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  1. Article ; Online: Thomas Alexander Waldmann.

    Berzofsky, Jay A

    Immunity

    2021  Volume 54, Issue 12, Page(s) 2671–2672

    MeSH term(s) Allergy and Immunology/history ; History, 20th Century ; History, 21st Century ; Humans ; Immunoglobulins/metabolism ; Interleukin-15/metabolism ; Interleukin-2/metabolism ; Mentors ; T-Lymphocytes, Regulatory/immunology ; United States
    Chemical Substances Immunoglobulins ; Interleukin-15 ; Interleukin-2
    Language English
    Publishing date 2021-12-03
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2021.11.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4227: Show issues Location:
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  2. Article ; Online: Myeloid Cell-Mediated Trained Innate Immunity in Mucosal AIDS Vaccine Development.

    Sui, Yongjun / Berzofsky, Jay A

    Frontiers in immunology

    2020  Volume 11, Page(s) 315

    Abstract: Trained innate immunity has recently emerged as a novel concept of innate immune cells, such as myeloid cells, exhibiting immune memory, and nonspecific heterologous immunity to protect against infections. The memory and specificity are mediated by ... ...

    Abstract Trained innate immunity has recently emerged as a novel concept of innate immune cells, such as myeloid cells, exhibiting immune memory, and nonspecific heterologous immunity to protect against infections. The memory and specificity are mediated by epigenetic, metabolic, and functional reprogramming of the myeloid cells and myeloid progenitors (and/or NK cells) in the bone marrow and peripheral tissues such as gut and lung mucosa. A variety of agents, such as BCG, viruses, and their components, as well as TLR agonists, and cytokines have been shown to be involved in the induction of trained immunity. Since these agents have been widely used in AIDS vaccine development as antigen delivery vectors or adjuvants, myeloid cell mediated trained immunity might also play an important role in protecting against mucosal AIDS virus transmission or in control of virus replication in the major gut mucosal reservoir. Here we review the trained innate immunity induced by these vectors/adjuvants that have been used in AIDS vaccine studies and discuss their role in mucosal vaccine efficacy and possible utilization in AIDS vaccine development. Delineating the protective effect of the trained innate immunity mediated by myeloid cells will guide the design of novel AIDS vaccines.
    MeSH term(s) AIDS Vaccines/immunology ; Acquired Immunodeficiency Syndrome/immunology ; Adaptive Immunity ; Animals ; HIV-1/physiology ; Hematopoietic Stem Cells/physiology ; Humans ; Immunity, Innate ; Immunologic Memory ; Intestinal Mucosa/immunology ; Myeloid Cells/immunology
    Chemical Substances AIDS Vaccines
    Language English
    Publishing date 2020-02-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.00315
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Potential SARS-CoV-2 Immune Correlates of Protection in Infection and Vaccine Immunization.

    Sui, Yongjun / Bekele, Yonas / Berzofsky, Jay A

    Pathogens (Basel, Switzerland)

    2021  Volume 10, Issue 2

    Abstract: Both SARS-CoV-2 infections and vaccines induce robust immune responses. Current data suggested that high neutralizing antibody titers with sustained Th1 responses might correlate with protection against viral transmission and disease development and ... ...

    Abstract Both SARS-CoV-2 infections and vaccines induce robust immune responses. Current data suggested that high neutralizing antibody titers with sustained Th1 responses might correlate with protection against viral transmission and disease development and severity. In addition, genetic and innate immune factors, including higher levels of type I interferons, as well as the induction of trained immunity and local mucosal immunity also contribute to lower risk of infection and amelioration of disease severity. The identification of immune correlates of protection will facilitate the development of effective vaccines and therapeutics strategies.
    Language English
    Publishing date 2021-01-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens10020138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The role of NKT cells in gastrointestinal cancers.

    Burks, Julian / Olkhanud, Purevdorj B / Berzofsky, Jay A

    Oncoimmunology

    2021  Volume 11, Issue 1, Page(s) 2009666

    Abstract: Gastrointestinal (GI) cancers represent a complex array of cancers that affect the digestive system. This includes liver, pancreatic, colon, rectal, anal, gastric, esophageal, intestinal and gallbladder cancer. Patients diagnosed with certain GI cancers ... ...

