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  1. Article: Urine Biomarkers in the Management of Adult Neurogenic Lower Urinary Tract Dysfunction: A Systematic Review.

    Koukourikis, Periklis / Papaioannou, Maria / Papanikolaou, Dimitrios / Apostolidis, Apostolos

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 3

    Abstract: Background: Neurogenic lower urinary tract dysfunction requires lifelong surveillance and management for the perseveration of patients' quality of life and the prevention of significant morbidity and mortality. Urine biomarkers are an attractive ... ...

    Abstract Background: Neurogenic lower urinary tract dysfunction requires lifelong surveillance and management for the perseveration of patients' quality of life and the prevention of significant morbidity and mortality. Urine biomarkers are an attractive noninvasive method of surveillance for these patients. The aim of this systematic review is to search for and critically appraise studies that investigate the clinical usefulness of urine biomarkers in the management of neurogenic lower urinary tract dysfunction (NLUTD) in adults.
    Methods: This review was conducted according to PRISMA and MOOSE guidelines. Search strategy included PubMed, CENTRAL, and Scopus (until October 2022). Studies investigating potential urine biomarkers for the management of adults with NLUTD were included.
    Results: Fifteen studies fulfilled the criteria. To date, a variety of different urine molecules have been investigated for the diagnosis and management of neurogenic overactive bladder and detrusor overactivity (nerve growth factor, brain-derived neurotrophic factor, prostaglandin E2, prostaglandin F2α, transformation growth factor β-1, tissue inhibitor metalloproteinase-2, matrix metalloproteinase-2, substance P, microRNA), diagnosis of vesicoureteral reflux (exosomal vitronectin), urinary tract infection (neutrophil gelatinase-associated lipocalin, interleukin 6) and bladder cancer screening (cytology, BTA stat, survivin) in neurological patients.
    Conclusion: Further studies are needed to specify the utility of each molecule in the management algorithm of adult NLUTD.
    Language English
    Publishing date 2023-01-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13030468
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Bioactive and biomimetic 3D scaffolds for bone tissue engineering using graphitic carbon nitride as a sustainable visible light photoinitiator.

    Papaioannou, Anna / Vasilaki, Evangelia / Loukelis, Konstantinos / Papadogianni, Danai / Chatzinikolaidou, Maria / Vamvakaki, Maria

    Biomaterials advances

    2023  Volume 157, Page(s) 213737

    Abstract: Graphitic carbon nitride (g- ... ...

    Abstract Graphitic carbon nitride (g-C
    MeSH term(s) Tissue Engineering ; Biomimetics ; Light ; Hydrogels ; Acrylamides ; Graphite ; Pyrenes ; Nitrogen Compounds
    Chemical Substances methacrylamide (K67NG89J77) ; graphitic carbon nitride ; N-hydroxy-2-aminopyrene (85964-28-9) ; Hydrogels ; Acrylamides ; Graphite (7782-42-5) ; Pyrenes ; Nitrogen Compounds
    Language English
    Publishing date 2023-12-27
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2772-9508
    ISSN (online) 2772-9508
    DOI 10.1016/j.bioadv.2023.213737
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Overcoming phenotypic switching: targeting protein-protein interactions in cancer.

    Ladias, Christos / Papakotoulas, Pavlos / Papaioannou, Maria / Papanikolaou, Nikolaos A

    Exploration of targeted anti-tumor therapy

    2023  Volume 4, Issue 5, Page(s) 1071–1081

    Abstract: Alternative protein-protein interactions (PPIs) arising from mutations or post-translational modifications (PTMs), termed phenotypic switching (PS), are critical for the transmission of alternative pathogenic signals and are particularly significant in ... ...

