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  1. Article ; Online: Effects of Mycophenolate Mofetil, Methotrexate and Pimecrolimus on cdk4 and p16 in Erosive Oral Lichen Planus.

    Goel, Sinny / Khurana, Nita

    Indian journal of dermatology

    2021  Volume 66, Issue 5, Page(s) 490–495

    Abstract: Background: This study evaluated the effect of mycophenolate mofetil, methotrexate, and pimecrolimus on the expression of cdk4 and p16, important proteins implicated in hyperproliferation and arrest in the G1 phase, in oral lichen planus (OLP).: ... ...

    Abstract Background: This study evaluated the effect of mycophenolate mofetil, methotrexate, and pimecrolimus on the expression of cdk4 and p16, important proteins implicated in hyperproliferation and arrest in the G1 phase, in oral lichen planus (OLP).
    Materials and methods: In this randomized clinical trial, 60 patients were randomly assigned in three equal groups to receive either pimecrolimus cream, or mycophenolate mofetil or methotrexate, both supplemented with pimecrolimus. Pretreatment and post-treatment specimens were immunohistochemically stained for detecting cdk4 and p16.
    Results: A significant decrease in cdk4 cytoplasmic positivity was noted in all three treatment groups and was especially more significant in the MTX group (
    Conclusion: By decreasing the expression of cdk4 and p16, pimecrolimus, methotrexate, and mycophenolate mofetil decrease the malignant potential of OLP lesions. However, methorexate can be a better alternative in cases showing high cdk4 expression.
    Language English
    Publishing date 2021-08-11
    Publishing country India
    Document type Journal Article
    ZDB-ID 416069-1
    ISSN 1998-3611 ; 0019-5154
    ISSN (online) 1998-3611
    ISSN 0019-5154
    DOI 10.4103/ijd.IJD_237_17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A rare case of beaten copper skull pattern associated with Treacher Collins syndrome

    Sunita Gupta / Anju Garg / Khusboo Singh / Sinny Goel

    Journal of Oral and Maxillofacial Radiology, Vol 4, Iss 3, Pp 76-

    2016  Volume 79

    Abstract: Treacher Collins syndrome (TCS) is an autosomal dominant disorder with craniofacial abnormality. Typical features are downslanting palpebral fissures, lower eyelid colobomas, microtia, and malar and mandibular hypoplasia. Management requires a ... ...

    Abstract Treacher Collins syndrome (TCS) is an autosomal dominant disorder with craniofacial abnormality. Typical features are downslanting palpebral fissures, lower eyelid colobomas, microtia, and malar and mandibular hypoplasia. Management requires a multidisciplinary team from birth through adulthood with proper planning, counselling, and surgical techniques. Here, we present a case of TCS with a very unusual and rare finding of beaten copper skull appearance on the radiograph.
    Keywords Beaten copper skull ; face ; Treacher Collins syndrome ; Dentistry ; RK1-715 ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Expression of cdk4 and p16 in Oral Lichen Planus

    Sinny Goel / Nita Khurana / Akanksha Marvah / Sunita Gupta

    Journal of Oral & Maxillofacial Research, Vol 6, Iss 2, p e

    2015  Volume 4

    Abstract: Objectives: The purpose of this study was to evaluate the expression of cdk4 and p16, the proteins implicated in hyperproliferation and arrest in oral lichen planus and to compare their expression in erosive and non-erosive oral lichen planus and with ... ...