    Abstract Gastrointestinal (GI) cancers represent a complex array of cancers that affect the digestive system. This includes liver, pancreatic, colon, rectal, anal, gastric, esophageal, intestinal and gallbladder cancer. Patients diagnosed with certain GI cancers typically have low survival rates, so new therapeutic approaches are needed. A potential approach is to harness the potent immunoregulatory properties of natural killer T (NKT) cells which are true T cells, not natural killer (NK) cells, that recognize lipid instead of peptide antigens presented by the non-classical major histocompatibility (MHC) molecule CD1d. The NKT cell subpopulation is known to play a vital role in tumor immunity by bridging innate and adaptive immune responses. In GI cancers, NKT cells can contribute to either antitumor or protumor immunity depending on the cytokine profile expressed and type of cancer. This review discusses the complexities of the role of NKT cells in liver, colon, pancreatic and gastric cancers with an emphasis on type I NKT cells.
    Language English
    Publishing date 2021-12-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2645309-5
    ISSN 2162-402X ; 2162-402X
    ISSN (online) 2162-402X
    ISSN 2162-402X
    DOI 10.1080/2162402X.2021.2009666
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: IL-7 in SARS-CoV-2 Infection and as a Potential Vaccine Adjuvant.

    Bekele, Yonas / Sui, Yongjun / Berzofsky, Jay A

    Frontiers in immunology

    2021  Volume 12, Page(s) 737406

    Abstract: IL-7/IL-7R signaling is critical for development, maturation, maintenance and survival of many lymphocytes in the thymus and periphery. IL-7 has been used as immunotherapy in pre-clinical and clinical studies to treat cancer, HIV infection and sepsis. ... ...

    Abstract IL-7/IL-7R signaling is critical for development, maturation, maintenance and survival of many lymphocytes in the thymus and periphery. IL-7 has been used as immunotherapy in pre-clinical and clinical studies to treat cancer, HIV infection and sepsis. Here, we discuss the critical function of IL-7 in diagnosis, prognosis and treatment of COVID-19 patients. We also summarize a promising role of IL-7 as a vaccine adjuvant. It could potentially enhance the immune responses to vaccines especially against SARS-CoV-2 or other new vaccines.
    MeSH term(s) Adjuvants, Immunologic ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19 Vaccines/immunology ; Humans ; Immunogenicity, Vaccine/immunology ; Interleukin-7/immunology ; Interleukin-7/metabolism ; Receptors, Interleukin-7/metabolism ; SARS-CoV-2/immunology
    Chemical Substances Adjuvants, Immunologic ; COVID-19 Vaccines ; IL7 protein, human ; Interleukin-7 ; Receptors, Interleukin-7
    Language English
    Publishing date 2021-09-17
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.737406
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Undetectable Anti-HBs Antibodies: Need of a Booster Dose for HIV-1-Infected Individuals.

    Bekele, Yonas / Berzofsky, Jay A / Chiodi, Francesca

    Vaccines

    2021  Volume 9, Issue 12

    Abstract: HBV vaccination effectively prevents HBV transmission and the development of liver cancer. Disease progression and liver-related complications are more common in HIV-1/HBV co-infected than HBV mono-infected individuals. A considerable body of literature, ...

    Abstract HBV vaccination effectively prevents HBV transmission and the development of liver cancer. Disease progression and liver-related complications are more common in HIV-1/HBV co-infected than HBV mono-infected individuals. A considerable body of literature, which will be reviewed here, indicates that response to HBV vaccine is suboptimal in HIV-1-infected individuals and that the poor maintenance of protective immunity to HBV vaccines in these individuals is an important medical issue. Several factors affect HBV vaccine response during HIV-1 infection including CD4+ T cell counts, B cell response, vaccine formulation, schedules, and timing of antiretroviral therapy (ART). The initial response to HBV vaccination also plays a critical role in the sustainability of antibody responses in both HIV-1-infected and uninfected vaccinees. Thus, regular follow-up for antibody titer and a booster dose is warranted to prevent HBV transmission in HIV-1 infected people.
    Language English
    Publishing date 2021-12-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines9121484
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Strategies for developing and optimizing cancer vaccines.

    Maeng, Hoyoung M / Berzofsky, Jay A

    F1000Research

    2019  Volume 8

    Abstract: With the spotlight on cancer immunotherapy and the expanding use of immune checkpoint inhibitors, strategies to improve the response rate and duration of current cancer immunotherapeutics are highly sought. In that sense, investigators around the globe ... ...

