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  1. Article ; Online: Fu-Zheng-Tong-Luo formula promotes autophagy and alleviates idiopathic pulmonary fibrosis by controlling the Janus kinase 2/signal transducer and activator of transcription 3 pathway.

    Zhang, Xing / Su, Jie / Lin, Jiacheng / Liu, Lujiong / Wu, Jiamin / Yuan, Wenli / Zhang, Yibao / Chen, Qi / Su, Zi Jian / Xu, Guihua / Sun, Meng / Zhang, Yile / Chen, Xuan / Zhang, Wei

    Journal of ethnopharmacology

    2023  Volume 314, Page(s) 116633

    Abstract: Ethnopharmacological relevance: Fu-Zheng-Tong-Luo (FZTL) formula is a Chinese herbal prescription ...

    Abstract Ethnopharmacological relevance: Fu-Zheng-Tong-Luo (FZTL) formula is a Chinese herbal prescription which is used to treat idiopathic pulmonary fibrosis (IPF). We previously reported that the FZTL formula could improve IPF injury in rats; however, the mechanism remains unelucidated.
    Aim of the study: To elucidate the effects and mechanisms of the FZTL formula on IPF.
    Materials and methods: The bleomycin-induced pulmonary fibrosis rat model and transforming growth factor-β-induced lung fibroblast model were used. Histological changes and fibrosis formation were detected in the rat model after treatment with the FZTL formula. Furthermore, the effects of the FZTL formula on autophagy and lung fibroblast activation were determined. Moreover, the mechanism of FZTL was explored using transcriptomics analysis.
    Results: We observed that FZTL alleviated IPF injury in rats and inhibited inflammatory responses and fibrosis formation in rats. Moreover, it promoted autophagy and inhibited lung fibroblast activation in vitro. Transcriptomics analysis revealed that FZTL regulates the Janus kinase 2 (JAK)/signal transducer and activator of the transcription 3 (STAT) signaling pathway. The JAK2/STAT3 signaling activator interleukin 6 inhibited the anti-fibroblast activation effect of the FZTL formula. Combined treatment with the JAK2 inhibitor (AZD1480) and autophagy inhibitor (3-methyladenine) did not enhance the antifibrotic effect of FZTL.
    Conclusions: The FZTL formula can inhibit IPF injury and lung fibroblast activation. Its effects are mediated via the JAK2/STAT3 signaling pathway. The FZTL formula may be a potential complementary therapy for pulmonary fibrosis.
    MeSH term(s) Rats ; Animals ; Janus Kinase 2/metabolism ; STAT3 Transcription Factor/metabolism ; Idiopathic Pulmonary Fibrosis/chemically induced ; Idiopathic Pulmonary Fibrosis/drug therapy ; Idiopathic Pulmonary Fibrosis/pathology ; Signal Transduction ; Fibrosis ; Bleomycin ; Fluorouracil/pharmacology
    Chemical Substances Janus Kinase 2 (EC 2.7.10.2) ; STAT3 Transcription Factor ; Bleomycin (11056-06-7) ; Fluorouracil (U3P01618RT)
    Language English
    Publishing date 2023-05-17
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.116633
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Evidence-Based ZHENG

    Shi-Bing Su / Wei Jia / Aiping Lu / Shao Li

    Evidence-Based Complementary and Alternative Medicine, Vol

    A Traditional Chinese Medicine Syndrome 2013

    2014  Volume 2014

    Keywords Medicine (General) ; R5-920 ; Medicine ; R
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Evidence-Based ZHENG

    Shi-Bing Su / Wei Jia / Aiping Lu / Shao Li

    Evidence-Based Complementary and Alternative Medicine, Vol

    A Traditional Chinese Medicine Syndrome 2013

    2014  Volume 2014

    Keywords Other systems of medicine ; RZ201-999
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Applications of New Technologies and New Methods in ZHENG Differentiation.