    Abstract Objectives: The purpose of this study was to evaluate the expression of cdk4 and p16, the proteins implicated in hyperproliferation and arrest in oral lichen planus and to compare their expression in erosive and non-erosive oral lichen planus and with normal mucosa and oral squamous cell carcinoma. Material and Methods: Analysis of cdk4 and p16 expression was done in 43 erosive oral lichen planus (EOLP) and 17 non-erosive oral lichen planus (NOLP) cases, 10 normal mucosa and 10 oral squamous cell carcinoma (OSCC) cases with immunohistochemistry. Results: This study demonstrated a significantly increased expression of cytoplasmic cdk4 (80% cases, cells stained - 19.6%), and cytoplasmic p16 (68.3% cases, cells stained - 16.4%) in oral lichen planus (OLP) compared to normal mucosa. cdk4 was much higher in OSCC in both cytoplasm and nuclei compared to normal mucosa. Also, while comparing OLP with positive control, significant difference was noted for cdk4 and p16, with expression being more in OSCC. While comparing EOLP with NOLP; significant differences were seen for cdk4 cytoplasmic staining only, for number of cases with positive staining as well as number of cells stained. Conclusions: Overexpression of cytoplasmic cdk4 and p16 was registered in oral lichen planus, however considerably lower than in squamous cell carcinoma. Erosive oral lichen planus demonstrated overexpression of cytoplasmic cdk4 and premalignant nature compared to non-erosive lesion. Therefore there is an obvious possibility for cytoplasmic expression of cdk4 and p16 to predict malignant potential of oral lichen planus lesions.
    Keywords cell cycle checkpoints ; immunohistochemistry ; lichen planus ; Dentistry ; RK1-715 ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2015-06-01T00:00:00Z
    Publisher STILUS OPTIMUS
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Expression of cdk4 and p16 in Oral Lichen Planus.

    Goel, Sinny / Khurana, Nita / Marwah, Akanksha / Gupta, Sunita

    Journal of oral & maxillofacial research

    2015  Volume 6, Issue 2, Page(s) e4

    Abstract: Objectives: The purpose of this study was to evaluate the expression of cdk4 and p16, the proteins implicated in hyperproliferation and arrest in oral lichen planus and to compare their expression in erosive and non-erosive oral lichen planus and with ... ...

    Abstract Objectives: The purpose of this study was to evaluate the expression of cdk4 and p16, the proteins implicated in hyperproliferation and arrest in oral lichen planus and to compare their expression in erosive and non-erosive oral lichen planus and with normal mucosa and oral squamous cell carcinoma.
    Material and methods: Analysis of cdk4 and p16 expression was done in 43 erosive oral lichen planus (EOLP) and 17 non-erosive oral lichen planus (NOLP) cases, 10 normal mucosa and 10 oral squamous cell carcinoma (OSCC) cases with immunohistochemistry.
    Results: This study demonstrated a significantly increased expression of cytoplasmic cdk4 (80% cases, cells stained - 19.6%), and cytoplasmic p16 (68.3% cases, cells stained - 16.4%) in oral lichen planus (OLP) compared to normal mucosa. cdk4 was much higher in OSCC in both cytoplasm and nuclei compared to normal mucosa. Also, while comparing OLP with positive control, significant difference was noted for cdk4 and p16, with expression being more in OSCC. While comparing EOLP with NOLP; significant differences were seen for cdk4 cytoplasmic staining only, for number of cases with positive staining as well as number of cells stained.
    Conclusions: Overexpression of cytoplasmic cdk4 and p16 was registered in oral lichen planus, however considerably lower than in squamous cell carcinoma. Erosive oral lichen planus demonstrated overexpression of cytoplasmic cdk4 and premalignant nature compared to non-erosive lesion. Therefore there is an obvious possibility for cytoplasmic expression of cdk4 and p16 to predict malignant potential of oral lichen planus lesions.
    Language English
    Publishing date 2015-06-30
    Publishing country Lithuania
    Document type Journal Article
    ZDB-ID 2580511-3
    ISSN 2029-283X
    ISSN 2029-283X
    DOI 10.5037/jomr.2015.6204
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cleidocranial dysplasia

    Shikha Gupta / Sunita Gupta / Khushboo Singh / Prajat Arora / Sinny Goel

    Journal of Oral and Maxillofacial Radiology, Vol 3, Iss 2, Pp 58-

    Spectrum of clinical and radiological findings in seven cases

    2015  Volume 62

    Abstract: Introduction: Cleidocranial dysplasia (CCD) is an autosomal dominant disorder primarily affecting bones, which undergo membranous ossification. It commonly presents with significant dental and facial problems, including the hypoplastic maxilla, retained ... ...