    Abstract With the spotlight on cancer immunotherapy and the expanding use of immune checkpoint inhibitors, strategies to improve the response rate and duration of current cancer immunotherapeutics are highly sought. In that sense, investigators around the globe have been putting spurs on the development of effective cancer vaccines in humans after decades of efforts that led to limited clinical success. In more than three decades of research in pursuit of targeted and personalized immunotherapy, several platforms have been incorporated into the list of cancer vaccines from live viral or bacterial agents harboring antigens to synthetic peptides with the hope of stronger and durable immune responses that will tackle cancers better. Unlike adoptive cell therapy, cancer vaccines can take advantage of using a patient's entire immune system that can include more than engineered receptors or ligands in developing antigen-specific responses. Advances in molecular technology also secured the use of genetically modified genes or proteins of interest to enhance the chance of stronger immune responses. The formulation of vaccines to increase chances of immune recognition such as nanoparticles for peptide delivery is another area of great interest. Studies indicate that cancer vaccines alone may elicit tumor-specific cellular or humoral responses in immunologic assays and even regression or shrinkage of the cancer in select trials, but novel strategies, especially in combination with other cancer therapies, are under study and are likely to be critical to achieve and optimize reliable objective responses and survival benefit. In this review, cancer vaccine platforms with different approaches to deliver tumor antigens and boost immunity are discussed with the intention of summarizing what we know and what we need to improve in the clinical trial setting.
    MeSH term(s) Antigens, Neoplasm ; Cancer Vaccines ; Drug Development ; Humans ; Immune System ; Immunotherapy ; Neoplasms/therapy
    Chemical Substances Antigens, Neoplasm ; Cancer Vaccines
    Language English
    Publishing date 2019-05-13
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2699932-8
    ISSN 2046-1402 ; 2046-1402
    ISSN (online) 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.18693.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: BepiTBR: T-B reciprocity enhances B cell epitope prediction.

    Zhu, James / Gouru, Anagha / Wu, Fangjiang / Berzofsky, Jay A / Xie, Yang / Wang, Tao

    iScience

    2022  Volume 25, Issue 2, Page(s) 103764

    Abstract: The ability to predict B cell epitopes is critical for biomedical research and many clinical applications. Investigators have observed the phenomenon of T-B reciprocity, in which candidate B cell epitopes with nearby ... ...

    Abstract The ability to predict B cell epitopes is critical for biomedical research and many clinical applications. Investigators have observed the phenomenon of T-B reciprocity, in which candidate B cell epitopes with nearby CD4
    Language English
    Publishing date 2022-01-12
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2022.103764
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  9. Article ; Online: Potential SARS-CoV-2 Immune Correlates of Protection in Infection and Vaccine Immunization

    Yongjun Sui / Yonas Bekele / Jay A. Berzofsky

    Pathogens, Vol 10, Iss 2, p

    2021  Volume 138

    Abstract: Both SARS-CoV-2 infections and vaccines induce robust immune responses. Current data suggested that high neutralizing antibody titers with sustained Th1 responses might correlate with protection against viral transmission and disease development and ... ...

    Abstract Both SARS-CoV-2 infections and vaccines induce robust immune responses. Current data suggested that high neutralizing antibody titers with sustained Th1 responses might correlate with protection against viral transmission and disease development and severity. In addition, genetic and innate immune factors, including higher levels of type I interferons, as well as the induction of trained immunity and local mucosal immunity also contribute to lower risk of infection and amelioration of disease severity. The identification of immune correlates of protection will facilitate the development of effective vaccines and therapeutics strategies.
    Keywords SARS-CoV-2 ; neutralizing antibody ; Th1 responses ; T-cell immunity ; innate immunity ; type I interferon ; Medicine ; R
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Undetectable Anti-HBs Antibodies

    Yonas Bekele / Jay A. Berzofsky / Francesca Chiodi

    Vaccines, Vol 9, Iss 1484, p

    Need of a Booster Dose for HIV-1-Infected Individuals

    2021  Volume 1484

    Abstract: HBV vaccination effectively prevents HBV transmission and the development of liver cancer. Disease progression and liver-related complications are more common in HIV-1/HBV co-infected than HBV mono-infected individuals. A considerable body of literature, ...

    Abstract HBV vaccination effectively prevents HBV transmission and the development of liver cancer. Disease progression and liver-related complications are more common in HIV-1/HBV co-infected than HBV mono-infected individuals. A considerable body of literature, which will be reviewed here, indicates that response to HBV vaccine is suboptimal in HIV-1-infected individuals and that the poor maintenance of protective immunity to HBV vaccines in these individuals is an important medical issue. Several factors affect HBV vaccine response during HIV-1 infection including CD4+ T cell counts, B cell response, vaccine formulation, schedules, and timing of antiretroviral therapy (ART). The initial response to HBV vaccination also plays a critical role in the sustainability of antibody responses in both HIV-1-infected and uninfected vaccinees. Thus, regular follow-up for antibody titer and a booster dose is warranted to prevent HBV transmission in HIV-1 infected people.
    Keywords HBV ; HBV vaccine ; anti-HBs antibodies ; HIV-1 ; booster dose ; B cells ; Medicine ; R
    Subject code 570
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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