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Article ; Online: m

Ries, Ryan J / Pickering, Brian F / Poh, Hui Xian / Namkoong, Sim / Jaffrey, Samie R

2023 Volume 30, Issue 10, Page(s) 1525–1535

Abstract: Stress granules are biomolecular condensates composed of protein and mRNA. One feature of stress granule-enriched mRNAs is that they are often longer than average. Another feature of stress granule-enriched mRNAs is that they often contain multiple ... ...

Abstract	Stress granules are biomolecular condensates composed of protein and mRNA. One feature of stress granule-enriched mRNAs is that they are often longer than average. Another feature of stress granule-enriched mRNAs is that they often contain multiple N
MeSH term(s)	Animals ; RNA, Messenger/metabolism ; Stress Granules ; Mammals/genetics
Chemical Substances	RNA, Messenger
Language	English
Publishing date	2023-09-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2126708-X
ISSN	1545-9985 ; 1545-9993
ISSN (online)	1545-9985
ISSN	1545-9993
DOI	10.1038/s41594-023-01089-2
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Zs.A 4101: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 56: Show issues

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Article ; Online: m

Ries, Ryan J / Zaccara, Sara / Klein, Pierre / Olarerin-George, Anthony / Namkoong, Sim / Pickering, Brian F / Patil, Deepak P / Kwak, Hojoong / Lee, Jun Hee / Jaffrey, Samie R

Nature

2019 Volume 571, Issue 7765, Page(s) 424–428

Abstract: ... ...

Abstract	N
MeSH term(s)	Adenosine/analogs & derivatives ; Adenosine/metabolism ; Animals ; Biological Transport ; Cell Compartmentation ; Cell Line ; Cytoplasmic Granules/chemistry ; Cytoplasmic Granules/metabolism ; Humans ; Methylation ; Methyltransferases/deficiency ; Mice ; Phase Transition ; RNA, Messenger/analysis ; RNA, Messenger/chemistry ; RNA, Messenger/metabolism ; RNA-Binding Proteins/chemistry ; RNA-Binding Proteins/metabolism ; Stress, Physiological
Chemical Substances	RNA, Messenger ; RNA-Binding Proteins ; YTHDF1 protein, human ; YTHDF2 protein, human ; YTHDF3 protein, human ; N-methyladenosine (CLE6G00625) ; Methyltransferases (EC 2.1.1.-) ; Mettl14 protein, mouse (EC 2.1.1.-) ; Adenosine (K72T3FS567)
Language	English
Publishing date	2019-07-10
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-019-1374-1
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Zs.MG 9: Show issues
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Article ; Online: Muscarinic Receptor M

Welliver, R Ross / Polanco, Jessie J / Seidman, Richard A / Sinha, Anjali K / O'Bara, Melanie A / Khaku, Zainab M / Santiago González, Diara A / Nishiyama, Akiko / Wess, Jurgen / Feltri, M Laura / Paez, Pablo M / Sim, Fraser J

The Journal of neuroscience : the official journal of the Society for Neuroscience

2018 Volume 38, Issue 31, Page(s) 6921–6932

Abstract: ... we hypothesized that M ...

Abstract	Muscarinic receptor antagonists act as potent inducers of oligodendrocyte differentiation and accelerate remyelination. However, the use of muscarinic antagonists in the clinic is limited by poor understanding of the operant receptor subtype, and questions regarding possible species differences between rodents and humans. Based on high selective expression in human oligodendrocyte progenitor cells (OPCs), we hypothesized that M
MeSH term(s)	Animals ; Brain Tissue Transplantation ; Calcium Signaling ; Cells, Cultured ; Fetal Tissue Transplantation ; Gene Knockdown Techniques ; Humans ; Mice ; Mice, Neurologic Mutants ; Muscarinic Agonists/pharmacology ; Muscarinic Antagonists/pharmacology ; Myelin Sheath/physiology ; Neurogenesis/physiology ; Oligodendrocyte Precursor Cells/physiology ; Prosencephalon/embryology ; Prosencephalon/transplantation ; RNA Interference ; Receptor, Muscarinic M3/agonists ; Receptor, Muscarinic M3/antagonists & inhibitors ; Receptor, Muscarinic M3/physiology ; Remyelination/physiology ; Spinal Cord/chemistry ; Spinal Cord/ultrastructure
Chemical Substances	CHRM3 protein, human ; Chrm3 protein, mouse ; Muscarinic Agonists ; Muscarinic Antagonists ; Receptor, Muscarinic M3
Language	English
Publishing date	2018-06-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.1862-17.2018
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Article ; Online: The Bisindole Alkaloids Angustilongines M and A from