    Abstract Introduction: Cleidocranial dysplasia (CCD) is an autosomal dominant disorder primarily affecting bones, which undergo membranous ossification. It commonly presents with significant dental and facial problems, including the hypoplastic maxilla, retained primary teeth, unerupted permanent teeth and supernumerary teeth. It is usually diagnosed based on clinical and radiographic findings, which are pathognomic. Here, we report clinical and radiographic findings of 7 patients with CCD who reported to our Institute during 2013-2014. Results: Age of patient ranged from 13 to 55 years, out of which 5 were males and 2 were females. Characteristic clinical findings, which were present in all cases include frontal and parietal bossing, brachycephalic skull, hypertelorism, broad nasal bridge and shoulder hypermobility. Radiographic findings seen were hypoplasia/aplasia of the clavicle, open skull suture, wide, open fontanel, and the presence of impacted permanent and supernumerary teeth. In one case, there was follicular cyst associated with impacted mandibular canine. Conclusion: Successful treatment involves a multidisciplinary approach and involves timely diagnosis at an early stage of development
    Keywords Cleidocranial ; dysostosis ; dysplasia ; Marie-Sainton ; Dentistry ; RK1-715 ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Subject code 610
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: The current approach to the diagnosis of vascular anomalies of the head and neck: A pictorial essay.

    Goel, Sinny / Gupta, Swati / Singh, Aarti / Prakash, Anjali / Ghosh, Sujoy / Narang, Poonam / Gupta, Sunita

    Imaging science in dentistry

    2015  Volume 45, Issue 2, Page(s) 123–131

    Abstract: Throughout the years, various classifications have evolved for the diagnosis of vascular anomalies. However, it remains difficult to classify a number of such lesions. Because all hemangiomas were previously considered to involute, if a lesion with ... ...

    Abstract Throughout the years, various classifications have evolved for the diagnosis of vascular anomalies. However, it remains difficult to classify a number of such lesions. Because all hemangiomas were previously considered to involute, if a lesion with imaging and clinical characteristics of hemangioma does not involute, then there is no subclass in which to classify such a lesion, as reported in one of our cases. The recent classification proposed by the International Society for the Study of Vascular Anomalies (ISSVA, 2014) has solved this problem by including non-involuting and partially involuting hemangioma in the classification. We present here five cases of vascular anomalies and discuss their diagnosis in accordance with the ISSVA (2014) classification. A non-involuting lesion should not always be diagnosed as a vascular malformation. A non-involuting lesion can be either a hemangioma or a vascular malformation depending upon its clinicopathologic and imaging characteristics.
    Language English
    Publishing date 2015-06-19
    Publishing country Korea (South)
    Document type Case Reports
    ZDB-ID 2631801-5
    ISSN 2233-7830 ; 2233-7822
    ISSN (online) 2233-7830
    ISSN 2233-7822
    DOI 10.5624/isd.2015.45.2.123
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  7. Article ; Online: Florid osseous dysplasia with Klebsiella associated osteomyelitis and periapical osseous dysplasia in Asian females

    Sinny Goel / Aarti Singh / Anju Garg / Sujoy Ghosh / Shikha Gupta / Sunita Gupta

    Journal of Oral and Maxillofacial Radiology, Vol 3, Iss 1, Pp 19-

    A report of two cases

    2015  Volume 24

    Abstract: Periapical osseous dysplasia (POD) and florid osseous dysplasia (FOD) are benign jaw conditions with normal architecture of bone replaced by fibroblast, collagen fibers and mineralized material. We are presenting a case of FOD with Klebsiella infection ... ...