    Abstract Alternative protein-protein interactions (PPIs) arising from mutations or post-translational modifications (PTMs), termed phenotypic switching (PS), are critical for the transmission of alternative pathogenic signals and are particularly significant in cancer. In recent years, PPIs have emerged as promising targets for rational drug design, primarily because their high specificity facilitates targeting of disease-related signaling pathways. However, obstacles exist at the molecular level that arise from the properties of the interaction interfaces and the propensity of small molecule drugs to interact with more than one cleft surface. The difficulty in identifying small molecules that act as activators or inhibitors to counteract the biological effects of mutations raises issues that have not been encountered before. For example, small molecules can bind tightly but may not act as drugs or bind to multiple sites (interaction promiscuity). Another reason is the absence of significant clefts on protein surfaces; if a pocket is present, it may be too small, or its geometry may prevent binding. PS, which arises from oncogenic (alternative) signaling, causes drug resistance and forms the basis for the systemic robustness of tumors. In this review, the properties of PPI interfaces relevant to the design and development of targeting drugs are examined. In addition, the interactions between three tyrosine kinase inhibitors (TKIs) employed as drugs are discussed. Finally, potential novel targets of one of these drugs were identified
    Language English
    Publishing date 2023-10-30
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2692-3114
    ISSN (online) 2692-3114
    DOI 10.37349/etat.2023.00181
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: A Study of DNA Methylation of Bladder Cancer Biomarkers in the Urine of Patients with Neurogenic Lower Urinary Tract Dysfunction.

    Koukourikis, Periklis / Papaioannou, Maria / Georgopoulos, Petros / Apostolidis, Ioannis / Pervana, Stavroula / Apostolidis, Apostolos

    Biology

    2023  Volume 12, Issue 8

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-08-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12081126
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Urine Biomarkers in the Management of Adult Neurogenic Lower Urinary Tract Dysfunction

    Periklis Koukourikis / Maria Papaioannou / Dimitrios Papanikolaou / Apostolos Apostolidis

    Diagnostics, Vol 13, Iss 468, p

    A Systematic Review

    2023  Volume 468

    Abstract: Background: Neurogenic lower urinary tract dysfunction requires lifelong surveillance and management for the perseveration of patients’ quality of life and the prevention of significant morbidity and mortality. Urine biomarkers are an attractive ... ...

    Abstract Background: Neurogenic lower urinary tract dysfunction requires lifelong surveillance and management for the perseveration of patients’ quality of life and the prevention of significant morbidity and mortality. Urine biomarkers are an attractive noninvasive method of surveillance for these patients. The aim of this systematic review is to search for and critically appraise studies that investigate the clinical usefulness of urine biomarkers in the management of neurogenic lower urinary tract dysfunction (NLUTD) in adults. Methods: This review was conducted according to PRISMA and MOOSE guidelines. Search strategy included PubMed, CENTRAL, and Scopus (until October 2022). Studies investigating potential urine biomarkers for the management of adults with NLUTD were included. Results: Fifteen studies fulfilled the criteria. To date, a variety of different urine molecules have been investigated for the diagnosis and management of neurogenic overactive bladder and detrusor overactivity (nerve growth factor, brain-derived neurotrophic factor, prostaglandin E2, prostaglandin F2α, transformation growth factor β-1, tissue inhibitor metalloproteinase-2, matrix metalloproteinase-2, substance P, microRNA), diagnosis of vesicoureteral reflux (exosomal vitronectin), urinary tract infection (neutrophil gelatinase-associated lipocalin, interleukin 6) and bladder cancer screening (cytology, BTA stat, survivin) in neurological patients. Conclusion: Further studies are needed to specify the utility of each molecule in the management algorithm of adult NLUTD.
    Keywords neurogenic lower urinary tract dysfunction ; neurogenic bladder ; urine biomarkers ; Medicine (General) ; R5-920
    Subject code 306
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: A Survey on Quantitative Risk Estimation Approaches for Secure and Usable User Authentication on Smartphones.

    Papaioannou, Maria / Pelekoudas-Oikonomou, Filippos / Mantas, Georgios / Serrelis, Emmanouil / Rodriguez, Jonathan / Fengou, Maria-Anna

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 6

    Abstract: Mobile user authentication acts as the first line of defense, establishing confidence in the claimed identity of a mobile user, which it typically does as a precondition to allowing access to resources in a mobile device. NIST states that password ... ...