Tan, Chun-Hoe / Yeap, Joanne Soon-Yee / Lim, Siew-Huah / Low, Yun-Yee / Sim, Kae-Shin / Kam, Toh-Seok

Journal of natural products

2021 Volume 84, Issue 5, Page(s) 1524–1533

Abstract: A new linearly fused macroline-sarpagine bisindole, angustilongine M ( ...

Abstract	A new linearly fused macroline-sarpagine bisindole, angustilongine M (
MeSH term(s)	Alstonia/chemistry ; Antineoplastic Agents, Phytogenic/pharmacology ; Apoptosis/drug effects ; Drug Screening Assays, Antitumor ; G1 Phase Cell Cycle Checkpoints/drug effects ; HT29 Cells ; Humans ; Indole Alkaloids/pharmacology ; Mitochondria/drug effects ; Molecular Docking Simulation ; Molecular Structure ; Oxindoles/pharmacology ; Tubulin Modulators/pharmacology
Chemical Substances	Antineoplastic Agents, Phytogenic ; Indole Alkaloids ; Oxindoles ; Tubulin Modulators ; macroline ; sarpagine (XD54MPV6VQ)
Language	English
Publishing date	2021-04-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/acs.jnatprod.1c00013
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Article ; Online: M/g-C

Hak, Chen Hong / Sim, Lan Ching / Leong, Kah Hon / Lim, Ping Feng / Chin, Yik Heng / Saravanan, Pichiah

Environmental science and pollution research international

2018 Volume 25, Issue 25, Page(s) 25401–25412

Abstract: In this work, natural sunlight successfully induced the deposition of gold (Au), silver (Ag), and palladium (Pd) nanoparticles (NPs) with 17.10, 9.07, and 12.70 wt% onto the surface of graphitic carbon nitride (g- ... ...

Abstract	In this work, natural sunlight successfully induced the deposition of gold (Au), silver (Ag), and palladium (Pd) nanoparticles (NPs) with 17.10, 9.07, and 12.70 wt% onto the surface of graphitic carbon nitride (g-C
MeSH term(s)	Benzhydryl Compounds ; Catalysis ; Gold/radiation effects ; Graphite/chemistry ; Light ; Nanoparticles ; Nitriles/chemistry ; Palladium/radiation effects ; Particle Size ; Phenols ; Silver/radiation effects ; Sunlight ; Surface Plasmon Resonance ; Water Pollutants, Chemical/radiation effects
Chemical Substances	Benzhydryl Compounds ; Nitriles ; Phenols ; Water Pollutants, Chemical ; Silver (3M4G523W1G) ; cyanogen (534Q0F66RK) ; Palladium (5TWQ1V240M) ; Gold (7440-57-5) ; Graphite (7782-42-5) ; bisphenol A (MLT3645I99)
Language	English
Publishing date	2018-06-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-018-2632-8
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Article: Effects of muscle damage indicators and antioxidant capacity after interval training on the 800-m records of adolescent middle-distance runners.

Zhao, Yaowei / Sim, Young-Je

Journal of exercise rehabilitation

2023 Volume 19, Issue 3, Page(s) 181–186

Abstract: ... damage indicators and antioxidant capacity and determine its effect on the 800-m records of adolescent ... were measured, and their effects on the 800-m records were analyzed. The 10-week training reduced serum ... IT also reduced the 800-m records in middle-distance running, and the effect was stronger in the HIIT ...

