 1096-3634 ; 1084-9521
    ISSN (online) 1096-3634
    ISSN 1084-9521
    DOI 10.1016/j.semcdb.2021.03.007
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  5. Article: Sphingolipid Turnover Turns Over the Fate of Aneuploid Cells.

    Storchová, Zuzana

    Trends in genetics : TIG

    2018  Volume 34, Issue 4, Page(s) 255–256

    Abstract: Aneuploidy, or unbalanced chromosome number, is a hallmark of cancer. Recently established model systems revealed that aneuploidy affects many aspects of cellular physiology, among them sphingolipid metabolism. The new finding that the proliferation of ... ...

    Abstract Aneuploidy, or unbalanced chromosome number, is a hallmark of cancer. Recently established model systems revealed that aneuploidy affects many aspects of cellular physiology, among them sphingolipid metabolism. The new finding that the proliferation of aneuploid cells depends on sphingolipid homeostasis offers an appealing opportunity for cancer treatment.
    MeSH term(s) Aneuploidy ; Homeostasis ; Humans ; Neoplasms ; Serine ; Sphingolipids
    Chemical Substances Sphingolipids ; Serine (452VLY9402)
    Language English
    Publishing date 2018-02-21
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 619240-3
    ISSN 1362-4555 ; 0168-9525 ; 0168-9479
    ISSN (online) 1362-4555
    ISSN 0168-9525 ; 0168-9479
    DOI 10.1016/j.tig.2018.02.004
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  6. Article ; Online: Evolution of aneuploidy: overcoming the original CIN.

    Storchova, Zuzana

    Genes & development

    2019  Volume 32, Issue 23-24, Page(s) 1459–1460

    Abstract: Chromosomal instability (CIN) generates continuously novel aneuploid genomes-unbalanced chromosome combinations that differ from the haploid chromosome set and its multiples. On one hand, this causes problems for cells, as high CIN and aneuploidy impair ... ...

    Abstract Chromosomal instability (CIN) generates continuously novel aneuploid genomes-unbalanced chromosome combinations that differ from the haploid chromosome set and its multiples. On one hand, this causes problems for cells, as high CIN and aneuploidy impair cellular proliferation by inducing multiple cellular stresses. At the same time, some genomes might provide an advantage under suboptimal conditions. However, what happens to cells that carry a mutation generating extremely high CIN? Are they sentenced to death, or can their instability help them to avert that fate? The elegant work from Ravichandran and colleagues (pp. 1485-1498) in this issue of
    MeSH term(s) Aneuploidy ; Chromosomal Instability ; Chromosomes ; DNA Copy Number Variations ; Humans ; Saccharomyces cerevisiae/genetics
    Language English
    Publishing date 2019-01-29
    Publishing country United States
    Document type Journal Article ; Review ; Comment
    ZDB-ID 806684-x
    ISSN 1549-5477 ; 0890-9369
    ISSN (online) 1549-5477
    ISSN 0890-9369
    DOI 10.1101/gad.321810.118
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  7. Article ; Online: Too much to differentiate: aneuploidy promotes proliferation and teratoma formation in embryonic stem cells.

    Storchová, Zuzana

    The EMBO journal

    2016  Volume 35, Issue 21, Page(s) 2265–2267

    MeSH term(s) Aneuploidy ; Cell Differentiation ; Embryonic Stem Cells ; Humans ; Teratoma
    Language English
    Publishing date 2016-09-28
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 586044-1
    ISSN 1460-2075 ; 0261-4189
    ISSN (online) 1460-2075
    ISSN 0261-4189
    DOI 10.15252/embj.201695486
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  8. Article: Consequences of trisomy syndromes - 21 and beyond.

    Krivega, Maria / Storchova, Zuzana

    Trends in genetics : TIG

    2022  Volume 39, Issue 3, Page(s) 172–174

    Abstract: The mechanisms underlying pathologies in Down syndrome remain poorly understood. In this forum article we compare the cellular phenotypes of chromosome 21 trisomy with other trisomic cells. We argue that both effects of the extra chromosome 21 and the ... ...

    Abstract The mechanisms underlying pathologies in Down syndrome remain poorly understood. In this forum article we compare the cellular phenotypes of chromosome 21 trisomy with other trisomic cells. We argue that both effects of the extra chromosome 21 and the global consequences of chromosome gain must be considered to understand complex pathologies of Down syndrome.
    MeSH term(s) Humans ; Down Syndrome/genetics ; Trisomy
    Language English
    Publishing date 2022-12-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 619240-3
    ISSN 1362-4555 ; 0168-9525 ; 0168-9479
    ISSN (online) 1362-4555
    ISSN 0168-9525 ; 0168-9479
    DOI 10.1016/j.tig.2022.11.004
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  9. Book ; Online ; Thesis: The impact of genomic aberrations on cancer cells - from mitotic to replication failures

    Keuper, Kristina [Verfasser] / Storchová, Zuzana [Akademischer Betreuer]

    2023  

    Author's details Kristina Keuper ; Betreuer: Zuzana Storchová
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau
    Publishing place Kaiserslautern-Landau
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  10. Article ; Online: Distinct types of intramitochondrial protein aggregates protect mitochondria against proteotoxic stress.

    Bertgen, Lea / Bökenkamp, Jan-Eric / Schneckmann, Tim / Koch, Christian / Räschle, Markus / Storchová, Zuzana / Herrmann, Johannes M

    Cell reports

    2024  Volume 43, Issue 4, Page(s) 114018

    Abstract: Mitochondria consist of hundreds of proteins, most of which are inaccessible to the proteasomal quality control system of the cytosol. How cells stabilize the mitochondrial proteome during challenging conditions remains poorly understood. Here, we show ... ...

    Abstract Mitochondria consist of hundreds of proteins, most of which are inaccessible to the proteasomal quality control system of the cytosol. How cells stabilize the mitochondrial proteome during challenging conditions remains poorly understood. Here, we show that mitochondria form spatially defined protein aggregates as a stress-protecting mechanism. Two different types of intramitochondrial protein aggregates can be distinguished. The mitoribosomal protein Var1 (uS3m) undergoes a stress-induced transition from a soluble, chaperone-stabilized protein that is prevalent under benign conditions to an insoluble, aggregated form upon acute stress. The formation of Var1 bodies stabilizes mitochondrial proteostasis, presumably by sequestration of aggregation-prone proteins. The AAA chaperone Hsp78 is part of a second type of intramitochondrial aggregate that transiently sequesters proteins and promotes their folding or Pim1-mediated degradation. Thus, mitochondrial proteins actively control the formation of distinct types of intramitochondrial protein aggregates, which cooperate to stabilize the mitochondrial proteome during proteotoxic stress conditions.
    MeSH term(s) Mitochondria/metabolism ; Protein Aggregates ; Mitochondrial Proteins/metabolism ; Stress, Physiological ; Humans ; Saccharomyces cerevisiae Proteins/metabolism ; Saccharomyces cerevisiae/metabolism ; Molecular Chaperones/metabolism ; Proteostasis ; Proteome/metabolism ; Proteotoxic Stress
    Chemical Substances Protein Aggregates ; Mitochondrial Proteins ; Saccharomyces cerevisiae Proteins ; Molecular Chaperones ; Proteome
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2024.114018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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