    Dai, Jianye / Sun, Shujun / Cao, Huijuan / Zheng, Ningning / Wang, Wenyu / Gou, Xiaojun / Su, Shibing / Zhang, Yongyu

    Evidence-based complementary and alternative medicine : eCAM

    2012  Volume 2012, Page(s) 298014

    Abstract: ... treatment based on ZHENG (TCM syndrome) differentiation, which could be identified as clinical special ... phenotypes by symptoms and signs of patients. However, it caused skepticism and criticism because ZHENG ... touching), in this paper, the applications of new technologies and new methods on the ZHENG differentiation ...

    Abstract With the hope to provide an effective approach for personalized diagnosis and treatment clinically, Traditional Chinese Medicine (TCM) is being paid increasing attention as a complementary and alternative medicine. It performs treatment based on ZHENG (TCM syndrome) differentiation, which could be identified as clinical special phenotypes by symptoms and signs of patients. However, it caused skepticism and criticism because ZHENG classification only depends on observation, knowledge, and clinical experience of TCM practitioners, which is lack of objectivity and repeatability. Scientists have done fruitful researches for its objectivity and standardization. Compared with traditional four diagnostic methods (looking, listening and smelling, asking, and touching), in this paper, the applications of new technologies and new methods on the ZHENG differentiation were systemically reviewed, including acquisition, analysis, and integration of clinical data or information. Furthermore, the characteristics and application range of these technologies and methods were summarized. It will provide reference for further researches.
    Language English
    Publishing date 2012-05-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2012/298014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5995: Show issues Location:
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  5. Article ; Online: Fu-Zheng-Tong-Luo formula promotes autophagy and alleviates idiopathic pulmonary fibrosis by controlling the Janus kinase 2/signal transducer and activator of transcription 3 pathway

    Zhang, Xing / Su, Jie / Lin, Jiacheng / Liu, Lujiong / Wu, Jiamin / Yuan, Wenli / Zhang, Yibao / Chen, Qi / Su, Zi jian / Xu, Guihua / Sun, Meng / Zhang, Yile / Chen, Xuan / Zhang, Wei

    Journal of Ethnopharmacology. 2023 Oct., v. 314 p.116633-

    2023  

    Abstract: Fu-Zheng-Tong-Luo (FZTL) formula is a Chinese herbal prescription which is used to treat ...

    Abstract Fu-Zheng-Tong-Luo (FZTL) formula is a Chinese herbal prescription which is used to treat idiopathic pulmonary fibrosis (IPF). We previously reported that the FZTL formula could improve IPF injury in rats; however, the mechanism remains unelucidated. To elucidate the effects and mechanisms of the FZTL formula on IPF. The bleomycin-induced pulmonary fibrosis rat model and transforming growth factor-β-induced lung fibroblast model were used. Histological changes and fibrosis formation were detected in the rat model after treatment with the FZTL formula. Furthermore, the effects of the FZTL formula on autophagy and lung fibroblast activation were determined. Moreover, the mechanism of FZTL was explored using transcriptomics analysis. We observed that FZTL alleviated IPF injury in rats and inhibited inflammatory responses and fibrosis formation in rats. Moreover, it promoted autophagy and inhibited lung fibroblast activation in vitro. Transcriptomics analysis revealed that FZTL regulates the Janus kinase 2 (JAK)/signal transducer and activator of the transcription 3 (STAT) signaling pathway. The JAK2/STAT3 signaling activator interleukin 6 inhibited the anti-fibroblast activation effect of the FZTL formula. Combined treatment with the JAK2 inhibitor (AZD1480) and autophagy inhibitor (3-methyladenine) did not enhance the antifibrotic effect of FZTL. The FZTL formula can inhibit IPF injury and lung fibroblast activation. Its effects are mediated via the JAK2/STAT3 signaling pathway. The FZTL formula may be a potential complementary therapy for pulmonary fibrosis.
    Keywords animal models ; autophagy ; fibroblasts ; fibrosis ; histology ; interleukin-6 ; lungs ; non-specific protein-tyrosine kinase ; pulmonary fibrosis ; therapeutics ; traditional medicine ; transactivators ; transcriptomics ; Traditional Chinese medicine ; Fu-zheng-Tong-Luo formula ; Idiopathic pulmonary fibrosis ; Janus kinase 2/signal transducer and activator of transcription 3
    Language English
    Dates of publication 2023-10
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.116633
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 90/710: Show issues

