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  1. Article: A stochastic framework for downscaling processes of spatial averages based on the property of spectral multiscaling and its statistical diagnosis on spatio-temporal rainfall fields

    Pavlopoulos, Harry

    Advances in water resources. 2011 Aug., v. 34, no. 8

    2011  

    Abstract: Spectral multi-scaling postulates a power-law type of scaling of spectral distribution functions of stationary processes of spatial averages, over nested and geometrically similar sub-regions of the spatial parameter space of a given spatio-temporal ... ...

    Abstract Spectral multi-scaling postulates a power-law type of scaling of spectral distribution functions of stationary processes of spatial averages, over nested and geometrically similar sub-regions of the spatial parameter space of a given spatio-temporal random field. Presently a new framework is formulated for down-scaling processes of spatial averages, following naturally from the postulate of spectral multi-scaling, and key ingredients required for its implementation are described. Moreover, results from an extensive diagnostic study are presented, seeking statistical evidence supportive of spectral multi-scaling. Such evidence emerges from two sources of data. One is a 13year long historical record of radar observations of rainfall in southeastern UK (Chenies radar), with high spatial (2km) and temporal (5min) resolution. The other is an ensemble of rain rate fields simulated by a spatio-temporal random pulse model fitted to the historical data. The results are consistent between historical and simulated rainfall data, indicating frequency-dependent scaling relationships interpreted as evidence of spectral multi-scaling across a range of spatial scales.
    Keywords meteorological data ; models ; radar ; rain ; rainfall simulation ; spectral analysis ; water resources ; United Kingdom
    Language English
    Dates of publication 2011-08
    Size p. 990-1011.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 2023320-6
    ISSN 1872-9657 ; 0309-1708
    ISSN (online) 1872-9657
    ISSN 0309-1708
    DOI 10.1016/j.advwatres.2011.05.006
    Database NAL-Catalogue (AGRICOLA)

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  2. Article: A diagnostic study of spectral multiscaling on spatio-temporal accumulations of rainfall fields based on radar measurements over Iowa

    Pavlopoulos, Harry / Witold Krajewski

    Advances in water resources. 2014 Dec., v. 74

    2014  

    Abstract: Spectral multiscaling postulates a power-law type of scaling of spectral distribution functions of stationary processes of spatial averages or their temporal accumulations, over nested and geometrically similar sub-regions of the spatial parameter space ... ...

    Abstract Spectral multiscaling postulates a power-law type of scaling of spectral distribution functions of stationary processes of spatial averages or their temporal accumulations, over nested and geometrically similar sub-regions of the spatial parameter space of a given spatio-temporal random field. Presently, the validity of this property is investigated using time series of spatio-temporal accumulations of rain rate fields measured by a network of Doppler radars covering the region of Iowa. Statistical evidence of spectral multiscaling is gathered and discussed through a systematic study of appropriate regression diagnostics, using two records of data. One is a 120-month record of hourly (60-min) accumulations of spatially averaged rain rate on square pixels of side length 4km, comprising a rectangular grid of dimension 80×160 covering almost the entire State of Iowa. The other is a 74-month record of quarterly (15-min) accumulations of spatially averaged rain rate on square pixels of side length 1km, comprising a rectangular grid of dimension 68×106 over the Cedar River basin in eastern Iowa. The diagnostic results indicate frequency-dependent scaling relationships interpreted as evidence of spectral multiscaling across a range of spatial scales.
    Keywords diagnostic techniques ; Doppler radar ; rain ; rivers ; spectral analysis ; time series analysis ; watersheds ; Iowa
    Language English
    Dates of publication 2014-12
    Size p. 258-278.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 2023320-6
    ISSN 1872-9657 ; 0309-1708
    ISSN (online) 1872-9657
    ISSN 0309-1708
    DOI 10.1016/j.advwatres.2014.10.001
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Recent advances in cardiac resynchronization therapy: echocardiographic modalities, patient selection, optimization, non-responders--all you need to know for more efficient CRT.

    Pavlopoulos, Harry / Nihoyannopoulos, Petros

    The international journal of cardiovascular imaging

    2009  Volume 26, Issue 2, Page(s) 177–191

    Abstract: Cardiac resynchronization therapy (CRT) constitutes an established way of treatment for patients suffering from severe heart failure. However, this technologically based and expensive mode of therapy may not be effective for a substantial number of ... ...

