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  1. Article ; Online: The Imperative to Vaccinate.

    Hedrick, Stephen M

    The Journal of pediatrics

    2018  Volume 201, Page(s) 259–263

    MeSH term(s) Measles-Mumps-Rubella Vaccine ; Vaccination
    Chemical Substances Measles-Mumps-Rubella Vaccine
    Keywords covid19
    Language English
    Publishing date 2018-07-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2018.06.041
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  2. Article ; Online: Editorial overview: Lymphocyte effector subsets: blurring the frontiers.

    Reynaud, Claude-Agnès / Hedrick, Stephen M

    Current opinion in immunology

    2020  Volume 63, Page(s) iii–v

    MeSH term(s) Animals ; B-Lymphocytes/immunology ; Humans ; Lymphocyte Subsets/immunology ; T-Lymphocytes/immunology
    Language English
    Publishing date 2020-05-02
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2020.04.001
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    Zs.A 2773: Show issues Location:
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  3. Article ; Online: Understanding Immunity through the Lens of Disease Ecology.

    Hedrick, Stephen M

    Trends in immunology

    2017  Volume 38, Issue 12, Page(s) 888–903

    Abstract: As we describe the immune system in ever more exquisite detail, we might find that no matter how successful, this approach will not be sufficient to understand the spread of infectious agents, their susceptibility to vaccine therapy, and human disease ... ...

    Abstract As we describe the immune system in ever more exquisite detail, we might find that no matter how successful, this approach will not be sufficient to understand the spread of infectious agents, their susceptibility to vaccine therapy, and human disease resistance. Compared with the strict reductionism practiced as a means of characterizing most biological processes, I propose that the progression and outcome of disease-causing host-parasite interactions will be more clearly understood through a focus on disease ecology.
    MeSH term(s) Animals ; Biological Evolution ; Coinfection/immunology ; Disease Transmission, Infectious ; Host-Pathogen Interactions/immunology ; Humans ; Immunity ; Infection/immunology ; Models, Immunological ; Virulence ; Virulence Factors ; Zoonoses/immunology
    Chemical Substances Virulence Factors
    Language English
    Publishing date 2017
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2017.08.001
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  4. Article ; Online: A key control point in the T cell response to chronic infection and neoplasia: FOXO1.

    Marcel, Nimi / Hedrick, Stephen M

    Current opinion in immunology

    2020  Volume 63, Page(s) 51–60

    Abstract: T cells able to control neoplasia or chronic infections display a signature gene expression profile similar or identical to that of central memory T cells. These cells have qualities of self-renewal and a plasticity that allow them to repeatedly undergo ... ...

    Abstract T cells able to control neoplasia or chronic infections display a signature gene expression profile similar or identical to that of central memory T cells. These cells have qualities of self-renewal and a plasticity that allow them to repeatedly undergo activation (growth, proliferation, and differentiation), followed by quiescence. It is these qualities that define the ability of T cells to establish an equilibrium with chronic infectious agents, and also preserve the ability of T cells to be re-activated (by checkpoint therapy) in response to malignant cancers. Here we describe distinctions between the forms of inhibition mediated by tumors and persistent viruses, we review the properties of T cells associated with long-term immunity, and we identify the transcription factor, FOXO1, as the control point for a program of gene expression that allows CD8
    MeSH term(s) Animals ; Cell Differentiation/immunology ; Chronic Disease ; Forkhead Box Protein O1/metabolism ; Humans ; Neoplasms/immunology ; T-Lymphocytes/immunology ; Virus Diseases/immunology
    Chemical Substances Forkhead Box Protein O1
    Language English
    Publishing date 2020-03-02
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2020.02.001
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  5. Article ; Online: A rheostat tuning thymic selection.

    Morris, Gerald P / Hedrick, Stephen M

    Nature immunology

    2017  Volume 18, Issue 7, Page(s) 713–714

    MeSH term(s) Cell Differentiation ; Endosomal Sorting Complexes Required for Transport ; Thymocytes
    Chemical Substances Endosomal Sorting Complexes Required for Transport
    Language English
    Publishing date 2017-06-20
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/ni.3778
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  6. Article ; Online: A

    Lai, Chen-Yen / Marcel, Nimi / Yaldiko, Allen W / Delpoux, Arnaud / Hedrick, Stephen M

    Journal of immunology (Baltimore, Md. : 1950)

    2022  Volume 209, Issue 6, Page(s) 1118–1127

    Abstract: In response to an intracellular infectious agent, the immune system produces a specific cellular response as well as a T cell-dependent Ab response. Precursor T cells differentiate into effector T cells, including Th1 cells, and T follicular helper ( ... ...

    Abstract In response to an intracellular infectious agent, the immune system produces a specific cellular response as well as a T cell-dependent Ab response. Precursor T cells differentiate into effector T cells, including Th1 cells, and T follicular helper (T
    MeSH term(s) Animals ; Germinal Center ; Humans ; Introns/genetics ; Mice ; Proto-Oncogene Proteins c-bcl-6/genetics ; Proto-Oncogene Proteins c-bcl-6/metabolism ; T Follicular Helper Cells ; T-Lymphocytes, Helper-Inducer ; Transcription Factors/metabolism
    Chemical Substances BCL6 protein, human ; Bcl6 protein, mouse ; Proto-Oncogene Proteins c-bcl-6 ; Transcription Factors
    Language English
    Publishing date 2022-08-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2100777
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    Ud II Zs.37: Show issues Location:
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    Zs.MG 28: Show issues

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  7. Article ; Online: Positive selection in the thymus: an enigma wrapped in a mystery.

