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  1. Book ; Online: A framework for model-assisted T x E x M exploration in maize

    Hsiao, Jennifer / Kim, Soo-Hyung / Timlin, Dennis J. / Mueller, Nathaniel D. / Swann, Abigail L. S.

    2022  

    Abstract: Breeding for new crop characteristics and adjusting management practices are critical avenues to mitigate yield loss and maintain yield stability under a changing climate. However, identifying high-performing plant traits and management options for ... ...

    Abstract Breeding for new crop characteristics and adjusting management practices are critical avenues to mitigate yield loss and maintain yield stability under a changing climate. However, identifying high-performing plant traits and management options for different growing regions through traditional breeding practices and agronomic field trials is often time and resource-intensive. Mechanistic crop simulation models can serve as powerful tools to help synthesize cropping information, set breeding targets, and develop adaptation strategies to sustain food production. In this study, we develop a modeling framework for a mechanistic crop model (MAIZSIM) to run many simulations within a trait x environment x management landscape and demonstrate how such a modeling framework could be used to identify ideal trait-management combinations that maximize yield and yield stability for different agro-climate regions in the US.
    Keywords Quantitative Biology - Populations and Evolution
    Publishing date 2022-06-06
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: TRAP1 controls cell cycle G2-M transition through the regulation of CDK1 and MAD2 expression/ubiquitination.

    Sisinni, Lorenza / Maddalena, Francesca / Condelli, Valentina / Pannone, Giuseppe / Simeon, Vittorio / Li Bergolis, Valeria / Lopes, Elvira / Piscazzi, Annamaria / Matassa, Danilo Swann / Mazzoccoli, Carmela / Nozza, Filomena / Lettini, Giacomo / Amoroso, Maria Rosaria / Bufo, Pantaleo / Esposito, Franca / Landriscina, Matteo

    The Journal of pathology

    2017  Volume 243, Issue 1, Page(s) 123–134

    Abstract: ... in TRAP1 regulation of the G2-M transition. Indeed, TRAP1 silencing results in enhanced CDK1 ubiquitination ... forced up-regulation partially rescues low cyclin B1 and MAD2 levels and G2-M transit in a TRAP1-poor ...

    Abstract Regulation of tumour cell proliferation by molecular chaperones is still a complex issue. Here, the role of the HSP90 molecular chaperone TRAP1 in cell cycle regulation was investigated in a wide range of human breast, colorectal, and lung carcinoma cell lines, and tumour specimens. TRAP1 modulates the expression and/or the ubiquitination of key cell cycle regulators through a dual mechanism: (i) transcriptional regulation of CDK1, CYCLIN B1, and MAD2, as suggested by gene expression profiling of TRAP1-silenced breast carcinoma cells; and (ii) post-transcriptional quality control of CDK1 and MAD2, being the ubiquitination of these two proteins enhanced upon TRAP1 down-regulation. Mechanistically, TRAP1 quality control on CDK1 is crucial for its regulation of mitotic entry, since TRAP1 interacts with CDK1 and prevents CDK1 ubiquitination in cooperation with the proteasome regulatory particle TBP7, this representing the limiting factor in TRAP1 regulation of the G2-M transition. Indeed, TRAP1 silencing results in enhanced CDK1 ubiquitination, lack of nuclear translocation of CDK1/cyclin B1 complex, and increased MAD2 degradation, whereas CDK1 forced up-regulation partially rescues low cyclin B1 and MAD2 levels and G2-M transit in a TRAP1-poor background. Consistently, the CDK1 inhibitor RO-3306 is less active in a TRAP1-high background. Finally, a significant correlation was observed between TRAP1 and Ki67, CDK1 and/or MAD2 expression in breast, colorectal, and lung human tumour specimens. This study represents the first evidence that TRAP1 is relevant in the control of the complex machinery that governs cell cycle progression and mitotic entry and provides a strong rationale to regard TRAP1 as a biomarker to select tumours with deregulated cell cycle progression and thus likely poorly responsive to novel cell cycle inhibitors. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
    MeSH term(s) ATPases Associated with Diverse Cellular Activities ; Adult ; Aged ; Aged, 80 and over ; CDC2 Protein Kinase ; Cell Line, Tumor ; Cell Proliferation ; Cyclin B1/metabolism ; Cyclin-Dependent Kinases/genetics ; Cyclin-Dependent Kinases/metabolism ; Female ; G2 Phase Cell Cycle Checkpoints ; Gene Expression Regulation, Neoplastic ; HSP90 Heat-Shock Proteins/genetics ; HSP90 Heat-Shock Proteins/metabolism ; Humans ; Ki-67 Antigen/metabolism ; Mad2 Proteins/genetics ; Mad2 Proteins/metabolism ; Male ; Middle Aged ; Neoplasms/enzymology ; Neoplasms/genetics ; Neoplasms/pathology ; Proteasome Endopeptidase Complex/metabolism ; RNA Interference ; Signal Transduction ; Time Factors ; Transcription, Genetic ; Transfection ; Ubiquitination
    Chemical Substances CCNB1 protein, human ; Cyclin B1 ; HSP90 Heat-Shock Proteins ; Ki-67 Antigen ; MAD2L1 protein, human ; Mad2 Proteins ; TRAP1 protein, human ; CDC2 Protein Kinase (EC 2.7.11.22) ; CDK1 protein, human (EC 2.7.11.22) ; Cyclin-Dependent Kinases (EC 2.7.11.22) ; PSMC4 protein, human (EC 3.4.25.1) ; Proteasome Endopeptidase Complex (EC 3.4.25.1) ; ATPases Associated with Diverse Cellular Activities (EC 3.6.4.-)
    Language English
    Publishing date 2017-08-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3119-7
    ISSN 1096-9896 ; 0022-3417
    ISSN (online) 1096-9896
    ISSN 0022-3417
    DOI 10.1002/path.4936
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    Ud II Zs.12: Show issues Location:
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  3. Article ; Online: Fertilization differently affects the levels of cyclin B1 and M-phase promoting factor activity in maturing and metaphase II mouse oocytes.