    Abstract Cardiac resynchronization therapy (CRT) constitutes an established way of treatment for patients suffering from severe heart failure. However, this technologically based and expensive mode of therapy may not be effective for a substantial number of individuals. Recent research and advanced echocardiographic modalities have provided new insight on the proper patient selection, lead implantation, optimization and reasons for non-response. Based on this evidence, an overall assessment of parameters that appear to contribute significantly to the outcome of CRT in addition to electrical or mechanical dyssynchrony, seems to be a reasonable approach for more effective resynchronization therapy.
    MeSH term(s) Cardiac Pacing, Artificial/adverse effects ; Echocardiography, Doppler ; Equipment Design ; Evidence-Based Medicine ; Heart Conduction System/diagnostic imaging ; Heart Conduction System/physiopathology ; Heart Failure/complications ; Heart Failure/diagnostic imaging ; Heart Failure/physiopathology ; Heart Failure/therapy ; Humans ; Pacemaker, Artificial ; Patient Selection ; Practice Guidelines as Topic ; Predictive Value of Tests ; Severity of Illness Index ; Time Factors ; Treatment Outcome ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/etiology ; Ventricular Dysfunction, Left/therapy ; Ventricular Function, Left
    Language English
    Publishing date 2009-11-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2055311-0
    ISSN 1875-8312 ; 1573-0743 ; 1569-5794 ; 0167-9899
    ISSN (online) 1875-8312 ; 1573-0743
    ISSN 1569-5794 ; 0167-9899
    DOI 10.1007/s10554-009-9523-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Regional left ventricular distribution of abnormal segmental relaxation evaluated by strain echocardiography and the incremental value over annular diastolic velocities in hypertensive patients with normal global diastolic function.

    Pavlopoulos, Harry / Nihoyannopoulos, Petros

    European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology

    2009  Volume 10, Issue 5, Page(s) 654–662

    Abstract: Aims: Diastolic dysfunction (DD) identifies patients with increased cardiovascular risk. The aim of this study was to investigate the regional distribution of abnormal segmental relaxation in hypertensives with normal global DD and to demonstrate the ... ...

    Abstract Aims: Diastolic dysfunction (DD) identifies patients with increased cardiovascular risk. The aim of this study was to investigate the regional distribution of abnormal segmental relaxation in hypertensives with normal global DD and to demonstrate the incremental value of strain echocardiography over annular diastolic velocities and global indices of DD derived by conventional echocardiography.
    Methods and results: We evaluated 70 individuals, consisting of 35 hypertensives and 35 middle-aged volunteers as a control. None had DD based on global indices (deceleration time, isovolumic relaxation time, and E/A). Segmental early and late diastolic Doppler-derived strain rates (SRs) were recorded from 18 segments in the longitudinal axis. The number of segments with SR(E)/SR(A)<1.1 was represented as segmental DD. Mean relaxation of the basal, mid, and apical regions was also calculated. Septal and mean mitral annular Ea velocities were also recorded. Non-hypertensive, middle-aged individuals had evidence of segmental DD that was mostly distributed at the basal parts of the heart, and in particular at the septal wall. Hypertensive patients had a lower mean relaxation based on SR(E) and SR(E/A) at the basal, mid, and apical regions, with the basal parts appearing more compromised and with higher segmental DD compared with controls. Segmental DD in that group was more extensive towards the mid and even apical regions, with the septal and basal inferior walls being the most heavily affected areas. The lateral wall appeared to be the region that was most resistant to diastolic abnormalities in both groups. Even individuals with 'normal' septal and mean Ea had evidence of segmental DD. However, contrary to global indices of DD, septal Ea could predict the presence of segmental DD.
    Conclusion: Abnormal relaxation appears to have a particular distribution over the myocardial walls. Basal parts are generally more heavily affected, particularly the septal and inferior walls. The lateral wall and apical regions are more resistant to diastolic abnormalities. In subjects with normal global DD, strain echocardiography has an incremental value over mitral annular diastolic velocities and global indices of DD for early detection of diastolic abnormalities.
    MeSH term(s) Case-Control Studies ; Diastole/physiology ; Echocardiography, Doppler/methods ; Female ; Humans ; Hypertension/physiopathology ; Image Processing, Computer-Assisted ; Male ; Middle Aged ; ROC Curve ; Regression Analysis ; Reproducibility of Results ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/physiopathology
    Language English
    Publishing date 2009-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2021408-X
    ISSN 1532-2114 ; 1525-2167
    ISSN (online) 1532-2114
    ISSN 1525-2167
    DOI 10.1093/ejechocard/jep028
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  5. Article ; Online: Pulse pressure/stroke volume: a surrogate index of arterial stiffness and the relation to segmental relaxation and longitudinal systolic deformation in hypertensive disease.

