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  1. Article ; Online: Reseña de "Hacedores de frontera. Estudios sobre el contexto social de la frontera en la España Medieval" de Manuel Alejandro Rodríguez de la Peña (dir.)

    Eloísa Ramírez Vaquero

    Anuario de Historia de la Iglesia, Vol 19, Pp 558-

    2010  Volume 559

    Keywords History (General) ; D1-2009 ; History (General) and history of Europe ; D
    Language Spanish
    Publishing date 2010-01-01T00:00:00Z
    Publisher Universidad de Navarra
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: SIRT7: a novel molecular target for personalized cancer treatment?

    Ianni, Alessandro / Kumari, Poonam / Tarighi, Shahriar / Braun, Thomas / Vaquero, Alejandro

    Oncogene

    2024  Volume 43, Issue 14, Page(s) 993–1006

    Abstract: The Sirtuin family of ... ...

    Abstract The Sirtuin family of NAD
    MeSH term(s) Humans ; Sirtuins/physiology ; Carcinogenesis/genetics ; Cell Transformation, Neoplastic ; Neoplasms/drug therapy ; Neoplasms/genetics
    Chemical Substances Sirtuins (EC 3.5.1.-) ; SIRT7 protein, human ; SIRT6 protein, human (EC 3.5.1.-)
    Language English
    Publishing date 2024-02-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639046-8
    ISSN 1476-5594 ; 0950-9232
    ISSN (online) 1476-5594
    ISSN 0950-9232
    DOI 10.1038/s41388-024-02976-8
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  3. Article ; Online: Additive manufacturing in compact high-gain wideband antennas operating in mm-wave frequencies.

    Vaquero, Álvaro F / Rebollo, Alejandro / Arrebola, Manuel

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 10998

    Abstract: A wideband dual-reflector 3D-printed antenna is proposed to operate in the mm-Wave band. The design is based on a Cassegrain reflector optics but including a dielectric piece for merging the feeding system and the support structure of the subreflector. ... ...

    Abstract A wideband dual-reflector 3D-printed antenna is proposed to operate in the mm-Wave band. The design is based on a Cassegrain reflector optics but including a dielectric piece for merging the feeding system and the support structure of the subreflector. The operational principle of this antenna is presented, as well as the design parameters. Then, a prototype to operate at Ka-band is manufactured combining a 3D-printed technique using PLA as printable material and a spray to coating the antenna, providing a low-cost affordable solution. The different pieces of the antenna are evaluated, and the antenna is also measured in a spherical compact range. An excellent agreement between simulations and measurements is obtained, resulting in a [Formula: see text] of operational bandwidth. These results validate the use of coating procedures and the design technique at these demanding frequencies. Its operation shows a stable gain in the entire Ka-band (including [Formula: see text] and [Formula: see text]), which makes the antenna as a suitable light, low-cost, and broadband solution for mm-Wave applications.
    Language English
    Publishing date 2023-07-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-38247-x
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  4. Article ; Online: Additive manufacturing in compact high-gain wideband antennas operating in mm-wave frequencies

    Álvaro F. Vaquero / Alejandro Rebollo / Manuel Arrebola

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Volume 9

    Abstract: Abstract A wideband dual-reflector 3D-printed antenna is proposed to operate in the mm-Wave band. The design is based on a Cassegrain reflector optics but including a dielectric piece for merging the feeding system and the support structure of the ... ...

    Abstract Abstract A wideband dual-reflector 3D-printed antenna is proposed to operate in the mm-Wave band. The design is based on a Cassegrain reflector optics but including a dielectric piece for merging the feeding system and the support structure of the subreflector. The operational principle of this antenna is presented, as well as the design parameters. Then, a prototype to operate at Ka-band is manufactured combining a 3D-printed technique using PLA as printable material and a spray to coating the antenna, providing a low-cost affordable solution. The different pieces of the antenna are evaluated, and the antenna is also measured in a spherical compact range. An excellent agreement between simulations and measurements is obtained, resulting in a $$48.2\%$$ 48.2 % of operational bandwidth. These results validate the use of coating procedures and the design technique at these demanding frequencies. Its operation shows a stable gain in the entire Ka-band (including $$28$$ 28 and $$39 \mathrm{GHz}$$ 39 GHz ), which makes the antenna as a suitable light, low-cost, and broadband solution for mm-Wave applications.
    Keywords Medicine ; R ; Science ; Q
    Subject code 600
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: SIRT7 regulates NUCKS1 chromatin binding to elicit metabolic and inflammatory gene expression in senescence and liver aging.