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  6. Article ; Online: Evidence-Based ZHENG

    Shi-Bing Su / Aiping Lu / Shao Li / Wei Jia

    Evidence-Based Complementary and Alternative Medicine, Vol

    A Traditional Chinese Medicine Syndrome

    2012  Volume 2012

    Keywords Other systems of medicine ; RZ201-999
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Evidence-Based ZHENG: A Traditional Chinese Medicine Syndrome.

    Su, Shi-Bing / Lu, Aiping / Li, Shao / Jia, Wei

    Evidence-based complementary and alternative medicine : eCAM

    2012  Volume 2012, Page(s) 246538

    Language English
    Publishing date 2012-08-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2012/246538
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5995: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Serum cytokine profiling analysis for zheng differentiation in chronic hepatitis B.

    Lu, Yi-Yu / Zhao, Yu / Song, Ya-Nan / Dong, Shu / Wei, Bin / Chen, Qi-Long / Hu, Yi-Yang / Su, Shi-Bing

    Chinese medicine

    2015  Volume 10, Page(s) 24

    Abstract: ... syndromes are Chinese medicine (CM) zhengs in chronic hepatitis B (CHB) patients. This study aims ...

    Abstract Background: Liver-gallbladder dampness-heat (LGDH) and liver kidney yin deficiency (LKYD) syndromes are Chinese medicine (CM) zhengs in chronic hepatitis B (CHB) patients. This study aims to investigate the changes in cytokines and their profiles accompanied by different biological responses in LGDH and LKYD in CHB.
    Methods: During 2010-2012, a total of 138 morning fasting venous blood samples were obtained from participants in Shuguang Hospital, Shanghai University of Traditional Chinese Medicine in Shanghai, China. First, serum samples from 20 health controls (HCs) and 40 CHB patients (20 LGDH, 20 LKYD) were collected to detect the profiles of cytokines by multiplex biometric ELISA-based immunoassay. Random forest (RF) with a fivefold cross-validation was used to analyze the significant cytokines. Then the significant cytokines were validated using serum samples from an independent cohort of 60 CHB patients (30 LGDH, 30 LKYD) and 18 HCs.
    Results: There were different profiles of cytokines in LGDH and LKYD. Twenty-three significantly differentially expressed cytokines were detected, among which three cytokines, interleukin (IL)-17, macrophage inflammatory protein (MIP)-1α, and MIP-1β, with the largest Gini scores were identified by RF, and further evaluated for their significant changes in serum levels. A receiver-operator characteristic analysis revealed that the logistic regression panel could differentiate LGDH from LKYD (P < 0.001; AUC = 0.827). A functional pathway analysis showed that cytokine-cytokine receptor interaction, cytosolic DNA-sensing pathway, and chemokine signaling pathway overlapped between LGDH and LKYD, whereas Toll-like receptor signaling pathway, intestinal immune network for IgA production, NOD-like receptor signaling pathway, and Jak-STAT signaling pathway were only enriched in LGDH.
    Conclusions: There were characteristic cytokines profiles in LGDH and LKYD with different inflammatory and immune responses. IL-17, MIP-1α, and MIP-1β might be involved in the differentiation of LGDH and LKYD in CHB.
    Language English
    Publishing date 2015-08-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2260322-0
    ISSN 1749-8546
    ISSN 1749-8546
    DOI 10.1186/s13020-015-0055-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Evidence-Based ZHENG: A Traditional Chinese Medicine Syndrome 2013.