    Pavlopoulos, Harry / Nihoyannopoulos, Petros

    European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology

    2009  Volume 10, Issue 4, Page(s) 519–526

    Abstract: Aims: Pulse pressure/stroke volume (PP/SV) is regarded as a surrogate index of arterial stiffness (AS). Strain echocardiography is a novel method to evaluate systolic and diastolic left ventricular (LV) function. The aim of this study was to investigate ...

    Abstract Aims: Pulse pressure/stroke volume (PP/SV) is regarded as a surrogate index of arterial stiffness (AS). Strain echocardiography is a novel method to evaluate systolic and diastolic left ventricular (LV) function. The aim of this study was to investigate the effect of AS on segmental relaxation and systolic deformation in hypertensive disease.
    Methods and results: We evaluated 70 hypertensive patients and 30 non-hypertensive volunteers. The patients were divided as follows: without global diastolic dysfunction (HTN-N) and with global diastolic dysfunction (HTN-DD). The segmental and global longitudinal strain (S) and strain rate (SR) and early and late diastolic SR were recorded from 18 segments. The number of segments with abnormal relaxation (SR(E)/SR(A) < 1.1) was calculated as segmental DD. Pulse pressure/SV index was used as a surrogate marker of AS. Arterial stiffness was higher in HTN-N and was more pronounced in the HTN-DD group compared with the control (1.45 +/- 0.38 vs. 1.79 +/- 0.36 vs.1.21 +/- 0.31 mmHg m2/ml, all P < 0.05). HTN-N had increased segmental DD compared to control despite the normal conventional indices of diastolic dysfunction. Global longitudinal deformation of the HTN-N group was similar to the control; HTN-DD also showed evidence of LV hypertrophy (LVH) and had more extensive segmental DD and deteriorated global systolic deformation compared with the control, despite the normal ejection fraction (segmental DD: 11 +/- 3 vs. 4 +/- 2, P < 0.05 and strain: 17.7 +/- 2.8 vs. 21.2 +/- 2.3%, P < 0.05). The deterioration of AS in the hypertensive group was accompanied with a particular distribution of segmental DD that was more pronounced at the basal regions compared with apical LV territories. Arterial stiffness and LV mass index are found to be independent predictors of segmental DD, mean Ea, and global systolic deformation.
    Conclusion: Arterial stiffness and LVH are independently related to abnormal segmental relaxation and global longitudinal systolic deformation in hypertensive disease.
    MeSH term(s) Arteries/diagnostic imaging ; Arteries/physiology ; Arteries/physiopathology ; Blood Pressure ; Case-Control Studies ; Chi-Square Distribution ; Echocardiography, Doppler ; Echocardiography, Doppler, Pulsed ; Elasticity ; Female ; Humans ; Hypertension/diagnostic imaging ; Hypertension/physiopathology ; Hypertrophy, Left Ventricular/diagnostic imaging ; Hypertrophy, Left Ventricular/physiopathology ; Linear Models ; Male ; Middle Aged ; Reproducibility of Results ; Severity of Illness Index ; Statistics, Nonparametric ; Stroke Volume ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/physiopathology
    Language English
    Publishing date 2009-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2021408-X
    ISSN 1532-2114 ; 1525-2167
    ISSN (online) 1532-2114
    ISSN 1525-2167
    DOI 10.1093/ejechocard/jen324
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  6. Article ; Online: Left atrial size: a structural expression of abnormal left ventricular segmental relaxation evaluated by strain echocardiography.