    Tran, Khoa / Gilbert, Michael / Vazquez, Berta N / Ianni, Alessandro / Garcia, Benjamin A / Vaquero, Alejandro / Berger, Shelley

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Sirtuins, a class of highly conserved histone/protein deacetylases, are heavily implicated in senescence and aging. The regulation of sirtuin proteins is tightly controlled both transcriptionally and translationally and via localization within the cell. ... ...

    Abstract Sirtuins, a class of highly conserved histone/protein deacetylases, are heavily implicated in senescence and aging. The regulation of sirtuin proteins is tightly controlled both transcriptionally and translationally and via localization within the cell. While Sirtiun proteins are implicated with aging, how their levels are regulated during aging across cell types and eliciting tissue specific age-related cellular changes is unclear. Here, we demonstrate that SIRT7 is targeted for degradation during senescence and liver aging. To uncover the significance of SIRT7 loss, we performed proteomics analysis and identified a new SIRT7 interactor, the HMG box protein NUCKS1. We found that the NUCKS1 transcription factor is recruited onto chromatin during senescence and this is mediated by SIRT7 loss. Further, depletion of NUCKS1 delayed senescence upon DNA damage leading to reduction of inflammatory gene expression. Examination of NUCKS1 transcriptional regulation during senescence revealed gene targets of transcription factors NFKB1, RELA, and CEBPβ. Consistently, in both Sirt7 KO mouse liver and in naturally aged livers, Nucks1 was recruited to chromatin. Further, Nucks1 was bound at promoters and enhancers of age-related genes, including transcription factor Rela, and, moreover, these bound sites had increased accessibility during aging. Overall, our results uncover NUCKS1 as a novel interactor of SIRT7, and show that loss of SIRT7 during senescence and liver aging promotes NUCKS1 chromatin binding to regulate metabolic and inflammatory genes.
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.05.578810
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Lack of the Histone Deacetylase SIRT1 Leads to Protection against Endoplasmic Reticulum Stress through the Upregulation of Heat Shock Proteins.

    Latorre, Jessica / de Vera, Nuria / Santalucía, Tomàs / Balada, Rafel / Marazuela-Duque, Anna / Vaquero, Alejandro / Planas, Anna M / Petegnief, Valérie

    International journal of molecular sciences

    2024  Volume 25, Issue 5

    Abstract: Histone deacetylase SIRT1 represses gene expression through the deacetylation of histones and transcription factors and is involved in the protective cell response to stress and aging. However, upon endoplasmic reticulum (ER) stress, SIRT1 impairs the ... ...

    Abstract Histone deacetylase SIRT1 represses gene expression through the deacetylation of histones and transcription factors and is involved in the protective cell response to stress and aging. However, upon endoplasmic reticulum (ER) stress, SIRT1 impairs the IRE1α branch of the unfolded protein response (UPR) through the inhibition of the transcriptional activity of XBP-1 and SIRT1 deficiency is beneficial under these conditions. We hypothesized that SIRT1 deficiency may unlock the blockade of transcription factors unrelated to the UPR promoting the synthesis of chaperones and improving the stability of immature proteins or triggering the clearance of unfolded proteins. SIRT1+/+ and SIRT1-/- fibroblasts were exposed to the ER stress inducer tunicamycin and cell survival and expression of heat shock proteins were analyzed 24 h after the treatment. We observed that SIRT1 loss significantly reduced cell sensitivity to ER stress and showed that SIRT1-/- but not SIRT1+/+ cells constitutively expressed high levels of phospho-STAT3 and heat shock proteins. Hsp70 silencing in SIRT1-/- cells abolished the resistance to ER stress. Furthermore, accumulation of ubiquitinated proteins was lower in SIRT1-/- than in SIRT1+/+ cells. Our data showed that SIRT1 deficiency enabled chaperones upregulation and boosted the proteasome activity, two processes that are beneficial for coping with ER stress.
    MeSH term(s) Heat-Shock Proteins/metabolism ; Up-Regulation ; Sirtuin 1/metabolism ; Endoribonucleases/metabolism ; Protein Serine-Threonine Kinases/metabolism ; Endoplasmic Reticulum Stress ; Unfolded Protein Response ; Molecular Chaperones/metabolism ; Transcription Factors/metabolism
    Chemical Substances Heat-Shock Proteins ; Sirtuin 1 (EC 3.5.1.-) ; Endoribonucleases (EC 3.1.-) ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Molecular Chaperones ; Transcription Factors
    Language English
    Publishing date 2024-03-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25052856
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  7. Article: The Effect of Resistance Training with Outdoor Fitness Equipment on the Body Composition, Physical Fitness, and Physical Health of Middle-Aged and Older Adults: A Randomized Controlled Trial.