    Abstract Periapical osseous dysplasia (POD) and florid osseous dysplasia (FOD) are benign jaw conditions with normal architecture of bone replaced by fibroblast, collagen fibers and mineralized material. We are presenting a case of FOD with Klebsiella infection that rarely infects the jaws and a case of POD with rare maxillary involvement and role of cone beam computed tomography (CBCT) in its diagnosis. Evaluation with conventional and higher imaging was done. Pus culture was done for FOD associated infection. The case with POD was followed-up for 2 years to differentiate it from FOD. Case with extensive multiquadrant swellings and discharging sinus was diagnosed as FOD with Klebsiella infection and minor surgery performed successfully under antibiotic coverage. Another case was diagnosed as POD with CBCT, which revealed maxillary lesions not seen in two-dimensional imaging. Diagnosis was confirmed after a long follow-up due to its limited extent. Elective surgery can be performed under antibiotic coverage in FOD. POD can be seen in maxilla, and CBCT and long follow-up have important role in diagnosis.
    Keywords klebsiella ; osseous dysplasia ; osteomyelitis ; Dentistry ; RK1-715 ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Subject code 616
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Role of serum interleukin-6 in deciding therapy for multidrug resistant oral lichen planus.

    Goel, Sinny / Marwah, Akanksha / Kaushik, Smita / Garg, Vijay K / Gupta, Sunita

    Journal of clinical and experimental dentistry

    2015  Volume 7, Issue 4, Page(s) e477–82

    Abstract: Background: Oral lichen planus (OLP) is a T cell mediated immune response. T cells locally present in the involved tissues release cytokines like interleukin-6 (IL-6), which contributes to pathogenesis of OLP. Also IL-6 has been associated with ... ...

    Abstract Background: Oral lichen planus (OLP) is a T cell mediated immune response. T cells locally present in the involved tissues release cytokines like interleukin-6 (IL-6), which contributes to pathogenesis of OLP. Also IL-6 has been associated with multidrug resistance protein (MRP) expression by keratinocytes. Correspondingly, upregulation of MRP was found in OLP. We conducted this study to evaluate the effects of various drugs on serum IL-6 in OLP; and correlation of these effects with the nature of clinical response and resistance pattern seen in OLP lesions with various therapeutic modalities. Thus we evaluated the role of serum IL-6 in deciding therapy for multidrug resistant OLP.
    Material and methods: Serum IL-6 was evaluated in 42 erosive OLP (EOLP) patients and 10 normal mucosa and 10 oral squamous cell carcinoma cases using ELISA technique. OLP patients were randomly divided into 3 groups of 14 patients each and were subjected to Pimecrolimus local application, oral Mycophenolate Mofetil (MMF) and Methotrexate (MTX) alongwith Pimecrolimus local application. IL-6 levels were evaluated before and after treatment.
    Results: Serum IL-6 levels were raised above 3pg/ml in 26.19% erosive OLP (EOLP) cases (mean- 3.72±8.14). EOLP (5%) cases with IL-6 levels above 5pg/ml were resistant in MTX group. However significant decrease in serum IL-6 corresponding with the clinical resolution was seen in MMF group.
    Conclusions: Significantly raised IL-6 levels in EOLP reflect the chronic inflammatory nature of the disease. As serum IL-6 levels significantly decreased in MMF group, correspondingly no resistance to treatment was noted. However with MTX there was no significant decrease in IL-6 and resistance to treatment was noted in some, especially plaque type lesions. Thus IL-6 can be a possible biomarker in deciding the best possible therapy for treatment resistant OLP.
    Key words: Lichen planus, biological markers, cytokines, enzyme-linked immunosorbent assay, immunosuppressive agents.
    Language English
    Publishing date 2015-10-01
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2586647-3
    ISSN 1989-5488
    ISSN 1989-5488
    DOI 10.4317/jced.52376
    Database MEDical Literature Analysis and Retrieval System OnLINE

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