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Article ; Online: The recent use of Swietenia mahagoni (L.) Jacq. as antidiabetes type 2 phytomedicine: A systematic review

Sukardiman / Ervina, Martha

Heliyon. 2020 Mar., v. 6, no. 3 p.e03536-

2020

Abstract: Natural resources provide more efficient and safer alternatives in managing diabetes compare to the synthetic oral anti diabetes (OAD). The plants not only have hypoglycemic effect, but also prevent its complications; in which no synthetic drugs provide ... ...

Abstract	Natural resources provide more efficient and safer alternatives in managing diabetes compare to the synthetic oral anti diabetes (OAD). The plants not only have hypoglycemic effect, but also prevent its complications; in which no synthetic drugs provide of both properties. Among antidiabetes plants, mahogany seed (Swietenia macrophylla) has been used as traditional medicine in Indonesia and India, though most popular utilized as timber wood. The present study was performed of chemotaxonomic approach to review its phytochemical and anti-diabetic properties of Swietenia mahagoni (L.) Jacq seed/bark/leaves. The qualitative systematic review (SR) was carried out by analysing indexed journals and peer reviewed of Swietenia and Swietenia spp from Scopus, PubMed, Medline, Google Scholar, and Research Gate. Data selection criteria are accordance to botany, phytochemistry, in vitro, in vivo, and clinical test of related subject. The keywords used for the search in the databases were Swietenia, Swietenia mahagony, diabetes, and diabetes plants. Swietenia mahagoni (L.) Jacq. extracts have shown in vitro, in vivo and limited clinically test of its anti-diabetic properties. Ethanolic/methanolic/aqueous/petroleum/n-hexane extracts of mahagonis's seed/bark or leaves have anti-diabetic activities comparable to the synthetic drug and observed no to relatively mild toxic effect. The hypoglycemic mechanism suggested via reducing blood glucose level, restoring liver and β-cells islet function (might) blocking epinephrine function, inhibiting of α-amylase and β-glucosidase, antioxidant and antihiperlipidemia. Phytochemical compounds of S. mahagoni consist of the phenolics (flavonoids (swietemacrophyllanin, catechins and epichatechins) and tannins), triterpenoids and tetranortriterpenoids (limonoids: mahonin, secomahoganin, swietmanins, swiemahogins, swietenine and swietenolide), saponins and alkaloids which are known as anti-diabetic bioactive principles. S. mahagoni was potentially used and developed as an antidiabetes source. To use it as an antidiabetic further, more extensive clinical trials and biomarkers of active compounds determination are needed.
Keywords	Swietenia macrophylla ; Swietenia mahagoni ; alpha-amylase ; antioxidants ; bark ; biomarkers ; blood glucose ; chemotaxonomy ; diabetes ; drugs ; epinephrine ; flavanols ; glycemic effect ; limonoids ; liver ; phenolic compounds ; saponins ; systematic review ; toxicity ; traditional medicine ; wood ; India ; Indonesia ; Toxicology ; Hypoglycemic ; Mahogany ; Meliaceae ; Swietenia sp
Language	English
Dates of publication	2020-03
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2020.e03536
Database	NAL-Catalogue (AGRICOLA)

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Article: The recent use of

Sukardiman / Ervina, Martha

Heliyon

2020 Volume 6, Issue 3, Page(s) e03536

Abstract: Background: Natural resources provide more efficient and safer alternatives in managing diabetes compare to the synthetic oral anti diabetes (OAD). The plants not only have hypoglycemic effect, but also prevent its complications; in which no synthetic ... ...

Abstract	Background: Natural resources provide more efficient and safer alternatives in managing diabetes compare to the synthetic oral anti diabetes (OAD). The plants not only have hypoglycemic effect, but also prevent its complications; in which no synthetic drugs provide of both properties. Among antidiabetes plants, mahogany seed ( Methods: The present study was performed of chemotaxonomic approach to review its phytochemical and anti-diabetic properties of Results: Swietenia mahagoni Conclusion: S. mahagoni
Language	English
Publishing date	2020-03-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2020.e03536
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Eksistensi Tradisi Mertuq pada Masyarakat Sasak di Desa Wakan Kecamatan Jerowaru Kabupaten Lombok Timur

Sukron Azhari / Sukardiman

Jurnal Sosiologi Agama Indonesia, Vol 2, Iss

2021 Volume 2

Abstract: This article examines the mertuq tradition among the Sasak people, who are faced with sophisticated modern medical tools in treating diseases. This study uses a quantitative descriptive model. Data were obtained from in-depth interviews with several key ... ...