    Abstract Mobile user authentication acts as the first line of defense, establishing confidence in the claimed identity of a mobile user, which it typically does as a precondition to allowing access to resources in a mobile device. NIST states that password schemes and/or biometrics comprise the most conventional user authentication mechanisms for mobile devices. Nevertheless, recent studies point out that nowadays password-based user authentication is imposing several limitations in terms of security and usability; thus, it is no longer considered secure and convenient for the mobile users. These limitations stress the need for the development and implementation of more secure and usable user authentication methods. Alternatively, biometric-based user authentication has gained attention as a promising solution for enhancing mobile security without sacrificing usability. This category encompasses methods that utilize human physical traits (physiological biometrics) or unconscious behaviors (behavioral biometrics). In particular, risk-based continuous user authentication, relying on behavioral biometrics, appears to have the potential to increase the reliability of authentication without sacrificing usability. In this context, we firstly present fundamentals on risk-based continuous user authentication, relying on behavioral biometrics on mobile devices. Additionally, we present an extensive overview of existing quantitative risk estimation approaches (QREA) found in the literature. We do so not only for risk-based user authentication on mobile devices, but also for other security applications such as user authentication in web/cloud services, intrusion detection systems, etc., that could be possibly adopted in risk-based continuous user authentication solutions for smartphones. The target of this study is to provide a foundation for organizing research efforts toward the design and development of proper quantitative risk estimation approaches for the development of risk-based continuous user authentication solutions for smartphones. The reviewed quantitative risk estimation approaches have been divided into the following five main categories: (i) probabilistic approaches, (ii) machine learning-based approaches, (iii) fuzzy logic models, (iv) non-graph-based models, and (v) Monte Carlo simulation models. Our main findings are summarized in the table in the end of the manuscript.
    MeSH term(s) Humans ; Smartphone ; Reproducibility of Results ; Computer Security ; Biometric Identification/methods ; Biometry ; Confidentiality ; Telemedicine
    Language English
    Publishing date 2023-03-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23062979
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Vitamin D and Acute Kidney Injury: A Two-Way Causality Relation and a Predictive, Prognostic, and Therapeutic Role of Vitamin D.

    Graidis, Spyridon / Papavramidis, Theodosios S / Papaioannou, Maria

    Frontiers in nutrition

    2021  Volume 7, Page(s) 630951

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-03-04
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2020.630951
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  8. Book ; Online: Self-Attention Based Generative Adversarial Networks For Unsupervised Video Summarization

    Minaidi, Maria Nektaria / Papaioannou, Charilaos / Potamianos, Alexandros

    2023  

    Abstract: In this paper, we study the problem of producing a comprehensive video summary following an unsupervised approach that relies on adversarial learning. We build on a popular method where a Generative Adversarial Network (GAN) is trained to create ... ...

    Abstract In this paper, we study the problem of producing a comprehensive video summary following an unsupervised approach that relies on adversarial learning. We build on a popular method where a Generative Adversarial Network (GAN) is trained to create representative summaries, indistinguishable from the originals. The introduction of the attention mechanism into the architecture for the selection, encoding and decoding of video frames, shows the efficacy of self-attention and transformer in modeling temporal relationships for video summarization. We propose the SUM-GAN-AED model that uses a self-attention mechanism for frame selection, combined with LSTMs for encoding and decoding. We evaluate the performance of the SUM-GAN-AED model on the SumMe, TVSum and COGNIMUSE datasets. Experimental results indicate that using a self-attention mechanism as the frame selection mechanism outperforms the state-of-the-art on SumMe and leads to comparable to state-of-the-art performance on TVSum and COGNIMUSE.
    Keywords Computer Science - Computer Vision and Pattern Recognition
    Publishing date 2023-07-16
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Multiple Myeloma With Amplification of Chr1q: Therapeutic Opportunity and Challenges.

    Sklavenitis-Pistofidis, Romanos / Getz, Gad / Ghobrial, Irene / Papaioannou, Maria

    Frontiers in oncology

    2022  Volume 12, Page(s) 961421

    Abstract: Multiple myeloma (MM) is an incurable plasma cell malignancy with a heterogeneous genetic background. Each MM subtype may have its own therapeutic vulnerabilities, and tailored therapy could improve outcomes. However, the cumulative frequency of ... ...

