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Book ; Online: Differential Undercounts in the U.S. Census

O’Hare, William P.

Who is Missed?

(SpringerBriefs in Population Studies)

2019

Author's details	by William P. O’Hare
Series title	SpringerBriefs in Population Studies
Keywords	Demography ; Mathematical statistics ; Social sciences/Methodology
Subject code	304.6
Language	English
Size	1 Online-Ressource (XI, 167 p. 15 illus., 13 illus. in color)
Publisher	Springer International Publishing ; Imprint: Springer
Publishing place	Cham
Document type	Book ; Online
HBZ-ID	HT019992533
ISBN	978-3-030-10973-8 ; 9783030109721 ; 9783030109745 ; 3-030-10973-9 ; 3030109720 ; 3030109747
DOI	10.1007/978-3-030-10973-8
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online: Differential Undercounts in the U.S. Census : Who is Missed?

O'Hare, William P.

2019

Keywords	Social research & statistics ; Population & demography ; Probability & statistics ; Social sciences ; Demography ; Statistics
Size	1 electronic resource (167 pages)
Publisher	Springer Nature
Publishing place	Cham
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021026974
ISBN	978-3-030-10973-8 ; 3-030-10973-9
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: S-Nitrosoglutathione Reductase Deficiency Causes Aberrant Placental S-Nitrosylation and Preeclampsia.

Kulandavelu, Shathiyah / Dulce, Raul A / Murray, Christopher I / Bellio, Michael A / Fritsch, Julia / Kanashiro-Takeuchi, Rosemeire / Arora, Himanshu / Paulino, Ellena / Soetkamp, Daniel / Balkan, Wayne / Van Eyk, Jenny E / Hare, Joshua M

Journal of the American Heart Association

2022 Volume 11, Issue 5, Page(s) e024008

Abstract: ... characterized by an increase in S-nitrosylated proteins and reactive oxygen species, suggesting ... that mice lacking S-nitrosoglutathione reductase ( ...

Abstract	Background Preeclampsia, a leading cause of maternal and fetal mortality and morbidity, is characterized by an increase in S-nitrosylated proteins and reactive oxygen species, suggesting a pathophysiologic role for dysregulation in nitrosylation and nitrosative stress. Methods and Results Here, we show that mice lacking S-nitrosoglutathione reductase (
MeSH term(s)	Alcohol Dehydrogenase/deficiency ; Alcohol Dehydrogenase/metabolism ; Aldehyde Oxidoreductases/genetics ; Aldehyde Oxidoreductases/metabolism ; Animals ; Female ; Mice ; Nitric Oxide/metabolism ; Placenta/enzymology ; Placenta/metabolism ; Pre-Eclampsia/enzymology ; Pre-Eclampsia/metabolism ; Pregnancy ; Reactive Oxygen Species/metabolism
Chemical Substances	Reactive Oxygen Species ; Nitric Oxide (31C4KY9ESH) ; Adh5 protein, mouse (EC 1.1.1.1) ; Alcohol Dehydrogenase (EC 1.1.1.1) ; Aldehyde Oxidoreductases (EC 1.2.-) ; formaldehyde dehydrogenase, glutathione-independent (EC 1.2.1.46)
Language	English
Publishing date	2022-02-22
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.121.024008
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Proposed Specifiers for Conduct Disorder (PSCD): Further validation of the parent-report version in a nationally representative U.S. sample of 10- to 17-year-olds.

Bellamy, Nicholas A / Neumann, Craig S / Mendez, Beatriz / Batky, Blair D / DeGroot, Harriet R / Hare, Robert D / Salekin, Randall T

Psychological assessment

2024 Volume 36, Issue 3, Page(s) 175–191

Abstract: ... U.S. sample of children and adolescents (N = 1,091, Mage = 13.39, SD = 2.20, range age = 10-17; 50.0 ... The Proposed Specifiers for Conduct Disorder (PSCD; Salekin & Hare, 2016) is a new self-report and ...