Abstract	This article examines the mertuq tradition among the Sasak people, who are faced with sophisticated modern medical tools in treating diseases. This study uses a quantitative descriptive model. Data were obtained from in-depth interviews with several key informants selected using purposive techniques. The research was conducted in Wakan Village, Jerowaru District, East Lombok Regency. This study indicates that the existence of the mertuq treatment of the Sasak community cannot be separated from the belief and trust in carrying it out. The people of Wakan Village still maintain mertuq as traditional medicine in overcoming disease even though medical treatment has been so rapid. The people of Wakan Village believe in the magic and efficacy of Mertuq's therapy because it is part of their ancestral heritage.
Keywords	Metuq Tradition ; Traditional Medicine ; Sasak ; Social Sciences ; H
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	UIN Ar-raniry, Program Studi Sosiologi Agama
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Antiosteoarthritis activities of 70% ethanol extract of eleutherine bulbosa (mill.) urb. bulb on rats monosodium iodoacetate-induced osteoarthritis

Riza Ambar Sari / Fina Luthfiana / Irawati Sholihah / Katsuyoshi Matsunami / Sukardiman Sukardiman / Retno Widyowati

Journal of Public Health in Africa, Vol 14, Iss s

2023 Volume 1

Abstract: Background: Osteoarthritis (OA) is a common degenerative joint situation that induces pain and disability in the elderly. Traditionally, Eleutherine bulbosa bulb from Pasuruan, East Java, is used to treat many diseases, also as an anti-inflammatory. ... ...

Abstract	Background: Osteoarthritis (OA) is a common degenerative joint situation that induces pain and disability in the elderly. Traditionally, Eleutherine bulbosa bulb from Pasuruan, East Java, is used to treat many diseases, also as an anti-inflammatory. Objective: In this research, we employed an in vivo model to examine the effects of 70% ethanol extracts of E. bulbosa (EBE) on the progression and development of OA. Methods: A singular intraarticular injection of Monosodium Iodoacetate (MIA) was used to create the OA model in rats. The progression of OA was observed for three weeks. Furthermore, treatment of EBE at a dose of 6, 12, and 24 mg/200g BW orally for four weeks was conducted to assess the effects on decreasing IL- 1ß level, joint swelling, and hyperalgesia. Results: Induction was successful, indicated by a significant difference (P<0.05) in decreasing latency time, increasing joint swelling, and IL-1ß level. EBE 24 mg/200 g BW treatment has significantly (P<0.05) reduced IL-1ß levels, joint swelling, and response to hyperalgesia. Conclusion: The 70% ethanol extract of E. bulbosa bulb has therapeutic effects on inflammation through reducing IL-1ß in experimental MIA-induced osteoarthritis in a rat model. According to this study, EBE may have an effective potential new agent for OA therapy.
Keywords	Osteoarthritis ; Antiinflammatory ; Eleutherine bulbosa ; MIA ; IL-1β ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	PAGEPress Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of eleutherine bulbosa (mill.) urb. bulb extract on mice glucocorticoid-induced osteoporosis models

Fina Luthfiana / Riza Ambar Sari / Irawati Sholikhah / Katsuyoshi Matsunami / Sukardiman Sukardiman / Retno Widyowati

Journal of Public Health in Africa, Vol 14, Iss s

2023 Volume 1

Abstract: Background: Low bone mass accompanied by microarchitectural alterations in the bone that cause fragility fractures is known as secondary osteoporosis and occurs when there is an underlying condition or medication present. Eleutherine bulbosa bulb extract ...

