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  1. Article ; Online: Low-Profile Altura Endograft System for Endovascular Abdominal Aorta Aneurysm Repair. Preliminary Results in Elective and Emergent Situations.

    Karaolanis, Georgios I / Hadjis, Demetrios / Samara, Evangelia / Gomatos, Ilias P / Tzimas, Petros / Glantzounis, Georgios K

    Annals of vascular surgery

    2023  Volume 92, Page(s) 188–194

    Abstract: Background: The objective of this study was to assess the Altura endoprosthesis outcomes up to 12 months for patients affected by infrarenal abdominal aortic aneurysms (AAA) either in elective or emergent situations.: Methods: This was a single- ... ...

    Abstract Background: The objective of this study was to assess the Altura endoprosthesis outcomes up to 12 months for patients affected by infrarenal abdominal aortic aneurysms (AAA) either in elective or emergent situations.
    Methods: This was a single-center retrospective study identifying all patients undergoing endovascular aneurysm repair (EVAR) with the Altura endoprosthesis from January 2021 to August 2022. Outcomes evaluated included mortality, technical and clinical success (freedom from procedure-related death, endoleak, migration, thrombosis, and reintervention), and the freedom from reintervention rate.
    Results: A total of 34 (25 elective and 8 emergent) patients who underwent AAA with Altura endoprosthesis were retrospectively reviewed. The technical success of the Altura endograft either in elective or emergent situations was 100%. There was no inhospital mortality, but 1 (3%) patient who underwent AAA repair emergently, died unexpectedly 7 days after the discharge due to massive pulmonary embolism. The clinical success and the freedom from reintervention during the median follow-up of 12 months (interquartile range [IQR] 12-18), were 97%. One patient presented with disabling intermittent claudication at third month postoperatively, and the computed tomographic angiography (CTA) revealed thrombosis of one of the iliac endografts (3%). The patient underwent femorofemoral bypass with an uneventful postoperative course and immediate relief of the symptoms. One type II endoleak was spontaneously resolved on the sixth month. Sac shrinkage (>3 mm) was registered in 12 patients (35%), but the sac size was stable in the remaining 22 (65%) patients.
    Conclusions: The preliminary outcomes of the Altura endograft seem to be promising, suggesting that the endograft could be safely used either in elective or emergent situations. Further studies with a major number of participants are needed to document its technical and clinical performance, especially in emergency situations that could be amenable to improvement.
    MeSH term(s) Humans ; Blood Vessel Prosthesis ; Retrospective Studies ; Blood Vessel Prosthesis Implantation/adverse effects ; Endoleak/diagnostic imaging ; Endoleak/etiology ; Endoleak/surgery ; Aortic Aneurysm, Abdominal/diagnostic imaging ; Aortic Aneurysm, Abdominal/surgery ; Treatment Outcome ; Risk Factors ; Endovascular Procedures/adverse effects ; Prosthesis Design
    Language English
    Publishing date 2023-01-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1027366-9
    ISSN 1615-5947 ; 0890-5096
    ISSN (online) 1615-5947
    ISSN 0890-5096
    DOI 10.1016/j.avsg.2023.01.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Radiological simultaneous portohepatic vein embolization (RASPE) and major hepatectomy with hepatocellular carcinoma (HCC).

    Glantzounis, Georgios K / Karampa, Anastasia / Peristeri, Dimitra

    Hepatobiliary surgery and nutrition

    2021  Volume 10, Issue 2, Page(s) 267–269

    Language English
    Publishing date 2021-04-09
    Publishing country China (Republic : 1949- )
    Document type Editorial ; Comment
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn-20-865
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Impact of intraoperative flow cytometry in management of colorectal liver metastases: Simultaneous assessment of tumor biology and resection margin status.

    Markopoulos, Georgios S / Alexiou, George Α / Goussia, Anna C / Glantzounis, Georgios K / Vartholomatos, George

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

    2022  Volume 49, Issue 2, Page(s) 529–531

    MeSH term(s) Humans ; Margins of Excision ; Flow Cytometry ; Retrospective Studies ; Liver Neoplasms/surgery ; Colorectal Neoplasms/surgery ; Colorectal Neoplasms/pathology ; Biology ; Hepatectomy
    Language English
    Publishing date 2022-10-25
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 632519-1
    ISSN 1532-2157 ; 0748-7983
    ISSN (online) 1532-2157
    ISSN 0748-7983
    DOI 10.1016/j.ejso.2022.10.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Role of Preoperative Chemotherapy in the Management of Synchronous Resectable Colorectal Liver Metastases: A Meta-Analysis.

    Tepelenis, Kostas / Pappas-Gogos, Georgios / Ntellas, Panagiotis / Tsimogiannis, Konstantinos / Dadouli, Katerina / Mauri, Davide / Glantzounis, Georgios K

    Current oncology (Toronto, Ont.)

    2023  Volume 30, Issue 5, Page(s) 4499–4511

    Abstract: Background: The indications of preoperative chemotherapy, for initially resectable synchronous colorectal liver metastases, remain controversial. This meta-analysis aimed to assess the efficacy and safety of preoperative chemotherapy in such patients.!## ...

