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  1. Article ; Online: Regina Elena Institute (R.E.I.) Protocol for Breast Implant Salvage: Preliminary Results.

    Zoccali, Giovanni / Pozzi, Marcello / Gullo, Pierpaolo / Michelina, Veronica Vietti / Botti, Claudio / De Vita, Roy

    Clinical breast cancer

    2023  Volume 24, Issue 1, Page(s) 65–71

    Abstract: Introduction: implants are the most popular means of restoring the breast mound after mastectomy; the most feared complication is implant infection accounting for 4.8% to 35.4% of cases. Various antibiotic regimens or other surgical revisions to treat ... ...

    Abstract Introduction: implants are the most popular means of restoring the breast mound after mastectomy; the most feared complication is implant infection accounting for 4.8% to 35.4% of cases. Various antibiotic regimens or other surgical revisions to treat implant infections have been reported, but their failure rates are unacceptable. Implant removal is subsequently the most common recourse for managing prosthesis infections. we report preliminary results of infected breast implant salvage using our Regina Elena Institute (REI) protocol.
    Methods: Since June 2021, a prospective single-centre study has been ongoing for patients burdened by implant infection or exposure. All qualifying participants underwent our REI protocol. They receive a temporary smooth implant and 1 week of implant's pocket irrigation with antibiotic solution along with systemic antibiotic and then a new permanent prosthesis positioning.
    Results: Ten of whom completed at least 6 months of follow-up and were eligible for this preliminary analysis. Overall, the REI protocol was applied to 13 breasts. No infections relapsed during the 6-month minimum follow-up intervals; and no early capsular contraction was evident, resulting in good cosmetic outcomes for every treated breast.
    Discussion: The smooth-surfaced implant's sizer helps maintain tissue expansion, preventing skin retraction; and the slightly smaller diameters used (compared with originals) facilitate antibiotic wash distribution. Combining a targeted systemic antibiotic and a topical agent is the best way to optimise infection resolution. This preliminary analysis has clear limitations. A larger population is warranted to increase the level of evidence. Longer follow-up is also advisable to monitor for delayed infection recurrence.
    MeSH term(s) Humans ; Female ; Breast Implants/adverse effects ; Prospective Studies ; Breast Neoplasms/surgery ; Breast Neoplasms/drug therapy ; Mastectomy/adverse effects ; Mammaplasty/methods ; Anti-Bacterial Agents/therapeutic use ; Retrospective Studies
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-09-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2106734-X
    ISSN 1938-0666 ; 1526-8209
    ISSN (online) 1938-0666
    ISSN 1526-8209
    DOI 10.1016/j.clbc.2023.09.015
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  2. Article: Radiofrequency Echographic Multi Spectrometry (R.E.M.S.): New Frontiers for Ultrasound Use in the Assessment of Bone Status-A Current Picture.

    Al Refaie, Antonella / Baldassini, Leonardo / Mondillo, Caterina / Giglio, Elisa / De Vita, Michela / Tomai Pitinca, Maria Dea / Gonnelli, Stefano / Caffarelli, Carla

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 10

    Abstract: Osteoporosis is a frequently occurring skeletal disease, and osteoporosis-related fractures represent a significant burden for healthcare systems. Dual-Energy X-ray Absorptiometry (DXA) is the most commonly used method for assessing bone mineral density ( ...