    Hedrick, Stephen M

    Journal of immunology (Baltimore, Md. : 1950)

    2012  Volume 188, Issue 5, Page(s) 2043–2045

    MeSH term(s) Animals ; Peptide Fragments/physiology ; Receptors, Antigen, T-Cell/antagonists & inhibitors ; Receptors, Antigen, T-Cell/physiology ; T-Lymphocyte Subsets/immunology ; Thymus Gland/cytology
    Chemical Substances Peptide Fragments ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2012-01-25
    Publishing country United States
    Document type Journal Article ; Review ; Comment
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1200077
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  8. Article: Examining Multiteam Systems Across Context and Type: A Historiometric Analysis of Failed MTS Performance.

    Campbell, Lauren N P / Torres, Elisa M / Zaccaro, Stephen J / Zhou, Steven / Hedrick, Katelyn N / Wallace, David M / Luning, Celeste Raver / Zakzewski, Joanna E

    Frontiers in psychology

    2022  Volume 13, Page(s) 813624

    Abstract: Multiteam systems (MTSs) are complex organizational forms comprising interdependent teams that work towards their own proximal goals within and across teams to also accomplish a shared superordinate goal. MTSs operate within high-stakes, dangerous ... ...

    Abstract Multiteam systems (MTSs) are complex organizational forms comprising interdependent teams that work towards their own proximal goals within and across teams to also accomplish a shared superordinate goal. MTSs operate within high-stakes, dangerous contexts with high consequences for suboptimal performance. We answer calls for nuanced exploration and cross-context comparison of MTSs "in the wild" by leveraging the MTS action sub-phase behavioral taxonomy to determine where and how MTS failures occur. To our knowledge, this is the first study to also examine how key MTS attributes (boundary status, goal type) influence MTS processes and performance. We conducted historiometric analysis on 40 cases of failed MTS performance across various contexts (e.g., emergency response, commercial transportation, military, and business) to uncover patterns of within- and between-team behaviors of failing MTSs, resulting in four themes. First, component teams of failing MTSs over-engaged in within-team alignment behaviors (vs. between-team behaviors) by enacting acting, monitoring, and recalibrating behaviors more often within than between teams. Second, failing MTSs over-focused on acting behaviors (vs. monitoring or recalibrating) and tended to not fully enact the action sub-phase cycle. Third and fourth, boundary status and goal type exacerbated these behavioral patterns, as external and physical MTSs were less likely to enact sufficient between-team behaviors or fully enact the action sub-phase cycle compared to internal and intellectual MTSs. We propose entrainment as a mechanism for facilitating MTS performance wherein specific, cyclical behavioral patterns enacted by teams align to facilitate goal achievement
    Language English
    Publishing date 2022-03-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.813624
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  9. Article ; Online: Immune system: not so superior.

    Hedrick, Stephen M

    Science (New York, N.Y.)

    2009  Volume 325, Issue 5948, Page(s) 1623–1624

    MeSH term(s) Animals ; Biological Evolution ; Immune System/physiology ; Immunity ; Immunity, Innate ; Invertebrates/immunology ; Selection, Genetic ; Vertebrates/immunology
    Language English
    Publishing date 2009-09-24
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.325_1623a
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  10. Article ; Online: Disentangling Mechanical and Sensory Modules in the Radiation of Noctilionoid Bats.

    Mutumi, Gregory L / Hall, Ronald P / Hedrick, Brandon P / Yohe, Laurel R / Sadier, Alexa / Davies, Kalina T J / Rossiter, Stephen J / Sears, Karen E / Dávalos, Liliana M / Dumont, Elizabeth R

    The American naturalist

    2023  Volume 202, Issue 2, Page(s) 216–230

    Abstract: AbstractWith diverse mechanical and sensory functions, the vertebrate cranium is a complex anatomical structure whose shifts between modularity and integration, especially in mechanical function, have been implicated in adaptive diversification. Yet how ... ...

    Abstract AbstractWith diverse mechanical and sensory functions, the vertebrate cranium is a complex anatomical structure whose shifts between modularity and integration, especially in mechanical function, have been implicated in adaptive diversification. Yet how mechanical and sensory systems and their functions coevolve, as well as how their interrelationship contributes to phenotypic disparity, remain largely unexplored. To examine the modularity, integration, and evolutionary rates of sensory and mechanical structures within the head, we analyzed hard and soft tissue scans from ecologically diverse bats in the superfamily Noctilionoidea, a clade that ranges from insectivores and carnivores to frugivores and nectarivores. We identified eight regions that evolved in a coordinated fashion, thus recognizable as evolutionary modules: five associated with bite force and three linked to olfactory, visual, and auditory systems. Interrelationships among these modules differ between Neotropical leaf-nosed bats (family Phyllostomidae) and other noctilionoids. Consistent with the hypothesis that dietary transitions begin with changes in the capacity to detect novel food items followed by adaptations to process them, peak rates of sensory module evolution predate those of some mechanical modules. We propose that the coevolution of structures influencing bite force, olfaction, vision, and hearing constituted a structural opportunity that allowed the phyllostomid ancestor to take advantage of existing ecological opportunities and contributed to the clade's remarkable radiation.
    MeSH term(s) Animals ; Chiroptera ; Skull ; Adaptation, Physiological ; Diet ; Acclimatization ; Phylogeny ; Biological Evolution
    Language English
    Publishing date 2023-06-12
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 207092-3
    ISSN 1537-5323 ; 0003-0147
    ISSN (online) 1537-5323
    ISSN 0003-0147
    DOI 10.1086/725368
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