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  1. Book: Sensory nerves

    Baron, Ralf / Canning, Brendan J.

    (Handbook of experimental pharmacology ; 194)

    2009  

    Author's details Brendan J. Canning ... ed. Contributors R. Baron
    Series title Handbook of experimental pharmacology ; 194
    Collection
    Keywords Nervensystem ; Sensorik ; Neuralgie ; Schmerztherapie
    Subject Schmerz ; Nervenschmerz ; Neurogener Schmerz ; Neuropathischer Schmerz ; Sensorisches System ; Systema nervosum ; NS
    Language English
    Size XII, 624 S. : graph. Darst., 24 cm
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    Note Literaturangaben
    HBZ-ID HT016063931
    ISBN 978-3-540-79089-1 ; 3-540-79089-6
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2004 A 6754 order for loan Magazin
    2009 A 4349 order for loan Magazin

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  2. Article ; Online: Is There (Will There Be) a Post-COVID-19 Chronic Cough?

    Dicpinigaitis, Peter V / Canning, Brendan J

    Lung

    2020  Volume 198, Issue 6, Page(s) 863–865

    MeSH term(s) COVID-19/complications ; Chronic Disease ; Cough/epidemiology ; Cough/virology ; Humans ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-11-13
    Publishing country United States
    Document type Editorial
    ZDB-ID 6165-7
    ISSN 1432-1750 ; 0341-2040
    ISSN (online) 1432-1750
    ISSN 0341-2040
    DOI 10.1007/s00408-020-00406-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: P2X3-Receptor Antagonists as Potential Antitussives: Summary of Current Clinical Trials in Chronic Cough.

    Dicpinigaitis, Peter V / McGarvey, Lorcan P / Canning, Brendan J

    Lung

    2020  Volume 198, Issue 4, Page(s) 609–616

    Abstract: Cough is among the most common complaints for which patients worldwide seek medical attention. In a majority of patients with chronic cough (defined as cough of greater than 8 weeks' duration), successful management results from a thorough evaluation and ...

    Abstract Cough is among the most common complaints for which patients worldwide seek medical attention. In a majority of patients with chronic cough (defined as cough of greater than 8 weeks' duration), successful management results from a thorough evaluation and treatment of underlying causes. In a subgroup of patients, however, cough proves refractory to therapeutic trials aimed at known reversible causes of chronic cough. Such patients are appropriately termed as having refractory chronic cough. At present, safe and effective medications are lacking for this challenging patient population. Currently available therapeutic options are usually ineffective or achieve antitussive effect at the expense of intolerable side effects, typically sedation. Fortunately, the past decade has witnessed great progress in elucidating underlying mechanisms of cough. From that knowledge, aided by the development of validated instruments to measure objective and subjective cough-related end points, numerous antitussive drug development programs have emerged. The most active area of inquiry at present involves antagonists of the purinergic P2X receptors. Indeed, four clinical programs (one in Phase 3 and three in Phase 2) are currently underway investigating antagonists of receptors comprised entirely or partially of the P2X3 subunit as potential antitussive medications. Herein we review the foundation on which P2X receptor antagonists were developed as potential antitussive medications and provide an update on current clinical trials.
    MeSH term(s) Ageusia/chemically induced ; Antitussive Agents/therapeutic use ; Chronic Disease ; Clinical Trials as Topic ; Cough/drug therapy ; Cough/metabolism ; Humans ; Imidazoles/therapeutic use ; Piperidines/therapeutic use ; Purinergic P2X Receptor Antagonists/therapeutic use ; Pyridines/therapeutic use ; Pyrimidines/therapeutic use ; Receptors, Purinergic P2X3 ; Sulfonamides/therapeutic use
    Chemical Substances Antitussive Agents ; BLU-5937 ; Imidazoles ; Piperidines ; Purinergic P2X Receptor Antagonists ; Pyridines ; Pyrimidines ; Receptors, Purinergic P2X3 ; Sulfonamides ; Gefapixant (6K6L7E3F1L)
    Language English
    Publishing date 2020-07-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 6165-7
    ISSN 1432-1750 ; 0341-2040
    ISSN (online) 1432-1750
    ISSN 0341-2040
    DOI 10.1007/s00408-020-00377-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Functional implications of the multiple afferent pathways regulating cough.