    Abstract Osteoporosis is a frequently occurring skeletal disease, and osteoporosis-related fractures represent a significant burden for healthcare systems. Dual-Energy X-ray Absorptiometry (DXA) is the most commonly used method for assessing bone mineral density (BMD). Today, particular attention is being directed towards new technologies, especially those that do not use radiation, for the early diagnosis of altered bone status. Radiofrequency Echographic Multi Spectrometry (REMS) is a non-ionizing technology that evaluates the bone status at axial skeletal sites by analyzing raw ultrasound signals. In this review, we evaluated the data on the REMS technique present in the literature. The literature data confirmed diagnostic concordance between BMD values obtained using DXA and REMS. Furthermore, REMS has adequate precision and repeatability characteristics, is able to predict the risk of fragility fractures, and may be able to overcome some of the limitations of DXA. In conclusion, REMS could become the method of choice for the assessment of bone status in children, in women of childbearing age or who are pregnant, and in several secondary osteoporosis conditions due to its good precision and replicability, its transportability, and the absence of ionizing radiation. Finally, REMS may allow qualitative and not just quantitative assessments of bone status.
    Language English
    Publishing date 2023-05-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13101666
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  3. Article ; Online: The inward FDI - Energy intensity nexus in OECD countries: A sectoral R&D threshold analysis.

    De Vita, Glauco / Li, Chengchun / Luo, Yun

    Journal of environmental management

    2021  Volume 287, Page(s) 112290

    Abstract: ... development (R&D) technological absorptive capacity. Our sample covers 34 OECD countries over 1987-2013 ... with FDI and R&D data disaggregated at three sectoral levels (primary, secondary and tertiary sectors ... an analysis that is absent in existing literature. We uncover a significant R&D input threshold ...

    Abstract Over recent years, concerns about the need to reduce energy intensity have intensified due to the increasing volume of greenhouse gas emissions that has amplified problems related to global climate change and environmental pollution. At the same time, foreign direct investment (FDI) has been found to have a prominent effect on energy intensity. This study empirically examines the relationship between sectoral FDI inflows and energy intensity by investigating the possibility of a threshold effect of research and development (R&D) technological absorptive capacity. Our sample covers 34 OECD countries over 1987-2013, with FDI and R&D data disaggregated at three sectoral levels (primary, secondary and tertiary sectors), an analysis that is absent in existing literature. We uncover a significant R&D input threshold in the relationship between FDI inflows to non-primary sectors and energy intensity. FDI inflows to non-primary sectors increase the level of energy intensity when the level of sectoral R&D is below the threshold, but such effect decreases when the sectoral R&D level is above the threshold point. Important implications flow from our findings with respect to the type of FDI and the level of indigenous R&D to be encouraged (or discouraged) by policymakers to effectively reduce energy intensity.
    MeSH term(s) Carbon Dioxide ; Economic Development ; Investments ; Organisation for Economic Co-Operation and Development ; Research
    Chemical Substances Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2021-03-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2021.112290
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  4. Article ; Online: A Randomized Controlled Trial of Long-Term (R)-α-Lipoic Acid Supplementation Promotes Weight Loss in Overweight or Obese Adults without Altering Baseline Elevated Plasma Triglyceride Concentrations.

    Bobe, Gerd / Michels, Alexander J / Zhang, Wei-Jian / Purnell, Jonathan Q / Woffendin, Clive / Pereira, Cliff / Vita, Joseph A / Thomas, Nicholas O / Traber, Maret G / Frei, Balz / Hagen, Tory M

    The Journal of nutrition

    2020  Volume 150, Issue 9, Page(s) 2336–2345

    Abstract: ... trial, assigned to either (R)-α-lipoic acid (R-LA; 600 mg/d) or matching placebo, and advised not ... from baseline for primary and secondary endpoints.: Results: R-LA did not decrease triglyceride ... concentrations, but individuals on R-LA had a greater reduction in BMI at 24 wk than the placebo group (-0.8; P ...