Abstract	The Proposed Specifiers for Conduct Disorder (PSCD; Salekin & Hare, 2016) is a new self-report and informant measure designed to assess psychopathic characteristic domains along with symptoms of conduct disorder in youth. Previous factor analytic studies on the PSCD have found that the items are accounted for by a four-factor model reflecting grandiose-manipulative, callous-unemotional, daring-impulsive, and conduct disorder (CD) symptoms. The present study examined the factor structure, psychometric properties, and criterion-related validity of the parent-report version of the PSCD (PSCD-P) in a nationally representative U.S. sample of children and adolescents (N = 1,091, Mage = 13.39, SD = 2.20, range age = 10-17; 50.0% boys, 76% White). Confirmatory factor analyses for the full (24-item) and a shortened (13-item) PSCD-P revealed good internal reliability estimates and support for the four-factor model (grandiose-manipulative, callous-unemotional, daring-impulsive, CD). Results also provided evidence for (a) measurement invariance of the PSCD-P items across sex, race/ethnicity, and age of the child; (b) convergent validity with CD/oppositional defiant disorder symptoms and discriminant validity with a measure of neuroticism; and (c) criterion-related validity with respect to prosociality, peer and family functioning, reactive and proactive aggression, delinquency, academic performance, and substance use. The prevalence for psychopathic personality propensity was found to be 2%. We discuss clinical and research implications regarding the use of the parent-report version of the PSCD for school-aged children. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
MeSH term(s)	Adolescent ; Child ; Female ; Humans ; Male ; Aggression ; Conduct Disorder/diagnosis ; Oppositional Defiant Disorder ; Parents ; Reproducibility of Results
Language	English
Publishing date	2024-02-22
Publishing country	United States
Document type	Journal Article ; Validation Study
ZDB-ID	1000939-5
ISSN	1939-134X ; 1040-3590
ISSN (online)	1939-134X
ISSN	1040-3590
DOI	10.1037/pas0001302
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Article ; Online: S-nitrosylation of CSF1 receptor increases the efficacy of CSF1R blockage against prostate cancer.

Firdaus, Fakiha / Kuchakulla, Manish / Qureshi, Rehana / Dulce, Raul Ariel / Soni, Yash / Van Booven, Derek J / Shah, Khushi / Masterson, Thomas / Rosete, Omar Joel / Punnen, Sanoj / Hare, Joshua M / Ramasamy, Ranjith / Arora, Himanshu

Cell death & disease

2022 Volume 13, Issue 10, Page(s) 859

Abstract: ... nitric oxide (NO) required for S-nitrosylation of CSF1R at specific cysteine sites (Cys 224, Cys 278, and Cys ... 830). Exogenous S-nitrosothiol administration (with S-nitrosoglutathione (GSNO)) induces S ...

Abstract	Sustained oxidative stress in castration-resistant prostate cancer (CRPC) cells potentiates the overall tumor microenvironment (TME). Targeting the TME using colony-stimulating factor 1 receptor (CSF1R) inhibition is a promising therapy for CRPC. However, the therapeutic response to sustained CSF1R inhibition (CSF1Ri) is limited as a monotherapy. We hypothesized that one of the underlying causes for the reduced efficacy of CSF1Ri and increased oxidation in CRPC is the upregulation and uncoupling of endothelial nitric oxide synthase (NOS3). Here we show that in high-grade PCa human specimens, NOS3 abundance positively correlates with CSF1-CSF1R signaling and remains uncoupled. The uncoupling diminishes NOS3 generation of sufficient nitric oxide (NO) required for S-nitrosylation of CSF1R at specific cysteine sites (Cys 224, Cys 278, and Cys 830). Exogenous S-nitrosothiol administration (with S-nitrosoglutathione (GSNO)) induces S-nitrosylation of CSF1R and rescues the excess oxidation in tumor regions, in turn suppressing the tumor-promoting cytokines which are ineffectively suppressed by CSF1R blockade. Together these results suggest that NO administration could act as an effective combinatorial partner with CSF1R blockade against CRPC. In this context, we further show that exogenous NO treatment with GSNOR successfully augments the anti-tumor ability of CSF1Ri to effectively reduce the overall tumor burden, decreases the intratumoral percentage of anti-inflammatory macrophages, myeloid-derived progenitor cells and increases the percentage of pro-inflammatory macrophages, cytotoxic T lymphocytes, and effector T cells, respectively. Together, these findings support the concept that the NO-CSF1Ri combination has the potential to act as a therapeutic agent that restores control over TME, which in turn could improve the outcomes of PCa patients.
MeSH term(s)	Cysteine ; Humans ; Macrophage Colony-Stimulating Factor ; Male ; Nitric Oxide ; Nitric Oxide Synthase Type III ; Prostatic Neoplasms, Castration-Resistant ; Receptor, Macrophage Colony-Stimulating Factor ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/antagonists & inhibitors ; S-Nitrosoglutathione ; Tumor Microenvironment
Chemical Substances	CSF1R protein, human ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor ; Nitric Oxide (31C4KY9ESH) ; S-Nitrosoglutathione (57564-91-7) ; Macrophage Colony-Stimulating Factor (81627-83-0) ; Nitric Oxide Synthase Type III (EC 1.14.13.39) ; Receptor, Macrophage Colony-Stimulating Factor (EC 2.7.10.1) ; Cysteine (K848JZ4886)
Language	English
Publishing date	2022-10-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-022-05289-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Ketamine increases vmPFC activity: Effects of (R)- and (S)-stereoisomers and (2R,6R)-hydroxynorketamine metabolite.

