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  1. Article ; Online: Hardiness predicts mental health recovery during the COVID-19 pandemic.

    Wu, Emily W / Hagan, Melissa J / Eschleman, Kevin / Gard, David E

    Psychological trauma : theory, research, practice and policy

    2024  

    Abstract: Objective: The COVID-19 pandemic has elicited wide-scale general psychological distress; however, longitudinal investigations are required to identify the critical resources that support individuals' adaptation to this type of unique situation over time. ...

    Abstract Objective: The COVID-19 pandemic has elicited wide-scale general psychological distress; however, longitudinal investigations are required to identify the critical resources that support individuals' adaptation to this type of unique situation over time. Hardiness, a cognitive trait that facilitates adaptation in the context of adversity and possible posttraumatic growth, may be particularly influential on mental health recovery during health disasters when other resources are not available or effective.
    Method: We tested the hypothesis that greater psychological hardiness prior to the pandemic would predict lower traumatic stress symptoms (TSSs) and loneliness early into the pandemic and decreases in TSSs and loneliness between early 2020 and late 2021. Predominantly ethnic minority (77% Latina/o/x or Asian American) female young adults (
    Results: Latent growth curve analyses indicated that hardiness was associated with lower initial loneliness as well as decreases in TSSs and loneliness over time.
    Conclusions: Consistent with previous research on adaptation to other potentially traumatic stressors, the current findings suggest that psychological hardiness may play a critical protective role during a global health disaster, both in terms of initial distress and changes in distress over time. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2497028-1
    ISSN 1942-969X ; 1942-9681
    ISSN (online) 1942-969X
    ISSN 1942-9681
    DOI 10.1037/tra0001660
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A Rare Case of Esophageal Carcinoma Cuniculatum Palliated by Esophageal and Endobronchial Stenting.

    Bell, Matthew T / Woo, Kenneth K / Wu, Meifang / Yap, Caroline / Hsia, David W / Reicher, Sofiya

    ACG case reports journal

    2024  Volume 11, Issue 2, Page(s) e01254

    Abstract: Carcinoma cuniculatum is a rare variant of well-differentiated squamous cell carcinoma. To date, there are less than 30 cases of esophageal carcinoma cuniculatum reported. It is frequently a diagnostic challenge: A definitive diagnosis typically cannot ... ...

    Abstract Carcinoma cuniculatum is a rare variant of well-differentiated squamous cell carcinoma. To date, there are less than 30 cases of esophageal carcinoma cuniculatum reported. It is frequently a diagnostic challenge: A definitive diagnosis typically cannot be made before esophagectomy. We present a uniquely aggressive case of esophageal carcinoma cuniculatum complicated by a bronchoesophageal fistula and successfully palliated with dual esophageal and endobronchial stenting.
    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2814825-3
    ISSN 2326-3253
    ISSN 2326-3253
    DOI 10.14309/crj.0000000000001254
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Mind-Body Interventions for Youth with Chronic Medical Conditions: A Scoping Review of the Literature.

    Srinivasan, Roshini / McVoy, Molly / Neudecker, Mandy / Divan, Mina Kumari / Wu, Amy / Cascio, Michelle E / Dusek, Jeffery A / Miller, David W

    Journal of integrative and complementary medicine

    2024  

    Abstract: Background and purpose: ...

    Abstract Background and purpose:
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article
    ISSN 2768-3613
    ISSN (online) 2768-3613
    DOI 10.1089/jicm.2023.0427
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  4. Article ; Online: Limbic-predominant age-related TDP-43 encephalopathy (LATE-NC): Co-pathologies and genetic risk factors provide clues about pathogenesis.

    Nelson, Peter T / Fardo, David W / Wu, Xian / Aung, Khine Zin / Cykowski, Matthew D / Katsumata, Yuriko

    Journal of neuropathology and experimental neurology

    2024  

    Abstract: Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is detectable at autopsy in more than one-third of people beyond age 85 years and is robustly associated with dementia independent of other pathologies. Although LATE- ... ...