    Abstract Background: The indications of preoperative chemotherapy, for initially resectable synchronous colorectal liver metastases, remain controversial. This meta-analysis aimed to assess the efficacy and safety of preoperative chemotherapy in such patients.
    Methods: Six retrospective studies were included in the meta-analysis with 1036 patients. Some 554 patients were allocated to the preoperative group, and 482 others were allocated to the surgery group.
    Results: Major hepatectomy was more common in the preoperative group than in the surgery group (43.1% vs. 28.8%,
    Conclusions: Preoperative chemotherapy should be suggested in patients with high disease burden. The number of cycles of preoperative chemotherapy should be low (3-4) to avoid increased postoperative morbidity. However more prospective studies are needed to clarify the exact role of preoperative chemotherapy in patients with synchronous resectable colorectal liver metastases.
    MeSH term(s) Humans ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/surgery ; Colorectal Neoplasms/pathology ; Retrospective Studies ; Neoplasm Recurrence, Local/drug therapy ; Chemotherapy, Adjuvant ; Liver Neoplasms/drug therapy ; Liver Neoplasms/surgery ; Liver Neoplasms/secondary
    Language English
    Publishing date 2023-04-25
    Publishing country Switzerland
    Document type Meta-Analysis ; Journal Article ; Review
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol30050340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Individualized Approach in the Surgical Management of Hepatocellular Carcinoma: Results from a Greek Multicentre Study.

    Glantzounis, Georgios K / Korkolis, Dimitrios / Sotiropoulos, Georgios C / Tzimas, Georgios / Karampa, Anastasia / Paliouras, Athanasios / Asimakopoulos, Alexandros-Georgios / Davakis, Spyridon / Papalampros, Alexandros / Moris, Dimitrios / Felekouras, Evangelos

    Cancers

    2022  Volume 14, Issue 18

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-09-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14184387
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Long-term outcomes of thoracic endovascular aortic repair for the treatment of descending thoracic aortic aneurysms: a systematic review and meta-analysis.

    Karaolanis, Georgios I / Georgakarakos, Efstratios / Karakosta, Agathi / Glantzounis, Georgios K / Moulakakis, Konstantinos G / Dorweiler, Bernhard / Mylonas, Spyridon N

    The Journal of cardiovascular surgery

    2023  

    Abstract: Introduction: We undertook a systematic review of the currently published literature on TEVAR for DTAAs and we combined the eligible studies into a meta-analysis with the intention of evaluating the efficacy and the long-term durability of this ... ...

    Abstract Introduction: We undertook a systematic review of the currently published literature on TEVAR for DTAAs and we combined the eligible studies into a meta-analysis with the intention of evaluating the efficacy and the long-term durability of this treatment option.
    Evidence acquisition: A systematic search of the literature from January 2015 up to December 2022 was performed according to the PRISMA (preferred reporting items for systematic reviews and meta-analyses) guidelines. For events during follow up we calculated the incidence rates (IRs) with 95% confidence intervals (95% CIs) per 100 patient-years (p-ys) as the number of patients with outcome events occurring during the specific time period divided by the total number of p-ys.
    Evidence synthesis: A total of 4127 study titles were identified by the initial search strategy, of which 12 were considered eligible for inclusion in the meta-analysis. A Total of 1976 patients (62% male) were identified among the eligible studies. One-year survival was 90.1% (95% CI 86.3% to 93.0%), 3-year survival was estimated at 80.5% (95% CI 69.2% to 88.4%) and the 5-year survival was estimated at 73.2% (95%CI 64.3% to 80.5%) with significant heterogeneity among studies regarding these outcomes. Regarding freedom from reintervention analysis for 1 year and 5 years was 96.5% (95% CI 94.5% to 97.8%) and 85.4% (95% CI 56.7% to 96.3%) respectively. The pooled late complications IR per 100 p-ys was 55.0 (95% CI 39.1 to 70.9), whereas the pooled IR for late reinterventions per 100 p-ys was 21.2 (95% CI 26.0 to 87.5). Late type I endoleak was reported with a pooled IR of 26.7 per 100 p-ys (95% CI 19.8 to 33.6) and late type III endoleak with a pooled IR of 7.6 per 100 p-ys (95% CI 5.5 to 9.7).
    Conclusions: TEVAR presents a safe and feasible solution for the treatment of DTAA with sustained long-term effectivity. Current evidence supports a satisfactory 5-year survival with low rates of reinterventions.
    Language English
    Publishing date 2023-06-19
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 80143-4
    ISSN 1827-191X ; 0021-9509
    ISSN (online) 1827-191X
    ISSN 0021-9509
    DOI 10.23736/S0021-9509.23.12648-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Colour Duplex and/or Contrast-Enhanced Ultrasound Compared with Computed Tomography Angiography for Endoleak Detection after Endovascular Abdominal Aortic Aneurysm Repair: A Systematic Review and Meta-Analysis.