Hare, Brendan D / Pothula, Santosh / DiLeone, Ralph J / Duman, Ronald S

Neuropharmacology

2020 Volume 166, Page(s) 107947

Abstract: ... We sought to characterize the effects of ketamine and its stereoisomers (R and S), as well as a metabolite ... to determine correspondance of activity between compounds. We observed dose dependent effects with (R,S ... S)-ketamine (15 mg/kg), which has high affinity for the NMDA receptor channel produced similar ...

Abstract	Ketamine, an NMDA receptor antagonist and fast acting antidepressant, produces a rapid burst of glutamate in the ventral medial prefrontal cortex (mPFC). Preclinical studies have demonstrated that pyramidal cell activity in the vmPFC is necessary for the rapid antidepressant response to ketamine in rodents. We sought to characterize the effects of ketamine and its stereoisomers (R and S), as well as a metabolite, (2R,6R)-hydroxynorketamine (HNK), on vmPFC activity using a genetically encoded calcium indicator (GCaMP6f). Ratiometric fiber photometry was utilized to monitor GCaMP6f fluorescence in pyramidal cells of mouse vmPFC prior to and immediately following administration of compounds. GCaMP6f signal was assessed to determine correspondance of activity between compounds. We observed dose dependent effects with (R,S)-ketamine (3-100 mg/kg), with the greatest effects on GCaMP6f activity at 30 mg/kg and lasting up to 20 min. (S)-ketamine (15 mg/kg), which has high affinity for the NMDA receptor channel produced similar effects to (R,S)-ketamine, but compounds with low NMDA receptor affinity, including (R)-ketamine (15 mg/kg) and (2R,6R)-HNK (30 mg/kg) had little or no effect on GCaMP6f activity. The initial response to administration of (R,S)-ketamine as well as (S)-ketamine is characterized by a brief period of robust GCaMP6f activation, consistent with increased activity of vmPFC pyramidal neurons. Because (2R,6R)-HNK and (R)-ketamine are reported to have antidepressant activity in rodent models the current results indicate that different initiating mechanisms lead to similar brain adaptive consequences that underlie the rapid antidepressant responses.
MeSH term(s)	Animals ; Dose-Response Relationship, Drug ; Excitatory Amino Acid Antagonists/chemistry ; Excitatory Amino Acid Antagonists/metabolism ; Excitatory Amino Acid Antagonists/pharmacology ; Ketamine/analogs & derivatives ; Ketamine/chemistry ; Ketamine/metabolism ; Ketamine/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Photometry/methods ; Prefrontal Cortex/drug effects ; Prefrontal Cortex/metabolism ; Stereoisomerism
Chemical Substances	Excitatory Amino Acid Antagonists ; Ketamine (690G0D6V8H) ; 6-hydroxynorketamine (81395-70-2)
Language	English
Publishing date	2020-01-09
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	218272-5
ISSN	1873-7064 ; 0028-3908
ISSN (online)	1873-7064
ISSN	0028-3908
DOI	10.1016/j.neuropharm.2020.107947
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Article ; Online: S-Nitrosoglutathione Reductase (GSNOR) Deficiency Results in Secondary Hypogonadism.