Abstract	To examine the effect of 10-week interval training (IT) at varying intensities on serum muscle damage indicators and antioxidant capacity and determine its effect on the 800-m records of adolescent middle-distance runners. Twenty male high-school middle-distance runners were randomized between the high-intensity IT (HIIT; n=10) and the medium-intensity IT (MIIT; n=10) groups. Three sessions/week for 10 weeks (total of 30 sessions) were performed; one session of IT was for 60 min. The high and medium exercise intensities were set at 90%-95% and 60%-70% heart rate reserve (HRR), respectively. Intensity at rest was 40% HRR for both groups. Weight training was performed at 60%-70% of one repetition maximum for two sessions/week. The changes in serum muscle damage indicators and antioxidant capacity in the two groups were measured, and their effects on the 800-m records were analyzed. The 10-week training reduced serum muscle damage indicators in middle-distance runners, but only the HIIT group displayed a decrease in creatine kinase. For the change in antioxidant capacity, the two groups demonstrated no significant change in malondialdehyde (MDA), whereas the HIIT group exhibited a significant increase in super-oxide dismutase (SOD). IT also reduced the 800-m records in middle-distance running, and the effect was stronger in the HIIT group. In conclusion, 10-week HIIT can have a positive effect on muscle damage indicators, showed a significant increase in SOD as a key indicator of anti-oxidant capacity, and improved the 800-m records in middle-distance runners.
Language	English
Publishing date	2023-06-28
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2756291-8
ISSN	2288-1778 ; 2288-176X
ISSN (online)	2288-1778
ISSN	2288-176X
DOI	10.12965/jer.2346212.106
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Article ; Online: Repeat Application of Ischemic Preconditioning Improves Maximal 1,000-m Kayak Ergometer Performance in a Simulated Competition Format.

Halley, Samuel L / Peeling, Peter / Brown, Henry / Sim, Marc / Mallabone, Jason / Dawson, Brian / Binnie, Martyn J

Journal of strength and conditioning research

2020

Abstract: Halley, SL, Peeling, P, Brown, H, Sim, M, Mallabone, J, Dawson, B, and Binnie, MJ. Repeat ... application of ischemic preconditioning improves maximal 1,000-m kayak ergometer performance in a simulated ... of ischemic preconditioning (IPC) on repeat 1,000-m kayak ergometer time-trial (TT) performance, completed in a simulated ...

Abstract	Halley, SL, Peeling, P, Brown, H, Sim, M, Mallabone, J, Dawson, B, and Binnie, MJ. Repeat application of ischemic preconditioning improves maximal 1,000-m kayak ergometer performance in a simulated competition format. J Strength Cond Res XX(X): 000-000, 2020-This study examined the effects of ischemic preconditioning (IPC) on repeat 1,000-m kayak ergometer time-trial (TT) performance, completed in a simulated competition format. Eight well-trained male kayak athletes performed 3 experimental trials, each consisting of two 1,000-m TTs separated by 80 minutes (TT 1 and TT 2). Trials included; (a) IPC (4 × 5 minutes 220 mm Hg alternating bilateral leg occlusion) 40 minutes before TT 1 only (IPC1); (b) IPC 40 minutes before TT 1 and 20 minutes before TT 2 (IPC2); and (c) no IPC (CON). Time, power, stroke rate, and expired gas variables (V[Combining Dot Above]O2 and accumulated oxygen deficit) were measured throughout each TT; blood gas variables (blood lactate, partial pressure of oxygen and blood pH) and rating of perceived exertion were measured before and after each effort. Physiological, perceptual, and physical measures were analyzed via a repeated measures analysis of variance with the level of significance set at p ≤ 0.05. There were large improvements in completion time for TT 1 in IPC1 (d = 1.24 ± 0.68, p < 0.05) and IPC2 (d = 1.53 ± 0.99, p < 0.05) versus CON. There was also a large improvement in TT 2 completion time in IPC2 versus CON (d = 1.26 ± 1.13, p = 0.03) whereas, IPC1 and CON were indifferent (d = 0.3 ± 0.54, p = 0.23). This study showed that a repeat application of IPC in a simulated competition format may offer further benefit in comparison to a single pre-exercise application of IPC.
Language	English
Publishing date	2020-10-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1156349-7
ISSN	1533-4287 ; 1064-8011
ISSN (online)	1533-4287
ISSN	1064-8011
DOI	10.1519/JSC.0000000000003748
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Article ; Online: Observations on Riccia sorocarpa Bisch. subsp. erythrophora R.M.Schust. ex Konstant. & L.Söderstr. and its occurrence in Portugal and the Azores

Sérgio, C. / Gabriel, R. / Sim-Sim, M. / Martins, A. / Porley, R. D. / Garcia, C. A.

Journal of Bryology. 2022 Apr. 03, v. 44, no. 2 p.134-139

2022

Abstract: ... sorocarpa Bisch. subsp. erythrophora R.M.Schust. ex Konstant. & L.Söderstr. New data are presented ...