    Canning, Brendan J

    Pulmonary pharmacology & therapeutics

    2011  Volume 24, Issue 3, Page(s) 295–299

    Abstract: At least 2 airway vagal afferent nerve subtypes can directly initiate coughing upon activation. The capsaicin-insensitive, acid-sensitive mechanoreceptors innervating the larynx, trachea and large bronchi regulate coughing in both conscious and ... ...

    Abstract At least 2 airway vagal afferent nerve subtypes can directly initiate coughing upon activation. The capsaicin-insensitive, acid-sensitive mechanoreceptors innervating the larynx, trachea and large bronchi regulate coughing in both conscious and anesthetized animals. Activation of capsaicin-sensitive C-fibers innervating these airways will also produce coughing, but C-fiber dependent cough is prevented entirely by anesthesia. The different stimuli activating these afferent nerve subtypes and their differential sensitivity to anesthesia implies the existence of 2 parallel pathways for cough, and by extension, 2 types of cough, one essential and homeostatic, the second nonessential and pathophysiologic. The basic properties of the afferent nerves regulating cough, their interactions both centrally and peripherally and their responsiveness to tussive stimuli are briefly reviewed. Also reviewed is evidence against the notion of 2 completely separate types of cough regulated by parallel afferent pathways, asserting instead that multiple afferent nerve subtypes contribute to all types of cough.
    MeSH term(s) Anesthetics/pharmacology ; Animals ; Capsaicin ; Cough/physiopathology ; Humans ; Nerve Fibers, Unmyelinated/metabolism ; Neurons, Afferent/metabolism ; Vagus Nerve/metabolism
    Chemical Substances Anesthetics ; Capsaicin (S07O44R1ZM)
    Language English
    Publishing date 2011-01-25
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1399707-5
    ISSN 1522-9629 ; 1094-5539
    ISSN (online) 1522-9629
    ISSN 1094-5539
    DOI 10.1016/j.pupt.2011.01.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Nicotinic receptor dependent regulation of cough and other airway defensive reflexes.

    Tao, Mayuko / Liu, Qi / Miyazaki, Yasunari / Canning, Brendan J

    Pulmonary pharmacology & therapeutics

    2019  Volume 58, Page(s) 101810

    Abstract: Nicotinic receptor activation in the airways evokes airway defensive reflexes including cough. These reflexes are the direct result of bronchopulmonary afferent nerve activation, which may occur directly, through activation of nicotinic receptors ... ...

    Abstract Nicotinic receptor activation in the airways evokes airway defensive reflexes including cough. These reflexes are the direct result of bronchopulmonary afferent nerve activation, which may occur directly, through activation of nicotinic receptors expressed on the terminals of airway sensory nerves, or indirectly, secondary to the end organ effects associated with autonomic nerve stimulation. The irritating effects of nicotine delivered topically to the airways are counterbalanced by an inhibitory effect of nicotinic receptor activation in the central nervous system. We present evidence that these nicotinic receptors are components of essential transducing and encoding mechanisms regulating airway defense.
    MeSH term(s) Animals ; Cough/physiopathology ; Humans ; Nicotine ; Nicotinic Antagonists/pharmacology ; Receptors, Nicotinic/physiology ; Reflex ; Respiratory Physiological Phenomena ; Respiratory System/drug effects ; Respiratory System/physiopathology
    Chemical Substances Nicotinic Antagonists ; Receptors, Nicotinic ; Nicotine (6M3C89ZY6R)
    Language English
    Publishing date 2019-06-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1399707-5
    ISSN 1522-9629 ; 1094-5539
    ISSN (online) 1522-9629
    ISSN 1094-5539
    DOI 10.1016/j.pupt.2019.101810
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Afferent nerves regulating the cough reflex: mechanisms and mediators of cough in disease.