    Ajduk, Anna / Ciemerych, Maria A / Nixon, Victoria / Swann, Karl / Maleszewski, Marek

    Reproduction (Cambridge, England)

    2008  Volume 136, Issue 6, Page(s) 741–752

    Abstract: Fertilization affects levels of cyclin B1 and M-phase promoting factor (MPF) activity in maturing ...

    Abstract Fertilization affects levels of cyclin B1 and M-phase promoting factor (MPF) activity in maturing and metaphase II mouse oocytes in two distinct ways. In metaphase II oocytes, it leads to a Ca(2)(+)-dependent, continuous degradation of cyclin B1 and inactivation of cyclin dependent kinase (CDC2A)-cyclin B1 complex (MPF). In this paper, we show that neither mono- nor polyspermic fertilization of prometaphase I and metaphase I oocytes triggered degradation of cyclin B1. However, polyspermic fertilization of prometaphase I oocytes led to a transient decrease in MPF activity that lasted for 2 h. The inactivation of MPF in polyspermic prometaphase I oocytes did not depend on the fertilization-induced increase in the cytoplasmic concentration of free Ca(2)(+) ions, but was caused, at least in part, by dephosphorylation of CDC2A at threonine 161 (Thr161). We found that polyspermic fertilization did not affect glutathione levels in prometaphase I oocytes, and concluded that the decrease in MPF activity and dephosphorylation of CDC2A at Thr161 in polyspermic prometaphase I oocytes were not caused by a change in the redox status of the cell induced by an introduction of excessive amount of sperm protamines. Instead, we propose that inactivation of MPF activity in polyspermic maturing oocytes is caused by a change in nucleo-cytoplasmic ratio that leads to a 'titration' of kinases and phosphatases responsible for keeping MPF in an active state. This idea is supported by the finding that oocytes fused with thymocytes rather than spermatozoa also showed a transient decrease in MPF activity.
    MeSH term(s) Animals ; CDC2 Protein Kinase/analysis ; CDC2 Protein Kinase/metabolism ; Calcium/metabolism ; Cells, Cultured ; Cyclin B/analysis ; Cyclin B/genetics ; Cyclin B/metabolism ; Cyclin B1 ; Cycloheximide/pharmacology ; Female ; Fertilization/physiology ; Fertilization in Vitro/methods ; Gene Expression ; Glutathione/analysis ; Glutathione/metabolism ; Luciferases/genetics ; Maturation-Promoting Factor/analysis ; Maturation-Promoting Factor/metabolism ; Metaphase/drug effects ; Mice ; Mice, Inbred C57BL ; Mice, Inbred CBA ; Oocytes/metabolism ; Oogenesis/physiology ; Protein Kinases/analysis ; Protein Kinases/metabolism ; Protein Synthesis Inhibitors/pharmacology
    Chemical Substances Ccnb1 protein, mouse ; Cyclin B ; Cyclin B1 ; Protein Synthesis Inhibitors ; Cycloheximide (98600C0908) ; Luciferases (EC 1.13.12.-) ; Protein Kinases (EC 2.7.-) ; histone H1 kinase (EC 2.7.1.-) ; CDC2 Protein Kinase (EC 2.7.11.22) ; Maturation-Promoting Factor (EC 2.7.11.22) ; Glutathione (GAN16C9B8O) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2008-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2034501-X
    ISSN 1741-7899 ; 1470-1626 ; 1476-3990
    ISSN (online) 1741-7899
    ISSN 1470-1626 ; 1476-3990
    DOI 10.1530/REP-08-0271
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.362: Show issues Location:
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  4. Article: M. & B. 1863, a homologue of hexamethonium, in treatment of hypertension.