Abstract	Background: Low bone mass accompanied by microarchitectural alterations in the bone that cause fragility fractures is known as secondary osteoporosis and occurs when there is an underlying condition or medication present. Eleutherine bulbosa bulb extract has been shown to affect bone because of its content, which can help osteoblast differentiation and inhibit osteoclast differentiation. Objective: This study aimed to assess the effects of 70% ethanol extract of E. bulbosa Bulbs (EBE) from Pasuruan-East Java on blood calcium levels, osteoblast cell count, and bone density of trabecular femur in osteoporosis rats. Methods: Six groups of 30 female Wistar rats were created. There were no test materials offered to the healthy group; the negative group received 0.5% CMC; the positive group received alendronate 0.9 mg/kg BW; and the dose group received 30, 60, and 120 mg/kg BW. Glucocorticoid (Dexamethasone) 0.1015 mg/kg BW/day induction was given to all groups except the healthy group to create osteoporosis rats for approximately four weeks. Then they were given oral therapy for approximately 28 days. Followed by the determination of blood calcium levels, the number of osteoblast cells, and bone density of the rat femur trabecular. Results: The result showed that E. bulbosa bulbs extract could raise blood calcium levels and bone density percentage at doses of 60 and 120 mg/kg BW, as well as raise osteoblast cell levels at doses of 120 mg/kg BW. Conclusions: The findings indicate that E.bulbosa bulb extract is a potential complementary medicine for osteoporosis.
Keywords	Eleutherine bulbosa ; Calcium ; Osteoblast cell ; Bone density ; Osteoporosis ; Public aspects of medicine ; RA1-1270
Subject code	630
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	PAGEPress Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The recent use of Swietenia mahagoni (L.) Jacq. as antidiabetes type 2 phytomedicine

Sukardiman / Martha Ervina

Heliyon, Vol 6, Iss 3, Pp e03536- (2020)

A systematic review

2020

Abstract	Background: Natural resources provide more efficient and safer alternatives in managing diabetes compare to the synthetic oral anti diabetes (OAD). The plants not only have hypoglycemic effect, but also prevent its complications; in which no synthetic drugs provide of both properties. Among antidiabetes plants, mahogany seed (Swietenia macrophylla) has been used as traditional medicine in Indonesia and India, though most popular utilized as timber wood. Methods: The present study was performed of chemotaxonomic approach to review its phytochemical and anti-diabetic properties of Swietenia mahagoni (L.) Jacq seed/bark/leaves. The qualitative systematic review (SR) was carried out by analysing indexed journals and peer reviewed of Swietenia and Swietenia spp from Scopus, PubMed, Medline, Google Scholar, and Research Gate. Data selection criteria are accordance to botany, phytochemistry, in vitro, in vivo, and clinical test of related subject. The keywords used for the search in the databases were Swietenia, Swietenia mahagony, diabetes, and diabetes plants. Results: Swietenia mahagoni (L.) Jacq. extracts have shown in vitro, in vivo and limited clinically test of its anti-diabetic properties. Ethanolic/methanolic/aqueous/petroleum/n-hexane extracts of mahagonis's seed/bark or leaves have anti-diabetic activities comparable to the synthetic drug and observed no to relatively mild toxic effect. The hypoglycemic mechanism suggested via reducing blood glucose level, restoring liver and β-cells islet function (might) blocking epinephrine function, inhibiting of α-amylase and β-glucosidase, antioxidant and antihiperlipidemia. Phytochemical compounds of S. mahagoni consist of the phenolics (flavonoids (swietemacrophyllanin, catechins and epichatechins) and tannins), triterpenoids and tetranortriterpenoids (limonoids: mahonin, secomahoganin, swietmanins, swiemahogins, swietenine and swietenolide), saponins and alkaloids which are known as anti-diabetic bioactive principles. Conclusion: S. mahagoni was potentially used and ...
Keywords	Toxicology ; Diabetes ; Hypoglycemic ; Mahogany ; Meliaceae ; Swietenia sp ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	571
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Effects of

Luthfiana, Fina / Sari, Riza Ambar / Sholikhah, Irawati / Matsunami, Katsuyoshi / Sukardiman / Widyowati, Retno