    Pavlopoulos, Harry / Nihoyannopoulos, Petros

    European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology

    2009  Volume 10, Issue 7, Page(s) 865–871

    Abstract: Aims: Left atrial (LA) enlargement is related to left ventricular (LV) remodelling and diastolic dysfunction (DD), reflecting cardiac target organ damage. The aim of this study was to investigate the relation of one-dimensional (1D) and volume derived ... ...

    Abstract Aims: Left atrial (LA) enlargement is related to left ventricular (LV) remodelling and diastolic dysfunction (DD), reflecting cardiac target organ damage. The aim of this study was to investigate the relation of one-dimensional (1D) and volume derived indexes of LA enlargement with abnormal segmental relaxation in hypertensive patients.
    Methods and results: We evaluated 90 hypertensive patients and 50 non-hypertensive volunteers with normal ejection fraction (EF). Global DD was evaluated based on conventional indexes (E/A, deceleration time, LV isovolumic relaxation time), and segmental early and late diastolic strain rates (SR) were recorded from 18 LV segments. The number of segments with abnormal relaxation (SR(E)/SR(A) < 1.1) was represented as segmental DD. LA size was evaluated based on 1D left atrial dimension (LAD) and left atrial volume (LAV), and indexed by body surface area (BSA) and height. The hypertensive patients had higher segmental DD (9.5 +/- 4.2 vs. 5.2 +/- 3.2, P < 0.05) and appeared to have higher 1D and volume-derived indexes of LA size compared to the controls. Individuals with global DD had more deteriorated segmental relaxation and higher LA size compared with those without global DD. When participants were separated according to normal, mildly dilated, and moderately to severely dilated LA size, there was progressive deterioration of segmental DD, mean Ea, and filling pressures, along with the progression of LA enlargement. Volume-derived indexes, LAV/BSA, LAV/height, and LAV, appeared to have better correlations with segmental DD, as well as with linearly changed parameters of DD (Mean Ea, E/Ea), LV remodelling (LVMI, relative wall thickness), age, and systolic blood pressure (SBP), compared to the respective 1D-based (LAD) LA indexes. LAV/BSA was proved to be an independent predictor of segmental DD (beta: 0.23, R(2): 0.48), along with LVMI, SBP and age, irrespective of gender.
    Conclusion: LA size constitutes a morphological expression of abnormal segmental relaxation, with volume-derived indexes of LA enlargement, exhibiting higher correlation with segmental DD compared to the respective 1D indexes, and LAV/BSA to be an independent predictor of segmental DD in hypertensive heart disease.
    MeSH term(s) Adult ; Echocardiography, Doppler ; Female ; Heart Atria/diagnostic imaging ; Heart Atria/pathology ; Humans ; Male ; Middle Aged ; Muscle Relaxation/physiology ; Ventricular Dysfunction, Left/diagnostic imaging
    Language English
    Publishing date 2009-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2021408-X
    ISSN 1532-2114 ; 1525-2167
    ISSN (online) 1532-2114
    ISSN 1525-2167
    DOI 10.1093/ejechocard/jep093
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  7. Article: The constellation of hypertensive heart disease.

    Pavlopoulos, Harry / Nihoyannopoulos, Petros

    Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese

    2008  Volume 49, Issue 2, Page(s) 92–99

    Abstract: Hypertension should be regarded not as a simple elevation of blood pressure, but as a constellation of functional and structural abnormalities that create a phenotypic portrait of hypertensive disease. Recent research has expanded our knowledge related ... ...

    Abstract Hypertension should be regarded not as a simple elevation of blood pressure, but as a constellation of functional and structural abnormalities that create a phenotypic portrait of hypertensive disease. Recent research has expanded our knowledge related to hypertensive heart disease. Future assessment of hypertensive patients' global risk should probably incorporate not only evaluation of the known traditional risk factors, such as hypercholesterolaemia, smoking, glucose levels and left ventricular hypertrophy, but also myocardial fibrosis, microvascular ischaemia, arterial stiffness, systemic inflammation, endothelial dysfunction and level of apoptosis.
    MeSH term(s) Heart Diseases/etiology ; Heart Diseases/pathology ; Heart Diseases/physiopathology ; Humans ; Hypertension/complications ; Hypertension/pathology ; Hypertension/physiopathology
    Language English
    Publishing date 2008-03-29
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2215027-4
    ISSN 1109-9666
    ISSN 1109-9666
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  8. Article ; Online: Abnormal segmental relaxation patterns in hypertensive disease and symptomatic diastolic dysfunction detected by strain echocardiography.