Masterson, Thomas A / Arora, Himanshu / Kulandavelu, Shathiyah / Carroll, Rona S / Kaiser, Ursula B / Gultekin, Sakir H / Hare, Joshua M / Ramasamy, Ranjith

The journal of sexual medicine

2018 Volume 15, Issue 5, Page(s) 654–661

Abstract: ... the S-nitrosoglutathione reductase-null (Gsnor: Methods: Testis size, pup number, and epididymal ... variability in hormone levels.: Conclusion: Deficiency of S-nitrosoglutathione reductase results ... from the pituitary gland. Masterson TA, Arora H, Kulandavelu S, et al. S-Nitrosoglutathione Reductase (GSNOR) Deficiency ...

Abstract	Background: Excess reactive oxygen species and reactive nitrogen species are implicated in male infertility and impaired spermatogenesis. Aim: To investigate the effect of excess reactive nitrogen species and nitrosative stress on testicular function and the hypothalamic-pituitary-gonadal axis using the S-nitrosoglutathione reductase-null (Gsnor Methods: Testis size, pup number, and epididymal sperm concentration and motility of Gsnor Outcomes: Evaluation of fertility and reproductive hormones in Gsnor Results: Gsnor Clinical translation: These findings provide novel insight to a possible mechanism of secondary hypogonadism from increased reactive nitrogen species and excess nitrosative stress. Strengths and limitations: Limitations of this study are its small samples and variability in hormone levels. Conclusion: Deficiency of S-nitrosoglutathione reductase results in secondary hypogonadism, suggesting that excess nitrosative stress can affect LH production from the pituitary gland. Masterson TA, Arora H, Kulandavelu S, et al. S-Nitrosoglutathione Reductase (GSNOR) Deficiency Results in Secondary Hypogonadism. J Sex Med 2018;15:654-661.
MeSH term(s)	17-Hydroxysteroid Dehydrogenases/metabolism ; Aldehyde Oxidoreductases/deficiency ; Animals ; Chorionic Gonadotropin/metabolism ; Follicle Stimulating Hormone/metabolism ; Gonadotropin-Releasing Hormone/metabolism ; Hypogonadism/etiology ; Hypogonadism/pathology ; Luteinizing Hormone/metabolism ; Male ; Mice ; Nitrosative Stress/physiology ; Sperm Count ; Testis/pathology ; Testosterone/metabolism
Chemical Substances	Chorionic Gonadotropin ; Gonadotropin-Releasing Hormone (33515-09-2) ; Testosterone (3XMK78S47O) ; Luteinizing Hormone (9002-67-9) ; Follicle Stimulating Hormone (9002-68-0) ; 17-Hydroxysteroid Dehydrogenases (EC 1.1.-) ; 3 (or 17)-beta-hydroxysteroid dehydrogenase (EC 1.1.1.51) ; Aldehyde Oxidoreductases (EC 1.2.-) ; formaldehyde dehydrogenase, glutathione-independent (EC 1.2.1.46)
Language	English
Publishing date	2018-03-30
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2251959-2
ISSN	1743-6109 ; 1743-6095
ISSN (online)	1743-6109
ISSN	1743-6095
DOI	10.1016/j.jsxm.2018.03.002
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Article ; Online: COVID-19 Vaccination Effectiveness Against Infection or Death in a National U.S. Health Care System : A Target Trial Emulation Study.

Ioannou, George N / Locke, Emily R / O'Hare, Ann M / Bohnert, Amy S B / Boyko, Edward J / Hynes, Denise M / Berry, Kristin

Annals of internal medicine

2021 Volume 175, Issue 3, Page(s) 352–361

Abstract: ... vaccinated persons with matched unvaccinated controls.: Setting: U.S. Department of Veterans Affairs ... for pandemic control, even with vaccination.: Primary funding source: U.S. Department of Veterans Affairs. ...