    LOCKET, S / SWANN, P G / GRIEVE, W S / PLAYER, H P

    British medical journal

    2003  Volume 1, Issue 4752, Page(s) 254–258

    MeSH term(s) Cardiovascular Agents ; Hexamethonium ; Hypertension/therapy ; Muscle Relaxants, Central/therapeutic use
    Chemical Substances Cardiovascular Agents ; Muscle Relaxants, Central ; Hexamethonium (3C9PSP36Z2)
    Language English
    Publishing date 2003-12-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 80088-0
    ISSN 0007-1447 ; 0267-0623 ; 0959-8138 ; 0959-8146
    ISSN 0007-1447 ; 0267-0623 ; 0959-8138 ; 0959-8146
    DOI 10.1136/bmj.1.4752.254
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    Ua VI Zs.10: Show issues Location:
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  5. Article ; Online: Academic bullying and diversity: challenges and solutions.

    Swann, Jennifer M

    FEBS letters

    2022  Volume 596, Issue 22, Page(s) 2855–2858

    Abstract: The academy remains disproportionally white despite decades of efforts to diversify the professoriate. Recruitment of faculty from underrepresented populations continues to challenge and little attention has been placed on retention. Bullying threatens ... ...

    Abstract The academy remains disproportionally white despite decades of efforts to diversify the professoriate. Recruitment of faculty from underrepresented populations continues to challenge and little attention has been placed on retention. Bullying threatens all workplaces and is particularly insidious in higher education where the practice of tenure grants bad actors immunity from many corrective measures. Strategies and approaches summarized here have been proposed and should be adopted to provide a better workplace for all.
    MeSH term(s) Bullying
    Language English
    Publishing date 2022-10-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 212746-5
    ISSN 1873-3468 ; 0014-5793
    ISSN (online) 1873-3468
    ISSN 0014-5793
    DOI 10.1002/1873-3468.14504
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    Zs.B 282: Show issues Location:
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  6. Article: [Rezension von: Swann, G. M. P., Quality innovation]

    Stoneman, Paul / Swann, G. M. P

    The economic journal : the journal of the Royal Economic Society 384 = Vol. 96 ,December, S. 1120-1122

    1986  Volume 96

    Author's details Paul Stoneman
    Keywords 40;49
    Language English
    Publisher Wiley-Blackwell
    Publishing place Oxford [u.a.]
    Document type Article
    ZDB-ID 3025-9 ; 1473822-3
    ISSN 1468-0297 ; 0013-0133
    ISSN (online) 1468-0297
    ISSN 0013-0133
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  7. Article: Fertilization differently affects the levels of cyclin B1 and M-phase promoting factor activity in maturing and metaphase II mouse oocytes

    Ajduk, Anna / Ciemerych, Maria A / Nixon, Victoria / Swann, Karl / Maleszewski, Marek

    Reproduction. 2008 Dec., v. 136, no. 6

    2008  

    Abstract: Fertilization affects levels of cyclin B1 and M-phase promoting factor (MPF) activity in maturing ...