    Pavlopoulos, Harry / Nihoyannopoulos, Petros

    Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

    2008  Volume 21, Issue 8, Page(s) 899–906

    Abstract: Background: An abnormal segmental relaxation pattern exists as an early sign of diastolic dysfunction (DD), detectable by strain (S) echocardiography.: Objective: The objective of this study was to investigate the relation of segmental relaxation ... ...

    Abstract Background: An abnormal segmental relaxation pattern exists as an early sign of diastolic dysfunction (DD), detectable by strain (S) echocardiography.
    Objective: The objective of this study was to investigate the relation of segmental relaxation patterns with longitudinal systolic function and symptomatic DD in patients with hypertension (HTN).
    Methods: We evaluated 30 healthy volunteers and 78 volunteers with HTN, divided as follows: (1) patients without DD (n: 28); (2) patients with asymptomatic DD (n: 25); and (3) patients with symptomatic DD (n: 25). All groups had normal ejection fraction greater than or equal to 55%. The symptomatic group had mild exertional dyspnea. All participants underwent 2-dimensional and color Doppler myocardial imaging, and the mean longitudinal strain (S) and S rate (SR) were estimated. Early and late diastolic SR parameters (SR(E) and SR(A)) were also recorded from the basal, mid, and apical segments for each wall. Altered segmental relaxation (SR(E)/SR(A) < 1.1) was regarded as an index of segmental DD.
    Results: Patients who were symptomatic with DD were found to have more segments with an abnormal relaxation pattern (segmental DD) and more deteriorated longitudinal systolic function based on S and SR, compared with patients with asymptomatic HTN and control subjects. Segmental DD was correlated with structural changes of left ventricular (LV) remodeling such as wall thickness (r: 0.64), relative wall thickness (r: 0.58), and LV mass index (r: 0.59), as well as mean S (r: -0.61), SR (r: -0.62), systolic blood pressure (r: 0.44), age (r: 0.49), and filling pressures (r: 0.50), all P less than .01. In multiple regression analysis, segmental DD and systolic blood pressure were independently related to symptomatic status (segmental DD: beta = 0.33, P = .003; systolic blood pressure: beta = 0.24, P = .009, R(2): 0.33). Compared with conventional indices of DD (deceleration time of the E wave, isovolumic relaxation time, E, A, and E/A), segmental DD was the only parameter that predicted symptomatic status (coefficient: 0.3817, SE: 0.1101, P = .0005, odds ratio: 1.4648, 95% confidence interval: 1.1761-1.7485).
    Conclusion: LV segmental relaxation demonstrates progressive deterioration in HTN disease, which is more pronounced in patients with symptomatic DD. Altered segmental relaxation is related to structural changes of LV remodeling and constitutes an independent predictor for the presence of a symptomatic status.
    MeSH term(s) Echocardiography/methods ; Elasticity Imaging Techniques/methods ; Female ; Humans ; Hypertension/diagnostic imaging ; Image Processing, Computer-Assisted/methods ; Male ; Middle Aged ; Reproducibility of Results ; Sensitivity and Specificity ; Ventricular Dysfunction, Left/diagnostic imaging
    Language English
    Publishing date 2008-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1035622-8
    ISSN 1097-6795 ; 0894-7317
    ISSN (online) 1097-6795
    ISSN 0894-7317
    DOI 10.1016/j.echo.2008.01.017
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  9. Article: Strain and strain rate deformation parameters: from tissue Doppler to 2D speckle tracking.

    Pavlopoulos, Harry / Nihoyannopoulos, Petros

    The international journal of cardiovascular imaging

    2007  Volume 24, Issue 5, Page(s) 479–491

    Abstract: Strain and strain rate deformation parameters based on Color Doppler Myocardial Imaging, and more recently on two-dimensional (2D) gray scale images, have evolved as important methods for the quantification of myocardial function. Although these ... ...