Abstract	Background: Little is known about real-world COVID-19 vaccine effectiveness (VE) in racially and ethnically diverse, elderly populations with high comorbidity burden. Objective: To determine the effectiveness of messenger RNA COVID-19 vaccines. Design: Target trial emulation study comparing newly vaccinated persons with matched unvaccinated controls. Setting: U.S. Department of Veterans Affairs health care system. Participants: Among persons receiving care in the Veterans Affairs health care system ( Intervention: Follow-up for SARS-CoV-2 infection or SARS-CoV-2-related death, defined as death within 30 days of infection, began after the vaccination date or an identical index date for the matched unvaccinated controls and continued until up to 30 June 2021. Measurements: Vaccine effectiveness against SARS-CoV-2 infection or SARS-CoV-2-related death. Results: Vaccinated and unvaccinated groups were well matched; both were predominantly male (92.9% vs. 93.4%), had advanced age (mean, 68.7 years in both groups), had diverse racial and ethnic distribution (for example, Black: 17.3% vs. 17.0%, Hispanic: 6.5% vs. 6.1%), and had substantial comorbidity burden. Vaccine effectiveness 7 or more days after the second vaccine dose was 69% (95% CI, 67% to 70%) against SARS-CoV-2 infection and 86% (CI, 82% to 89%) against SARS-CoV-2-related death and was similar when follow-up was extended to 31 March versus 30 June. Vaccine effectiveness against infection decreased with increasing age and comorbidity burden. Limitation: Predominantly male population and lack of data on SARS-CoV-2 variants. Conclusion: In an elderly, diverse, high-comorbidity population, COVID-19 VE against infection was substantially lower than previously reported, but VE against death was high. Complementary infection mitigation efforts remain important for pandemic control, even with vaccination. Primary funding source: U.S. Department of Veterans Affairs.
MeSH term(s)	Aged ; BNT162 Vaccine ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines ; Delivery of Health Care ; Female ; Humans ; Male ; SARS-CoV-2 ; Vaccination
Chemical Substances	COVID-19 Vaccines ; BNT162 Vaccine (N38TVC63NU)
Language	English
Publishing date	2021-12-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	336-0
ISSN	1539-3704 ; 0003-4819
ISSN (online)	1539-3704
ISSN	0003-4819
DOI	10.7326/M21-3256
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Book ; Online: Differential Undercounts in the U.S. Census

O’Hare, William P.

2019

Abstract: This open access book describes the differences in US census coverage, also referred to as “differential undercount”, by showing which groups have the highest net undercounts and which groups have the greatest undercount differentials, and discusses why ... ...

Abstract	This open access book describes the differences in US census coverage, also referred to as “differential undercount”, by showing which groups have the highest net undercounts and which groups have the greatest undercount differentials, and discusses why such undercounts occur. In addition to focusing on measuring census coverage for several demographic characteristics, including age, gender, race, Hispanic origin status, and tenure, it also considers several of the main hard-to-count populations, such as immigrants, the homeless, the LBGT community, children in foster care, and the disabled. However, given the dearth of accurate undercount data for these groups, they are covered less comprehensively than those demographic groups for which there is reliable undercount data from the Census Bureau. This book is of interest to demographers, statisticians, survey methodologists, and all those interested in census coverage.
Keywords	Social sciences ; Demography ; Statistics
Language	English
Publisher	Springer Nature
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Differential Undercounts in the U.S. Census

William P. O’Hare

Who is Missed?

2019

Abstract	This open access book describes the differences in US census coverage, also referred to as “differential undercount”, by showing which groups have the highest net undercounts and which groups have the greatest undercount differentials, and discusses why such undercounts occur. In addition to focusing on measuring census coverage for several demographic characteristics, including age, gender, race, Hispanic origin status, and tenure, it also considers several of the main hard-to-count populations, such as immigrants, the homeless, the LBGT community, children in foster care, and the disabled. However, given the dearth of accurate undercount data for these groups, they are covered less comprehensively than those demographic groups for which there is reliable undercount data from the Census Bureau. This book is of interest to demographers, statisticians, survey methodologists, and all those interested in census coverage.
Keywords	Social sciences ; Demography ; Statistics ; JHBC ; JHBD ; PBT
Language	English
Publisher	Springer
Publishing country	nl
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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