    Abstract Background: α-Lipoic acid (LA) is a dietary supplement for maintaining energy balance, but well-controlled clinical trials in otherwise healthy, overweight adults using LA supplementation are lacking.
    Objectives: The primary objective was to evaluate whether LA supplementation decreases elevated plasma triglycerides in overweight or obese adults. Secondary aims examined if LA promotes weight loss and improves oxidative stress and inflammation.
    Methods: Overweight adults [n = 81; 57% women; 21-60 y old; BMI (in kg/m2) ≥ 25] with elevated plasma triglycerides ≥100 mg/dL were enrolled in a 24-wk, randomized, double-blind, controlled trial, assigned to either (R)-α-lipoic acid (R-LA; 600 mg/d) or matching placebo, and advised not to change their diet or physical activity. Linear models were used to evaluate treatment effects from baseline for primary and secondary endpoints.
    Results: R-LA did not decrease triglyceride concentrations, but individuals on R-LA had a greater reduction in BMI at 24 wk than the placebo group (-0.8; P = 0.04). The effect of R-LA on BMI was correlated to changes in plasma triglycerides (r = +0.50, P = 0.004). Improvement in body weight was greater at 24 wk in R-LA subgroups than in placebo subgroups. Women and obese participants (BMI ≥ 35) showed greater weight loss (-5.0% and -4.8%, respectively; both P < 0.001) and loss of body fat (-9.4% and -8.6%, respectively; both P < 0.005). Antioxidant gene expression in mononuclear cells at 24 wk was greater in the R-LA group (Heme oxygenase 1 [HMOX1] : +22%; P = 0.02) than in placebo. Less urinary F2-isoprostanes (-25%; P = 0.005), blood leukocytes (-10.1%; P = 0.01), blood thrombocytes (-5.1%; P = 0.03), and ICAM-1 (-7.4%; P = 0.04) at 24 wk were also observed in the R-LA group than in placebo.
    Conclusions: Long-term LA supplementation results in BMI loss, greater antioxidant enzyme synthesis, and less potential for inflammation in overweight adults. Improved cellular bioenergetics is also evident in some individuals given R-LA.This trial was registered at clinicaltrials.gov as NCT00765310.
    MeSH term(s) Adult ; Dietary Supplements ; Drug Administration Schedule ; Exercise ; Female ; Humans ; Male ; Middle Aged ; Overweight/drug therapy ; Thioctic Acid/administration & dosage ; Triglycerides/blood ; Weight Loss ; Young Adult
    Chemical Substances Triglycerides ; Thioctic Acid (73Y7P0K73Y)
    Language English
    Publishing date 2020-07-15
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
    ZDB-ID 218373-0
    ISSN 1541-6100 ; 0022-3166
    ISSN (online) 1541-6100
    ISSN 0022-3166
    DOI 10.1093/jn/nxaa203
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  5. Book: Cancer drug development / A / Contrib. to this vol. R. W. Brockman ...

    Brockman, R. W. / Block, Jerome B. / DeVita, Vincent T.

    (Methods in cancer research ; 16)

    1979  

    Author's details ed. by Vincent T. DeVita
    Series title Methods in cancer research ; 16
    Cancer drug development
    Collection Cancer drug development
    Language English
    Size XX, 456 S. : graph. Darst.
    Publisher Academic Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT001550801
    ISBN 0-12-147676-6 ; 978-0-12-147676-2
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Se 414 -16- verfügbar in Königswinter Königswinter

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  6. Article ; Online: Aminoquinoline melanin-concentrating hormone 1-receptor (MCH1-R) antagonists.

    DeVita, Robert J

    Current topics in medicinal chemistry

    2007  Volume 7, Issue 15, Page(s) 1433–1439

    Abstract: Structure-activity relationships of a 4-aminoquinoline MCH-1R antagonist lead series were explored by synthesis of analogs with modifications at the 2-, 4- and 6-positions of the original HTS hit. Improvements to the original screening lead were made by ... ...