    Abstract Multiple myeloma (MM) is an incurable plasma cell malignancy with a heterogeneous genetic background. Each MM subtype may have its own therapeutic vulnerabilities, and tailored therapy could improve outcomes. However, the cumulative frequency of druggable targets across patients is very low, which has precluded the widespread adoption of precision therapy for patients with MM. Amplification of the long arm of chromosome 1 (Amp1q) is one of the most frequent genetic alterations observed in patients with MM, and its presence predicts inferior outcomes in the era of proteasome inhibitors and immunomodulatory agents. Therefore, establishing precision medicine for MM patients with Amp1q stands to benefit a large portion of patients who are otherwise at higher risk of relapse. In this article, we review the prevalence and clinical significance of Amp1q in patients with MM, its pathogenesis and therapeutic vulnerabilities, and discuss the opportunities and challenges for Amp1q-targeted therapy.
    Language English
    Publishing date 2022-07-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.961421
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Perceval-S over time. Clinical outcomes after ten years of usage.

    Schizas, Nikolaos / Samiotis, Ilias / Nazou, Georgia / Iliopoulos, Dimitrios C / Anagnostopoulos, Ioannis / Kousta, Maria / Papaioannou, Nafsika / Argiriou, Mihalis / Dedeilias, Panagiotis

    Journal of cardiothoracic surgery

    2024  Volume 19, Issue 1, Page(s) 192

    Abstract: Background: Perceval-S has become a reliable and commonly used option in surgical aortic valve replacement (AVR) since its first implantation in humans 15 years ago. Despite the fact that this aortic valve has been proven efficient enough in the short ... ...

    Abstract Background: Perceval-S has become a reliable and commonly used option in surgical aortic valve replacement (AVR) since its first implantation in humans 15 years ago. Despite the fact that this aortic valve has been proven efficient enough in the short and mid-term period, there is still lack of evidence for the long-term outcomes.
    Materials and methods: This is an observational retrospective study in a high-volume cardiovascular center. Pertinent data were collected for all the patients in whom Perceval-S was implanted from 2013 to 2020.
    Results: The total number of patients was 205 with a mean age 76.4 years. Mean survival time was 5.5 years (SE = 0.26). The overall survival probability of patients undergoing aortic valve replacement with Perceval-S at 6 months was 91.0% (Standard Error SE = 2.0%), at one year 88.4% (SE = 2.3%) and at 5-years 64.8% (SE = 4.4%). A detrimental cardiac event leading to death was the probable cause of death in 35 patients (55.6%). The initiation of Transcatheter Aortic Valve Replacement (TAVR) program in our center in 2017 was associated with a decline in the number of very high-risk patients treated with sutureless bioprosthesis. This fact is demonstrated by the significant shift towards lower surgical risk cases, as median Euroscore II was reduced from 5,550 in 2016 to 3,390 in 2020. Mini sternotomy was implemented in 79,5% of cases favoring less invasive approach. Low incidence of reinterventions, patient prosthesis mismatch and structural valve degeneration was detected.
    Conclusions: The survival rate after aortic valve replacement with implantation of Perceval-S is satisfactory in the long-term follow-up. Cases of bioprosthesis dysfunction were limited. Mini sternotomy was used in the majority of cases. TAVR initiation program impacted on the proportion of patients treated with Perceval-S with reduction of high-risk patients submitted to surgery.
    MeSH term(s) Humans ; Aged ; Heart Valve Prosthesis Implantation/adverse effects ; Aortic Valve Stenosis/surgery ; Aortic Valve Stenosis/etiology ; Retrospective Studies ; Prosthesis Design ; Aortic Valve/surgery ; Heart Valve Prosthesis ; Bioprosthesis ; Treatment Outcome
    Language English
    Publishing date 2024-04-09
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2227224-0
    ISSN 1749-8090 ; 1749-8090
    ISSN (online) 1749-8090
    ISSN 1749-8090
    DOI 10.1186/s13019-024-02617-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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