Journal of public health in Africa

2023 Volume 14, Issue Suppl 1, Page(s) 2507

Abstract	Background: Low bone mass accompanied by microarchitectural alterations in the bone that cause fragility fractures is known as secondary osteoporosis and occurs when there is an underlying condition or medication present. Eleutherine bulbosa bulb extract has been shown to affect bone because of its content, which can help osteoblast differentiation and inhibit osteoclast differentiation. Objective: This study aimed to assess the effects of 70% ethanol extract of Methods: Six groups of 30 female Wistar rats were created. There were no test materials offered to the healthy group; the negative group received 0.5% CMC; the positive group received alendronate 0.9 mg/kg BW; and the dose group received 30, 60, and 120 mg/kg BW. Glucocorticoid (Dexamethasone) 0.1015 mg/kg BW/day induction was given to all groups except the healthy group to create osteoporosis rats for approximately four weeks. Then they were given oral therapy for approximately 28 days. Followed by the determination of blood calcium levels, the number of osteoblast cells, and bone density of the rat femur trabecular. Results: The result showed that Conclusions: The findings indicate that
Language	English
Publishing date	2023-03-16
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2574977-8
ISSN	2038-9930 ; 2038-9922
ISSN (online)	2038-9930
ISSN	2038-9922
DOI	10.4081/jphia.2023.2507
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Antiosteoarthritis activities of 70% ethanol extract of

Sari, Riza Ambar / Luthfiana, Fina / Sholihah, Irawati / Matsunami, Katsuyoshi / Sukardiman / Widyowati, Retno

Journal of public health in Africa

2023 Volume 14, Issue Suppl 1, Page(s) 2506

Abstract: Background: Osteoarthritis (OA) is a common degenerative joint situation that induces pain and disability in the elderly. Traditionally, : Objective: In this research, we employed an : Methods: A singular intraarticular injection of Monosodium ... ...

Abstract	Background: Osteoarthritis (OA) is a common degenerative joint situation that induces pain and disability in the elderly. Traditionally, Objective: In this research, we employed an Methods: A singular intraarticular injection of Monosodium Iodoacetate (MIA) was used to create the OA model in rats. The progression of OA was observed for three weeks. Furthermore, treatment of EBE at a dose of 6, 12, and 24 mg/200g BW orally for four weeks was conducted to assess the effects on decreasing IL- 1. level, joint swelling, and hyperalgesia. Results: Induction was successful, indicated by a significant difference (P<0.05) in decreasing latency time, increasing joint swelling, and IL-1. level. EBE 24 mg/200 g BW treatment has significantly (P<0.05) reduced IL-1. levels, joint swelling, and response to hyperalgesia. Conclusion: The 70% ethanol extract of
Language	English
Publishing date	2023-03-16
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2574977-8
ISSN	2038-9930 ; 2038-9922
ISSN (online)	2038-9930
ISSN	2038-9922
DOI	10.4081/jphia.2023.2506
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Pregnane Steroids from the Leaves of Melia Azedarach and Apoptotic Activity against T47D Cells.

Ervina, Martha / Poerwono, Hadi / Widyowati, Retno / Otsuka, Hideaki / Matsunami, Katsuyoshi / Sukardiman, Sukardiman

Asian Pacific journal of cancer prevention : APJCP

2021 Volume 22, Issue 6, Page(s) 1967–1973

Abstract: Objective: Nature has provided us with many pharmaceutical resources so far. Breast cancer shows an increasing trend in the world for the last decade and becomes one of five leading causes of death. Among the plants, Melia azedarach L. has been used ... ...