    Abstract Structure-activity relationships of a 4-aminoquinoline MCH-1R antagonist lead series were explored by synthesis of analogs with modifications at the 2-, 4- and 6-positions of the original HTS hit. Improvements to the original screening lead were made by addition of lipophilic groups at the 2-position and biphenyl, cyclohexyl phenyl and hydrocinnamyl carboxamides at the 6-position. Viable modifications of the 4-amino group were limited and did not allow further optimization of the physical-chemical properties of this class of compounds. Transposition of the 4-amino group to the 2-position of the quinoline core structure provided the 2-aminoquinoline lead class with similar MCH1R binding affinity. A series of 2-aminoquinoline compounds was prepared and evaluated in MCH-1R binding and functional antagonist assays. Small dialkyl, methylalkyl, methylcycloalkyl and cyclic amines along with 3-substituted pyrrolidines were tolerated at the quinoline 2-position. The in vivo efficacy of compound A was explored and compared to that of a related inactive compound B to determine their effects on food intake and body weight in rodents. The biological activities of this matched active -inactive pair provide in vivo proof of concept in rodents that antagonism of MCH1R by a 2-aminoquinoline MCH1R antagonist which led to a reduction of food intake in an acute feeding assay paradigm.
    MeSH term(s) Amination ; Aminoquinolines/chemistry ; Aminoquinolines/pharmacology ; Animals ; Drug Design ; Humans ; Receptors, Pituitary Hormone/antagonists & inhibitors ; Receptors, Pituitary Hormone/classification ; Receptors, Pituitary Hormone/metabolism ; Structure-Activity Relationship
    Chemical Substances Aminoquinolines ; Receptors, Pituitary Hormone ; melanin-concentrating hormone receptor
    Language English
    Publishing date 2007-09-25
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2064823-6
    ISSN 1873-4294 ; 1568-0266
    ISSN (online) 1873-4294
    ISSN 1568-0266
    DOI 10.2174/156802607782194789
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    Zs.A 5572: Show issues Location:
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  7. Article ; Online: Safety and efficacy of local periadventitial delivery of sirolimus for improving hemodialysis graft patency: first human experience with a sirolimus-eluting collagen membrane (Coll-R).

    Paulson, William D / Kipshidze, Nicholas / Kipiani, Konstantine / Beridze, Nutsa / DeVita, Maria V / Shenoy, Surendra / Iyer, Sriram S

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2012  Volume 27, Issue 3, Page(s) 1219–1224

    Abstract: ... Thus, therapies that inhibit neointimal hyperplasia are urgently needed. The Coll-R is a sirolimus-eluting ... polytetrafluoroethylene grafts + Coll-R and were followed for up to 24 months. The primary endpoint was safety (freedom ... of Coll-R implantation and primary unassisted graft patency.: Results: There were no technical failures ...

    Abstract Background: Neointimal hyperplasia causes a high rate of hemodialysis synthetic graft failure. Thus, therapies that inhibit neointimal hyperplasia are urgently needed. The Coll-R is a sirolimus-eluting collagen matrix designed for intra-operative perivascular implantation around the graft-venous anastomosis. Sirolimus is an anti-proliferative drug that has proven clinical utility in suppressing neointimal tissue growth in coronary artery disease when delivered locally to the vascular wall by an endovascular drug eluting stent.
    Methods: A cohort of 12 chronic hemodialysis patients underwent surgical placement of 13 polytetrafluoroethylene grafts + Coll-R and were followed for up to 24 months. The primary endpoint was safety (freedom from device related adverse events). Secondary endpoints were pharmacokinetics of sirolimus release, success of Coll-R implantation and primary unassisted graft patency.
    Results: There were no technical failures, infections, vascular anastomotic or wound-healing problems. Whole blood sirolimus levels rose to a mean peak of 4.8 ng/mL at 6 h and fell to <1 ng/mL at 1 week (n = 5). Twelve and 24-month primary unassisted patencies were 76 and 38%, respectively, and the thrombosis rate was 0.37/patient-year.
    Conclusions: Perivascular implantation of the Coll-R during graft surgery safely delivered sirolimus to the vascular wall. Systemic sirolimus levels were sub-therapeutic for immunosuppression. This small first-in-human study supports the concept that the Coll-R can safely deliver sirolimus to the graft-venous anastomosis. Safety and patency in this small study were sufficiently encouraging to justify randomized controlled trials to further test the efficacy of the Coll-R.
    MeSH term(s) Adolescent ; Adult ; Aged ; Blood Vessel Prosthesis Implantation ; Coated Materials, Biocompatible ; Collagen/metabolism ; Drug Delivery Systems ; Female ; Follow-Up Studies ; Humans ; Hypertension/drug therapy ; Hypertension/mortality ; Male ; Microscopy, Electron, Scanning ; Middle Aged ; Polytetrafluoroethylene ; Renal Dialysis ; Safety ; Sirolimus/administration & dosage ; Survival Rate ; Thrombosis/prevention & control ; Vascular Patency/drug effects ; Young Adult
    Chemical Substances Coated Materials, Biocompatible ; Polytetrafluoroethylene (9002-84-0) ; Collagen (9007-34-5) ; Sirolimus (W36ZG6FT64)
    Language English
    Publishing date 2012-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfr667
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    Zs.A 2198: Show issues Location:
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    Zs.MO 329: Show issues