    Abstract Fertilization affects levels of cyclin B1 and M-phase promoting factor (MPF) activity in maturing and metaphase II mouse oocytes in two distinct ways. In metaphase II oocytes, it leads to a Ca²⁺-dependent, continuous degradation of cyclin B1 and inactivation of cyclin dependent kinase (CDC2A)-cyclin B1 complex (MPF). In this paper, we show that neither mono- nor polyspermic fertilization of prometaphase I and metaphase I oocytes triggered degradation of cyclin B1. However, polyspermic fertilization of prometaphase I oocytes led to a transient decrease in MPF activity that lasted for 2 h. The inactivation of MPF in polyspermic prometaphase I oocytes did not depend on the fertilization-induced increase in the cytoplasmic concentration of free Ca²⁺ ions, but was caused, at least in part, by dephosphorylation of CDC2A at threonine 161 (Thr161). We found that polyspermic fertilization did not affect glutathione levels in prometaphase I oocytes, and concluded that the decrease in MPF activity and dephosphorylation of CDC2A at Thr161 in polyspermic prometaphase I oocytes were not caused by a change in the redox status of the cell induced by an introduction of excessive amount of sperm protamines. Instead, we propose that inactivation of MPF activity in polyspermic maturing oocytes is caused by a change in nucleo-cytoplasmic ratio that leads to a 'titration' of kinases and phosphatases responsible for keeping MPF in an active state. This idea is supported by the finding that oocytes fused with thymocytes rather than spermatozoa also showed a transient decrease in MPF activity.
    Keywords calcium ; dephosphorylation ; glutathione ; ions ; kinases ; metaphase ; mice ; oocytes ; protamines ; spermatozoa ; threonine ; thymocytes ; titration
    Language English
    Size p. 741-752.
    Publishing place BioScientifica Ltd
    Document type Article
    ZDB-ID 2034501-X
    ISSN 1741-7899 ; 1470-1626 ; 1476-3990
    ISSN (online) 1741-7899
    ISSN 1470-1626 ; 1476-3990
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    In stock of ZB MED Bonn / Germany

    Z 2067: Show issues

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  8. Article ; Online: Recognising the importance of language in effective pain assessment.

    Swann, Meriel

    Nursing standard (Royal College of Nursing (Great Britain) : 1987)

    2021  Volume 36, Issue 2, Page(s) 43–50

    Abstract: Pain is a highly personal experience that can be challenging to define. In addition, evidence has indicated that the assessment of pain by healthcare professionals is often suboptimal and its severity often underestimated. In clinical practice, the use ... ...

    Abstract Pain is a highly personal experience that can be challenging to define. In addition, evidence has indicated that the assessment of pain by healthcare professionals is often suboptimal and its severity often underestimated. In clinical practice, the use of language can be a significant influencing factor in the effective management of pain, with terms such as pain, discomfort and comfort used interchangeably. This article explores how language can both act as a barrier to, and assist, nurses to understand the patient's pain experience.
    MeSH term(s) Humans ; Language ; Pain/diagnosis ; Pain Management ; Pain Measurement
    Language English
    Publishing date 2021-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 645016-7
    ISSN 2047-9018 ; 0029-6570
    ISSN (online) 2047-9018
    ISSN 0029-6570
    DOI 10.7748/ns.2021.e11563
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    Zs.A 2410: Show issues Location:
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    Zs.MO 273: Show issues

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  9. Article ; Online: Academic bullying and diversity: challenges and solutions

    Swann, Jennifer M.

    FEBS Letters. 2022 Nov., v. 596, no. 22 p.2855-2858

    2022  

    Abstract: The academy remains disproportionally white despite decades of efforts to diversify the professoriate. Recruitment of faculty from underrepresented populations continues to challenge and little attention has been placed on retention. Bullying threatens ... ...

    Abstract The academy remains disproportionally white despite decades of efforts to diversify the professoriate. Recruitment of faculty from underrepresented populations continues to challenge and little attention has been placed on retention. Bullying threatens all workplaces and is particularly insidious in higher education where the practice of tenure grants bad actors immunity from many corrective measures. Strategies and approaches summarized here have been proposed and should be adopted to provide a better workplace for all.
    Keywords education ; immunity ; working conditions
    Language English
    Dates of publication 2022-11
    Size p. 2855-2858.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note EDITORIAL
    ZDB-ID 212746-5
    ISSN 1873-3468 ; 0014-5793
    ISSN (online) 1873-3468
    ISSN 0014-5793
    DOI 10.1002/1873-3468.14504
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  10. Article: Editorial Extracts and Gleanings.

    Burnett, Swann M

    The Southern medical record

    2022  Volume 4, Issue 2, Page(s) 96–99

    Language English
    Publishing date 2022-08-26
    Publishing country United States
    Document type Journal Article
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