    Abstract Strain and strain rate deformation parameters based on Color Doppler Myocardial Imaging, and more recently on two-dimensional (2D) gray scale images, have evolved as important methods for the quantification of myocardial function. Although these parameters are already applicable in the research field, their acquisition and analysis involve a number of technical challenges and complexities. Accurate knowledge of the basic principles of those techniques, as presented in this article, will further enhance their applicability to clinical practice.
    MeSH term(s) Animals ; Blood Flow Velocity ; Coronary Circulation ; Echocardiography, Doppler, Color ; Echocardiography, Doppler, Pulsed ; Elasticity ; Heart Diseases/diagnostic imaging ; Heart Diseases/physiopathology ; Humans ; Image Interpretation, Computer-Assisted ; Models, Cardiovascular ; Myocardial Contraction ; Predictive Value of Tests ; Reproducibility of Results ; Stress, Mechanical ; Time Factors ; Ventricular Function
    Language English
    Publishing date 2007-12-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2055311-0
    ISSN 1573-0743 ; 1569-5794 ; 0167-9899
    ISSN (online) 1573-0743
    ISSN 1569-5794 ; 0167-9899
    DOI 10.1007/s10554-007-9286-9
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  10. Article ; Online: Right ventricular remodelling in pulmonary arterial hypertension with three-dimensional echocardiography: comparison with cardiac magnetic resonance imaging.

    Grapsa, Julia / O'Regan, Declan P / Pavlopoulos, Harry / Durighel, Giuliana / Dawson, David / Nihoyannopoulos, Petros

    European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology

    2010  Volume 11, Issue 1, Page(s) 64–73

    Abstract: Aims: Right ventricular (RV) mass and volume calculations are important correlates of survival in patients with pulmonary arterial hypertension (PAH). We tested the hypothesis that RV mass, volumes and function could be measured accurately with real- ... ...

    Abstract Aims: Right ventricular (RV) mass and volume calculations are important correlates of survival in patients with pulmonary arterial hypertension (PAH). We tested the hypothesis that RV mass, volumes and function could be measured accurately with real-time three-dimensional echocardiography (3DE) in patients with PAH and compared those against cardiac magnetic resonance (CMR).
    Methods and results: Sixty consecutive PAH patients and 20 normals were examined with 3DE and CMR. RV end-diastolic volumes (EDV), end-systolic (ESV), stroke volume (SV), ejection fraction (EF), and mass were measured in all patients and in normals. Two independent observers assessed variability using the Bland-Altman analysis agreement. RV volumes (in mL) and mass were similar between 3DE and CMR in PAH patients: [EDV (in mL) 183.2 +/- 38 vs. 187.3 +/- 41, P = 0.32; ESV (in mL) 122 +/- 33 vs. 126 +/- 36, P = 0.99; SV (in mL) 63 +/- 15 vs. 65 +/- 19, P = 0.06; EF (in %) 33 +/- 7 vs. 31 +/- 9, P = 0.16 and RV mass (g) 99 +/- 20 vs. 96 +/- 22, P = 0.42], respectively. Interobserver variability was similar between 3DE and CMR in PAH for all variables, with CMR showing less interobserver variability for EDV compared with 3DE in both patients and normals (patients: mean bias: CMR-EDV: 0.4 +/- 16 mL vs. 3DE-EDV: 6.9 +/- 17.9 and in normals: CMR-EDV: 0.1 +/- 9.8 vs. 3DE-EDV: 5.7 +/- 16.3, respectively), whereas EF and RV mass were poorly reproducible with no correlation between observers for 3DE and CMR.
    Conclusions: RV remodelling in PAH patients can be accurately assessed with both 3DE and CMR. Both modalities are robust and reproducible with CMR being more reproducible for measurements of EF and RV mass.
    MeSH term(s) Adult ; Case-Control Studies ; Confidence Intervals ; Echocardiography, Three-Dimensional ; Female ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/pathology ; Humans ; Hypertension, Pulmonary/complications ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/diagnostic imaging ; Hypertension, Pulmonary/pathology ; Hypertrophy, Right Ventricular ; Magnetic Resonance Imaging ; Male ; Statistics as Topic ; Stroke Volume ; Ventricular Function, Left ; Ventricular Remodeling
    Language English
    Publishing date 2010-01
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2021408-X
    ISSN 1532-2114 ; 1525-2167
    ISSN (online) 1532-2114
    ISSN 1525-2167
    DOI 10.1093/ejechocard/jep169
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