Abstract	Recent bryological research in Portugal has revealed the occurrence of a little-known segregate of the Riccia sorocarpa group, representing the first record for mainland Portugal and the Azores of Riccia sorocarpa Bisch. subsp. erythrophora R.M.Schust. ex Konstant. & L.Söderstr. New data are presented on the taxonomy and phytogeography of this globally rare taxon. A revision of approximately 200 samples of Riccia sorocarpa s.l. from selected Portuguese herbaria, together with some recent field collections, was carried out, based on the results of light and scanning electron microscopy. Our findings confirm that Riccia sorocarpa subsp. erythrophora is a distinct subspecies, and show that morphological differences of the thallus, primarily the violet-red purple bases of the ventral scales, are the most important characters for its delimitation. Scanning electron micrographs of spores of this taxon are presented for the first time. Phytogeographically, our data significantly extend the known distribution of the subspecies.
Keywords	Riccia ; bryology ; electron microscopy ; phytogeography ; taxonomy ; thallus ; Azores ; Portugal ; Distribution ; liverwort flora ; Macaronesia ; SEM ; spore morphology
Language	English
Dates of publication	2022-0403
Size	p. 134-139.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2080324-2
ISSN	1743-2820 ; 0373-6687
ISSN (online)	1743-2820
ISSN	0373-6687
DOI	10.1080/03736687.2022.2106008
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Comment on MaaniHessari, N.; van Schalkwyk, M.C.; Thomas, S.; Petticrew, M. Alcohol Industry CSR Organisations

Fiona Sim / Jonathan Chick / Stephen Neidle / Graham Ogden / Sarah Jarvis / Iona Lidington / Helene Leslie

International Journal of Environmental Research and Public Health, Vol 16, Iss 13, p

What Can Their Twitter Activity Tell Us about Their Independence and Their Priorities? A Comparative Analysis. Int. J. Environ. Res. Public Health 2019, 16 , 892

2019 Volume 2421

Abstract: We noted with concern that you published recently (12 March 2019) an article about so-called “Alcohol industry CSR Organisations”, which selectively targets criticism of Drinkaware [.] ...

Abstract	We noted with concern that you published recently (12 March 2019) an article about so-called “Alcohol industry CSR Organisations”, which selectively targets criticism of Drinkaware [.]
Keywords	n/a ; Medicine ; R
Language	English
Publishing date	2019-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Effect of changes in blood fatigue indicators, inflammatory markers, and stress hormone levels on 100-m records of sprinters following an 8-week intense interval training.

Du, HongYing / Sim, Young-Je

Journal of exercise rehabilitation

2021 Volume 17, Issue 5, Page(s) 348–353

Abstract: ... the effects on changes in the 100-m sprint records. Twenty sprinters from a boys' high school were equally ... m sprint records were different in high- and medium-intensity interval training groups, based ... in the high-intensity interval training group were found to have a significant effect on the 100-m sprinting ...

Abstract	This study aimed to examine the changes in the blood fatigue indicators, inflammatory markers, and stress hormones following an 8-week intensity interval training in sprinters, and to investigate the effects on changes in the 100-m sprint records. Twenty sprinters from a boys' high school were equally assigned to high-intensity and medium-intensity interval training groups, and three 60-min interval training sessions were performed per week for 8 weeks, for a total of 24 sessions. Exercise intensity was defined as 85%-95% and 75%-85% of heart rate reserve for high- and medium-intensity training, respectively. At rest, both groups had an exercise intensity of 60% of the heart rate reserve. Our results showed decreased fatigue indicators, inflammatory markers, and stress hormone levels after high-intensity and medium-intensity interval training, with no difference between the training levels. In addition, the 100-m sprint records were different in high- and medium-intensity interval training groups, based on the lactate dehydrogenase and adrenocorticotropic hormone levels. In conclusion, medium-intensity interval training with a reserve heart rate of ≥75% can have a positive effect on blood fatigue indicators, inflammatory markers, and stress hormones in sprinters. Specifically, the changes in adrenocorticotropic hormone level seen in the high-intensity interval training group were found to have a significant effect on the 100-m sprinting records.
Language	English
Publishing date	2021-10-26
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2756291-8
ISSN	2288-1778 ; 2288-176X
ISSN (online)	2288-1778
ISSN	2288-176X
DOI	10.12965/jer.2142536.268
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