    Canning, Brendan J

    Otolaryngologic clinics of North America

    2010  Volume 43, Issue 1, Page(s) 15–25, vii

    Abstract: Bronchopulmonary C fibers and acid-sensitive, capsaicin-insensitive mechanoreceptors innervating the larynx, trachea, and large bronchi regulate the cough reflex. These vagal afferent nerves may interact centrally with sensory input arising from afferent ...

    Abstract Bronchopulmonary C fibers and acid-sensitive, capsaicin-insensitive mechanoreceptors innervating the larynx, trachea, and large bronchi regulate the cough reflex. These vagal afferent nerves may interact centrally with sensory input arising from afferent nerves innervating the intrapulmonary airways or even extrapulmonary afferents such as those innervating the nasal mucosa and esophagus to produce chronic cough or enhanced cough responsiveness. The mechanisms of cough initiation in health and in disease are briefly described.
    MeSH term(s) Animals ; Asthma/complications ; Asthma/physiopathology ; Bradykinin/metabolism ; Capsaicin/metabolism ; Cough/etiology ; Cough/metabolism ; Cough/physiopathology ; Gastroesophageal Reflux/complications ; Gastroesophageal Reflux/physiopathology ; Humans ; Mechanoreceptors/physiology ; N-Methylaspartate/metabolism ; Neurons, Afferent/physiology ; Reflex
    Chemical Substances N-Methylaspartate (6384-92-5) ; Capsaicin (S07O44R1ZM) ; Bradykinin (S8TIM42R2W)
    Language English
    Publishing date 2010-02-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 417489-6
    ISSN 1557-8259 ; 0030-6665
    ISSN (online) 1557-8259
    ISSN 0030-6665
    DOI 10.1016/j.otc.2009.11.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Evidence for Alpha

    Canning, Brendan J / Liu, Qi / Tao, Mayuko / DeVita, Robert / Perelman, Michael / Hay, Douglas W / Dicpinigaitis, Peter V / Liang, Jing

    The Journal of pharmacology and experimental therapeutics

    2021  Volume 380, Issue 2, Page(s) 94–103

    Abstract: Studies performed in healthy smokers have documented a diminished responsiveness to tussive challenges, and several lines of experimental evidence implicate nicotine as an antitussive component in both cigarette smoke and the vapors generated by ... ...

    Abstract Studies performed in healthy smokers have documented a diminished responsiveness to tussive challenges, and several lines of experimental evidence implicate nicotine as an antitussive component in both cigarette smoke and the vapors generated by electronic cigarettes (eCigs). We set out to identify the nicotinic receptor subtype involved in the antitussive actions of nicotine and to further evaluate the potential of nicotinic receptor-selective agonists as cough-suppressing therapeutics. We confirmed an antitussive effect of nicotine in guinea pigs. We additionally observed that the alpha-4 beta-2 (
    MeSH term(s) Animals ; Antitussive Agents/pharmacology ; Antitussive Agents/therapeutic use ; Benzofurans/pharmacology ; Benzofurans/therapeutic use ; Cough/drug therapy ; Cough/metabolism ; Guinea Pigs ; Male ; Nicotine/metabolism ; Nicotine/pharmacology ; Nicotinic Agonists/pharmacology ; Nicotinic Agonists/therapeutic use ; Quinuclidines/pharmacology ; Quinuclidines/therapeutic use ; alpha7 Nicotinic Acetylcholine Receptor/agonists ; alpha7 Nicotinic Acetylcholine Receptor/metabolism
    Chemical Substances Antitussive Agents ; Benzofurans ; N-(2-(pyridin-3-ylmethyl)-1-azabicyclo(2.2.2)oct-3-yl)-1-benzofuran-2-carboxamide ; Nicotinic Agonists ; Quinuclidines ; alpha7 Nicotinic Acetylcholine Receptor ; Nicotine (6M3C89ZY6R)
    Language English
    Publishing date 2021-11-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3106-9
    ISSN 1521-0103 ; 0022-3565
    ISSN (online) 1521-0103
    ISSN 0022-3565
    DOI 10.1124/jpet.121.000641
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Central regulation of the cough reflex: therapeutic implications.