    Abstract Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is detectable at autopsy in more than one-third of people beyond age 85 years and is robustly associated with dementia independent of other pathologies. Although LATE-NC has a large impact on public health, there remain uncertainties about the underlying biologic mechanisms. Here, we review the literature from human studies that may shed light on pathogenetic mechanisms. It is increasingly clear that certain combinations of pathologic changes tend to coexist in aging brains. Although "pure" LATE-NC is not rare, LATE-NC often coexists in the same brains with Alzheimer disease neuropathologic change, brain arteriolosclerosis, hippocampal sclerosis of aging, and/or age-related tau astrogliopathy (ARTAG). The patterns of pathologic comorbidities provide circumstantial evidence of mechanistic interactions ("synergies") between the pathologies, and also suggest common upstream influences. As to primary mediators of vulnerability to neuropathologic changes, genetics may play key roles. Genes associated with LATE-NC include TMEM106B, GRN, APOE, SORL1, ABCC9, and others. Although the anatomic distribution of TDP-43 pathology defines the condition, important cofactors for LATE-NC may include Tau pathology, endolysosomal pathways, and blood-brain barrier dysfunction. A review of the human phenomenology offers insights into disease-driving mechanisms, and may provide clues for diagnostic and therapeutic targets.
    Language English
    Publishing date 2024-04-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 3088-0
    ISSN 1554-6578 ; 0022-3069
    ISSN (online) 1554-6578
    ISSN 0022-3069
    DOI 10.1093/jnen/nlae032
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  5. Article ; Online: Kidney Failure Events, Cardiovascular Disease Events, and All-Cause Mortality in Patients with IgA Nephropathy in a Real-World Database.

    Lerma, Edgar V / Thakker, Kamlesh M / Bensink, Mark E / Lieblich, Richard / Bunke, C Martin / Gong, Wu / Rava, Andrew R / Wang, Kaijun / Amari, Diana T / Oliveri, David / Murphy, Michael V / Cork, David M W / Velez, Juan Carlos Q

    Kidney360

    2024  Volume 5, Issue 3, Page(s) 427–436

    MeSH term(s) Humans ; Glomerulonephritis, IGA/complications ; Cardiovascular Diseases/epidemiology ; Kidney ; Renal Insufficiency
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Journal Article
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0000000000000379
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  6. Article: Differentiation of Andean and Mesoamerican accessions in a proposed core collection of grain amaranths.

    Blair, Matthew W / Londoño, Jorge M / Buitrago-Bitar, María A / Wu, Xingbo / Brenner, David M

    Frontiers in plant science

    2023  Volume 14, Page(s) 1144681

    Abstract: Grain amaranths are made up of three New World species of pseudo-cereals with ... ...

    Abstract Grain amaranths are made up of three New World species of pseudo-cereals with C
    Language English
    Publishing date 2023-03-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1144681
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  7. Article ; Online: Network proteomic analysis identifies inter-alpha-trypsin inhibitor heavy chain 4 during early human Achilles tendon healing as a prognostic biomarker of good long-term outcomes.

    Wu, Xinjie / Chen, Junyu / Sun, Wei / Hart, David A / Ackermann, Paul W / Ahmed, Aisha S

    Frontiers in immunology

    2023  Volume 14, Page(s) 1191536

    Abstract: The suboptimal or protracted regeneration of injured connective tissues often results in significant dysfunction, pain, and functional disability. Despite the prevalence of the condition, few studies have been conducted which focused on biomarkers or key ...

    Abstract The suboptimal or protracted regeneration of injured connective tissues often results in significant dysfunction, pain, and functional disability. Despite the prevalence of the condition, few studies have been conducted which focused on biomarkers or key molecules involved in processes governing healing outcomes. To gain insight into injured connective tissue repair, and using the Achilles tendon as a model system, we utilized quantitative proteomic and weighted co-expression network analysis of tissues acquired from Achilles tendon rupture (ATR) patients with different outcomes at 1-year postoperatively. Two modules were detected to be associated with prognosis. The initial analysis identified inter-alpha-trypsin inhibitor heavy chain 4
    Trial registration: http://clinicaltrials.gov, identifiers NCT02318472, NCT01317160.
    MeSH term(s) Humans ; Achilles Tendon/surgery ; Prognosis ; Proteomics ; Biomarkers
    Chemical Substances inter-alpha-inhibitor (39346-44-6) ; Biomarkers
    Language English
    Publishing date 2023-07-06
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1191536
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  8. Article ; Online: Post-Application Field Persistence and Efficacy of

    Wu, Shaohui / Toews, Michael D / Behle, Robert W / Barman, Apurba K / Sparks, Alton N / Simmons, Alvin M / Shapiro-Ilan, David I

    Journal of fungi (Basel, Switzerland)

    2023  Volume 9, Issue 8

    Abstract: Previously, ...