    Su, Shi-Bing / Jia, Wei / Lu, Aiping / Li, Shao

    Evidence-based complementary and alternative medicine : eCAM

    2014  Volume 2014, Page(s) 484201

    Language English
    Publishing date 2014-05-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2014/484201
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5995: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Study of ZHENG differentiation in hepatitis B-caused cirrhosis: a transcriptional profiling analysis.

    Lu, Yi-Yu / Chen, Qi-Long / Guan, Yan / Guo, Zhi-Zhong / Zhang, Hui / Zhang, Wei / Hu, Yi-Yang / Su, Shi-Bing

    BMC complementary and alternative medicine

    2014  Volume 14, Page(s) 371

    Abstract: Background: In traditional Chinese medicine (TCM) clinical practice, ZHENG (also known as TCM ... However, the scientific basis of ZHENG remains unclear due to limitations of current reductionist approaches.: Methods ... PSMD2 may be involved in ZHENG differentiation of DHAS and LDSDS in HBC. ...

    Abstract Background: In traditional Chinese medicine (TCM) clinical practice, ZHENG (also known as TCM syndrome) helps to understand the human homeostasis and guide individualized treatment. However, the scientific basis of ZHENG remains unclear due to limitations of current reductionist approaches.
    Methods: We collected the leukocyte samples of three hepatitis B-caused cirrhosis (HBC) patients with dampness-heat accumulation syndrome (DHAS) and three HBC patients with liver depression and spleen deficiency syndrome (LDSDS) for microarray analysis. We generated Gene-Regulatory-Networks (GeneRelNet) from the differentially expressed genes (DEGs) of microarray date. Core genes were validated using anther independent cohort of 40 HBC patients (20 DHAS, 20 LDSDS) with RT-PCR.
    Results: There were 2457 mapped genes were differentially expressed between DHAS and LDSDS (Fold change ≥ 2.0, P < 0.05). There were markedly different genes co-expression patterns in DHAS and LDSDS. Furthermore, three differential co-expression genes including purine nucleoside phosphorylase (PNP); aquaporin 7 (AQP7) and proteasome 26S subunit, non-ATPase 2 (PSMD2) were screened by GeneRelNets, and their mRNA expressions were further validated by real time RT-PCR. The results were consistent with microarray. The PNP (P = 0.007), AQP7 (P = 0.038) and PSMD2 (P = 0.009) mRNA expression is significant difference between DHAS and LDSDS using the non-parametric test. Furthermore, we constructed an mRNA panel of PNP, AQP7 and PSMD2 (PAP panel) by logistic regression model, and evaluated the PAP panel to distinguish DHAS from LDSDS by area under the receiver operating characteristic curve (AUC) analysis, which showed a higher accuracy (AUC = 0.835). Gene ontology (GO) analysis indicated that the DHAS is most likely related to system process while the functions overrepresented by LDSDS most related to the response to stimulus.
    Conclusions: This study suggested that there are particular transcriptional profiles, genes co-expressions patterns and functional properties of DHAS and LDSDS, and PNP, AQP7, and PSMD2 may be involved in ZHENG differentiation of DHAS and LDSDS in HBC.
    MeSH term(s) Cluster Analysis ; Female ; Gene Expression Profiling/methods ; Hepatitis B/blood ; Hepatitis B/genetics ; Hepatitis B/metabolism ; Hepatitis B/pathology ; Humans ; Liver Cirrhosis/genetics ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/pathology ; Liver Cirrhosis/virology ; Male ; Medicine, Chinese Traditional/methods ; Middle Aged ; ROC Curve ; Transcriptome
    Language English
    Publishing date 2014-10-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2050429-9
    ISSN 1472-6882 ; 1472-6882
    ISSN (online) 1472-6882
    ISSN 1472-6882
    DOI 10.1186/1472-6882-14-371
    Database MEDical Literature Analysis and Retrieval System OnLINE

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