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  8. Article ; Online: Ex Vivo Uniaxial Tensile Properties of Rat Uterosacral Ligaments.

    Donaldson, Kandace / De Vita, Raffaella

    Annals of biomedical engineering

    2023  Volume 51, Issue 4, Page(s) 702–714

    Abstract: This manuscript presents new experimental methods for testing the ex vivo tensile properties of the uterosacral ligaments (USLs) in rats. The USL specimens ([Formula: see text]) were carefully dissected to preserve their anatomical attachments, and they ... ...

    Abstract This manuscript presents new experimental methods for testing the ex vivo tensile properties of the uterosacral ligaments (USLs) in rats. The USL specimens ([Formula: see text]) were carefully dissected to preserve their anatomical attachments, and they were loaded along their main in vivo loading direction (MD) using a custom-built uniaxial tensile testing device. During loading, strain maps in both the MD and the perpendicular direction (PD) were collected using the digital image correlation technique. The mean (± S.E.M.) maximum load and displacement at the maximum load were [Formula: see text] N and [Formula: see text] mm, respectively. The USLs were found to be highly heterogeneous structures, with some specimens experiencing strains in the MD that were lower than [Formula: see text] and others reaching strains that were up to [Formula: see text] in the intermediate region. At 0.5 kPa stress, a value reached by all the specimens, the mean strain in the MD was [Formula: see text] while at 5 kPa stress, a value achieved only by 9 out of the 21 specimens, the mean strain increased to [Formula: see text]. Under uniaxial loading, the specimens also elongated in the PD, with strains that were one order of magnitude lower than the strains in the MD; at the 0.5 kPa stress, the mean strain in the PD was recorded to be [Formula: see text] and, at the 5 kPa stress, the strain in the PD was [Formula: see text]. The directions of maximum principal strains remained almost unchanged with the increase in stress, indicating that little microstructural re-organization occurred due to uniaxial loading. This study serves as a springboard for future investigations on the supportive function of the USLs in the rat model by offering guidelines on testing methods that capture their complex mechanical behavior.
    MeSH term(s) Female ; Animals ; Rats ; Biomechanical Phenomena ; Stress, Mechanical ; Uterus ; Ligaments
    Language English
    Publishing date 2023-01-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 185984-5
    ISSN 1573-9686 ; 0191-5649 ; 0090-6964
    ISSN (online) 1573-9686
    ISSN 0191-5649 ; 0090-6964
    DOI 10.1007/s10439-023-03135-y
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  9. Article ; Online: Use of different options of anti-inflammatory therapy in patients with severe COVID-19

    Vita Skoryk

    ScienceRise: Medical Science, Iss 5(44), Pp 22-

    2021  Volume 27

    Abstract: The aim of the study. To compare the effectiveness of methylprednisolone, dexamethasone and tocilizumab in patients with severe coronavirus disease. Identify the most appropriate treatment option. Materials and methods. Patients of group 1 (n=20) ... ...