Abstract	Objective: Nature has provided us with many pharmaceutical resources so far. Breast cancer shows an increasing trend in the world for the last decade and becomes one of five leading causes of death. Among the plants, Melia azedarach L. has been used widely in traditional medicine for many ailments including breast cancer. Following our previous findings that the ethyl acetate fraction was the most active cytotoxic fraction against T47D cells, we aimed to isolate the cytotoxic compounds and further elucidate their apoptotic mechanisms. Methods: The compounds were isolated through a series of chromatography with cytotoxicity evaluations. Identification of the isolated compounds was achieved by intensive spectroscopic analysis such as NMR, MS, and IR spectra. Cytotoxicity was evaluated by MTT method using doxorubicin as a reference compound. The expression of apoptosis-related factors was quantified by flow cytometry and immunocytochemistry. Results: Two isomers of pregnane steroids with molecular weight 330.2087 (C21H30O3) were isolated from the EtOAc extract. Spectroscopic analysis revealed the structures as 17-ethylene-3,4-dihydroxy-14-methyl-18-norandrostene-16-one (1) and 17-ethylene-3,4-dihydroxy-5-pregnene-16-one (2), respectively. These compounds showed moderate cytotoxicity (IC50 172.9 and 62.2 µg/mL, respectively) comparable to doxorubicin (IC50 3.08 µg/mL). The execution of apoptosis may be related to the increase of the ratio of BAX/bcl-2 of the cells. Conclusion: The EtOAc fraction of Melia azedarach L. leaves and the isolated 5-pregnene-16-one steroids are promising reagents for breast cancer treatment by introducing apoptosis to tumor cells. However, further researches are required to highlight its safety and usage in vivo. .
MeSH term(s)	Apoptosis/drug effects ; Breast Neoplasms/drug therapy ; Doxorubicin/pharmacology ; Female ; Humans ; Melia azedarach/chemistry ; Molecular Structure ; Molecular Weight ; Plant Leaves/chemistry ; Pregnanes/pharmacology ; Steroids/pharmacology ; Tumor Cells, Cultured
Chemical Substances	Pregnanes ; Steroids ; Doxorubicin (80168379AG)
Language	English
Publishing date	2021-06-01
Publishing country	Thailand
Document type	Journal Article
ZDB-ID	2218955-5
ISSN	2476-762X ; 1513-7368
ISSN (online)	2476-762X
ISSN	1513-7368
DOI	10.31557/APJCP.2021.22.6.1967
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: ACUPRESSURE AND AROMATIC GINGER HERB FOR A MIGRAINE

Mayla Khayra Al ‘Amali / Ario Imandiri / Sukardiman Sukardiman

Journal of Vocational Health Studies, Vol 2, Iss 2, Pp 80-

2019 Volume 85

Abstract: Background: a Migraine is a headache with pain attacks lasting 4 - 72 hours. Pain is usually unilateral, it is pulsating, the intensity of pain is moderate to severe and aggravated by activity, and can be accompanied by nausea, vomiting, photophobia, and ...

Abstract	Background: a Migraine is a headache with pain attacks lasting 4 - 72 hours. Pain is usually unilateral, it is pulsating, the intensity of pain is moderate to severe and aggravated by activity, and can be accompanied by nausea, vomiting, photophobia, and phonophobia. Headaches are one of the most common disorders of the nervous system. It has been estimated that 47% of the adult population experience headaches at least once in the past year in general. According to TCM, headache is a disease with a headache accompanied by a variety of symptoms, where the cause is an external pathogen and causes in the body. Acupressure is one form of traditional treatment skills by suppressing acupuncture points with emphasis on using fingers or blunt objects on the surface of the body, in order to support promotive, effective, rehabilitative efforts. In addition to acupressure, herbal drinks can also be used to reduce pain, namely aromatic ginger. Purpose: Knowing the effect of acupressure and aromatic ginger herbs (Kaempferia galangal Linn.) combination therapy in reducing migraine complaints. Methods: Acupressure at Fengchi point (GB20) 50 times, Taiyang (EX-HN5) 50 times, Sanyinjiao (SP6) 30 times, Taichong (LR3) 50 times and aromatic ginger herbs (Kaempferia galangal Linn.) 15 grams for 28 days. Results: Migraine complaints decreased from 5 times a month to 3 times a month. No more complaints of nausea, hypochondrium pain, diarrhea, and insomnia. Conclusion: Acupressure at Fengchi point (GB20) was 50 times of the pressure, Taiyang (EX-HN5) was 50 times of the pressure, Sanyinjiao (SP6) was 30 times of the pressure, Taichong (LR3) was 50 times of the pressure and the aromatic ginger herbs (Kaempferia galangal Linn.) As much as 15 grams for 28 days could reduce migraine complaints.
Keywords	migraine ; acupressure ; herbs ; aromatic ginger ; Medicine ; R ; Microbiology ; QR1-502
Subject code	630
Language	Indonesian
Publishing date	2019-01-01T00:00:00Z
Publisher	Universitas Airlangga
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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