    Karaolanis, Georgios I / Antonopoulos, Constantine N / Georgakarakos, Efstratios / Lianos, Georgios D / Mitsis, Michail / Glantzounis, Georgios K / Giannoukas, Athanasios / Kouvelos, George

    Journal of clinical medicine

    2022  Volume 11, Issue 13

    Abstract: This study aims to assess the role of Color Duplex Ultrasound with or without contrast media for surveillance following endovascular aortic aneurysm repair (EVAR). A systematic search of the literature published until April 2022 was performed according ... ...

    Abstract This study aims to assess the role of Color Duplex Ultrasound with or without contrast media for surveillance following endovascular aortic aneurysm repair (EVAR). A systematic search of the literature published until April 2022 was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The pooled rates of endoleak detection through Contrast-Enhanced or Color Duplex Ultrasound (CEUS or CDUS) and Computed Tomography Angiography (CTA) with 95% confidence intervals (CIs) were estimated using random-effect analysis. Thirty-eight studies were considered eligible for inclusion. The total number of patients in the included studies was 5214 between 1997 and 2021. The overall pooled rate of endoleak detection using CDUS and CTA was 82.59% and 97.22%, while the rates for CEUS and CTA were 96.67% and 92.82%, respectively. The findings of the present study support the use of the CEUS for endoleak detection. However, it should be integrated into institutional protocols for EVAR surveillance to further evaluate its clinical utility in the post-EVAR period before it can be recommended as the sole imaging modality after EVAR.
    Language English
    Publishing date 2022-06-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11133628
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  8. Article ; Online: Synchronous colorectal liver metastases: treatment dilemmas and hopes for improving oncological outcomes.

    Lianos, Georgios D / Glantzounis, Georgios K

    Future oncology (London, England)

    2016  Volume 12, Issue 15, Page(s) 1743–1746

    MeSH term(s) Adenocarcinoma/secondary ; Adenocarcinoma/therapy ; Algorithms ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/therapy ; Humans ; Liver Neoplasms/secondary ; Liver Neoplasms/therapy ; Treatment Outcome
    Language English
    Publishing date 2016-08
    Publishing country England
    Document type Editorial
    ZDB-ID 2184533-5
    ISSN 1744-8301 ; 1479-6694
    ISSN (online) 1744-8301
    ISSN 1479-6694
    DOI 10.2217/fon-2016-0060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Surgical oncology during the post-COVID-19 era: What is next?

    Lianos, Georgios D / Frountzas, Maximos / Schizas, Dimitrios / Baltagiannis, Evangelos G / Alexiou, George A / Bali, Christina / Glantzounis, Georgios K / Mitsis, Michail / Vlachos, Konstantinos

    Journal of surgical oncology

    2022  Volume 127, Issue 1, Page(s) 7–10

    Abstract: During first outburst of COVID-19, several strategies had been applied for surgical oncology patients to minimize COVID-19 transmission. COVID-19 infection seemed to compromise survival and major complication rates of surgical oncology patients. However, ...

    Abstract During first outburst of COVID-19, several strategies had been applied for surgical oncology patients to minimize COVID-19 transmission. COVID-19 infection seemed to compromise survival and major complication rates of surgical oncology patients. However, survival, tumor progression and recurrence rates of surgical oncology patients were associated to the consequences of COVID-19 pandemic on their management. In addition, the severity of COVID-19 infections has been downgraded. Therefore, management of surgical oncology patients should be reconsidered.
    Language English
    Publishing date 2022-09-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 82063-5
    ISSN 1096-9098 ; 0022-4790
    ISSN (online) 1096-9098
    ISSN 0022-4790
    DOI 10.1002/jso.27104
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  10. Article: Autophagy and Exosomes: Cross-Regulated Pathways Playing Major Roles in Hepatic Stellate Cells Activation and Liver Fibrosis.

    Mastoridou, Eleftheria M / Goussia, Anna C / Glantzounis, Georgios K / Kanavaros, Panagiotis / Charchanti, Antonia V

    Frontiers in physiology

    2022  Volume 12, Page(s) 801340

    Abstract: Chronic liver injury, regardless of the underlying disease, results in gradual alteration of the physiological hepatic architecture and in excessive production of extracellular matrix, eventually leading to cirrhosis Liver cellular architecture consists ... ...

    Abstract Chronic liver injury, regardless of the underlying disease, results in gradual alteration of the physiological hepatic architecture and in excessive production of extracellular matrix, eventually leading to cirrhosis Liver cellular architecture consists of different cell populations, among which hepatic stellate cells (HSCs) have been found to play a major role in the fibrotic process. Under normal conditions, HSCs serve as the main storage site for vitamin A, however, pathological stimuli lead to their transdifferentiation into myofibroblast cells, with autophagy being the key regulator of their activation, through lipophagy of their lipid droplets. Nevertheless, the role of autophagy in liver fibrosis is multifaceted, as increased autophagic levels have been associated with alleviation of the fibrotic process. In addition, it has been found that HSCs receive paracrine stimuli from neighboring cells, such as injured hepatocytes, Kupffer cells, sinusoidal endothelial cells, which promote liver fibrosis. These stimuli have been found to be transmitted
    Language English
    Publishing date 2022-02-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2021.801340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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