    Abstract The aim of the study. To compare the effectiveness of methylprednisolone, dexamethasone and tocilizumab in patients with severe coronavirus disease. Identify the most appropriate treatment option. Materials and methods. Patients of group 1 (n=20) received for anti-inflammatory purposes tocilizumab at a dose of 600–800 mg. Patients in group 2 (n=82) received pulse therapy with methylprednisolone. Patients in group 3 (n=20) received dexamethasone 6 mg / day. Data are presented as M [25–75]. Statistical analysis of the results was performed using the program "Statistica 10". Significance of differences in indicators was assessed using the nonparametric Wilcoxon test. The results were considered reliable at values of p <0.05. Results. The severe course of coronavirus disease with the development of cytokine storm and respiratory distress syndrome is characterized by an increase in markers of inflammation: in group 1 the median CRP was 89.2 g / l, in group 2 – 64.2 g / l, and in 3 – 76.2 g / l, and did not differ significantly between groups (p> 0.05). The level of IL-6 in group 1 was 61.8 pg / ml, in group 2 – 64.6 pg / ml, and in group 3 – 46.5 pg / ml without significant differences between groups (p> 0.05). The level of ferritin in all groups exceeded normal values. Conclusions The most favourable result was obtained when using methylprednisolone: it was possible to reduce the mortality rate to 59.8 %. The relative risk of developing VTE was significantly higher in groups 1 and 3 (RR12 6.8 [2.7–16.8] p12 <0.0001, RR23 0.15 [0.06–0.35] p23 <0.0001), which gives grounds to confirm the presence of anticoagulant activity in methylprednisolone
    Keywords sars-ncov-2 ; covid-19 ; hypoxemic respiratory failure ; acute respiratory distress syndrome ; respiratory support ; cytokine storm ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher PC Technology Center
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Gender differences on the age-related distal-to-proximal shift in joint kinetics during running.

    Kearns, Zoey C / DeVita, Paul / Paquette, Max R

    Scandinavian journal of medicine & science in sports

    2023  Volume 34, Issue 1, Page(s) e14552

    Abstract: The increased running participation in women and men over 40 years has contributed to scientific interest on the age-related and gender differences in running performance and biomechanics over the last decade. Gender differences in running biomechanics ... ...

    Abstract The increased running participation in women and men over 40 years has contributed to scientific interest on the age-related and gender differences in running performance and biomechanics over the last decade. Gender differences in running biomechanics have been studied extensively in young runners, with inconsistent results. Understanding how gender influences the age-related differences in running mechanics could help develop population-specific training interventions or footwear to address any potential different mechanical demands. The purpose of this study was to assess gender and age effects on lower limb joint mechanics while running. Middle-aged men (57 ± 5 years) and women (57 ± 8 years) and young men (28 ± 6 years) and women (30 ± 6 years) completed five overground running trials at a set speed of 2.7 m/s while lower limb kinematics and ground reaction forces were collected. Lower limb joint kinetics were computed, normalized to body mass and compared between age and gender groups using two-factor analyses of variance. Women reported slower average running paces than men and middle-aged runners reported slower running paces than young runners. We confirmed that young runners run with more ankle, but less hip positive work and peak positive power compared to middle-aged runners (i.e., age-related distal-to-proximal shift in joint kinetics). We also present a novel finding that women run with more ankle, but less hip peak positive power compared to men suggesting an ankle dominant strategy in women at a preferred and comfortable running pace. However, the age-related distal-to-proximal shift in joint kinetics was not different between genders.
    MeSH term(s) Middle Aged ; Humans ; Female ; Male ; Knee Joint ; Sex Factors ; Lower Extremity ; Running ; Ankle ; Ankle Joint ; Biomechanical Phenomena ; Kinetics
    Language English
    Publishing date 2023-12-20
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1077418-x
    ISSN 1600-0838 ; 0905-7188
    ISSN (online) 1600-0838
    ISSN 0905-7188
    DOI 10.1111/sms.14552
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