    Canning, Brendan J

    Pulmonary pharmacology & therapeutics

    2009  Volume 22, Issue 2, Page(s) 75–81

    Abstract: In many species including humans, antagonists of NMDA-type glutamate receptors such as dextromethorphan, when used at sufficient doses, have been found to be relatively safe and effective antitussives. Similarly, now in five different species (guinea ... ...

    Abstract In many species including humans, antagonists of NMDA-type glutamate receptors such as dextromethorphan, when used at sufficient doses, have been found to be relatively safe and effective antitussives. Similarly, now in five different species (guinea pigs, rabbits, cats, dogs and pigs), neurokinin receptor antagonists have also proven to be safe and effective antitussive agents. Both of these classes of drugs act centrally to prevent cough. A brief review of what is known about the central encoding of cough is presented, as are the advantages of centrally acting antitussives. Also discussed are new insights into cough and NMDA receptor signaling that may lead to the development of more effective antitussive agents with limited side effects and broad application in treating cough associated with a variety of aetiologies.
    MeSH term(s) Afferent Pathways/physiopathology ; Animals ; Antitussive Agents/pharmacology ; Antitussive Agents/therapeutic use ; Cough/drug therapy ; Cough/etiology ; Cough/physiopathology ; Humans ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors ; Receptors, N-Methyl-D-Aspartate/physiology ; Receptors, Tachykinin/antagonists & inhibitors ; Receptors, Tachykinin/physiology ; Reflex/physiology ; Vagus Nerve/physiopathology
    Chemical Substances Antitussive Agents ; Receptors, N-Methyl-D-Aspartate ; Receptors, Tachykinin
    Language English
    Publishing date 2009-01-20
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1399707-5
    ISSN 1522-9629 ; 1094-5539
    ISSN (online) 1522-9629
    ISSN 1094-5539
    DOI 10.1016/j.pupt.2009.01.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Evidence for autocrine and paracrine regulation of allergen-induced mast cell mediator release in the guinea pig airways.

    Yu, Li / Liu, Qi / Canning, Brendan J

    European journal of pharmacology

    2017  Volume 822, Page(s) 108–118

    Abstract: Mast cells play an essential role in immediate type hypersensitivity reactions and in chronic allergic diseases of the airways, including asthma. Mast cell mediator release can be modulated by locally released autacoids and circulating hormones, but ... ...

    Abstract Mast cells play an essential role in immediate type hypersensitivity reactions and in chronic allergic diseases of the airways, including asthma. Mast cell mediator release can be modulated by locally released autacoids and circulating hormones, but surprisingly little is known about the autocrine effects of mediators released upon mast cell activation. We thus set out to characterize the autocrine and paracrine effects of mast cell mediators on mast cell activation in the guinea pig airways. By direct measures of histamine, cysteinyl-leukotriene and thromboxane release and with studies of allergen-evoked contractions of airway smooth muscle, we describe a complex interplay amongst these autacoids. Notably, we observed an autocrine effect of the cysteinyl-leukotrienes acting through cysLT
    MeSH term(s) Allergens/immunology ; Animals ; Autocrine Communication/immunology ; Cyclooxygenase 2/metabolism ; Cysteine/metabolism ; Guinea Pigs ; Histamine Release/immunology ; Leukotrienes/metabolism ; Lung/immunology ; Lung/physiology ; Mast Cells/cytology ; Mast Cells/immunology ; Mast Cells/metabolism ; Muscle Contraction ; Paracrine Communication/immunology ; Thromboxanes/metabolism
    Chemical Substances Allergens ; Leukotrienes ; Thromboxanes ; cysteinyl-leukotriene ; Cyclooxygenase 2 (EC 1.14.99.1) ; Cysteine (K848JZ4886)
    Language English
    Publishing date 2017-11-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/j.ejphar.2017.11.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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