    Abstract Previously,
    Language English
    Publishing date 2023-08-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof9080827
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  9. Article ; Online: Vascular thiol isomerases in thrombosis: The yin and yang.

    Wu, Yi / Essex, David W

    Journal of thrombosis and haemostasis : JTH

    2020  Volume 18, Issue 11, Page(s) 2790–2800

    Abstract: There has recently been considerable progress of the field of extracellular protein disulfide isomerases with vascular thiol isomerases in the forefront. Four members of protein disulfide isomerase (PDI) family of enzymes, PDI, ERp57, ERp72, and ERp5, ... ...

    Abstract There has recently been considerable progress of the field of extracellular protein disulfide isomerases with vascular thiol isomerases in the forefront. Four members of protein disulfide isomerase (PDI) family of enzymes, PDI, ERp57, ERp72, and ERp5, have been shown to be secreted from activated platelets and endothelial cells at the site of vascular injury. Each isomerase individually supports platelet accumulation and coagulation, as indicated by multiple levels of evidence, including inhibitory antibodies, targeted knockout mice, and mutant isomerases. The transmembrane PDI family member TMX1 was recently shown to inhibit platelet function and thrombosis, demonstrating that the PDIs can have opposing functions in thrombosis. These observations provide a new concept that thiol isomerases can both positively and negatively regulate hemostasis, constituting off-on redox switches controlling activation of hemostatic factors. This redox network serves to maintain vascular homeostasis. Integrins such as the αIIbβ3 fibrinogen receptor on platelets appear to be major substrates, with the platelet receptor for von Willebrand factor, glycoprotein Ibα, as another substrate. S-nitrosylation of the prothrombotic PDIs may additionally negatively regulate platelets and thrombosis. Thiol isomerases also regulate coagulation in mouse models, and a clinical trial with the oral PDI inhibitor isoquercetin substantially decreased markers of coagulation in patients at risk for thrombosis. This review updates recent findings in the field and addresses emerging evidence that thiol/disulfide-based reactions mediated by the prothrombotic secreted PDIs are balanced by the transmembrane member of this family, TMX1.
    MeSH term(s) Animals ; Blood Platelets ; Endothelial Cells ; Humans ; Mice ; Platelet Glycoprotein GPIIb-IIIa Complex ; Protein Disulfide-Isomerases ; Sulfhydryl Compounds ; Thrombosis
    Chemical Substances Platelet Glycoprotein GPIIb-IIIa Complex ; Sulfhydryl Compounds ; Protein Disulfide-Isomerases (EC 5.3.4.1)
    Language English
    Publishing date 2020-08-24
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/jth.15019
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  10. Article ; Online: Rolling of soft microbots with tunable traction.

    Gao, Yan / Sprinkle, Brennan / Springer, Ela / Marr, David W M / Wu, Ning

    Science advances

    2023  Volume 9, Issue 16, Page(s) eadg0919

    Abstract: Microbot (μbot)-based targeted drug delivery has attracted increasing attention due to its potential for avoiding side effects associated with systemic delivery. To date, most μbots are rigid. When rolling on surfaces, they exhibit substantial slip due ... ...

    Abstract Microbot (μbot)-based targeted drug delivery has attracted increasing attention due to its potential for avoiding side effects associated with systemic delivery. To date, most μbots are rigid. When rolling on surfaces, they exhibit substantial slip due to the liquid lubrication layer. Here, we introduce magnetically controlled soft rollers based on Pickering emulsions that, because of their intrinsic deformability, fundamentally change the nature of the lubrication layer and roll like deflated tires. With a large contact area between μbot and wall, soft μbots exhibit tractions higher than their rigid counterparts, results that we support with both theory and simulation. Upon changing the external field, surface particles can be reconfigured, strongly influencing both the translation speed and traction. These μbots can also be destabilized upon pH changes and used to deliver their contents to a desired location, overcoming the limitations of low translation efficiency and drug loading capacity associated with rigid structures.
    Language English
    Publishing date 2023-04-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adg0919
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