    Marcos-Pardo, Pablo J / Espeso-García, Alejandro / Vaquero-Cristóbal, Raquel / Abelleira-Lamela, Tomás / González-Gálvez, Noelia

    Healthcare (Basel, Switzerland)

    2024  Volume 12, Issue 7

    Abstract: This study examined the effect of outdoor-fitness-equipment-based resistance training on the health parameters of middle-aged and older adults, as well as analyzing the effect of age on the results found. A total of 149 volunteers were randomly assigned ... ...

    Abstract This study examined the effect of outdoor-fitness-equipment-based resistance training on the health parameters of middle-aged and older adults, as well as analyzing the effect of age on the results found. A total of 149 volunteers were randomly assigned to the training (TG) and control (CG) groups. The TG performed two weekly sessions of resistance training for 8 weeks using outdoor fitness equipment, while the CG continued with their regular daily activities. Body composition was measured using DXA, and the maximal isometric voluntary contraction in knee extension, elbow flexion, and hand grip were assessed, along with the 4 m walk test, the Timed Up and Go Test, and the Short Form 36 Health Survey Questionnaire. The TG showed a significant increase in the lean mass index (
    Language English
    Publishing date 2024-03-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare12070726
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  8. Article: Complex role of SIRT6 in NF-κB pathway regulation.

    Santos-Barriopedro, Irene / Vaquero, Alejandro

    Molecular & cellular oncology

    2018  Volume 5, Issue 4, Page(s) e1445942

    Abstract: The NF-κB pathway regulates cell physiology under stress conditions. We have recently described a novel NF-κB regulatory mechanism, by which SIRT6 induces cysteine monoubiquitination of the methyltransferase SUV39H1. This causes SUV39H1 dissociation from ...

    Abstract The NF-κB pathway regulates cell physiology under stress conditions. We have recently described a novel NF-κB regulatory mechanism, by which SIRT6 induces cysteine monoubiquitination of the methyltransferase SUV39H1. This causes SUV39H1 dissociation from the gene encoding the NF-κB inhibitor IκBα,  increasing its expression and leading to NF-κB pathway inactivation.
    Language English
    Publishing date 2018-05-24
    Publishing country United States
    Document type Journal Article
    ISSN 2372-3556
    ISSN 2372-3556
    DOI 10.1080/23723556.2018.1445942
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  9. Article ; Online: Sirtuins in female meiosis and in reproductive longevity.

    Vazquez, Berta N / Vaquero, Alejandro / Schindler, Karen

    Molecular reproduction and development

    2020  Volume 87, Issue 12, Page(s) 1175–1187

    Abstract: Transmission of genetic material through high-quality gametes to progeny requires accurate homologous chromosome recombination and segregation during meiosis. A failure to accomplish these processes can have major consequences in reproductive health, ... ...

    Abstract Transmission of genetic material through high-quality gametes to progeny requires accurate homologous chromosome recombination and segregation during meiosis. A failure to accomplish these processes can have major consequences in reproductive health, including infertility, and development disorders in offspring. Sirtuins, a family of NAD
    MeSH term(s) Aging/genetics ; Animals ; Female ; Gene Expression ; Humans ; Longevity/genetics ; Male ; Meiosis/genetics ; Mice ; Oogenesis/genetics ; Ovary/metabolism ; Reproduction/genetics ; Sirtuins/genetics ; Sirtuins/metabolism
    Chemical Substances Sirtuins (EC 3.5.1.-)
    Language English
    Publishing date 2020-11-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 20321-x
    ISSN 1098-2795 ; 1040-452X
    ISSN (online) 1098-2795
    ISSN 1040-452X
    DOI 10.1002/mrd.23437
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  10. Article ; Online: Raising the list of SirT7 targets to a new level.

    Simonet, Nicolas G / Vaquero, Alejandro

    Proteomics

    2017  Volume 17, Issue 13-14

    Abstract: Sirtuins are crucial proteins involved in sensing and coordinating the response to different forms of stress, mainly through ... ...

    Abstract Sirtuins are crucial proteins involved in sensing and coordinating the response to different forms of stress, mainly through NAD
    Language English
    Publishing date 2017-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2032093-0
    ISSN 1615-9861 ; 1615-9853
    ISSN (online) 1615-9861
    ISSN 1615-9853
    DOI 10.1002/pmic.201700137
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